Synthesis and in vitro evaluation of benzo[b]thiophene-3-carboxylic acid 1,1-dioxide derivatives as anticancer agents targeting the RhoA/ROCK pathway.

Authors: Liang, Jinhao¹ (AUTHOR), Huang, Jin¹ (AUTHOR), Yang, Jianzhan¹ (AUTHOR), Liang, Weihong^1,2 (AUTHOR), Li, Haoxiang¹ (AUTHOR), Wu, Yunshan^1,2 (AUTHOR), Liu, Bo^1,2,3 (AUTHOR) doctliu@263.net

Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2024, Vol. 39 Issue 1, p1-15. 15p.

Subject Terms: *RHO GTPases, *ANTINEOPLASTIC agents, *ACID derivatives, *STRUCTURE-activity relationships, *MOLECULAR docking

Clearing Amyloid-Beta by Astrocytes: The Role of Rho GTPases Signaling Pathways as Potential Therapeutic Targets.

Authors: Park, Gyeongah¹ (AUTHOR) gpark4@uthsc.edu, Jin, Zhen² (AUTHOR) zjin6@uthsc.edu, Lu, Hui³ (AUTHOR) huilu@email.gwu.edu, Du, Jianyang¹ (AUTHOR) jdu15@uthsc.edu

Source: Brain Sciences (2076-3425). Dec2024, Vol. 14 Issue 12, p1239. 18p.

Subject Terms: *RHO GTPases, *ALZHEIMER'S disease, *CENTRAL nervous system, *DISEASE progression, *PREPROENDOTHELIN

AAMP and MTSS1 Are Novel Negative Regulators of Endothelial Barrier Function Identified in a Proteomics Screen.

Authors: Podieh, Fabienne¹ (AUTHOR) f.a.podieh@amsterdamumc.nl, Overboom, Max C.¹ (AUTHOR), Knol, Jaco C.² (AUTHOR) c.jimenez@amsterdamumc.nl, Piersma, Sander R.² (AUTHOR), Goeij-de Haas, Richard² (AUTHOR), Pham, Thang V.² (AUTHOR), Jimenez, Connie R.² (AUTHOR), Hordijk, Peter L.¹ (AUTHOR) p.hordijk@amsterdamumc.nl

Source: Cells (2073-4409). Oct2024, Vol. 13 Issue 19, p1609. 22p.

Subject Terms: *UBIQUITIN ligases, *RHO GTPases, *PROTEOMICS, *TISSUE adhesions, *ENDOTHELIAL cells

Cortactin is in a complex with VE-cadherin and is required for endothelial adherens junction stability through Rap1/Rac1 activation.

Authors: Moztarzadeh, Sina¹ (AUTHOR), Sepic, Sara¹ (AUTHOR), Hamad, Ibrahim¹ (AUTHOR), Waschke, Jens¹ (AUTHOR), Radeva, Mariya Y.¹ (AUTHOR), García-Ponce, Alexander¹ (AUTHOR) alexander.garcia@med.uni-muenchen.de

Source: Scientific Reports. 1/12/2024, Vol. 14 Issue 1, p1-18. 18p.

Subject Terms: *ADHERENS junctions, *RHO GTPases, *CYTOSKELETON, *CELLULAR signal transduction, *ENDOTHELIAL cells, *CLAUDINS

The Important Role of p21-Activated Kinases in Pancreatic Exocrine Function.

Authors: Ramos-Alvarez, Irene¹ (AUTHOR) irene.ramosalvarez@nih.gov, Jensen, Robert T.¹ (AUTHOR) robertj@bdg10.niddk.nih.gov

Source: Biology (2079-7737). Feb2025, Vol. 14 Issue 2, p113. 34p.

Subject Terms: *PROTEIN kinases, *RHO GTPases, *PANCREATIC secretions, *PANCREATIC cancer, *CELL motility

RhoU forms homo-oligomers to regulate cellular responses.

Authors: Clayton, Natasha S.¹, Hodge, Richard G.², Infante, Elvira², Alibhai, Dominic³, Zhou, Felix^4,5, Ridley, Anne J.^1,2 anne.ridley@bristol.ac.uk

Source: Journal of Cell Science. Jan2025, Vol. 138 Issue 2, p1-10. 10p.

Subject Terms: *RHO GTPases, *GENE expression, *CELL morphology, *CELL migration, *ISOPRENYLATION

Function of a complex of p‐Y42 RhoA GTPase and pyruvate kinase M2 in EGF signaling pathway in glioma cells.

