An MRI assessment of mechanisms underlying lesion growth and shrinkage in multiple sclerosis

Authors: Ermelinda De Meo, Ferran Prados Carrasco, J. William L. Brown, Alasdair J. Coles, Nick G. Cunniffe, Amy E. Jolly, Baris Kanber, Rebecca Samson, Frederik Barkhof, Declan Chard

Source: Annals of Clinical and Translational Neurology, Vol 12, Iss 4, Pp 686-700 (2025)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/b6e8b28d4413479295641ab773978d8b

Enabling new insights from old scans by repurposing clinical MRI archives for multiple sclerosis research

Authors: Philipp Goebl, Jed Wingrove, Omar Abdelmannan, Barbara Brito Vega, Jonathan Stutters, Silvia Da Graca Ramos, Owain Kenway, Thomas Rossor, Evangeline Wassmer, Douglas L. Arnold, D. Louis Collins, Cheryl Hemingway, Sridar Narayanan, Jeremy Chataway, Declan Chard, Juan Eugenio Iglesias, Frederik Barkhof, Geoff J. M. Parker, Neil P. Oxtoby, Yael Hacohen, Alan Thompson, Daniel C. Alexander, Olga Ciccarelli, Arman Eshaghi

Source: Nature Communications, Vol 16, Iss 1, Pp 1-15 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/19344b6c063d468db4a240a77f49acce

Structured reporting of gliomas based on VASARI criteria to improve report content and consistency

Authors: Olivia Goodkin, Jiaming Wu, Hugh Pemberton, Ferran Prados, Sjoerd B. Vos, Stefanie Thust, John Thornton, Tarek Yousry, Sotirios Bisdas, Frederik Barkhof

Source: BMC Medical Imaging, Vol 25, Iss 1, Pp 1-11 (2025)

Subject Terms: Glioma, Magnetic resonance imaging (MRI), Structured reporting, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2342

Access URL: https://doaj.org/article/58559425940441d48d6e14f3c0e77749

TREM2 risk variants and associated endophenotypes in alzheimer’s disease

Authors: Janna I. R. Dijkstra, Lisa Vermunt, Vikram Venkatraghavan, Georgii Ozhegov, Emma M. Coomans, Rik Ossenkoppele, Elsmarieke van de Giessen, Marc Hulsman, Christa M. de Geus, Wiesje M. van der Flier, Sietske A. M. Sikkes, Frederik Barkhof, Betty Tijms, Alida A. Gouw, Willem de Haan, Everard G. B. Vijverberg, Yolande A. L. Pijnenburg, Henne Holstege, Charlotte E. Teunissen, Sven J. van der Lee

Source: Alzheimer’s Research & Therapy, Vol 17, Iss 1, Pp 1-15 (2025)

Subject Terms: TREM2, Alzheimer’s disease, Clinical measures, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/e9d1fa58367a4ea6b8f6da83c60e0755

Cortical lesions impact cognitive decline in multiple sclerosis via volume loss of nonlesional cortex

Authors: Eva A. Krijnen, Maureen vanDam, Albulena Bajrami, Piet M. Bouman, Samantha Noteboom, Frederik Barkhof, Bernard M.J. Uitdehaag, Martijn D. Steenwijk, Eric C. Klawiter, Ismail Koubiyr, Menno M. Schoonheim

Source: Annals of Clinical and Translational Neurology, Vol 12, Iss 1, Pp 121-136 (2025)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/cc90a1c3e7644d11b04f024555912f27

Corrigendum: Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study

Authors: Heinz Wiendl, Frederik Barkhof, Xavier Montalban, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Klaus Schmierer, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: multiple sclerosis, cladribine tablets, biomarkers, transcriptomics, immunophenotyping, immune reconstitution therapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571978/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/41742031307d4de18c3b9506865c501c

Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia

Authors: Aniek M. van Gils, Antti Tolonen, Argonde C. van Harten, Sinthujah Vigneswaran, Frederik Barkhof, Leonie N. C. Visser, Juha Koikkalainen, Sanna-Kaisa Herukka, Steen Gregers Hasselbalch, Patrizia Mecocci, Anne M. Remes, Hilkka Soininen, Afina W. Lemstra, Charlotte E. Teunissen, Linus Jönsson, Jyrki Lötjönen, Wiesje M. van der Flier, Hanneke F. M. Rhodius-Meester

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2024)

Subject Terms: Data-driven diagnosis, Differential diagnosis, Alzheimer’s disease, Eligibility, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/a2890bad16974239a6f09dd399617f9d

Biological mechanisms of resilience to tau pathology in Alzheimer’s disease

Authors: Anna L. Svenningsson, Diana I. Bocancea, Erik Stomrud, Anita van Loenhoud, Frederik Barkhof, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Oskar Hansson, Rik Ossenkoppele

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-17 (2024)

Subject Terms: Alzheimer’s disease, Tau, Brain resilience, Cognitive resilience, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/30afe2ef6d474f0e87dfb76fa9c6b8d9

Improving criteria for dissemination in space in multiple sclerosis by including additional regions

Authors: Michael A. Foster, Giuseppe Pontillo, Indran Davagnanam, Sara Collorone, Ferran Prados, Baris Kanber, Marios C. Yiannakas, Lola Ogunbowale, Ailbhe Burke, Claudia A. M. Gandini Wheeler‐Kingshott, Olga Ciccarelli, Wallace Brownlee, Frederik Barkhof, Ahmed T. Toosy

Source: Annals of Clinical and Translational Neurology, Vol 11, Iss 10, Pp 2572-2582 (2024)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/4cb54683dbd34dc184f0a58871bac033

Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study

Authors: Heinz Wiendl, Frederik Barkhof, Xavier Montalban, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Klaus Schmierer, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

Source: Frontiers in Immunology, Vol 16 (2025)

Subject Terms: multiple sclerosis, cladribine tablets, biomarkers, transcriptomics, immunophenotyping, immune reconstitution therapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2025.1512189/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/49252b9d439a4d23a12dc2404c36d7eb

Regional cerebellar atrophy related to disability and cognitive progression in multiple sclerosis

Authors: Myrte Strik, Iris Dekker, Aurélie Ruet, Hanneke Hulst, Mike P. Wattjes, Frederik Barkhof, Bernard Uitdehaag, Joep Killestein, Menno Schoonheim

Source: NeuroImage: Clinical, Vol 46, Iss , Pp 103792- (2025)

Subject Terms: Cerebellum, Structural MRI, Multiple sclerosis, Disability, Cognition, Atrophy, Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213158225000622; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/b5a72941df474ca78960b9cff6fcc8c3

Digital remote assessment of speech acoustics in cognitively unimpaired adults: feasibility, reliability and associations with amyloid pathology

Authors: Rosanne L. van den Berg, Casper de Boer, Marissa D. Zwan, Roos J. Jutten, Mariska van Liere, Marie-Christine A.B.J. van de Glind, Mark A. Dubbelman, Lisa Marie Schlüter, Argonde C. van Harten, Charlotte E. Teunissen, Elsmarieke van de Giessen, Frederik Barkhof, Lyduine E. Collij, Jessica Robin, William Simpson, John E Harrison, Wiesje M. van der Flier, Sietske A.M. Sikkes

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)

Subject Terms: Alzheimer’s disease, Amyloid, Language, Speech acoustics, Remote assessment, Digital biomarker, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/75ea7ee6329e4654a1896779b7cc2a38

Rationale and design of the BeyeOMARKER study: prospective evaluation of blood- and eye-based biomarkers for early detection of Alzheimer’s disease pathology in the eye clinic

