Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance

Authors: Garcia-Martinez, Irma, Alen, Rosa, Pereira, Laura, Povo-Retana, Adrián, Astudillo, Alma M., Hitos, Ana B., Gomez-Hurtado, Isabel, Lopez-Collazo, Eduardo, Boscá, Lisardo, Francés, Rubén, Lizasoain, Ignacio, Moro, María Ángeles, Balsinde, Jesús, Izquierdo, Manuel, Valverde, Ángela M.

Source: In JHEP Reports August 2023 5(8)

Bacterial antigen translocation and age as BMI‐independent contributing factors on systemic inflammation in NAFLD patients

Authors: Gómez‐Hurtado, Isabel, Gallego‐Durán, Rocío, Zapater, Pedro, Ampuero, Javier, Aller, Rocío, Crespo, Javier, Arias‐Loste, Mayte, García‐Monzón, Carmelo, Bellot, Pablo, González‐Rodríguez, Águeda, Juanola, Oriol, Romero‐Gómez, Manuel, Francés, Rubén

Source: Liver international. 40(9):2182-2193

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108145821.0x000001&indx=1&recIds=ETOCvdc_100108145821.0x000001

Regulatory T Cells Restrict Permeability to Bacterial Antigen Translocation and Preserve Short‐Chain Fatty Acids in Experimental Cirrhosis

Authors: Juanola, Oriol, Piñero, Paula, Gómez‐Hurtado, Isabel, Caparrós, Esther, García‐Villalba, Rocío, Marín, Alicia, Zapater, Pedro, Tarín, Fabián, González‐Navajas, José M., Tomás‐Barberán, Francisco A., Francés, Rubén

Source: Hepatology research. 2(12):1610-1623

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084334419.0x000001&indx=1&recIds=ETOCvdc_100084334419.0x000001

Microbiome and bacterial translocation in cirrhosis

Alternate Title: Microbioma y traslocación bacteriana en la cirrosis (Spanish; Castilian)

Authors: Gómez-Hurtado, Isabel, Such, José, Francés, Rubén

Source: In Gastroenterología y Hepatología (English Edition) December 2016 39(10):687-696

Microbioma y traslocación bacteriana en la cirrosis

Alternate Title: Microbiome and bacterial translocation in cirrhosis (English)

Authors: Gómez-Hurtado, Isabel, Such, José, Francés, Rubén

Source: In Gastroenterologia y Hepatologia December 2016 39(10):687-696

Bifidobacterium pseudocatenulatum CECT7765 induces an M2 anti-inflammatory transition in macrophages from patients with cirrhosis

Authors: Moratalla, Alba, Caparrós, Esther, Juanola, Oriol, Portune, Kevin, Puig-Kröger, Amaya, Estrada-Capetillo, Lizbeth, Bellot, Pablo, Gómez-Hurtado, Isabel, Piñero, Paula, Zapater, Pedro, González-Navajas, José M., Such, José, Sanz, Yolanda, Francés, Rubén

Source: In Journal of Hepatology January 2016 64(1):135-145

Cirrhosis‐downregulated LSECtin can be retrieved by cytokines, shifts the TLR‐induced LSECs secretome and correlates with the hepatic Th response.

Authors: Martínez‐López, Sebastián, Ángel‐Gomis, Enrique, Gómez‐Hurtado, Isabel, Fernández‐Iglesias, Anabel, Morante, Javier, Gracia‐Sancho, Jordi, Boix, Paula, Cubero, Francisco J., Zapater, Pedro, Caparrós, Esther, Francés, Rubén

Source: Liver International; Apr2024, Vol. 44 Issue 4, p996-1010, 15p

Subject Terms: CHEMOKINES, CYTOKINES, REGULATORY T cells, T helper cells, IMMUNE response, HEPATORENAL syndrome

Absent in melanoma 2 triggers a heightened inflammasome response in ascitic fluid macrophages of patients with cirrhosis

Authors: Lozano-Ruiz, Beatriz, Bachiller, Victoria, García-Martínez, Irma, Zapater, Pedro, Gómez-Hurtado, Isabel, Moratalla, Alba, Giménez, Paula, Bellot, Pablo, Francés, Rubén, Such, José, González-Navajas, José M.

