Phase 1/2 AAV5-hRKp.RPGR (Botaretigene Sparoparvovec) Gene Therapy: Safety and Efficacy in RPGR-Associated X-Linked Retinitis Pigmentosa

Authors: MICHAELIDES, MICHEL, BESIRLI, CAGRI G., YANG, YESA, DE GUIMARAES, THALES A.C., WONG, SUI CHIEN, HUCKFELDT, RACHEL M., COMANDER, JASON I., SAHEL, JOSÉ-ALAIN, SHAH, SYED MAHMOOD, TEE, JAMES J.L., KUMARAN, NERUBAN, GEORGIADIS, ANASTASIOS, MINNICK, PANSY, ZELDIN, ROBERT, NAYLOR, STUART, XU, JIALIN, CLARK, MICHAEL, ANGLADE, EDDY, WONG, PEGGY, FLECK, PENNY R., FUNG, ALBERT, PELUSO, COLLEEN, KALITZEOS, ANGELOS, GEORGIOU, MICHALIS, RIPAMONTI, CATERINA, SMITH, ALEXANDER J., ALI, ROBIN R., FORBES, ALEXANDRIA, BAINBRIDGE, JAMES

Source: In American Journal of Ophthalmology November 2024 267:122-134

Effective AAV-mediated gene replacement therapy in retinal organoids modeling AIPL1-associated LCA4

Authors: Sai, Hali, Ollington, Bethany, Rezek, Farah O., Chai, Niuzheng, Lane, Amelia, Georgiadis, Anastasios, Bainbridge, James, Michaelides, Michel, Sacristan-Reviriego, Almudena, Perdigão, Pedro R.L., Leung, Amy, van der Spuy, Jacqueline

Source: In Molecular Therapy - Nucleic Acids 12 March 2024 35(1)

First-in-Human Gene Therapy Trial of AAV8-hCARp.hCNGB3 in Adults and Children With CNGB3-associated Achromatopsia

Authors: Michaelides, Michel, Hirji, Nashila, Wong, Sui Chien, Besirli, Cagri G., Zaman, Serena, Kumaran, Neruban, Georgiadis, Anastasios, Smith, Alexander J., Ripamonti, Caterina, Gottlob, Irene, Robson, Anthony G., Thiadens, Alberta, Henderson, Robert H., Fleck, Penny, Anglade, Eddy, Dong, Xiangwen, Capuano, George, Lu, Wentao, Berry, Pamela, Kane, Thomas, Naylor, Stuart, Georgiou, Michalis, Kalitzeos, Angelos, Ali, Robin R., Forbes, Alexandria, Bainbridge, James

Source: American journal of ophthalmology. 253:243-251

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195431269.0x000001&indx=1&recIds=ETOCvdc_100195431269.0x000001

Antioxidant and lipid supplementation improve the development of photoreceptor outer segments in pluripotent stem cell-derived retinal organoids

Authors: West, Emma L., Majumder, Paromita, Naeem, Arifa, Fernando, Milan, O'Hara-Wright, Michelle, Lanning, Emily, Kloc, Magdalena, Ribeiro, Joana, Ovando-Roche, Patrick, Shum, Ian O., Jumbu, Neeraj, Sampson, Robert, Hayes, Matt, Bainbridge, James W.B., Georgiadis, Anastasios, Smith, Alexander J., Gonzalez-Cordero, Anai, Ali, Robin R.

Source: Stem cell reports. 17(4):775-788

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161521968.0x000001&indx=1&recIds=ETOCvdc_100161521968.0x000001

Gene therapy in children with AIPL1-associated severe retinal dystrophy: an open-label, first-in-human interventional study.

Authors: Michaelides, Michel^1,2, michel.michaelides@ucl.ac.uk, Laich, Yannik^1,2,3, Wong, Sui Chien^1,4, Oluonye, Ngozi^1,4, Zaman, Serena^1,2, Kumaran, Neruban^2,5, Kalitzeos, Angelos^1,2, Petrushkin, Harry^1,4, Georgiou, Michalis^1,2, Tailor, Vijay^1,2,6, Pabst, Marc^2,6, Staeubli, Kim^2,6, Maimon-Mor, Roni O^2,6, Jones, Peter R^2,7, Scholte, Steven H⁸, Georgiadis, Anastasios⁹, van der Spuy, Jacqueline², Naylor, Stuart⁹, Forbes, Alexandria⁹, Dekker, Tessa M^2,6

Source: Lancet; Feb2025, Vol. 405 Issue 10479, p648-657, 10p

RNAi‐mediated suppression of vimentin or glial fibrillary acidic protein prevents the establishment of Müller glial cell hypertrophy in progressive retinal degeneration

Authors: Hippert, Claire, Graca, Anna B., Basche, Mark, Kalargyrou, Aikaterini A., Georgiadis, Anastasios, Ribeiro, Joana, Matsuyama, Ayako, Aghaizu, Nozie, Bainbridge, James W., Smith, Alexander J., Ali, Robin R., Pearson, Rachael A.