Authors: Lee, Yoon‐Beom^1,2 (AUTHOR), Park, Yohan¹ (AUTHOR), Hamza, Amir^1,2 (AUTHOR), Min, Jung Ki¹ (AUTHOR), Dogsom, Oyungerel^1,3 (AUTHOR), Kim, Sung‐Chan¹ (AUTHOR), Park, Jae‐Bong^1,2,4 (AUTHOR) jbpark@hallym.ac.kr

Source: Journal of Neurochemistry. Jan2025, Vol. 169 Issue 1, p1-17. 17p.

Subject Terms: *GLIOMAS, *RHO GTPases, *UBIQUITINATION, *CATENINS, *EPIDERMAL growth factor receptors, *PYRUVATE kinase, *GENE expression, *PHOSPHORYLATION

Regulation and signaling of the LIM domain kinases.

Authors: Casanova‐Sepúlveda, Gabriela¹ (AUTHOR), Boggon, Titus J.^1,2,3 (AUTHOR) titus.boggon@yale.edu

Source: BioEssays. Jan2025, Vol. 47 Issue 1, p1-14. 14p.

Subject Terms: *CYTOSKELETON, *RHO GTPases, *WILLIAMS syndrome, *KINASES, *GUANOSINE triphosphatase

Mechanisms of Rho GTPases in regulating tumor proliferation, migration and invasion.

Authors: Liu, Cheng¹ (AUTHOR) 19923011798@163.com, Chen, Shutao¹ (AUTHOR) cst16634254665@163.com, Zhang, Yu¹ (AUTHOR) zhangyu5799@outlook.com, Zhou, Xinyi¹ (AUTHOR) a524448729@163.com, Wang, Haiwei² (AUTHOR) wahwe@163.com, Wang, Qigui^1,2 (AUTHOR) wangqigui@hotmail.com, Lan, Xi¹ (AUTHOR) xlan104@swu.edu.cn

Source: Cytokine & Growth Factor Reviews. Dec2024, Vol. 80, p168-174. 7p.

Subject Terms: *RHO GTPases, *CANCER cell proliferation, *CELL polarity, *CANCER invasiveness, *CELL division

Regulation of yeast polarized exocytosis by phosphoinositide lipids.

Authors: Volpiana, Matthew W.¹ (AUTHOR), Nenadic, Aleksa¹ (AUTHOR), Beh, Christopher T.^1,2 (AUTHOR) ctbeh@sfu.ca

Source: Cellular & Molecular Life Sciences. 11/19/2024, Vol. 81 Issue 1, p1-21. 21p.

Subject Terms: *RHO GTPases, *EUKARYOTIC cells, *CELL membranes, *EXOCYTOSIS, *SACCHAROMYCES cerevisiae

Stub1 promotes degradation of the activated Diaph3: A negative feedback regulatory mechanism of the actin nucleator.

Authors: Cui Qiu¹, Linqing Zhang¹, Chenxuan Yong¹, Ruixing Hu², Yuecen Sun¹, Busong Wang³, Lei Fang³, Guang-Jie Zhu^1,4, Qing Lu², Junguo Wang^1,4 wangjunguo2821@163.com, Xiaofeng Ma^1,4 mxfent@126.com, Luping Zhang⁵ zhanglp910@126.com, Guoqiang Wan^1,3,4 guoqiangwan@nju.edu.cn

Source: Journal of Biological Chemistry. Oct2024, Vol. 300 Issue 10, p1-15. 15p.

Subject Terms: *AUDITORY neuropathy, *RHO GTPases, *UBIQUITIN ligases, *INTERMOLECULAR interactions, *HAIR cells

Expression of Concern: Novel Split-Luciferase-Based Genetically Encoded Biosensors for Noninvasive Visualization of Rho GTPases.

Source: PLoS ONE. 6/23/2023, Vol. 18 Issue 6, p1-4. 4p.

Subject Terms: *RHO GTPases, *DATA visualization, *RENILLA luciferase, *EMISSION exposure

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro.

Authors: Koch, Daniel¹ (AUTHOR) dkoch.research@protonmail.com, Kho, Ay Lin¹ (AUTHOR), Fukuzawa, Atsushi¹ (AUTHOR), Alexandrovich, Alexander¹ (AUTHOR), Vanaanen, Kutti J.¹ (AUTHOR), Beavil, Andrew¹ (AUTHOR), Pfuhl, Mark¹ (AUTHOR), Rees, Martin¹ (AUTHOR) dkoch.research@protonmail.com, Gautel, Mathias¹ (AUTHOR) dkoch.research@protonmail.com

Source: PLoS ONE. 4/20/2023, Vol. 18 Issue 4, p1-23. 23p.

Subject Terms: *NUCLEOTIDE exchange factors, *RHO GTPases, *KINASES, *MUSCLE proteins, *GUANOSINE

Golgi screen identifies the RhoGEF Solo as a novel regulator of RhoB and endocytic transport.