Authors: Ilse Bader, Colin Groot, H. Stevie Tan, Jean-Marie A. Milongo, Jurre den Haan, Inge M. W. Verberk, Keir Yong, Julie Orellina, Shannon Campbell, David Wilson, Argonde C. van Harten, Pauline H. B. Kok, Wiesje M. van der Flier, Yolande A. L. Pijnenburg, Frederik Barkhof, Elsmarieke van de Giessen, Charlotte E. Teunissen, Femke H. Bouwman, Rik Ossenkoppele

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-18 (2024)

Subject Terms: Alzheimer’s disease, Screening, Blood-based biomarkers, Plasma p-tau, Hyperspectral retinal imaging, Retinal imaging, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/80e39a0fdb1b42279ca2d571671cea81

Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

Authors: Sophie E. Mastenbroek, Jacob W. Vogel, Lyduine E. Collij, Geidy E. Serrano, Cécilia Tremblay, Alexandra L. Young, Richard A. Arce, Holly A. Shill, Erika D. Driver-Dunckley, Shyamal H. Mehta, Christine M. Belden, Alireza Atri, Parichita Choudhury, Frederik Barkhof, Charles H. Adler, Rik Ossenkoppele, Thomas G. Beach, Oskar Hansson

Source: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8ead8da20952462faeaafda287e2a07f

Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure

Authors: Mario Tranfa, Luigi Lorenzini, Lyduine E. Collij, David Vállez García, Silvia Ingala, Giuseppe Pontillo, Leonard Pieperhoff, Alessio Maranzano, Robin Wolz, Sven Haller, Kaj Blennow, Giovanni Frisoni, Carole H. Sudre, Gael Chételat, Michael Ewers, Pierre Payoux, Adam Waldman, Pablo Martinez‐Lage, Adam J. Schwarz, Craig W. Ritchie, Joanna M. Wardlaw, Juan Domingo Gispert, Arturo Brunetti, Henk J. M. M. Mutsaerts, Alle Meije Wink, Frederik Barkhof

Source: Annals of Clinical and Translational Neurology, Vol 11, Iss 6, Pp 1541-1556 (2024)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/e26e34b52bc34c948ba296d241f25394

Amyloid-PET imaging predicts functional decline in clinically normal individuals

Authors: Lisa Quenon, Lyduine E. Collij, David Vállez Garcia, Isadora Lopes Alves, Thomas Gérard, Vincent Malotaux, Lara Huyghe, Juan Domingo Gispert, Frank Jessen, Pieter Jelle Visser, Anouk den Braber, Craig W. Ritchie, Mercè Boada, Marta Marquié, Rik Vandenberghe, Emma S. Luckett, Michael Schöll, Giovanni B. Frisoni, Christopher Buckley, Andrew Stephens, Daniele Altomare, Lisa Ford, Cindy Birck, Anja Mett, Rossella Gismondi, Robin Wolz, Sylke Grootoonk, Richard Manber, Mahnaz Shekari, Renaud Lhommel, Laurence Dricot, Adrian Ivanoiu, Gill Farrar, Frederik Barkhof, Bernard J. Hanseeuw, the AMYPAD Consortium

Source: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)

Subject Terms: Amyloid-PET, Centiloid, Preclinical Alzheimer, Functional decline, Instrumental activities of daily living, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/916789749e284220b7135dd30f36111c

Deep learning enables accurate brain tissue microstructure analysis based on clinically feasible diffusion magnetic resonance imaging

Authors: Yuxing Li, Zhizheng Zhuo, Chenghao Liu, Yunyun Duan, Yulu Shi, Tingting Wang, Runzhi Li, Yanli Wang, Jiwei Jiang, Jun Xu, Decai Tian, Xinghu Zhang, Fudong Shi, Xiaofeng Zhang, Aaron Carass, Frederik Barkhof, Jerry L Prince, Chuyang Ye, Yaou Liu

Source: NeuroImage, Vol 300, Iss , Pp 120858- (2024)

Subject Terms: Diffusion magnetic resonance imaging, Deep learning, Tissue microstructure reconstruction, Clinical brain analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1053811924003550; https://doaj.org/toc/1095-9572

