In-silico Screening of Arjun Plant (Terminalia arjuna) Compounds Against Cardiovascular Disease Targeting GRK2 Protein

Authors: Asaduzzaman, Md., Alom, Jahangir, Alam, Mohammad Taufiq, Karim, Md Anwarul

Source: 2021 International Conference on Computer, Communication, Chemical, Materials and Electronic Engineering (IC4ME2) Computer, Communication, Chemical, Materials and Electronic Engineering (IC4ME2),. :1-4 Dec, 2021

Relation: 2021 International Conference on Computer, Communication, Chemical, Materials and Electronic Engineering (IC4ME2)

Therapeutic Efficacy of a Novel Pharmacologic GRK2 Inhibitor in Multiple Animal Models of Heart Failure

Authors: Roy, Rajika ^{a, b}, Schumacher, Sarah M. ^c, Murphy, Haley Christine ^a, Grondolsky, Jessica ^c, Rosales, Thiele Osvaldt ^{a, b}, Chuprun, J. Kurt ^{a, b}, Gao, Erhe ^a, Zhao, Huaqing ^d, Berretta, Remus M. ^e, Hobby, Alexander R.H. ^e, Houser, Steven R. ^e, Avramova, Larisa V. ^{f, g}, Tesmer, John J.G. ^{f, g}, Koch, Walter J. ^{a, b, ∗}

Source: In JACC: Basic to Translational Science February 2025 10(2):202-217

Inhibition of GRK2 reduced doxorubicin-induced oxidative stress and apoptosis through upregulating ADH1

Authors: Jiang, Zihao ¹, Kan, Junyan ¹, Wang, Dongchen ¹, Lv, Yifei, Kong, Chaohua, Wu, Lida, Chen, Yunwei, Yang, Meng, Gu, Yue ^⁎, Chen, ShaoLiang ^⁎

Source: In Toxicology and Applied Pharmacology April 2025 497

GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis

Authors: Xuezhi Yang, Yingjie Zhao, Qi Wei, Xuemin Zhu, Luping Wang, Wankang Zhang, Xiaoyi Liu, Jiajie Kuai, Fengling Wang, Wei Wei

Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 1, Pp 241-255 (2024)

Subject Terms: GRK2, Monocyte-derived macrophages, Rheumatoid arthritis, PPARγ, Flt-1, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383523003660; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/f6639b3b6e3047ac96e86736878025d0

Nicotine Diminishes Alpha2-Adrenergic Receptor-Dependent Protection Against Oxidative Stress in H9c2 Cardiomyocytes

Authors: Del Calvo G, Pollard CM, Baggio Lopez T, Borges JI, Suster MS, Lymperopoulos A

Source: Drug Design, Development and Therapy, Vol Volume 18, Pp 71-80 (2024)

Subject Terms: α2-adrenergic receptor, oxidative stress, cardiac myocyte, nicotine, grk2, signal transduction, desensi-tization, α2-adrenergic agonist, adenylyl cyclase, superoxide dismutase., Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/nicotine-diminishes-alpha2-adrenergic-receptor-dependent-protection-ag-peer-reviewed-fulltext-article-DDDT; https://doaj.org/toc/1177-8881

Access URL: https://doaj.org/article/e94eac979d3240cd84145f79c3505448

A simple and scalable zebrafish model of Sonic hedgehog medulloblastoma

Authors: Casey, Mattie J. ¹, Chan, Priya P. ^{2, 3}, Li, Qing ⁴, Zu, Ju-Fen ^{1, 5, 6}, Jette, Cicely A. ¹, Kohler, Missia ⁷, Myers, Benjamin R. ^{1, 5, 6}, Stewart, Rodney A. ^{1, 8, ∗}

Source: In Cell Reports 27 August 2024 43(8)

GRK2 Protein Mediates the ANRIL, a lncRNA, to Affect the Proliferation and Apoptosis of Kasumi-1 Cells

