Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine

Authors: Hawman, David W., Meade-White, Kimberly, Clancy, Chad, Archer, Jacob, Hinkley, Troy, Leventhal, Shanna S., Rao, Deepashri, Stamper, Allie, Lewis, Matthew, Rosenke, Rebecca, Krieger, Kyle, Randall, Samantha, Khandhar, Amit P., Hao, Linhue, Hsiang, Tien-Ying, Greninger, Alexander L., Gale, Michael, Jr, Berglund, Peter, Fuller, Deborah Heydenburg, Rosenke, Kyle, Feldmann, Heinz, Erasmus, Jesse H.

Source: In eBioMedicine September 2022 83

Therapeutic conserved elements (CE) DNA vaccine induces strong T-cell responses against highly conserved viral sequences during simian-human immunodeficiency virus infection

Authors: Munson, Paul, Liu, Yi, Bratt, Debra, Fuller, James T., Hu, Xintao, Pavlakis, George N., Felber, Barbara K., Mullins, James I., Fuller, Deborah Heydenburg

Source: Human vaccines & immunotherapeutics. 14(7):1820-1831

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100065863622.0x000001&indx=1&recIds=ETOCvdc_100065863622.0x000001

Efficient ex vivo expansion of conserved element vaccinespecific CD8+ T-cells from SHIV-infected, ART-suppressed nonhuman primates .

Authors: Dross, Sandra, Venkataraman, Rasika, Patel, Shabnum, Huang, Meei-Li, Bollard, Catherine M., Rosati, Margherita, Pavlakis, George N., Felber, Barbara K., Bar, Katharine J., Shaw, George M., Jerome, Keith R., Mullins, James I., Kiem, Hans-Peter, Fuller, Deborah Heydenburg, Peterson, Christopher W.

Source: Frontiers in Immunology; 2023, p1-12, 12p

Subject Terms: T cells, HIV, CELLULAR recognition, CD8 antigen, VIRAL shedding, MANUFACTURING cells

Preparing for Pandemics: RNA Vaccines at the Forefront

Authors: Erasmus, Jesse H., Fuller, Deborah Heydenburg

Source: Molecular therapy. 28(7):1559-1560

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116634696.0x000001&indx=1&recIds=ETOCvdc_100116634696.0x000001

Early cellular innate immune responses drive Zika viral persistence and tissue tropism in pigtail macaques

Authors: O'Connor, Megan A., Tisoncik-Go, Jennifer, Lewis, Thomas B., Miller, Charlene J., Bratt, Debra, Moats, Cassie R., Edlefsen, Paul T., Smedley, Jeremy, Klatt, Nichole R., Gale, Michael, Fuller, Deborah Heydenburg

Source: Nature communications. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129889391.0x000001&indx=1&recIds=ETOCvdc_100129889391.0x000001

Immunogenicity of hybrid DNA vaccines expressing hepatitis B core particles carrying human and simian immunodeficiency virus epitopes in mice and rhesus macaques

Authors: Fuller, Deborah Heydenburg, Shipley, Tim, Allen, Todd M., Fuller, James T., Wu, Mary S., Horton, Helen, Wilson, Nancy, Widera, Georg, Watkins, David I.

Source: In Virology 2007 364(2):245-255

Effects of monotherapy with ( R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) on the evolution of a primary Simian immunodeficiency virus (SIV) isolate

Authors: Taber, Rachel, Rajakumar, Premeela A., Fuller, Deborah Heydenburg, Trichel, Anita M., Dowling, Patricia, Meleason, David, Amedee, Angela, Murphey-Corb, Michael

Source: In Virology 2006 354(1):116-131

DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued

Authors: Fuller, Deborah Heydenburg, Rajakumar, Premeela A., Wu, Mary S., McMahon, Christopher W., Shipley, Tim, Fuller, James T., Bazmi, Afrouz, Trichel, Anita M., Allen, Todd M., Mothe, Bianca, Haynes, Joel R., Watkins, David I., Murphey-Corb, Michael

Source: In Virology 2006 348(1):200-215

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern.