Access URL: https://doaj.org/article/2b52606b9adc482e9d825471ede16ca7

Brain reserve and physical disability in secondary progressive multiple sclerosis

Authors: Nevin John, Jeremy Chataway, Jacqueline Palace, Gavin Giovannoni, David Paling, Frederik Barkhof, Floriana De Angelis, Lorraine Smith, Thomas Williams, Martin Duddy, James Overell, Basil Sharrack, Sebastien Ourselin, Allan Walker, Siddharthan Chandran, Richard Nicholas, Shuna Colville, Peter Connick, Carolyn Young, Jeremy Hobart, Anisha Doshi, Sharmilee Gnanapavan, Helen Ford, Baljean Dhillon, Thanh Phan, Arman Eshaghi, Julia Aram, Nigel Stallard, James Cameron, Brendan McLean, Matthew Craner, Domenico Plantone, Jonathan Stutters, Ferran Prados Carrasco, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Clive Hawkins, Roger Bastow, Daisy Mollison, Waqar Rashid, Joe Guadagno, Nikolaos Evangelou, Seema Kalra, Alberto Calvi, Yingtong Li, Tiggy Beyene, Vanessa Bassan, Alvin Zapata, Dawn Lyle, Heinke Arndt

Source: BMJ Neurology Open, Vol 6, Iss 2 (2024)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://neurologyopen.bmj.com/content/6/2/e000670.full; https://doaj.org/toc/2632-6140

Access URL: https://doaj.org/article/03779c5cc9264a67966bb74f4a5ef24d

Investigating the relationship between thalamic iron concentration and disease severity in secondary progressive multiple sclerosis using quantitative susceptibility mapping: Cross-sectional analysis from the MS-STAT2 randomised controlled trial

Authors: Thomas Williams, Nevin John, Alberto Calvi, Alessia Bianchi, Floriana De Angelis, Anisha Doshi, Sarah Wright, Madiha Shatila, Marios C. Yiannakas, Fatima Chowdhury, Jon Stutters, Antonio Ricciardi, Ferran Prados, David MacManus, Francesco Grussu, Anita Karsa, Becky Samson, Marco Battiston, Claudia A.M. Gandini Wheeler-Kingshott, Karin Shmueli, Olga Ciccarelli, Frederik Barkhof, Jeremy Chataway, Wallace Brownlee, Claudia AM. Gandini Wheeler-Kingshott, Jonathan Stutters, Ferran Prados Carrasco, Marios Yiannakas, Megan Wynne, Marie Braisher, James Blackstone, Leanne Hockey, Josephine Parker, Jennifer Flight, Chris Frost, Jennifer Nicholas, Stuart Nixon, Judy Beveridge

Source: Neuroimage: Reports, Vol 4, Iss 3, Pp 100216- (2024)

Subject Terms: Multiple sclerosis, Deep grey matter, Thalamus, Iron, Quantitative susceptibility mapping, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666956024000229; https://doaj.org/toc/2666-9560

Access URL: https://doaj.org/article/a5f0c83cc2dc4adf9dbc117e4d8f1ca0

Validation of image-derived input function using a long axial field of view PET/CT scanner for two different tracers

Authors: Xavier Palard-Novello, Denise Visser, Nelleke Tolboom, Charlotte L. C. Smith, Gerben Zwezerijnen, Elsmarieke van de Giessen, Marijke E. den Hollander, Frederik Barkhof, Albert D. Windhorst, Bart NM van Berckel, Ronald Boellaard, Maqsood Yaqub

Source: EJNMMI Physics, Vol 11, Iss 1, Pp 1-13 (2024)

Subject Terms: [18F]DPA-714, [18F]FDG, LAFOV PET/CT, IDIF, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2197-7364

Access URL: https://doaj.org/article/14582a280aeb4cb5b8e15da9c4eba088