Subarachnoid CSF hyperintensities at 7 tesla FLAIR MRI: A novel marker in cerebral amyloid angiopathy

Authors: Koemans, Emma A., van Walderveen, Marianne A.A., Voigt, Sabine, Rasing, Ingeborg, van Harten, Thijs W., J.A van Os, Hine, van der Weerd, Nelleke, Terwindt, Gisela M., van Osch, Matthias J.P., van Veluw, Susanne J., Freeze, Whitney M., Wermer, Marieke J.H.

Source: In NeuroImage: Clinical 2023 38

Associations of increased interstitial fluid with vascular and neurodegenerative abnormalities in a memory clinic sample

Authors: van der Thiel, Merel M., Freeze, Whitney M., Verheggen, Inge C.M., Wong, Sau May, de Jong, Joost J.A., Postma, Alida A., Hoff, Erik I., Gronenschild, Ed H.B.M., Verhey, Frans R., Jacobs, Heidi I.L., Ramakers, Inez H.G.B., Backes, Walter H., Jansen, Jacobus F.A.

Source: In Neurobiology of Aging October 2021 106:257-267

CSF enhancement on post-contrast fluid-attenuated inversion recovery images; a systematic review

Authors: Freeze, Whitney M., van der Thiel, Merel, de Bresser, Jeroen, Klijn, Catharina J.M., van Etten, Ellis S., Jansen, Jacobus F.A., van der Weerd, Louise, Jacobs, Heidi I.L., Backes, Walter H., van Veluw, Susanne J.

Source: In NeuroImage: Clinical 2020 28

Linking APOE-ε4, blood-brain barrier dysfunction, and inflammation to Alzheimer's pathology

Authors: Riphagen, Joost M., Ramakers, Inez H.G.M., Freeze, Whitney M., Pagen, Linda H.G., Hanseeuw, Bernard J., Verbeek, Marcel M., Verhey, Frans R.J., Jacobs, Heidi I.L.

Source: In Neurobiology of Aging January 2020 85:96-103

White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed

Authors: Freeze, Whitney M., Jacobs, Heidi I.L., de Jong, Joost J., Verheggen, Inge C.M., Gronenschild, Ed H.B.M., Palm, Walter M., Hoff, Erik I., Wardlaw, Joanna M., Jansen, Jacobus F.A., Verhey, Frans R., Backes, Walter H.

Source: In Neurobiology of Aging January 2020 85:113-122

Sex differences in histopathological markers of cerebral amyloid angiopathy and related hemorrhage.

Authors: Koemans, Emma A, Perosa, Valentina, Freeze, Whitney M, Lee, Hang, Kozberg, Mariel G, Coughlan, Gillian T, Buckley, Rachel F, Wermer, Marieke JH, Greenberg, Steven M, van Veluw, Susanne J

Source: International Journal of Stroke; Oct2024, Vol. 19 Issue 8, p947-956, 10p

Subject Terms: ALZHEIMER'S disease, CEREBRAL amyloid angiopathy, MAGNETIC resonance imaging, CEREBRAL hemorrhage, DATABASES

Shades of white: diffusion properties of T1- and FLAIR-defined white matter signal abnormalities differ in stages from cognitively normal to dementia

Authors: Riphagen, Joost M., Gronenschild, Ed H.B.M., Salat, David H., Freeze, Whitney M., Ivanov, Dimo, Clerx, Lies, Verhey, Frans R.J., Aalten, Pauline, Jacobs, Heidi I.L.

Source: In Neurobiology of Aging August 2018 68:48-58

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Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study.

Authors: Oomens, Julie E., van Gils, Veerle, Vos, Stephanie J. B., Freeze, Whitney M., Maserejian, Nancy N., Curiale, Gioacchino, Gillis, Cai, Boada, Mercè, van der Flier, Wiesje M., Hort, Jakub, Johnson, Sterling C., Lleó, Alberto, Ramakers, Inez H., Rodrigue, Karen M., Sánchez-Juan, Pascual, Sarazin, Marie, Scarmeas, Nikolaos, Zetterberg, Henrik, Alcolea, Daniel, Barkhof, Frederik

Source: JAMA Network Open; 1/22/2025, Vol. 8 Issue 1, pe2455571-e2455571, 1p

Blood-brain barrier leakage and perivascular inflammation in cerebral amyloid angiopathy.

Authors: Kozberg, Mariel G., Irvin Yi, Freeze, Whitney M., Auger, Corinne A., Scherlek, Ashley A., Greenberg, Steven M., van Veluw, Susanne J.

Source: Brain Communications; 2022, Vol. 4 Issue 5, p1-13, 13p

Rich-Club Connectivity of the Structural Covariance Network Relates to Memory Processes in Mild Cognitive Impairment and Alzheimer's Disease.

Authors: Drenthen, Gerhard S., Backes, Walter H., Freeze, Whitney M., Jacobs, Heidi I.L., Verheggen, Inge C.M., van Boxtel, Martin P.J., Hoff, Erik I., Verhey, Frans R., Jansen, Jacobus F.A.