Authors: Siqi Wang, Chengsi Zhang, Huali Hu, Jianxia Xu, Jinxin Zhang, Wu Zhou, Fahua Deng, Yaming Zhang, Chenlong Hu, Yuancheng Liu, Hai Huang, Sixi Wei

Source: Frontiers in Bioscience-Landmark, Vol 29, Iss 10, p 362 (2024)

Subject Terms: acute myeloid leukemia, anril, grk2, proliferation, apoptosis, pi3k/akt/bcl-2 pathway, Biochemistry, QD415-436, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.imrpress.com/journal/FBL/29/10/10.31083/j.fbl2910362; https://doaj.org/toc/2768-6701

Access URL: https://doaj.org/article/db26cf3a504644e59697ac32888226f6

Paeoniflorin-6’-O-benzene sulfonate inhibits keratinocyte proliferation by restoring GRK2-JAK1 colocalization in mouse model of psoriasis

Authors: Tian, Tian ¹, Wei, Mengzhu ¹, Guan, Yanling ¹, Rao, Lulu, Luo, Tingting, Han, Chenchen ^⁎, Wei, Wei ^⁎, Ma, Yang ^⁎

Source: In Cellular Signalling July 2025 131

The selective serotonin reuptake inhibitor paroxetine improves right ventricular systolic function in experimental pulmonary hypertension

Authors: Mark T. Waddingham, Hirotsugu Tsuchimochi, Takashi Sonobe, Vasco Sequeira, Md Junayed Nayeem, Mikiyasu Shirai, James T. Pearson, Takeshi Ogo

Source: Journal of Molecular and Cellular Cardiology Plus, Vol 8, Iss , Pp 100072- (2024)

Subject Terms: Pulmonary hypertension, Right ventricular function, Paroxetine, Selective serotonin reuptake inhibitor, Myofilament protein phosphorylation, G protein-coupled receptor kinase 2 (GRK2), Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772976124000126; https://doaj.org/toc/2772-9761

Access URL: https://doaj.org/article/c799fd064dab4b7da859a49b8d77c099

Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake

Authors: Seungmin Ham, Saori Mukaida, Masaaki Sato, Peter Keov, Tore Bengtsson, Sebastian Furness, Nicholas D. Holliday, Bronwyn A. Evans, Roger J. Summers, Dana S. Hutchinson

Source: Pharmacology Research & Perspectives, Vol 12, Iss 1, Pp n/a-n/a (2024)

Subject Terms: glucose uptake, GRK2, β2 adrenoceptor, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2052-1707

Access URL: https://doaj.org/article/8b05f72e8cfe40dba5549ad1377f554f

GRK2 differentially regulates FcεRI and MRGPRB2-mediated responses in mast cells

Authors: Monica Thapaliya, Hydar Ali

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: MRGPRX2/MRGPRB2, GRK2, itch, anaphylaxis, mast cells, FcεRI, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1155777/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/729f8b864fc1416c8a2004a3068508e5

GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2

Authors: Monica Thapaliya, Aetas Amponnawarat, John J. G. Tesmer, Hydar Ali

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: GRK2, paroxetine, mast cells, MRGPRX2, FcϵRI, anaphylaxis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1032497/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/26fc1329f9ae43bcada9a57b6be7c3cc

GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo

Authors: Alba C. Arcones, Rocío Vila-Bedmar, Mercedes Mirasierra, Marta Cruces-Sande, Mario Vallejo, Ben Jones, Alejandra Tomas, Federico Mayor, Cristina Murga

Source: BMC Biology, Vol 19, Iss 1, Pp 1-16 (2021)

Subject Terms: Insulin signaling, Incretin, G protein-coupled receptor kinase 2 (GRK2), Glucagon-like peptide 1 (GLP-1), β-arrestin, Granule dynamics, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7007