Source: Glia. 69(9):2272-2290

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123866264.0x000001&indx=1&recIds=ETOCvdc_100123866264.0x000001

Letter to the editor: 'Emerging gene therapy products for RPGR-associated X-linked retinitis pigmentosa'

Authors: Georgiadis, Anastasios, Smith, Alexander J., Michaelides, Michel, Naylor, Stuart, Forbes, Alexandria

Source: Expert opinion on emerging drugs. 27(4):445-447

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178340062.0x000001&indx=1&recIds=ETOCvdc_100178340062.0x000001

Prevention of Photoreceptor Cell Loss in a Cln6nclf Mouse Model of Batten Disease Requires CLN6 Gene Transfer to Bipolar Cells

Authors: kleine Holthaus, Sophia-Martha, Ribeiro, Joana, Abelleira-Hervas, Laura, Pearson, Rachael A., Duran, Yanai, Georgiadis, Anastasios, Sampson, Robert D., Rizzi, Matteo, Hoke, Justin, Maswood, Ryea, Azam, Selina, Luhmann, Ulrich F.O., Smith, Alexander J., Mole, Sara E., Ali, Robin R.

Source: In Molecular Therapy 2 May 2018 26(5):1343-1353

Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration

Authors: Kruczek, Kamil, Gonzalez-Cordero, Anai, Goh, Debbie, Naeem, Arifa, Jonikas, Mindaugas, Blackford, Samuel J.I., Kloc, Magdalena, Duran, Yanai, Georgiadis, Anastasios, Sampson, Robert D., Maswood, Ryea N., Smith, Alexander J., Decembrini, Sarah, Arsenijevic, Yvan, Sowden, Jane C., Pearson, Rachael A., West, Emma L., Ali, Robin R.

Source: In Stem Cell Reports 6 June 2017 8(6):1659-1674

Use of bioreactors for culturing human retinal organoids improves photoreceptor yields

Authors: Ovando-Roche, Patrick, West, Emma, Branch, Matthew, Sampson, Robert, Fernando, Milan, Munro, Peter, Georgiadis, Anastasios, Rizzi, Matteo, Kloc, Magdalena, Naeem, Arifa, Ribeiro, Joana, Smith, Alexander, Gonzalez-Cordero, Anai, Ali, Robin

Source: Stem cell research & therapy. 9(1):1-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164924429.0x000001&indx=1&recIds=ETOCvdc_100164924429.0x000001

Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging

Authors: Robbie, Scott J., Georgiadis, Anastasios, Barker, Susie E., Duran, Yanai, Smith, Alexander J., Ali, Robin R., Luhmann, Ulrich F.O., Bainbridge, James W.

Source: In Neurobiology of Aging April 2016 40:110-119

AAV-RPGR Gene Therapy Rescues Opsin Mislocalisation in a Human Retinal Organoid Model of RPGR -Associated X-Linked Retinitis Pigmentosa.

Authors: Sladen, Paul E., Naeem, Arifa, Adefila-Ideozu, Toyin, Vermeule, Tijmen, Busson, Sophie L., Michaelides, Michel, Naylor, Stuart, Forbes, Alexandria, Lane, Amelia, Georgiadis, Anastasios

Source: International Journal of Molecular Sciences; Feb2024, Vol. 25 Issue 3, p1839, 14p

Subject Terms: RETINITIS pigmentosa, GENE therapy, CLINICAL trials, PLURIPOTENT stem cells, GENOME editing, GENETIC vectors, ANIMAL rescue

IL-4 Regulates Specific Arg-1+ Macrophage sFlt-1–Mediated Inhibition of Angiogenesis

Authors: Wu, Wei-Kang, Georgiadis, Anastasios, Copland, David A., Liyanage, Sidath, Luhmann, Ulrich F.O., Robbie, Scott J., Liu, Jian, Wu, Jiahui, Bainbridge, James W., Bates, David O., Ali, Robin R., Nicholson, Lindsay B., Dick, Andrew D.

