Advancing Chronic Liver Disease Diagnoses: Targeted Proteomics for the Non-Invasive Detection of Fibrosis

Authors: Andrea Villanueva Raisman, David Kotol, Ozlem Altay, Adil Mardinoglu, Dila Atak, Cihan Yurdaydin, Murat Akyildiz, Murat Dayangac, Hale Kirimlioglu, Müjdat Zeybel, Fredrik Edfors

Source: Livers, Vol 5, Iss 1, p 2 (2025)

Subject Terms: chronic liver disease (CLD), fibrosis biomarkers, targeted proteomics, plasma proteome profiling, mass spectrometry, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2673-4389/5/1/2; https://doaj.org/toc/2673-4389

Access URL: https://doaj.org/article/eadfea804076440a84143aaec91492f1

Metabolite interactions in the bacterial Calvin cycle and implications for flux regulation

Authors: Emil Sporre, Jan Karlsen, Karen Schriever, Johannes Asplund-Samuelsson, Markus Janasch, Linnéa Strandberg, Anna Karlsson, David Kotol, Luise Zeckey, Ilaria Piazza, Per-Olof Syrén, Fredrik Edfors, Elton P. Hudson

Source: Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/2c6980d3398e4e32bbf83c4737c7e657

Next generation pan-cancer blood proteome profiling using proximity extension assay

Authors: María Bueno Álvez, Fredrik Edfors, Kalle von Feilitzen, Martin Zwahlen, Adil Mardinoglu, Per-Henrik Edqvist, Tobias Sjöblom, Emma Lundin, Natallia Rameika, Gunilla Enblad, Henrik Lindman, Martin Höglund, Göran Hesselager, Karin Stålberg, Malin Enblad, Oscar E. Simonson, Michael Häggman, Tomas Axelsson, Mikael Åberg, Jessica Nordlund, Wen Zhong, Max Karlsson, Ulf Gyllensten, Fredrik Ponten, Linn Fagerberg, Mathias Uhlén

Source: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/79c8c836701a4495bc528c7ba433a269

Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism

Authors: Maria Jesus Iglesias, Laura Sanchez-Rivera, Manal Ibrahim-Kosta, Clément Naudin, Gaëlle Munsch, Louisa Goumidi, Maria Farm, Philip M. Smith, Florian Thibord, Julia Barbara Kral-Pointner, Mun-Gwan Hong, Pierre Suchon, Marine Germain, Waltraud Schrottmaier, Philip Dusart, Anne Boland, David Kotol, Fredrik Edfors, Mine Koprulu, Maik Pietzner, Claudia Langenberg, Scott M. Damrauer, Andrew D. Johnson, Derek M. Klarin, Nicholas L. Smith, David M. Smadja, Margareta Holmström, Maria Magnusson, Angela Silveira, Mathias Uhlén, Thomas Renné, Angel Martinez-Perez, Joseph Emmerich, Jean-Francois Deleuze, Jovan Antovic, Jose Manuel Soria Fernandez, Alice Assinger, Jochen M. Schwenk, Joan Carles Souto Andres, Pierre-Emmanuel Morange, Lynn Marie Butler, David-Alexandre Trégouët, Jacob Odeberg

Source: Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c60db97f387c490db06b926e375c503c

Targeted proteomics using stable isotope labeled protein fragments enables precise and robust determination of total apolipoprotein(a) in human plasma

Authors: Andreas Hober, Mirela Rekanovic, Björn Forsström, Sara Hansson, David Kotol, Andrew J. Percy, Mathias Uhlén, Jan Oscarsson, Fredrik Edfors, Tasso Miliotis

Source: PLoS ONE, Vol 18, Iss 2 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931122/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5d397d2c5f2c4715b0ef6fa11799ee3c

Targeted proteomics using stable isotope labeled protein fragments enables precise and robust determination of total apolipoprotein(a) in human plasma.

Authors: Andreas Hober, Mirela Rekanovic, Björn Forsström, Sara Hansson, David Kotol, Andrew J Percy, Mathias Uhlén, Jan Oscarsson, Fredrik Edfors, Tasso Miliotis

Source: PLoS ONE, Vol 18, Iss 2, p e0281772 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/7429b76562e64cb1b7908467c695472b

Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism

Authors: Maria Jesus Iglesias, Laura Sanchez-Rivera, Manal Ibrahim-Kosta, Clément Naudin, Gaëlle Munsch, Louisa Goumidi, Maria Farm, Philip M. Smith, Florian Thibord, Julia Barbara Kral-Pointner, Mun-Gwan Hong, Pierre Suchon, Marine Germain, Waltraud Schrottmaier, Philip Dusart, Anne Boland, David Kotol, Fredrik Edfors, Mine Koprulu, Maik Pietzner, Claudia Langenberg, Scott M. Damrauer, Andrew D. Johnson, Derek M. Klarin, Nicholas L. Smith, David M. Smadja, Margareta Holmström, Maria Magnusson, Angela Silveira, Mathias Uhlén, Thomas Renné, Angel Martinez-Perez, Joseph Emmerich, Jean-Francois Deleuze, Jovan Antovic, Jose Manuel Soria Fernandez, Alice Assinger, Jochen M. Schwenk, Joan Carles Souto Andres, Pierre-Emmanuel Morange, Lynn Marie Butler, David-Alexandre Trégouët, Jacob Odeberg

Source: Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/10828cb1b6164088b38dcda63f634aab

Targeted proteomics analysis of plasma proteins using recombinant protein standards for addition only workflows

Authors: David Kotol, Andreas Hober, Linnéa Strandberg, Anne-Sophie Svensson, Mathias Uhlén, Fredrik Edfors

Source: BioTechniques, Vol 71, Iss 3, Pp 473-483 (2021)

Subject Terms: blood plasma, internal standards, mass spectrometry, multiplex analysis, plasma profiling, room temperature storage, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/0736-6205; https://doaj.org/toc/1940-9818

Access URL: https://doaj.org/article/8dc11efd1e18465291d64bece981d9a8

Next generation plasma proteome profiling to monitor health and disease

Authors: Wen Zhong, Fredrik Edfors, Anders Gummesson, Göran Bergström, Linn Fagerberg, Mathias Uhlén

Source: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1bbb3cacc2fd454eb90474d2d27c313f

Integration of molecular profiles in a longitudinal wellness profiling cohort

Authors: Abdellah Tebani, Anders Gummesson, Wen Zhong, Ina Schuppe Koistinen, Tadepally Lakshmikanth, Lisa M. Olsson, Fredrik Boulund, Maja Neiman, Hans Stenlund, Cecilia Hellström, Max J. Karlsson, Muhammad Arif, Tea Dodig-Crnković, Adil Mardinoglu, Sunjae Lee, Cheng Zhang, Yang Chen, Axel Olin, Jaromir Mikes, Hanna Danielsson, Kalle von Feilitzen, Per-Anders Jansson, Oskar Angerås, Mikael Huss, Sanela Kjellqvist, Jacob Odeberg, Fredrik Edfors, Valentina Tremaroli, Björn Forsström, Jochen M. Schwenk, Peter Nilsson, Thomas Moritz, Fredrik Bäckhed, Lars Engstrand, Petter Brodin, Göran Bergström, Mathias Uhlen, Linn Fagerberg

Source: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4e06e15116714dfc930064890d3c4d1a

Whole-genome sequence association analysis of blood proteins in a longitudinal wellness cohort

Authors: Wen Zhong, Anders Gummesson, Abdellah Tebani, Max J. Karlsson, Mun-Gwan Hong, Jochen M. Schwenk, Fredrik Edfors, Göran Bergström, Linn Fagerberg, Mathias Uhlén

Source: Genome Medicine, Vol 12, Iss 1, Pp 1-16 (2020)

Subject Terms: Protein levels, Blood, Genetics, Whole-genome sequence, Genome-wide associations, Medicine, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13073-020-00755-0; https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/1ac36b5fc0e44471972ea4cbbc459c14

Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells

Authors: Rasool Saghaleyni, Magdalena Malm, Noah Moruzzi, Jan Zrimec, Ronia Razavi, Num Wistbacka, Hannes Thorell, Anton Pintar, Andreas Hober, Fredrik Edfors, Veronique Chotteau, Per-Olof Berggren, Luigi Grassi, Aleksej Zelezniak, Thomas Svensson, Diane Hatton, Jens Nielsen, Jonathan L. Robinson, Johan Rockberg

Source: Cell Reports, Vol 39, Iss 11, Pp 110936- (2022)

Subject Terms: CP: Molecular biology, CP: Cell biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124722007185; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/039c0d28027d41c49243a52c9ff39b2d

Proteomics in thrombosis research

Authors: Fredrik Edfors, Maria Jesus Iglesias, Lynn M. Butler, Jacob Odeberg

Source: Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 3, Pp n/a-n/a (2022)

Subject Terms: biomarker, mass spectrometry, plasma protein, proteome, proteomics, thrombosis, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2475-0379

Access URL: https://doaj.org/article/29cbfe73913c4d80b09bbe95589b36b5

Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms

Authors: Wen Zhong, Ozlem Altay, Muhammad Arif, Fredrik Edfors, Levent Doganay, Adil Mardinoglu, Mathias Uhlen, Linn Fagerberg

