Cancer prevention: past challenges and future directions

Authors: HeeKyung Seong, Runa Izutsu, Mitsuhiko Osaki, Futoshi Okada

Source: Genes and Environment, Vol 47, Iss 1, Pp 1-11 (2025)

Subject Terms: Chemoprevention, Carcinogenesis, Endogenous factors, Exogeneous factors, Oxidative stress, Medical intervention, Ecology, QH540-549.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1880-7062

Access URL: https://doaj.org/article/548fa7faf3104340ac2397668c1a4e75

Prevention of liver metastasis via the pharmacological suppression of AMIGO2 expression in tumor cells

Authors: HeeKyung Seong, Yusuke Kanda, Runa Izutsu, Jumond P. Jehung, Junichi Hamada, Mitsuhiko Osaki, Koji Okamoto, Futoshi Okada

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: AMIGO2, Liver metastasis, Pharmacological prevention, Drug screening, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/2085d92b19444fadbbed57d64a10acca

Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to intraperitoneal paclitaxel therapy in gastric cancer patients with peritoneal metastasis

Authors: Masahiro Makinoya, Kozo Miyatani, Yoshiaki Matsumi, Yu Sakano, Shota Shimizu, Yuji Shishido, Takehiko Hanaki, Kyoichi Kihara, Tomoyuki Matsunaga, Manabu Yamamoto, Naruo Tokuyasu, Shuichi Takano, Teruhisa Sakamoto, Toshimichi Hasegawa, Hiroaki Saito, Yuji Nakayama, Mitsuhiko Osaki, Futoshi Okada, Yoshiyuki Fujiwara

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/97a461a20ca146be8b96642cf7ce18ea

Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis

Authors: Kosaku Okuda, Kengo Nakahara, Akihiro Ito, Yuta Iijima, Ryosuke Nomura, Ashutosh Kumar, Kana Fujikawa, Kazuya Adachi, Yuki Shimada, Satoshi Fujio, Reina Yamamoto, Nobumasa Takasugi, Kunishige Onuma, Mitsuhiko Osaki, Futoshi Okada, Taichi Ukegawa, Yasuo Takeuchi, Norihisa Yasui, Atsuko Yamashita, Hiroyuki Marusawa, Yosuke Matsushita, Toyomasa Katagiri, Takahiro Shibata, Koji Uchida, Sheng-Yong Niu, Nhi B. Lang, Tomohiro Nakamura, Kam Y. J. Zhang, Stuart A. Lipton, Takashi Uehara

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2948479591604774a634757fd4634fae

The impact of AMIGO2 on prognosis and hepatic metastasis in gastric cancer patients

Authors: Keisuke Goto, Masaki Morimoto, Mitsuhiko Osaki, Akimitsu Tanio, Runa Izutsu, Yoshiyuki Fujiwara, Futoshi Okada

Source: BMC Cancer, Vol 22, Iss 1, Pp 1-9 (2022)

Subject Terms: AMIGO2, AMIGO, Gastric cancer, Hepatic metastasis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/bb21c97bf2804fd18632c3ba814eb339

AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells

Authors: Runa Izutsu, Mitsuhiko Osaki, Hideyuki Nemoto, Maho Jingu, Ryo Sasaki, Yusuke Yoshioka, Takahiro Ochiya, Futoshi Okada

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/1509bab1dc384ccc9a3082ae31e6f644

Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer

Authors: Keisuke Goto, Mitsuhiko Osaki, Runa Izutsu, Hiroshi Tanaka, Ryo Sasaki, Akimitsu Tanio, Hiroyuki Satofuka, Yasuhiro Kazuki, Manabu Yamamoto, Hiroyuki Kugoh, Hisao Ito, Mitsuo Oshimura, Yoshiyuki Fujiwara, Futoshi Okada

Source: Diagnostic Pathology, Vol 17, Iss 1, Pp 1-12 (2022)

