Additive genotoxic effects in cord blood cells upon indirect exposure to chemotherapeutic compounds crossing an in vitro placental barrier.

Authors: Velazquez, Carolina¹, Loier, Lien¹, Struys, Ilana¹, Verscheure, Eline², Persoons, Leentje³, Godderis, Lode^2,4, Lenaerts, Liesbeth¹, Amant, Frédéric^1,5,6 frederic.amant@uzleuven.be

Source: Scientific Reports. 8/23/2024, Vol. 14 Issue 1, p1-9. 9p.

Subject Terms: *GENETIC toxicology, *BLOOD cells, *TROPHOBLAST, *CORD blood, *PLACENTA, *CANCER chemotherapy, *CANCER patient care, *TISSUE culture

Plastic Fly: What Drosophila melanogaster Can Tell Us about the Biological Effects and the Carcinogenic Potential of Nanopolystyrene.

Authors: Aloisi, Massimo¹ (AUTHOR) massimo.aloisi@studenti.unite.it, Grifoni, Daniela¹ (AUTHOR) daniela.grifoni@univaq.it, Zarivi, Osvaldo¹ (AUTHOR) osvaldo.zarivi@univaq.it, Colafarina, Sabrina¹ (AUTHOR) sabrina.colafarina@univaq.it, Morciano, Patrizia^1,2 (AUTHOR) patrizia.morciano@guest.univaq.it, Poma, Anna Maria Giuseppina¹ (AUTHOR) annamariagiuseppina.poma@univaq.it

Source: International Journal of Molecular Sciences. Jul2024, Vol. 25 Issue 14, p7965. 20p.

Subject Terms: *DROSOPHILA melanogaster, *GENETIC toxicology, *FOOD contamination, *P53 antioncogene, *FOOD packaging, *PLASTICS

Geographic Terms: OREGON

In vitro evaluation of the selective cytotoxicity and genotoxicity of three synthetic ortho-nitrobenzyl derivatives in human cancer cell lines, with and without metabolic activation.

Authors: Teixeira De Oliveira, Júlia^1,2 (AUTHOR), Brito Tecchio, Kimberly^1,2 (AUTHOR), Silva Lopes, Marcela³ (AUTHOR), Nunes Andrade, Silmara² (AUTHOR), Iara Maciel De Azambuja Ribeiro, Rosy⁴ (AUTHOR), Varotti, Fernando De Pilla² (AUTHOR), Barbosa De Oliveira, Renata³ (AUTHOR), Henrique Ribeiro Viana, Gustavo² (AUTHOR), J. Da Silva Vieira Dos Santos, Vanessa¹ (AUTHOR), Vieira Dos Santos, Fabio^1,2 (AUTHOR) fabiosantos@ufsj.edu.br

Source: Drug & Chemical Toxicology. Jul2024, Vol. 47 Issue 4, p404-415. 12p.

Subject Terms: *BIOTRANSFORMATION (Metabolism), *GENETIC toxicology, *CYTOTOXINS, *CANCER cells, *CELL lines, *BIOLOGICAL assay

A Nonclinical Safety Evaluation of Cold Atmospheric Plasma for Medical Applications: The Role of Genotoxicity and Mutagenicity Studies.

Authors: Yarangsee, Piimwara¹ (AUTHOR) waraluk_ya@cmu.ac.th, Khacha-ananda, Supakit¹ (AUTHOR) ieynoghk@gmail.com, Pitchakarn, Pornsiri² (AUTHOR) pornsiri.p@cmu.ac.th, Intayoung, Unchisa¹ (AUTHOR) sirikhwan_sr@cmu.ac.th, Sriuan, Sirikhwan¹ (AUTHOR), Karinchai, Jirarat² (AUTHOR) jirarat.ka@cmu.ac.th, Wijaikhum, Apiwat³ (AUTHOR) apiwat.wijaikhum@egat.co.th, Boonyawan, Dheerawan⁴ (AUTHOR) dheerawan.b@cmu.ac.th

Source: Life (2075-1729). Jun2024, Vol. 14 Issue 6, p759. 22p.

Subject Terms: *COLD atmospheric plasmas, *GENETIC toxicology, *NON-thermal plasmas, *AMES test, *MUTAGENICITY testing, *PLASMA production

Toxicity of the New Psychoactive Substance (NPS) Clephedrone (4-Chloromethcathinone, 4-CMC): Prediction of Toxicity Using In Silico Methods for Clinical and Forensic Purposes.

Authors: Jurowski, Kamil^1,2 (AUTHOR) lukasz.niznik@iem.gov.pl, Niżnik, Łukasz² (AUTHOR)

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5867. 19p.

