Development and evaluation of Hsp90-targeting nanobodies for visualisation of extracellular Hsp90 in tumours using PET imaging

Authors: Valeria Narykina, Janke Kleynhans, Christopher Cawthorne, Joost Schymkowitz, Frederic Rousseau, Guy Bormans

Source: EJNMMI Radiopharmacy and Chemistry, Vol 10, Iss 1, Pp 1-23 (2025)

Subject Terms: Hsp90, Nanobodies, PET imaging, Gallium-68, Cancer, Diagnostics, Medical physics. Medical radiology. Nuclear medicine, R895-920, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2365-421X

Access URL: https://doaj.org/article/3478bddd699b4e7d8665556957dd341e

Native Fold Delay and its implications for co-translational chaperone binding and protein aggregation

Authors: Ramon Duran-Romaña, Bert Houben, Paula Fernández Migens, Ying Zhang, Frederic Rousseau, Joost Schymkowitz

Source: Nature Communications, Vol 16, Iss 1, Pp 1-14 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/22f3494354e7455b89086566d0ad0f3f

Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism

Authors: Laleh Khodaparast, Ladan Khodaparast, Ramon Duran-Romaña, Guiqin Wu, Bert Houben, Wouter Duverger, Matthias De Vleeschouwer, Katerina Konstantoulea, Fleur Nysen, Thomas Schalck, Daniel J. Curwen, Lisandra L. Martin, Sebastien Carpentier, Bernard Scorneaux, Jan Michiels, Joost Schymkowitz, Frederic Rousseau

Source: Nature Communications, Vol 16, Iss 1, Pp 1-18 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4c6d68abdfd24664b63f985c1e7b85da

Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity

Authors: Amy Dashwood, Ntombizodwa Makuyana, Rob van der Kant, Arman Ghodsinia, Alvaro R. Hernandez, Stephanie Lienart, Oliver Burton, James Dooley, Magda Ali, Lubna Kouser, Francisco Naranjo, Matthew G. Holt, Frederic Rousseau, Joost Schymkowitz, Adrian Liston

Source: Computational and Structural Biotechnology Journal, Vol 27, Iss , Pp 1112-1123 (2025)

Subject Terms: Interleukin-2, Cytokine, Protein engineering, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2001037025000716; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/bbf5a2197aa04d7885455a6e9ab2ddf3

Composition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery

Authors: Celien Bollen, Sofie Louwagie, Femke Deroover, Wouter Duverger, Ladan Khodaparast, Laleh Khodaparast, Dieter Hofkens, Joost Schymkowitz, Frederic Rousseau, Liselot Dewachter, Jan Michiels

Source: Nature Communications, Vol 16, Iss 1, Pp 1-16 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8252e88ff81846e88fd0577a2f874257

pTau pathology in the retina of TAU58 mice: association with ganglion cell degeneration and implications on seeding and propagation of pTau from human brain lysates

Authors: Grzegorz Walkiewicz, Alicja Ronisz, Simona Ospitalieri, Grigoria Tsaka, Sandra O. Tomé, Rik Vandenberghe, Christine A. F. von Arnim, Frederic Rousseau, Joost Schymkowitz, Lies De Groef, Dietmar Rudolf Thal

Source: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-24 (2024)

Subject Terms: Tauopathy, Retina, Alzheimer’s disease, Subretinal injections, Tau, Neuronal loss, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/3daffad52265471085dc09c7b65b9213

Emergence of the B.1.214.2 SARS-CoV-2 lineage with an Omicron-like spike insertion and a unique upper airway immune signature