Source: In Journal of Hepatology January 2015 62(1):64-71

THU-341 - Study of epigenetic control of LSECtin in hepatic antigen presenting cells during experimental cirrhosis

Authors: Angel, Enrique, Martinez, Sebastian, Gómez-Hurtado, Isabel, Boix, Paula, Caparrós, Esther, Francés, Rubén

Source: In Journal of Hepatology June 2023 78 Supplement 1:S210-S212

Role of interleukin 10 in norfloxacin prevention of luminal free endotoxin translocation in mice with cirrhosis

Authors: Gómez-Hurtado, Isabel, Moratalla, Alba, Moya-Pérez, Ángela, Peiró, Gloria, Zapater, Pedro, González-Navajas, José M., Giménez, Paula, Such, José, Sanz, Yolanda, Francés, Rubén

Source: In Journal of Hepatology October 2014 61(4):799-808

Improved hemodynamic and liver function in portal hypertensive cirrhotic rats after administration of B. pseudocatenulatum CECT 7765.

Authors: Gómez-Hurtado, Isabel¹, Zapater, Pedro^1,2,3, Portune, Kevin⁴, Juanola, Oriol^1,3, Fernández-Iglesias, Anabel^1,5, González-Navajas, José M.^1,2, Gracia-Sancho, Jordi^1,5, Sanz, Yolanda⁴, Francés, Rubén^1,2,3 frances_rub@gva.es

Source: European Journal of Nutrition. Jun2019, Vol. 58 Issue 4, p1647-1658. 12p. 1 Diagram, 6 Charts, 3 Graphs.

Subject Terms: *ABDOMINAL surgery, *ALKALINE phosphatase, *ANALYSIS of covariance, *ANIMAL experimentation, *BIFIDOBACTERIUM, *BILIRUBIN, *BIOMARKERS, *BIOLOGICAL models, *CYTOKINES, *GENE expression, *HEMODYNAMICS, *LIGATURE (Surgery), *LIVER, *ORAL drug administration, *PORTAL hypertension, *PORTAL vein, *RATS, *NITRIC-oxide synthases, *GUT microbiome, *PROBIOTICS, BILE duct surgery

WED-113 Histological, molecular, and neuromotor alterations of the liverbrain axis in an aged model of experimental cirrhosis

Authors: Juanola, Oriol, Martinez, Sebastian, Serrano-Macía, Marina, Angel, Enrique, Gómez-Hurtado, Isabel, Boix, Paula, Navarrete Rueda, Francisco, Salud García Gutierrez, Maria, Caparrós, Esther, Francés, Rubén

Source: In Journal of Hepatology June 2024 80 Supplement 1:S194-S194

Norfloxacin is more effective than Rifaximin in avoiding bacterial translocation in an animal model of cirrhosis.

Authors: García, Irma¹, Gómez‐Hurtado, Isabel^1,2, Gimenez, Paula^1,2, González‐Navajas, José M.^1,2, Bellot, Pablo^1,2, Zapater, Pedro^1,2,3, Francés, Rubén^1,2,4, Manichanh, Chaysavanh^1,5, Guarner, Francisco^1,5, Ramos, José M.⁶, Such, José^7,8

Source: Liver International. Feb2018, Vol. 38 Issue 2, p295-302. 8p. 2 Charts, 4 Graphs.

Subject Terms: *NORFLOXACIN, *BIOLOGICAL transport, *TREATMENT of cirrhosis of the liver, *LIVER diseases, *ANIMAL models in research, *BACTERIA, *RIFAXIMIN

Selective intestinal decontamination with norfloxacin enhances a regulatory T cell-mediated inflammatory control mechanism in cirrhosis.

Authors: Juanola, Oriol^1,2, Gómez ‐ Hurtado, Isabel¹, Zapater, Pedro^1,3, Moratalla, Alba¹, Caparrós, Esther², Piñero, Paula³, González ‐ Navajas, José M.^1,3, Giménez, Paula¹, Such, José⁴, Francés, Rubén^1,2,3 frances_rub@gva.es

Source: Liver International. Dec2016, Vol. 36 Issue 12, p1811-1820. 10p. 1 Diagram, 3 Charts, 2 Graphs.

Subject Terms: *TREATMENT of cirrhosis of the liver, *PERITONITIS, *TREATMENT effectiveness, *INTERLEUKIN-2, *NORFLOXACIN, *IMMUNOMODULATORS, *THERAPEUTICS

Bifidobacterium pseudocatenulatum CECT7765 promotes a TLR2-dependent anti-inflammatory response in intestinal lymphocytes from mice with cirrhosis.