Authors: Lungu, Cristiana^1,2 (AUTHOR), Meyer, Florian¹ (AUTHOR), Hörning, Marcel^2,3 (AUTHOR), Steudle, Jasmin¹ (AUTHOR), Braun, Anja¹ (AUTHOR), Noll, Bettina^1,2 (AUTHOR), Benz, David¹ (AUTHOR), Fränkle, Felix¹ (AUTHOR), Schmid, Simone¹ (AUTHOR), Eisler, Stephan A.^1,2 (AUTHOR), Olayioye, Monilola A.^1,2 (AUTHOR) monilola.olayioye@izi.uni-stuttgart.de

Source: Traffic. Apr2023, Vol. 24 Issue 4, p162-176. 15p.

Subject Terms: *GUANINE nucleotide exchange factors, *RHO GTPases

Rho GTPase Regulatory Proteins Contribute to Podocyte Morphology and Function.

Authors: Foxman, Emily¹ emily.foxman@mail.mcgill.ca, Ibrahim, Sajida², Tomoko Takano^2,3

Source: McGill Science Undergraduate Research Journal. Mar2023, Vol. 18 Issue 1, pA11-A17. 7p.

Subject Terms: *RHO GTPases, *NUCLEOTIDE exchange factors, *FILOPODIA

Rho GTPases in Model Systems.

Authors: Filić, Vedrana¹ (AUTHOR) vedrana.filic@irb.hr, Weber, Igor¹ (AUTHOR) vedrana.filic@irb.hr

Source: Cells (2073-4409). Mar2023, Vol. 12 Issue 5, p779. 4p.

Subject Terms: *RHO GTPases, *CELL adhesion molecules, *RAS proteins, *CELL motility, *PHAGOCYTOSIS, *INSULIN receptors

Transient Structural Properties of the Rho GDP‐Dissociation Inhibitor.

Authors: Medina Gomez, Sara¹ (AUTHOR), Visco, Ilaria² (AUTHOR), Merino, Felipe³ (AUTHOR), Bieling, Peter² (AUTHOR) peter.bieling@mpi-dortmund.mpg.de, Linser, Rasmus¹ (AUTHOR) rasmus.linser@tu-dortmund.de

Source: Angewandte Chemie International Edition. 8/19/2024, Vol. 63 Issue 34, p1-10. 10p.

Subject Terms: *RHO GTPases, *PEPTIDES, *MOLECULAR dynamics, *NUCLEAR magnetic resonance spectroscopy, *SURFACE interactions

Understanding P-Rex regulation: structural breakthroughs and emerging perspectives.

Authors: Jones, Gareth D.¹, Ellisdon, Andrew M.¹ andrew.ellisdon@monash.edu

Source: Biochemical Society Transactions. Aug2024, Vol. 52 Issue 4, p1849-1860. 12p.

Subject Terms: *GUANINE nucleotide exchange factors, *RHO GTPases, *PROTEIN-protein interactions, *CANCER invasiveness, *GUANOSINE triphosphatase

Activation Mechanism of RhoA Caused by Constitutively Activating Mutations G14V and Q63L.

Authors: Chen, Shiyao¹ (AUTHOR), Zhang, Zirui¹ (AUTHOR), Zhang, Yijing¹ (AUTHOR), Choi, Taeyoung¹ (AUTHOR), Zhao, Yaxue¹ (AUTHOR) yaxuezhao@sjtu.edu.cn

Source: International Journal of Molecular Sciences. Dec2022, Vol. 23 Issue 24, p15458. 18p.

Subject Terms: *RHO GTPases, *GUANOSINE triphosphate, *MOLECULAR dynamics, *HYDROPHOBIC interactions, *BACTERIAL diseases

Small G protein RAC‐2 regulates forgetting via the JNK‐1 signalling pathway in Caenorhabditis elegans.

Authors: Bai, Hua^1,2 (AUTHOR), Huang, Hui¹ (AUTHOR), Zhao, Ninghui³ (AUTHOR), Gu, Huan¹ (AUTHOR), Li, Yixin¹ (AUTHOR), Zou, Wei² (AUTHOR), Wu, Tingting³ (AUTHOR), Huang, Xiaowei¹ (AUTHOR) xwhuang@ynu.edu.cn

Source: European Journal of Neuroscience. Dec2022, Vol. 56 Issue 12, p6162-6173. 12p. 2 Color Photographs, 4 Graphs.

Subject Terms: *CAENORHABDITIS elegans, *RHO GTPases, *CELLULAR signal transduction, *G proteins, *GUANOSINE triphosphate