Authors: Hawman, David W., Meade-White, Kimberly, Archer, Jacob, Leventhal, Shanna S., Wilson, Drew, Shaia, Carl, Randall, Samantha, Khandhar, Amit P., Krieger, Kyle, Tien-Ying Hsiang, Gale, Michael, Berglund, Peter, Fuller, Deborah Heydenburg, Feldmann, Heinz, Erasmus, Jesse H.

Source: eLife; 4/5/2022, p1-21, 21p

DNA vaccines for immunotherapy of HIV

Authors: Fuller, Deborah Heydenburg.

Relation: Also available on the Internet.

Access URL: http://hdl.handle.net/2027/wu.89081079261

Effects of therapeutic vaccination on the control of SIV in rhesus macaques with variable responsiveness to antiretroviral drugs.

Authors: Tunggal, Hillary Claire, Munson, Paul Veness, O'Connor, Megan Ashley, Hajari, Nika, Dross, Sandra Elizabeth, Bratt, Debra, Fuller, James Thomas, Bagley, Kenneth, Fuller, Deborah Heydenburg

Source: PLoS ONE; 6/17/2021, Vol. 16 Issue 6, p1-27, 27p

Subject Terms: RHESUS monkeys, MACAQUES, ANTIRETROVIRAL agents, TREATMENT effectiveness, DNA vaccines, T cells

Therapeutic DNA Vaccine Induces Broad T Cell Responses in the Gut and Sustained Protection from Viral Rebound and AIDS in SIV-Infected Rhesus Macaques.

Authors: Fuller, Deborah Heydenburg^1,2,3,4 fullerdh@u.washington.edu, Rajakumar, Premeela¹, Che, Jenny W.^1,3, Narendran, Amithi², Nyaundi, Julia¹, Michael, Heather¹, Yager, Eric J.^2,5, Stagnar, Cristy², Wahlberg, Brendon¹, Taber, Rachel¹, Haynes, Joel R.^3,6, Cook, Fiona C.⁷, Ertl, Peter⁷, Tite, John^7,8, Amedee, Angela M.⁹, Murphey-Corb, Michael¹ mcorb@pitt.edu

Source: PLoS ONE. Mar2012, Vol. 7 Issue 3, p1-16. 16p.

Subject Terms: *DNA vaccines, *HIV infections, *T cells, *AIDS, *RHESUS monkeys

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A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response.

Authors: Koday, Merika Treants¹, Nelson, Jorgen², Chevalier, Aaron², Koday, Michael³, Kalinoski, Hannah¹, Stewart, Lance², Carter, Lauren², Nieusma, Travis⁴, Lee, Peter S.⁴, Ward, Andrew B.⁴, Wilson, Ian A.^4,5, Dagley, Ashley⁶, Smee, Donald F.⁶, Baker, David^2,7, Fuller, Deborah Heydenburg^1,3, fullerdh@u.washington.edu

Source: PLoS Pathogens; 2/4/2016, Vol. 12 Issue 2, p1-23, 23p

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O1 - Computationally engineered influenza antiviral affords broad prophylactic and therapeutic protection against influenza

Authors: Fuller, Deborah Heydenburg, Koday, Merika Treants, Nelson, Jorgen, Chevalier, Aaron, Koday, Michael, Smee, Donald F., Hartman, Amy L., Reed, Douglas S., Cole, Kelly Stefano, Baker, David

Source: In Journal of Virus Eradication May 2016 2 Supplement 1:8-8

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Examination of Parameters Affecting the Elicitation of Humoral Immune Responses by Particle Bombardment-Mediated Genetic Immunization.

Authors: EISENBRAUN, MICHAEL D., FULLER, DEBORAH HEYDENBURG, HAYNES, JOEL R.

Source: DNA & Cell Biology; Nov1993, Vol. 12 Issue 9, p791-797, 7p