Authors: Moratalla, Alba, Gómez-Hurtado, Isabel¹, Moya-Pérez, Ángela², Zapater, Pedro, Peiró, Gloria³, González-Navajas, José, Gómez Del Pulgar, Eva², Such, José, Sanz, Yolanda², Francés, Rubén frances_rub@gva.es

Source: European Journal of Nutrition. Feb2016, Vol. 55 Issue 1, p197-206. 10p.

Subject Terms: *ANTIGEN analysis, *INTESTINAL physiology, *LYMPHOCYTES, *LIVER analysis, *ANALYSIS of variance, *ANIMAL experimentation, *BIFIDOBACTERIUM, *BILIRUBIN, *BIOLOGICAL models, *CELL receptors, *CHEMOKINES, *CHI-squared test, *STATISTICAL correlation, *CYTOKINES, *ENZYME-linked immunosorbent assay, *HISTOLOGICAL techniques, *HOMEOSTASIS, *INTERLEUKINS, *INTESTINES, *CIRRHOSIS of the liver, *MICE, *ORAL drug administration, *PERMEABILITY, *PROBABILITY theory, *RESEARCH funding, *STATISTICAL hypothesis testing, *STATISTICS, *T-test (Statistics), *TUMOR necrosis factors, *WESTERN immunoblotting, *DATA analysis, *ALANINE aminotransferase, *PROBIOTICS, *DATA analysis software, *DESCRIPTIVE statistics, *IN vitro studies, *MANN Whitney U Test, *KRUSKAL-Wallis Test, *IN vivo studies, *PHYSIOLOGY

Geographic Terms: SPAIN

Protective effect of Bifidobacterium pseudocatenulatum CECT7765 against induced bacterial antigen translocation in experimental cirrhosis.

Authors: Moratalla, Alba^1,2, Gómez ‐ Hurtado, Isabel^1,2, Santacruz, Arlette³, Moya, Ángela³, Peiró, Gloria⁴, Zapater, Pedro^1,5, González ‐ Navajas, José M.^1,2, Giménez, Paula¹, Such, José^1,2,6, Sanz, Yolanda³, Francés, Rubén^1,2,6

Source: Liver International. Jul2014, Vol. 34 Issue 6, p850-858. 9p.

Subject Terms: *ABDOMINAL blood vessels, *GENETIC regulation, *GENERAL practitioners, *INFLAMMATORY mediators, *GENE expression, *ESCHERICHIA coli

PS-148-Liver sinusoidal endothelial cells significantly cooperate in the phagocytic immune activities and activation of the adaptive T cell response in a model of experimental cirrhosis by CCl4

Authors: Caparros, Esther, Juanola, Oriol, Piñero, Paula, Gómez-Hurtado, Isabel, Linares, Raquel, Boix, Paula, García-Román, Rebeca, Gracia-Sancho, Jordi, Francés, Rubén

Source: Journal of hepatology. 70(S):e93-e93

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132034795.0x000001&indx=1&recIds=ETOCvdc_100132034795.0x000001

Beta-Adrenergic Receptor 1 Selective Antagonism Inhibits Norepinephrine- Mediated TNF-Alpha Downregulation in Experimental Liver Cirrhosis.

Authors: Zapater, Pedro^1,2, Gómez-Hurtado, Isabel^1,3, Peiró, Gloria⁴, González-Navajas, José Manuel^1,2, García, Irma^1,2, Giménez, Paula^1,2, Moratalla, Alba^1,2, Such, José^1,2, Francés, Rubén^1,2 frances_rub@gva.es, Jacobs, Roland⁵

Source: PLoS ONE. Aug2012, Vol. 7 Issue 8, Special section p1-9. 9p.

Subject Terms: *BACTERIAL transformation, *CIRRHOSIS of the liver, *SPLANCHNIC nerves, *NORADRENALINE, *INFLAMMATION, *BACTERIAL DNA

Gut Microbiota Dysbiosis Is Associated with Inflammation and Bacterial Translocation in Mice with CCl4-Induced Fibrosis.

Authors: Gómez-Hurtado, Isabel^1,2, Santacruz, Arlette³, Peiró, Gloria⁴, Zapater, Pedro^1,2, Gutiérrez, Ana¹, Pérez-Mateo, Miguel¹, Sanz, Yolanda³, Francés, Rubén^1,2 frances_rub@gva.es

Source: PLoS ONE. 2011, Vol. 6 Issue 7, p1-10. 10p.

Subject Terms: *LABORATORY mice, *FIBROSIS, *CIRRHOSIS of the liver, *CARBON tetrachloride, *GENE expression, *TUMOR necrosis factors

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