Subject Terms: *CLINICAL toxicology, *GENETIC toxicology, *FORENSIC toxicology, *CARDIOTOXICITY, *ESTROGEN receptors, *DNA damage

Evaluation of the Effects of Imazalil on Genotoxicity and Behavioral Toxicity in Drosophila melanogaster.

Authors: ÖZDEMİR, Sezin¹, ozmen@aku.edu.tr, ÇİLEK, Mehmet Furkan¹, GİRGİN, Selcan¹, ŞEŞEN, Özkan¹, AKYIL, Dilek¹, ÖZKARA, Arzu¹, CİĞERCİ, İbrahim Hakkı¹

Source: Afyon Kocatepe University Journal of Science & Engineering / Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi; Jun2024, Vol. 24 Issue 3, p476-484, 9p

The HOCl dry fog–is it safe for human cells?

Authors: Lewandowski, Rafał Bogdan¹ (AUTHOR), Stępińska, Małgorzata¹ (AUTHOR), Osuchowski, Łukasz¹ (AUTHOR), Kasprzycka, Wiktoria¹ (AUTHOR), Dobrzyńska, Monika¹ (AUTHOR), Mierczyk, Zygmunt¹ (AUTHOR), Trafny, Elżbieta Anna¹ (AUTHOR) elzbieta.trafny@wat.edu.pl

Source: PLoS ONE. 5/29/2024, Vol. 19 Issue 5, p1-19. 19p.

Subject Terms: *GENETIC toxicology, *CYTOTOXINS, *CELL morphology, *FIBROBLASTS, *DNA damage, *CELL death

A study on assessing the toxic effects of ethyl paraben on rohu (Labeo rohita) using different biomarkers; hemato-biochemical assays, histology, oxidant and antioxidant activity and genotoxicity.

Authors: Akmal, Hasnain¹ (AUTHOR), Ahmad, Shabbir¹ (AUTHOR), Abbasi, Muddasir Hassan¹ (AUTHOR), Jabeen, Farhat² (AUTHOR), Shahzad, Khurram¹ (AUTHOR) dr.khurram@uo.edu.pk

Source: PLoS ONE. 5/6/2024, Vol. 19 Issue 5, p1-18. 18p.

Subject Terms: *POISONS, *GENETIC toxicology, *ROHU, *BIOMARKERS, *EMERGING contaminants, *ALANINE aminotransferase, *ASPARTATE aminotransferase

Evaluation of genotoxic effect via expression of DNA damage responsive gene induced by ivermectin on MDBK cell line.

Authors: Ali, Muhammad Muddassir¹ (AUTHOR) muddassir.ali@uvas.edu.pk, Farhad, Zainab¹ (AUTHOR), Wasim, Muhammad¹ (AUTHOR), Raza, Sohail² (AUTHOR), Almutairi, Mikhlid H.³ (AUTHOR), Zahra, Kainat⁴ (AUTHOR), Saleem, Muhammad Usman⁵ (AUTHOR), Mehmood, Khalid⁶ (AUTHOR) muddassir.ali@uvas.edu.pk

Source: PLoS ONE. 5/3/2024, Vol. 19 Issue 5, p1-11. 11p.

Subject Terms: *GENETIC toxicology, *GENE expression, *DNA repair, *CELL lines, *DNA damage, *TOXICITY testing

Genotoxic and mutagenic potential of 7-methylxanthine: an investigational drug molecule for the treatment of myopia.

Authors: Singh, Harjeet^1,2 (AUTHOR), Singh, Harmanpreet^1,3 (AUTHOR), Sharma, Sunil⁴ (AUTHOR), Kaur, Harmanpreet⁴ (AUTHOR), Kaur, Arvinder⁴ (AUTHOR), Kaur, Satwinderjeet⁵ (AUTHOR), Kaur, Sandeep⁵ (AUTHOR), Sahajpal, Nikhil Shri^1,3 (AUTHOR), Chaubey, Alka⁶ (AUTHOR), Shahtaghi, Navid Reza¹ (AUTHOR), Kaur, Inderjeet⁷ (AUTHOR), Jain, Subheet Kumar^1,8 (AUTHOR) subheetjain@rediffmail.com

Source: Drug & Chemical Toxicology. May2024, Vol. 47 Issue 3, p264-273. 10p.

Subject Terms: *GENETIC toxicology, *INVESTIGATIONAL drugs, *CHROMOSOME abnormalities, *AMES test, *MUTAGENS, *ORAL drug administration, *BONE marrow

Anticancer Effects of Ethanolic Extracts of Macaranga Peltata Leaves on Human Oral Squamous Carcinoma Cell Lines: An In Vitro Study.

