The transformation pathways and optimization of conditions for preparation minor ginsenosides from Panax notoginseng root by the fungus Aspergillus tubingensis.

Authors: Li, Fei-Xing¹ (AUTHOR), Lin, Dong-Mei¹ (AUTHOR), Yang, Jin¹ (AUTHOR), Cui, Xiu-Ming¹ (AUTHOR), Yang, Xiao-Yan^1,2 (AUTHOR) yangxy@kust.edu.cn

Source: PLoS ONE. 3/3/2025, Vol. 20 Issue 3, p1-14. 14p.

Subject Terms: *GINSENOSIDES, *MOLECULAR weights, *BIOCONVERSION, *SAPONINS, *PANAX

Biosynthesis of a Novel Ginsenoside with High Anticancer Activity by Recombinant UDP-Glycosyltransferase and Characterization of Its Biological Properties.

Authors: Wang, Dandan¹ (AUTHOR), Jin, Yan² (AUTHOR), Wang, Hongtao^1,3 (AUTHOR), Zhang, Chenwei^1,4 (AUTHOR), Li, Yao^1,5 (AUTHOR) jinyan224@hotmail.com, Subramaniyam, Sathiyamoorthy^1,3 (AUTHOR), Sohng, Jae-Kyung^2,4 (AUTHOR), Baek, Nam-In^3,5 (AUTHOR), Kim, Yeon-Ju^4,5 (AUTHOR) yeonjukim@khu.ac.kr

Source: Molecules. Feb2025, Vol. 30 Issue 4, p898. 17p.

Subject Terms: *GINSENOSIDES, *STOMACH cancer, *MOLECULAR docking, *PROTEIN structure, *INTERMOLECULAR interactions, *PROTEIN-ligand interactions

Coordinated gene expression and hormonal fluxes dictating ginsenoside Rb3 biosynthesis in floral development of Panax notoginseng.

Authors: Wang, Can¹ (AUTHOR), Sun, Hongwei¹ (AUTHOR), Yang, Yuling¹ (AUTHOR), Peng, Cuixian¹ (AUTHOR), Liu, Yuan^2,3 (AUTHOR) liuyuan513@kust.edu.cn, Tao, Yonghong¹ (AUTHOR) taoyhcaas@sina.cn

Source: BMC Plant Biology. 2/10/2025, Vol. 25, p1-18. 18p.

Subject Terms: *TRANSCRIPTION factors, *GINSENOSIDES, *LIFE sciences, *CYTOLOGY, *GENE regulatory networks

Experimental Validation of Antiobesogenic and Osteoprotective Efficacy of Ginsenoside CK via Targeting Lipid and Atherosclerosis Pathways.

Authors: Morshed, Md. Niaj^1,2 (AUTHOR) niajmorshed96@khu.ac.kr, Akter, Reshmi² (AUTHOR) kbg02076@naver.com, Mahmud, Imran³ (AUTHOR) imrmah@utu.fi, Gwon, Ah-Yeong² (AUTHOR) jinjang1218@nmr.kr, Jeang, Jin Woo² (AUTHOR) lyg629@khu.ac.kr, Lee, Yeong-Geun² (AUTHOR) parkdw@genencell.co.kr, Park, Dae Won² (AUTHOR) dcyang@khu.ac.kr, Yang, Deok Chun² (AUTHOR), Kim, Yeon Ju² (AUTHOR) yeonjukim@khu.ac.kr, Kang, Se-Chan² (AUTHOR) yeonjukim@khu.ac.kr

Source: Life (2075-1729). Jan2025, Vol. 15 Issue 1, p41. 14p.

Subject Terms: *REGULATOR genes, *GINSENOSIDES, *ALKALINE phosphatase, *OBESOGENIC environment, *GENE expression, *ADIPOGENESIS

Ginsenoside Rg1: A Neuroprotective Natural Dammarane‐Type Triterpenoid Saponin With Anti‐Depressive Properties.

Authors: Han, Dong¹ (AUTHOR), Zhao, Zheng² (AUTHOR), Mao, Tinghui³ (AUTHOR), Gao, Man⁴ (AUTHOR), Yang, Xue¹ (AUTHOR), Gao, Yan¹ (AUTHOR) cmu_gaoyan@163.com

Source: CNS Neuroscience & Therapeutics. Dec2024, Vol. 30 Issue 12, p1-26. 26p.