Access URL: https://doaj.org/article/ccbf37cbd62e460a8e2fb12157b56767

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling

Authors: Michaela Bosakova, Sara P Abraham, Alexandru Nita, Eva Hruba, Marcela Buchtova, S Paige Taylor, Ivan Duran, Jorge Martin, Katerina Svozilova, Tomas Barta, Miroslav Varecha, Lukas Balek, Jiri Kohoutek, Tomasz Radaszkiewicz, Ganesh V Pusapati, Vitezslav Bryja, Eric T Rush, Isabelle Thiffault, Deborah A Nickerson, Michael J Bamshad, University of Washington Center for Mendelian Genomics, Rajat Rohatgi, Daniel H Cohn, Deborah Krakow, Pavel Krejci

Source: EMBO Molecular Medicine, Vol 12, Iss 11, Pp 1-20 (2020)

Subject Terms: asphyxiating thoracic dystrophy, GRK2, hedgehog, smoothened, Wnt, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/83076ddc0da44600bc5e023ad4e46b45

Novel inhibitors of phosphorylation independent activity of GRK2 modulate cAMP signaling

Authors: Emiliana Echeverría, Sonia Ripoll, Lucas Fabián, Carina Shayo, Federico Monczor, Natalia C. Fernández

Source: Pharmacology Research & Perspectives, Vol 10, Iss 2, Pp n/a-n/a (2022)

Subject Terms: CADD, desensitization, GPCR, GRK2, RGS, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2052-1707

Access URL: https://doaj.org/article/33d0ffbbca0540c589fe3d44a3fc7aac

G Protein-Coupled Receptor Kinase 2 as Novel Therapeutic Target in Fibrotic Diseases

Authors: Nan Li, Shan Shan, Xiu-Qin Li, Ting-Ting Chen, Meng Qi, Sheng-Nan Zhang, Zi-Ying Wang, Ling-Ling Zhang, Wei Wei, Wu-Yi Sun

Source: Frontiers in Immunology, Vol 12 (2022)

Subject Terms: G protein-coupled receptor kinase 2 (GRK2), G protein-coupled receptors, fibrosis, phosphorylation, ECM - extracellular matrix, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.822345/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/40834aff4d454f3f8b9d8a6e12e781fe

Development of Inflammatory Immune Response-Related Drugs Based on G Protein-Coupled Receptor Kinase 2

Authors: Chenchen Han, Yifan Li, Yang Wang, Dongqian Cui, Tingting Luo, Yuwen Zhang, Yang Ma, Wei Wei

Source: Cellular Physiology and Biochemistry, Vol 51, Iss 2, Pp 729-745 (2018)

Subject Terms: Inflammatory immune response (IIR), Soft regulation of inflammatory immune responses (SRIIR), G protein-coupled receptor kinase 2 (GRK2), GRK2 inhibitors, Disease, Physiology, QP1-981, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://www.karger.com/Article/FullText/495329; https://doaj.org/toc/1015-8987; https://doaj.org/toc/1421-9778

Access URL: https://doaj.org/article/b233b62b9cd047fc8c31aa153ab1ce1b

Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis

Authors: Zi Lv, Li-ling Xiong, Xian Qin, Hua Zhang, Xin Luo, Wei Peng, Mark D. Kilby, Richard Saffery, Philip N. Baker, Hong-bo Qi

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: GRK2, necroptosis, preeclampsia, trophoblast, cell death, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.694261/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/0b3eaa4c576049f486867c818eab1535

Specialized structural and functional roles of residues selectively conserved in subfamilies of the pleckstrin homology domain family

Authors: Nagarajan Naveenkumar, Ramanathan Sowdhamini, Narayanaswamy Srinivasan

Source: FEBS Open Bio, Vol 9, Iss 11, Pp 1848-1859 (2019)

Subject Terms: Arf6, ARNO, GRK2, multidomain proteins, PH domain, phosphoinositide binding, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2211-5463

Access URL: https://doaj.org/article/f3d96cf0a2ea4ad0a996cd888729b9af

Potential Regulatory Roles of GRK2 in Endothelial Cell Activity and Pathological Angiogenesis

Authors: Jiajie Kuai, Chenchen Han, Wei Wei

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: GRK2, GPCRs, endothelial cells, activity, angiogenesis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.698424/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/ba7ce2285df24c5e9fd9cc1386905e91