Subject Terms: AMIGO2, Monoclonal antibody, Colorectal cancer, Liver metastasis, Prognosis, Pathology, RB1-214

File Description: electronic resource

Relation: https://doaj.org/toc/1746-1596

Access URL: https://doaj.org/article/9ad41b48f36f47758a608cc7a4b8266f

Prevention of tumor progression in inflammation-related carcinogenesis by anti-inflammatory and anti-mutagenic effects brought about by ingesting fermented brown rice and rice bran with Aspergillus oryzae (FBRA)

Authors: Hideyuki Nemoto, Marina Otake, Takahiro Matsumoto, Runa Izutsu, Jumond P Jehung, Keisuke Goto, Mitsuhiko Osaki, Masafumi Mayama, Masataka Shikanai, Hiroshi Kobayashi, Tetsushi Watanabe, Futoshi Okada

Source: Journal of Functional Foods, Vol 88, Iss , Pp 104907- (2022)

Subject Terms: Inflammation-related carcinogenesis, Chemoprevention, Tumor progression, Metastasis, Somatic mutation, Fermented brown rice and rice bran with Aspergillus oryzae (FBRA), Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464621005569; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/6de46323592143eb92f091e4e871540a

Ozone augments interleukin-8 production induced by ambient particulate matter

Authors: Jun Kurai, Kunishige Onuma, Hiroyuki Sano, Futoshi Okada, Masanari Watanabe

Source: Genes and Environment, Vol 40, Iss 1, Pp 1-8 (2018)

Subject Terms: Antioxidant, Interleukin-6, Interleukin-8, Ozone, Particulate matter, Pro-inflammatory cytokine, Ecology, QH540-549.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s41021-018-0102-7; https://doaj.org/toc/1880-7062

Access URL: https://doaj.org/article/ab3037f64f6b4e3a9138d420603b3bcb

Correction: The circadian rhythm of bladder clock genes in the spontaneously hypersensitive rat.

Authors: Yusuke Kimura, Masashi Honda, Ryo Sasaki, Tetsuya Yumioka, Hideto Iwamoto, Panagiota Tsounapi, Shuichi Morizane, Katsuya Hikita, Mitsuhiko Osaki, Futoshi Okada, Atsushi Takenaka

Source: PLoS ONE, Vol 14, Iss 12, p e0227321 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227321&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5b8a6f0af8174c4e8cfc66a1ab79f55d

PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription.

Authors: Takahito Ohira, Hirotada Kojima, Yuko Kuroda, Sayaka Aoki, Daigo Inaoka, Mitsuhiko Osaki, Hideki Wanibuchi, Futoshi Okada, Mitsuo Oshimura, Hiroyuki Kugoh

Source: PLoS ONE, Vol 14, Iss 8, p e0217605 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ae0eafbb777743f0b6ccad79149212d0

The circadian rhythm of bladder clock genes in the spontaneously hypersensitive rat.

Authors: Yusuke Kimura, Masashi Honda, Ryo Sasaki, Tetsuya Yumioka, Hideto Iwamoto, Panagiota Tsounapi, Shuichi Morizane, Katsuya Hikita, Mitsuhiko Osaki, Futoshi Okada, Atsushi Takenaka

Source: PLoS ONE, Vol 14, Iss 7, p e0220381 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/121814ae308641d1ae9d1f2e9d743e86

Exosomes and Their Role in Cancer Progression.

Authors: Mitsuhiko Osaki, Futoshi Okada

Source: Yonago Acta Medica; Jun2019, Vol. 62 Issue 2, p182-190, 9p

Subject Terms: EXOSOMES, CANCER invasiveness, EXTRACELLULAR matrix, BILAYER lipid membranes, HOMEOSTASIS

Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction.

Authors: Yusuke Kanda, Mitsuhiko Osaki, Futoshi Okada

Source: International Journal of Molecular Sciences; Apr2017, Vol. 18 Issue 4, p867, 36p, 2 Diagrams, 3 Charts, 2 Graphs

Subject Terms: INFLAMMATION, CARCINOGENESIS, CHEMOPREVENTION, FIBROBLASTS, DNA damage, CHEMOKINES, DNA methylation

PITX1 is a novel predictor of the response to chemotherapy in head and neck squamous cell carcinoma.