Source: EBioMedicine, Vol 74, Iss , Pp 103723- (2021)

Subject Terms: COVID-19, Protein profiling, Plasma proteome, Immune response, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S235239642100517X; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/7164b72146b44fdc9e77d6fdcc3f62b6

Rapid and sensitive detection of SARS-CoV-2 infection using quantitative peptide enrichment LC-MS analysis

Authors: Andreas Hober, Khue Hua Tran-Minh, Dominic Foley, Thomas McDonald, Johannes PC Vissers, Rebecca Pattison, Samantha Ferries, Sigurd Hermansson, Ingvar Betner, Mathias Uhlén, Morteza Razavi, Richard Yip, Matthew E Pope, Terry W Pearson, Leigh N Andersson, Amy Bartlett, Lisa Calton, Jessica J Alm, Lars Engstrand, Fredrik Edfors

Source: eLife, Vol 10 (2021)

Subject Terms: SARS CoV-2, COVID-19, SISCAPA, proteomics, diagnostics, mass spectrometry, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/70843; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/b86beb7f359342dfa0a6a2b4f3d48930

Longitudinal plasma protein profiling of newly diagnosed type 2 diabetes

Authors: Anders Gummesson, Elias Björnson, Linn Fagerberg, Wen Zhong, Abdellah Tebani, Fredrik Edfors, Caroline Schmidt, Annika Lundqvist, Martin Adiels, Fredrik Bäckhed, Jochen M Schwenk, Per-Anders Jansson, Mathias Uhlén, Göran Bergström

Source: EBioMedicine, Vol 63, Iss , Pp 103147- (2021)

Subject Terms: Type 2 diabetes, Plasma proteomics, Longitudinal profiling, Precision medicine, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396420305235; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/07a31bcd7e05499d8c624d8d087e5353

SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.

Authors: Simone De Meo, Valentina Dell'Oste, Rosa Molfetta, Valentina Tassinari, Lavinia Vittoria Lotti, Simone Vespa, Benedetta Pignoloni, Daniela Angela Covino, Laura Fantuzzi, Roberta Bona, Alessandra Zingoni, Ilaria Nardone, Matteo Biolatti, Alessandra Coscia, Rossella Paolini, Monsef Benkirane, Fredrik Edfors, Tatyana Sandalova, Adnane Achour, John Hiscott, Santo Landolfo, Angela Santoni, Cristina Cerboni

Source: PLoS Pathogens, Vol 16, Iss 9, p e1008855 (2020)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/f761f66d2d31441aba50004cfa6438dd

Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling

Authors: Tea Dodig-Crnković, Mun-Gwan Hong, Cecilia Engel Thomas, Ragna S. Häussler, Annika Bendes, Matilda Dale, Fredrik Edfors, Björn Forsström, Patrik K.E. Magnusson, Ina Schuppe-Koistinen, Jacob Odeberg, Linn Fagerberg, Anders Gummesson, Göran Bergström, Mathias Uhlén, Jochen M. Schwenk

Source: EBioMedicine, Vol 57, Iss , Pp 102854- (2020)

Subject Terms: Affinity proteomics, Longitudinal profiling, Plasma proteomics, pQTLs, Precision medicine, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396420302292; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/3bf396ecd736410fbedbd4648e4a6bf7

Enhanced validation of antibodies for research applications

Authors: Fredrik Edfors, Andreas Hober, Klas Linderbäck, Gianluca Maddalo, Alireza Azimi, Åsa Sivertsson, Hanna Tegel, Sophia Hober, Cristina Al-Khalili Szigyarto, Linn Fagerberg, Kalle von Feilitzen, Per Oksvold, Cecilia Lindskog, Björn Forsström, Mathias Uhlen

Source: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6c7d2dad78f143629130766c264377a4

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors

Authors: Alireza Azimi, Stefano Caramuta, Brinton Seashore‐Ludlow, Johan Boström, Jonathan L Robinson, Fredrik Edfors, Rainer Tuominen, Kristel Kemper, Oscar Krijgsman, Daniel S Peeper, Jens Nielsen, Johan Hansson, Suzanne Egyhazi Brage, Mikael Altun, Mathias Uhlen, Gianluca Maddalo

Source: Molecular Systems Biology, Vol 14, Iss 3, Pp 1-16 (2018)

Subject Terms: CDK2, Hsp90 and BRAF inhibitors, melanoma, MITF, proteomics, Biology (General), QH301-705.5, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/1744-4292

Access URL: https://doaj.org/article/6c5b851e266f45048761038c0f72ccff