Authors: Nizar, Amjitha¹, Ravindran, Rathy¹, Palani, Jayanthi^1,2, T., Nripan¹, S. D., Asha¹, Pynadath, Meera K.^3,4

Source: Journal of Pharmacy & Bioallied Sciences. 2024 Supplement, Vol. 16, pS1833-S1837. 5p.

Subject Terms: *GENETIC toxicology, *CELL lines, *SQUAMOUS cell carcinoma, *ANTINEOPLASTIC agents, *CELL cycle regulation, *PHYTOCHEMICALS, *ORAL cancer

In Vitro Cytotoxic, Genotoxic, Embryotoxic and Oxidative Damage Potentials by Empagliflozin.

Authors: Kenan Cadirci¹ (AUTHOR), Turkez, Hasan² (AUTHOR), Tozlu, Ozlem Ozdemir³ (AUTHOR), Yapca, Omer Erkan⁴ (AUTHOR), Bayrak, Muharrem¹ (AUTHOR), Emsen, Bugrahan⁵ (AUTHOR) bugrahanemsen@gmail.com, Mardinoglu, Adil^6,7 (AUTHOR)

Source: Biology Bulletin. Apr2024, Vol. 51 Issue 2, p243-250. 8p.

Subject Terms: *GENETIC toxicology, *OXIDANT status, *HUMAN cell culture, *TYPE 2 diabetes, *EMPAGLIFLOZIN, *OXIDATIVE stress, *ANTIBODY-dependent cell cytotoxicity

Anticancer Potential and Safety Profile of β-Lapachone In Vitro.

Authors: Lima, Karina Motta Melo^1,2 (AUTHOR) karina.melo@ufra.edu.br, Calandrini de Azevedo, Luana França¹ (AUTHOR) jorgerissino@yahoo.com.br, Rissino, Jorge Dores¹ (AUTHOR) cleusanagamachi@gmail.com, Vale, Valdicley Vieira³ (AUTHOR) valdicleyvale@gmail.com, Costa, Erica Vanessa Souza³ (AUTHOR) rcericavanessa@hotmail.com, Dolabela, Maria Fani³ (AUTHOR) fanidolabela@gmail.com, Nagamachi, Cleusa Yoshiko¹ (AUTHOR) juliopieczarka@gmail.com, Pieczarka, Julio Cesar¹ (AUTHOR)

Source: Molecules. Mar2024, Vol. 29 Issue 6, p1395. 11p.

Subject Terms: *GENETIC toxicology, *CELL lines, *COLON cancer, *CELL survival, *CANCER cells, *DNA damage

A study of the genotoxicity, fertility and early embryonic development toxicity of rotigotine behenate extended‐release microspheres.

Authors: Zhao, Xinyu¹ (AUTHOR), Guo, Chunmin¹ (AUTHOR), Zhang, Hong¹ (AUTHOR), Yu, Xin¹ (AUTHOR) yxin_yu@126.com, Du, Guagnying¹ (AUTHOR), Tian, Jingwei¹ (AUTHOR), Liu, Wanhui¹ (AUTHOR), Song, Tao² (AUTHOR), Chen, Xiaobo³ (AUTHOR), Guo, Wei³ (AUTHOR)

Source: Basic & Clinical Pharmacology & Toxicology. Mar2024, Vol. 134 Issue 3, p361-373. 13p.

Subject Terms: *EMBRYOLOGY, *GENETIC toxicology, *FERTILITY, *PARKINSON'S disease, *REPRODUCTION, *AMES test, *DRUG development

The Potential for Genotoxicity, Mutagenicity and Endocrine Disruption in Triclosan and Triclocarban Assessed through a Combination of In Vitro Methods.

Authors: Chrz, Jan^1,2 (AUTHOR) jan.chrz@szu.cz, Dvořáková, Markéta¹ (AUTHOR), Kejlová, Kristina¹ (AUTHOR), Očadlíková, Danuše¹ (AUTHOR), Svobodová, Lada¹ (AUTHOR), Malina, Lukáš² (AUTHOR), Hošíková, Barbora² (AUTHOR), Jírová, Dagmar¹ (AUTHOR), Bendová, Hana¹ (AUTHOR), Kolářová, Hana² (AUTHOR)

Source: Journal of Xenobiotics. Mar2024, Vol. 14 Issue 1, p15-30. 16p.

Subject Terms: *TRICLOCARBAN, *GENETIC toxicology, *CHROMOSOME abnormalities, *AMES test, *PRECAUTIONARY principle, *TRICLOSAN

Geographic Terms: SWITZERLAND

The Genotoxicity of Organic Extracts from Particulate Emissions Produced by Neat Gasoline (E0) and a Gasoline–Ethanol Blend (E15) in BEAS-2B Cells.