Authors: MASAO TAKENOBU, MITSUHIKO OSAKI, KAZUNORI FUJIWARA, TAKAHIRO FUKUHARA, HIROYA KITANO, HIROYUKI KUGOH, FUTOSHI OKADA

Source: Molecular & Clinical Oncology; Jul2016, Vol. 5 Issue 1, p89-94, 6p

Subject Terms: HOMEOBOX proteins, CANCER chemotherapy, SQUAMOUS cell carcinoma

Inhibitor of apoptosis proteins (IAPs) may be effective therapeutic targets for treating endometriosis.

Authors: Takashi Uegaki, Fuminori Taniguchi, Kazuomi Nakamura, Mitsuhiko Osaki, Futoshi Okada, Osamu Yamamoto, Tasuku Harada

Source: Human Reproduction; Jan2015, Vol. 30 Issue 1, p149-158, 10p

Subject Terms: TREATMENT of endometriosis, PROTEIN expression, ANIMAL models in research, STROMAL cells, ENZYME-linked immunosorbent assay, DISEASE progression, IMMUNOHISTOCHEMISTRY

PITX1 is a reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia.

Authors: MOTOKI NAKABAYASHI, MITSUHIKO OSAKI, ISAMU KODANI, FUTOSHI OKADA, KAZUO RYOKE, MITSUO OSHIMURA, HISAO ITO, HIROYUKI KUGOH

Source: Oncology Letters; 2014, Vol. 7 Issue 3, p750-754, 5p

Subject Terms: DYSPLASIA, ORAL mucosa diseases, CELL transformation, SQUAMOUS cell carcinoma, IMMUNOHISTOCHEMISTRY, BIOMARKERS, PATIENTS, PROGNOSIS

Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes.

Authors: Yoshihito Iuchi¹, Futoshi Okada¹, Rina Takamiya², Noriko Kibe¹, Satoshi Tsunoda¹, Osamu Nakajima³, Kazuyo Toyoda⁴, Ritsuko Nagae⁴, Makoto Suematsu², Tomoyoshi Soga⁵, Koji Uchida⁴, Junichi Fujii¹

Source: Biochemical Journal. Aug2009, Vol. 422 Issue 2, p313-320. 8p.

Subject Terms: *AUTOIMMUNE diseases, *OXIDATIVE stress, *ERYTHROCYTES, *SUPEROXIDE dismutase, *ANEMIA, *ETIOLOGY of diseases, *AUTOANTIBODIES, *TRANSGENE expression, *LABORATORY mice, *GENETICS

Peroxiredoxin 4 knockout results in elevated spermatogenic cell death via oxidative stress.

Authors: Yoshihito Iuchi¹, Futoshi Okada¹, Satoshi Tsunoda¹, Noriko Kibe¹, Nobuyuki Shirasawa², Masahito Ikawa³, Masaru Okabe³, Yoshitaka Ikeda⁴, Junichi Fujii¹

Source: Biochemical Journal. Apr2009, Vol. 419 Issue 1, p149-158. 10p.

Subject Terms: *THIOREDOXIN, *SPERMATOGENESIS, *CELL death, *OXIDATIVE stress, *PEROXIDASE, *ENDOPLASMIC reticulum, *CELL membranes, *PEPTIDES

Deficiency of the cystine-transporter gene, xCT , does not exacerbate the deleterious phenotypic consequences of SOD1 knockout in mice.

Authors: Yoshihito Iuchi, Noriko Kibe, Satoshi Tsunoda, Futoshi Okada, Shiro Bannai, Hideyo Sato, Junichi Fujii

Source: Molecular & Cellular Biochemistry; Dec2008, Vol. 319 Issue 1/2, p125-132, 8p