Subject Terms: *GINSENOSIDES, *GINSENG, *PROTEIN synthesis, *MOLECULAR docking, *MENTAL depression, *SUICIDE victims

A Novel Ginsenoside-Transforming α-L-Rhamnosidase from Bifidobacterium : Screening, Characterization and Application.

Authors: Cui, Chang-Hao¹ (AUTHOR) cchanghao@sempio.com, Shin, Doohang¹ (AUTHOR) sdoohang@sempio.com, Hurh, Byung-Serk¹ (AUTHOR) hbyungserk@sempio.com, Im, Wan-Taek^2,3 (AUTHOR) hbyungserk@sempio.com

Source: Biomolecules (2218-273X). Dec2024, Vol. 14 Issue 12, p1611. 16p.

Subject Terms: *ESCHERICHIA coli, *GINSENOSIDES, *THERMAL stability, *FUNCTIONAL foods, *BIOCONVERSION

Ginsenoside Rg1 Prevents and Treats Acute Pulmonary Injury Induced by High-Altitude Hypoxia.

Authors: Chen, Junru^1,2 (AUTHOR) 15088094928@163.com, Zhang, Zhuo² (AUTHOR) 15907489303@163.com, Huang, Mingyue² (AUTHOR) yjy19951025@163.com, Yan, Jiayi^2,3 (AUTHOR) cuijialu143021@163.com, Gao, Rong^1,2 (AUTHOR) gaoronger198@163.com, Cui, Jialu^2,3 (AUTHOR), Gao, Yue^1,2 (AUTHOR) gaoyue@bmi.ac.cn, Ma, Zengchun^1,2 (AUTHOR) gaoyue@bmi.ac.cn

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p12051. 20p.

Subject Terms: *GINSENOSIDES, *SHEARING force, *REACTIVE oxygen species, *OXYGEN in the blood, *BLOOD gases

Ginsenoside Rg3 Improved Age-Related Macular Degeneration Through Inhibiting ROS-Mediated Mitochondrion-Dependent Apoptosis In Vivo and In Vitro.

Authors: Hu, Rui-Yi¹ (AUTHOR) hry221510@163.com, Qi, Si-Min¹ (AUTHOR) ms77_1998@163.com, Wang, Ya-Jun^1,2 (AUTHOR) wangyj559@jlau.edu.cn, Li, Wen-Lin¹ (AUTHOR) liwenlin9974@163.com, Zou, Wan-Chen^1,2 (AUTHOR) wanchenzou@163.com, Wang, Zi¹ (AUTHOR) z.wang@jlau.edu.cn, Ren, Shen¹ (AUTHOR) rs0109@163.com, Li, Wei^1,2 (AUTHOR) rs0109@163.com

Source: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11414. 16p.

Subject Terms: *MACULAR degeneration, *GINSENOSIDES, *REACTIVE oxygen species, *DIABETIC retinopathy, *CHROMATOPHORES, *RHODOPSIN

Ginsenoside Rg1 Regulates the Activation of Astrocytes Through lncRNA‐Malat1/miR‐124‐3p/Lamc1 Axis Driving PI3K/AKT Signaling Pathway, Promoting the Repair of Spinal Cord Injury.

Authors: Zhu, Yin^1,2 (AUTHOR), Zou, Wenjun¹ (AUTHOR), Sun, Baihan^1,3 (AUTHOR), Shen, Kelv¹ (AUTHOR), Xia, Feiyun¹ (AUTHOR), Wang, Hao¹ (AUTHOR), Jiang, Fengxian¹ (AUTHOR), Lu, Zhengfeng¹ (AUTHOR) lzf@suda.edu.cn

Source: CNS Neuroscience & Therapeutics. Nov2024, Vol. 30 Issue 11, p1-13. 13p.

Subject Terms: *SPINAL cord injuries, *GINSENOSIDES, *HINDLIMB, *CELLULAR signal transduction, *WESTERN immunoblotting

人参皂苷 Rb1 和 Rg1 体外消化产物的 UHPLC-TSQ MS 分析.

Alternate Title: Analysis of Ginsenosides Rb1 and Rg1 Digestion Products in vitro Based on UHPLC-TSQ MS.

Authors: 牛华周¹, 郭雨欣¹, 周婷¹, 李慧¹, 吴巍¹

Source: Journal of Chinese Mass Spectrometry Society. Nov2024, Vol. 45 Issue 6, p800-809. 10p.