Source: Journal of Alzheimer's Disease; 2022, Vol. 89 Issue 1, p209-217, 9p

Subject Terms: ALZHEIMER'S disease, MEMORY, COGNITION disorders, MILD cognitive impairment, BRAIN, MAGNETIC resonance imaging

Corpus callosum lesions are associated with worse cognitive performance in cerebral amyloid angiopathy.

Authors: Freeze, Whitney M., Zanon Zotin, Maria Clara, Scherlek, Ashley A., Perosa, Valentina, Auger, Corinne A., Warren, Andrew D., van der Weerd, Louise, Schoemaker, Dorothee, Horn, Mitchell J., Gurol, M. Edip, Gokcal, Elif, Bacskai, Brian J., Viswanathan, Anand, Greenberg, Steven M., Reijmer, Yael D., van Veluw, Susanne J.

Source: Brain Communications; 2022, Vol. 4 Issue 3, p1-14, 14p

Perivascular space dilation is associated with vascular amyloid-β accumulation in the overlying cortex.

Authors: Perosa, Valentina, Oltmer, Jan, Munting, Leon P., Freeze, Whitney M., Auger, Corinne A., Scherlek, Ashley A., van der Kouwe, Andre J., Iglesias, Juan Eugenio, Atzeni, Alessia, Bacskai, Brian J., Viswanathan, Anand, Frosch, Matthew P., Greenberg, Steven M., van Veluw, Susanne J.

Source: Acta Neuropathologica; Mar2022, Vol. 143 Issue 3, p331-348, 18p

Subject Terms: CEREBRAL small vessel diseases, CEREBRAL amyloid angiopathy, ALZHEIMER'S disease, WASTE products

Histopathological correlates of haemorrhagic lesions on ex vivo magnetic resonance imaging in immunized Alzheimer's disease cases.

Authors: Scherlek, Ashley A., Kozberg, Mariel G., Nicoll, James A. R., Perosa, Valentina, Freeze, Whitney M., van der Weerd, Louise, Bacskai, Brian J., Greenberg, Steven M., Frosch, Matthew P., Boche, Delphine, van Veluw, Susanne J.

Source: Brain Communications; 2022, Vol. 4 Issue 1, p1-15, 15p

Interstitial fluid as a proxy of glymphatic dysfunction in patients with cognitive impairment: The necessity of three‐directional intravoxel incoherent motion.

Authors: Thiel, Merel M., Freeze, Whitney M., Jong, Joost J., Ramakers, Inez H.G.B., Backes, Walter H., Jansen, Jacobus F.A.

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2021 Supplement S5, Vol. 17, p1-4, 4p

Application of contrast-enhanced magnetic resonance imaging in the assessment of blood-cerebrospinal fluid barrier integrity.

Authors: Verheggen, Inge C.M.^1,2 (AUTHOR) inge.verheggen@maastrichtuniversity.nl, Freeze, Whitney M.^1,2,3 (AUTHOR), de Jong, Joost J.A.^2,4 (AUTHOR), Jansen, Jacobus F.A.^2,4 (AUTHOR), Postma, Alida A.^2,4 (AUTHOR), van Boxtel, Martin P.J.^1,2 (AUTHOR), Verhey, Frans R.J.^1,2 (AUTHOR), Backes, Walter H.^2,4,5 (AUTHOR)

Source: Neuroscience & Biobehavioral Reviews. Aug2021, Vol. 127, p171-183. 13p.

Subject Terms: *BLOOD-brain barrier, *CONTRAST-enhanced magnetic resonance imaging, *MAGNETICS, *CONTRAST media, *CENTRAL nervous system

Strategic corpus callosum lesions are associated with worse cognitive performance in cerebral amyloid angiopathy: Neuroimaging / Optimal neuroimaging measures for tracking disease progression.

Authors: Freeze, Whitney M., Zotin, Maria Clara Zanon, Warren, Andrew D., van der Weerd, Louise, Gurol, M. Edip, Viswanathan, Anand, Greenberg, Steven M, Reijmer, Yael D., van Veluw, Susanne J.

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2020 Supplement S11, Vol. 16 Issue 11, p1-4, 4p

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Cerebral microbleeds and amyloid pathology.

Authors: Oomens, Julie Elisabeth, Jansen, Willemijn J., Freeze, Whitney M., Maserejian, Nancy Nairi, Verhey, Frans R.J., Vos, Stephanie J. B., Visser, Pieter Jelle

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2023 Supplement 16, Vol. 19, p1-2, 2p

Imaging markers associated with the development of post-stroke depression and apathy: Results of the Cognition and Affect after Stroke – a Prospective Evaluation of Risks study.

Authors: Douven, Elles, Staals, Julie, Freeze, Whitney M, Schievink, Syenna HJ, Hellebrekers, Danique MJ, Wolz, Robin, Jansen, Jacobus FA, van Oostenbrugge, Robert J, Verhey, Frans RJ, Aalten, Pauline, Köhler, Sebastian

Source: European Stroke Journal; Mar2020, Vol. 5 Issue 1, p78-84, 7p