Source: In The American Journal of Pathology August 2015 185(8):2324-2335

Comparison and analysis of the emissions of a small non-road spark-ignition engine operating under different alcohol–gasoline blended fuels

Authors: Gravalos, Ioannis, Xyradakis, Panagiotis, Kateris, Dimitrios, Gialamas, Theodoros, Loutridis, Spiros, Avgousti, Avgoustinos, Georgiadis, Anastasios, Tsiropoulos, Zisis

Source: International journal of sustainable energy. 35(3):258-266

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100042792160.0x000001&indx=1&recIds=ETOCvdc_100042792160.0x000001

Correction: The Tight Junction Associated Signalling Proteins ZO-1 and ZONAB Regulate Retinal Pigment Epithelium Homeostasis in Mice.

Authors: Georgiadis, Anastasios (AUTHOR), Tschernutter, Marion (AUTHOR), Bainbridge, James W. B. (AUTHOR), Balaggan, Kamaljit S. (AUTHOR), Mowat, Freya (AUTHOR), West, Emma L. (AUTHOR), Munro, Peter M. G. (AUTHOR), Thrasher, Adrian J. (AUTHOR), Matter, Karl (AUTHOR), Balda, Maria S. (AUTHOR), Ali, Robin R. (AUTHOR)

Source: PLoS ONE. 12/7/2023, Vol. 18 Issue 12, p1-2. 2p.

Subject Terms: *TIGHT junctions, *HOMEOSTASIS, *EPITHELIUM, *MICE, *SAMPLING errors, *RHODOPSIN

Genetic treatment for autosomal dominant inherited retinal dystrophies: approaches, challenges and targeted genotypes.

Authors: Varela, Malena Daich, Georgiadis, Anastasios, Michaelides, Michel

Source: British Journal of Ophthalmology; Sep2023, Vol. 107 Issue 9, p1223-1230, 8p

Spontaneous abortion is associated with differentially expressed angiogenic chemokines in placenta and decidua.

Authors: Spathakis, Michail, Filidou, Eirini, Pappa, Chrysoula, Arzou, Bourazan Chalil, Georgiadis, Anastasios, Kontomanolis, Emmanuel N., Nikolettos, Nikos, Kolios, George, Galazios, George, Arvanitidis, Konstantinos

Source: Archives of Gynecology & Obstetrics; Sep2023, Vol. 308 Issue 3, p821-830, 10p

Subject Terms: MISCARRIAGE, DECIDUA, CHEMOKINES, ABORTION, PREGNANCY complications, RECURRENT miscarriage, PLACENTA praevia

Spatiotemporal control of actomyosin contractility by MRCKβ signaling drives phagocytosis

Authors: Zihni, Ceniz, Georgiadis, Anastasios, Ramsden, Conor M., Sanchez-Heras, Elena, Haas, Alexis J., Nommiste, Britta, Semenyuk, Olha, Bainbridge, James W.B., Coffey, Peter J., Smith, Alexander J.

Source: Journal of cell biology. 221(11):e202012042-e202012042

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630584862&indx=1&recIds=ETOCRN630584862

Cover Image, Volume 69, Issue 9

Authors: Hippert, Claire, Graca, Anna B., Basche, Mark, Kalargyrou, Aikaterini A., Georgiadis, Anastasios, Ribeiro, Joana, Matsuyama, Ayako, Aghaizu, Nozie, Bainbridge, James W., Smith, Alexander J., Ali, Robin R., Pearson, Rachael A.

Source: Glia. 69(9):C1-C1

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133042659.0x000001&indx=1&recIds=ETOCvdc_100133042659.0x000001

An experimental simulation of moisture distribution and its uniformity within the soil profile under laboratory conditions.

Authors: Gravalos, Ioannis¹ gravalos@teilar.gr, Georgiadis, Anastasios¹, Kateris, Dimitrios¹, Gialamas, Theodoros¹, Bompolas, Evagelos¹, Tsiropoulos, Zisis¹, Avgoustis, Avgoustinos¹, Xyradakis, Panagiotis¹

Source: Precision Agriculture. Feb2017, Vol. 18 Issue 1, p19-36. 18p.

Subject Terms: *MOISTURE, *SOIL profiles, *PLANT-soil relationships, *EXPERIMENTAL agriculture, *WATER efficiency