Subject Terms: *GINSENOSIDES, *GASTRIC juice, *GASTROINTESTINAL contents, *ALIMENTARY canal, *MASS spectrometry

A Novel Biosynthetic Strategy for Ginsenoside Ro: Construction of a Metabolically Engineered Saccharomyces cerevisiae Strain Using a Newly Identified UGAT Gene from Panax ginseng as the Key Enzyme Gene and Optimization of Fermentation Conditions.

Authors: Yu, Xiaochen¹ (AUTHOR) yu-xiaochen@foxmail.com, Yu, Jinghui¹ (AUTHOR) jinghui-yu@foxmail.com, Wang, Dinghui¹ (AUTHOR) dinghui-wang@foxmail.com, Liu, Sizhang¹ (AUTHOR) lsz512411412@163.com, Wang, Kangyu^1,2 (AUTHOR) kangyu.wang@jlau.edu.cn, Zhao, Mingzhu^1,2 (AUTHOR) mingzhuzhao@jlau.edu.cn, Chen, Ping^1,2 (AUTHOR) chenping201407@126.com, Wang, Yanfang³ (AUTHOR) yfwang2014@163.com, Wang, Yi^1,2 (AUTHOR) yi.wang@jlau.edu.cn, Zhang, Meiping^1,2 (AUTHOR) yi.wang@jlau.edu.cn

Source: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 20, p11331. 16p.

Subject Terms: *MOLECULAR structure, *GINSENOSIDES, *URIDINE diphosphate, *GINSENG, *MORPHOLOGY

Ginsenoside Rh 2 Alleviates LPS-Induced Inflammatory Responses by Binding to TLR 4 /MD-2 and Blocking TLR 4 Dimerization.

Authors: Pan, Shujuan^1,2 (AUTHOR) 18216620949@163.com, Peng, Luyuan³ (AUTHOR) pengly1992@163.com, Yi, Qion² (AUTHOR) 18286364283@163.com, Qi, Weijin² (AUTHOR) m15735011560@163.com, Yang, Hui² (AUTHOR), Wang, Hongying^1,2 (AUTHOR) 13002275214@163.com, Wang, Lu^1,2 (AUTHOR) luwang@gzu.edu.cn

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9546. 12p.

Subject Terms: *SURFACE plasmon resonance, *GINSENOSIDES, *MOLECULAR docking, *ANTI-inflammatory agents, *DIMERIZATION

Effects of Ginsenoside Rb1 on the Crosstalk between Intestinal Stem Cells and Microbiota in a Simulated Weightlessness Mouse Model.

Authors: Zong, Beibei¹ (AUTHOR) zongbeibei@pku.org.cn, Wang, Jingyi^2,3 (AUTHOR) 1810305326@pku.edu.cn, Wang, Kai^2,3 (AUTHOR) wangkai@bjmu.edu.cn, Hao, Jie^2,3 (AUTHOR) haojie@bjmu.edu.cn, Han, Jing-Yan¹ (AUTHOR) hanjingyan@bjmu.edu.cn, Jin, Rong^2,3 (AUTHOR) jinrong@bjmu.edu.cn, Ge, Qing^1,2,3 (AUTHOR) jinrong@bjmu.edu.cn

Source: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p8769. 15p.

Subject Terms: *GINSENOSIDES, *WNT signal transduction, *STEM cells, *BACTERIAL cultures, *EPITHELIAL cells

The protective effect of ginsenoside Rg1 against sepsis-induced lung injury through PI3K-Akt pathway: insights from molecular dynamics simulation and experimental validation.

Authors: Zhong, Kaiqiang¹ (AUTHOR), Huang, Yingui¹ (AUTHOR), Chen, Rui^2,3 (AUTHOR), Pan, Qiusha¹ (AUTHOR), Li, Jun^2,4 (AUTHOR) lijun@gzucm.edu.cn, Xi, Xiaotu^2,3 (AUTHOR) xxttm@gzucm.edu.cn

Source: Scientific Reports. 7/11/2024, Vol. 14 Issue 1, p1-19. 19p.

Subject Terms: *MOLECULAR dynamics, *GINSENOSIDES, *SEPSIS, *LUNG injuries, *CHINESE medicine, *EPITHELIAL cells

Ginsenoside Rb1 ameliorates neutrophil extracellular traps-induced vascular endothelial damage by suppressing apoptosis.

