A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Authors: Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison J. Cox, Sanae Miyake, Emma J. Petrie, Michael A. Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatti, Samuel N. Young, Cathrine Hall, Sarah E. Garnish, Jason Corbin, Michael D. Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C. Josefsson, Kristin Rigbye, Holly Anderton, James A. Rickard, Anne Tripaydonis, Julie Sheridan, Thomas S. Scerri, Victoria E. Jackson, Peter E. Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C. Allison, Marc Pellegrini, Gillian M. Tannahill, Esme C. Hatchell, Tracy A. Willson, Dina Stockwell, Carolyn A. de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K. Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M. Laxer, Alexander G. Bassuk, Benjamin W. Darbro, Maria A. Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David B. Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S. Hildebrand, Carola G. Vinuesa, Pamela McCombe, Matthew A. Brown, Benjamin T. Kile, Catriona McLean, Melanie Bahlo, Seth L. Masters, Hiroyasu Nakano, Polly J. Ferguson, James M. Murphy, Warren S. Alexander, John Silke

Source: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/eb684694de314067aac5b53c9a7c86cd

BCR-ABL1 Tyrosine Kinase Complex Signaling Transduction: Challenges to Overcome Resistance in Chronic Myeloid Leukemia

Authors: Gustavo P. Amarante-Mendes, Aamir Rana, Tarcila Santos Datoguia, Nelson Hamerschlak, Gabriela Brumatti

Source: Pharmaceutics, Vol 14, Iss 1, p 215 (2022)

Subject Terms: BCR-ABL1, chronic myeloid leukemia, tyrosine kinase inhibitors, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/1/215; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/93582f21368f4acba2d5ee7a24ad8718

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

Authors: Nicole L. Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J. Sandow, Melanie K. Pudney, Mara Dottore, Richard J. D'Andrea, Angel F. Lopez, Paul G. Ekert, Hayley S. Ramshaw

Source: Blood Advances, Vol 1, Iss 15, Pp 1067-1079 (2017)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920302202; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/06a3c0aaf2114e6a92cf5ba3f7cf2246

Combinatorial Treatment of Birinapant and Zosuquidar Enhances Effective Control of HBV Replication In Vivo

Authors: Emma Morrish, Liana Mackiewicz, Natasha Silke, Marc Pellegrini, John Silke, Gabriela Brumatti, Gregor Ebert

Source: Viruses, Vol 12, Iss 8, p 901 (2020)

Subject Terms: HBV, inhibitor of apoptosis proteins, IAP, IAP antagonist, Smac-mimetics, TNF, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/12/8/901; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/7539cde5a1dd4d14aa1973938e0299db

Future Therapeutic Directions for Smac-Mimetics

Authors: Emma Morrish, Gabriela Brumatti, John Silke

Source: Cells, Vol 9, Iss 2, p 406 (2020)

Subject Terms: smac/diablo, smac-mimetics, iaps, tnf, cell death, cancer, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/2/406; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/409ecd0ba5354ab998fdd451c56dff83

Correction: Bicaudal Is a Conserved Substrate for and Mammalian Caspases and Is Essential for Cell Survival.

Authors: Emma M. Creagh, Gabriela Brumatti, Clare Sheridan, Patrick J. Duriez, Rebecca C. Taylor, Sean P. Cullen, Colin Adrain, Seamus J. Martin

Source: PLoS ONE, Vol 4, Iss 3 (2009)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2669221; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a27ece0e923643e0b3a0f8c3bf9eeb2f

Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival.

Authors: Emma M Creagh, Gabriela Brumatti, Clare Sheridan, Patrick J Duriez, Rebecca C Taylor, Sean P Cullen, Colin Adrain, Seamus J Martin

Source: PLoS ONE, Vol 4, Iss 3, p e5055 (2009)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19330035/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2694c5ed2a8849ef8cf7796054f2aa09