Authors: Libalova, Helena¹ (AUTHOR) helena.libalova@iem.cas.cz, Zavodna, Tana² (AUTHOR) tana.zavodna@iem.cas.cz, Elzeinova, Fatima¹ (AUTHOR) fatima.elzeinova@iem.cas.cz, Barosova, Hana² (AUTHOR) hana.barosova@iem.cas.cz, Cervena, Tereza¹ (AUTHOR) tereza.cervena@iem.cas.cz, Milcova, Alena² (AUTHOR) alena.milcova@iem.cas.cz, Vankova, Jolana¹ (AUTHOR) jolana.vankova@iem.cas.cz, Paradeisi, Foteini² (AUTHOR) fotiniparadissi@gmail.com, Vojtisek-Lom, Michal³ (AUTHOR) michal.vojtisek@tul.cz, Sikorova, Jitka² (AUTHOR) jitka.sikorova@iem.cas.cz, Topinka, Jan² (AUTHOR) jan.topinka@iem.cas.cz, Rossner, Pavel¹ (AUTHOR) rossner.pavel@iem.cas.cz

Source: Journal of Xenobiotics. Mar2024, Vol. 14 Issue 1, p1-14. 14p.

Subject Terms: *GENETIC toxicology, *ETHANOL, *DNA repair, *ISOBUTANOL, *GASOLINE, *POLYCYCLIC aromatic hydrocarbons, *ARYL hydrocarbon receptors, *DNA damage

The impact of genetic polymorphisms on genotoxicity in workers occupationally exposed to pesticides: a systematic review.

Authors: Guedes Pinto, Thiago¹ (AUTHOR), da Silva, Glenda Nicioli² (AUTHOR), Renno, Ana Claudia Muniz¹ (AUTHOR), Salvadori, Daisy Maria Favero³ (AUTHOR), Ribeiro, Daniel Araki¹ (AUTHOR) daribeiro@unifesp.br

Source: Toxicology Mechanisms & Methods. Mar2024, Vol. 34 Issue 3, p237-244. 8p.

Subject Terms: *GENETIC polymorphisms, *GENETIC toxicology, *PESTICIDES, *NON-target organisms, *PEST control, *ORAL mucosa

Genistein Enhances TRAIL-Mediated Apoptosis Through the Inhibition of XIAP and DcR1 in Colon Carcinoma Cells Treated with 5-Fluorouracil.

Authors: ÇAL DOĞAN, Tuğbagül¹ tgcal89@gmail.com, AYDIN DİLSİZ, Sevtap², CANPINAR, Hande³, ÜNDEĞER BUCURGAT, Ülkü²

Source: Turkish Journal of Pharmaceutical Sciences. Feb2024, Vol. 21 Issue 1, p7-24. 18p.

Subject Terms: *APOPTOSIS inhibition, *GENETIC toxicology, *GENISTEIN, *TRAIL protein, *FLUOROURACIL, *ANTICARCINOGENIC agents

Sensing chemical-induced DNA damage using CRISPR/Cas9-mediated gene-deletion yeast-reporter strains.

Authors: Yamamoto, Kosuke¹ (AUTHOR), Tochikawa, Shintaro¹ (AUTHOR), Miura, Yuuki¹ (AUTHOR), Matsunobu, Shogo¹ (AUTHOR), Hirose, Yuu^1,2 (AUTHOR), Eki, Toshihiko¹ (AUTHOR) eki@chem.tut.ac.jp

Source: Applied Microbiology & Biotechnology. 2/1/2024, Vol. 108 Issue 1, p1-17. 17p.

Subject Terms: *GENETIC toxicology, *DNA damage, *DNA repair, *EXCISION repair, *CRISPRS, *METHYL methanesulfonate

Assessment of imidacloprid induced genotoxicity in Pethia conchonius (Rosy barb), a common freshwater fish of India.

Authors: Dutta, Debojit¹ (AUTHOR), Ray, Arpita¹ (AUTHOR), Ghosh, Bappaditya¹ (AUTHOR), Bahadur, Min¹ (AUTHOR) min.b@rediffmail.com

Source: Drug & Chemical Toxicology. Jan2024, Vol. 47 Issue 1, p101-114. 14p.

Subject Terms: *IMIDACLOPRID, *GENETIC toxicology, *FRESHWATER fishes, *NON-target organisms, *NUCLEAR DNA, *DNA damage, *NEONICOTINOIDS

Geographic Terms: INDIA