Authors: Biao Zhang¹, Junkai Zhao², Jiamin Yin¹, Jiaping Chen² cjpszmu@126.com, Lingqi Xu² xu.ling.qi@163.com

Source: Bangladesh Journal of Pharmacology. 2024, Vol. 19 Issue 3, p81-87. 7p.

Subject Terms: *GINSENOSIDES, *VASCULAR endothelium, *UMBILICAL veins, *FLOW cytometry, *NEUTROPHILS, *ENDOTHELIAL cells

Ginsenoside RK1 Induces Ferroptosis in Hepatocellular Carcinoma Cells through an FSP1-Dependent Pathway.

Authors: Jiang, Yulang^1,2,3 (AUTHOR) albert_jylss@163.com, Yu, Yongxin^1,2,3 (AUTHOR) yongxin0705@163.com, Pan, Ziyang^1,2,3 (AUTHOR) ashleytzuyang@163.com, Wang, Ziyuan^1,2,3 (AUTHOR) cjwzymerck@sina.com, Sun, Mingyu^1,2,3 (AUTHOR) cjwzymerck@sina.com

Source: Pharmaceuticals (14248247). Jul2024, Vol. 17 Issue 7, p871. 15p.

Subject Terms: *GINSENOSIDES, *IRON ions, *LACTATE dehydrogenase, *HEPATOCELLULAR carcinoma, *CYTOTOXINS

Structural Characters and Pharmacological Activity of Protopanaxadiol‐Type Saponins and Protopanaxatriol‐Type Saponins from Ginseng.

Authors: Zhang, Lancao¹ (AUTHOR), Gao, Xiang² (AUTHOR), Yang, Chunhui^1,3 (AUTHOR), Liang, Zuguo² (AUTHOR), Guan, Dongsong^1,4 (AUTHOR), Yuan, Tongyi² (AUTHOR), Qi, Wenxiu¹ (AUTHOR), Zhao, Daqing¹ (AUTHOR), Li, Xiangyan¹ (AUTHOR), Dong, Haisi¹ (AUTHOR) adonghaisi@163.com, Zhang, He^1,2,5 (AUTHOR) 13843148162@163.com, Ismail, Norsharina (AUTHOR)

Source: Advances in Pharmacological & Pharmaceutical Sciences. 6/24/2024, Vol. 2024, p1-17. 17p.

Subject Terms: *SAPONINS, *GINSENOSIDES, *GINSENG, *PHARMACOKINETICS, *METABOLISM

Therapeutic Potential of Ginsenosides on Bone Metabolism: A Review of Osteoporosis, Periodontal Disease and Osteoarthritis.

Authors: Ko, Seon-Yle¹ (AUTHOR) seonyleko@dankook.ac.kr

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5828. 32p.

Subject Terms: *GINSENOSIDES, *BONE metabolism, *PERIODONTAL disease, *HOMEOSTASIS, *MITOGEN-activated protein kinases, *OSTEOARTHRITIS, *ALVEOLAR process

Ginsenoside CK Induces the Mitochondrial Apoptosis in Glioma Cells through the Activation of the p53-Bax-Caspase Pathway.

Authors: Bai, Yang¹ (AUTHOR), Liu, Yuanhao¹ (AUTHOR), Lin, Lihao¹ (AUTHOR), Liu, Xinze² (AUTHOR), Wan, Xilin² (AUTHOR), Wu, Xinmin¹ (AUTHOR) wuxinmin@jlu.edu.cn

Source: Pharmacognosy Magazine. Jun2024, Vol. 20 Issue 2, p505-515. 11p.

Subject Terms: *GINSENOSIDES, *GLIOMAS, *APOPTOSIS, *INTRACRANIAL tumors, *CELL migration

入口电离-高分辨质谱法分析 人参皂苷同分异构体.

Alternate Title: Analysis of Ginsenoside Isomers by Inlet Ionization-High Resolution Mass Spectrometry.

Authors: 郭云龙¹, 迟鸿悦¹, 王洋¹, 郑飞¹, 戴雨霖¹, 黄鑫¹, 越皓¹, 刘淑莹^1,2

Source: Journal of Chinese Mass Spectrometry Society. May2024, Vol. 45 Issue 3, p396-400. 5p.

Subject Terms: *MASS spectrometry, *GINSENOSIDES, *ANIONS, *CATIONS, *ISOMERS