Authors: Andrew Holtz, Johan Van Weyenbergh, Samuel L. Hong, Lize Cuypers, Áine O’Toole, Gytis Dudas, Marco Gerdol, Barney I. Potter, Francine Ntoumi, Claujens Chastel Mfoutou Mapanguy, Bert Vanmechelen, Tony Wawina-Bokalanga, Bram Van Holm, Soraya Maria Menezes, Katja Soubotko, Gijs Van Pottelbergh, Elke Wollants, Pieter Vermeersch, Ann-Sophie Jacob, Brigitte Maes, Dagmar Obbels, Veerle Matheeussen, Geert Martens, Jérémie Gras, Bruno Verhasselt, Wim Laffut, Carl Vael, Truus Goegebuer, Rob van der Kant, Frederic Rousseau, Joost Schymkowitz, Luis Serrano, Javier Delgado, Tom Wenseleers, Vincent Bours, Emmanuel André, Marc A. Suchard, Andrew Rambaut, Simon Dellicour, Piet Maes, Keith Durkin, Guy Baele

Source: BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-18 (2024)

Subject Terms: SARS-CoV-2, Genomic epidemiology, Phylogeography, Phylodynamics, Disease spread, COVID-19, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2334

Access URL: https://doaj.org/article/e0f6914f63ac463b94c41b5682afba1e

An end-to-end approach for single-cell infrared absorption spectroscopy of bacterial inclusion bodies: from AFM-IR measurement to data interpretation of large sample sets

Authors: Wouter Duverger, Grigoria Tsaka, Ladan Khodaparast, Laleh Khodaparast, Nikolaos Louros, Frederic Rousseau, Joost Schymkowitz

Source: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-15 (2024)

Subject Terms: AFM-IR, Image analysis, Protein aggregation, Escherichia coli, Infrared spectroscopy, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/4239ed71b40d41ee977281559da021dd

Local structural preferences in shaping tau amyloid polymorphism

Authors: Nikolaos Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D’Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R. Mackenzie, Rosa Rademakers, Neil A. Ranson, Sheena E. Radford, Frederic Rousseau, Joost Schymkowitz

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f3710df2103c4621bd7f36ca9c11b864

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Authors: Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/577fe276aea04bb88f22a8e1a4973c8a

TDP-43 pathology is associated with increased tau burdens and seeding

Authors: Sandra O. Tomé, Grigoria Tsaka, Alicja Ronisz, Simona Ospitalieri, Klara Gawor, Luis Aragão Gomes, Markus Otto, Christine A. F. von Arnim, Philip Van Damme, Ludo Van Den Bosch, Estifanos Ghebremedhin, Celeste Laureyssen, Kristel Sleegers, Rik Vandenberghe, Frederic Rousseau, Joost Schymkowitz, Dietmar Rudolf Thal

Source: Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-18 (2023)

Subject Terms: Alzheimer’s Disease, TDP-43, LATE-NC, Co-pathologies seeding, Tau, Protein aggregation, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: https://doaj.org/toc/1750-1326

Access URL: https://doaj.org/article/6d4c20f39ade433fbec5db315642c427

SNPeffect 5.0: large-scale structural phenotyping of protein coding variants extracted from next-generation sequencing data using AlphaFold models

Authors: Kobe Janssen, Ramon Duran-Romaña, Guy Bottu, Mainak Guharoy, Alexander Botzki, Frederic Rousseau, Joost Schymkowitz

Source: BMC Bioinformatics, Vol 24, Iss 1, Pp 1-9 (2023)

Subject Terms: SNPeffect, AlphaFold, Protein stability, Single nucleotide variants, Coding missense variants, Protein aggregation, Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2105

Access URL: https://doaj.org/article/c87eed1678864af89b194b57ff135748

Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers

Authors: Nikolaos Louros, Meine Ramakers, Emiel Michiels, Katerina Konstantoulea, Chiara Morelli, Teresa Garcia, Nele Moonen, Sam D’Haeyer, Vera Goossens, Dietmar Rudolf Thal, Dominique Audenaert, Frederic Rousseau, Joost Schymkowitz

Source: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e15b998d4cc744bfad75519cf5ead39e

PyUUL provides an interface between biological structures and deep learning algorithms

Authors: Gabriele Orlando, Daniele Raimondi, Ramon Duran-Romaña, Yves Moreau, Joost Schymkowitz, Frederic Rousseau

Source: Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ee159eb4a39446e8a25f11bb47a97ff7

HPMPdb: A machine learning-ready database of protein molecular phenotypes associated to human missense variants

Authors: Daniele Raimondi, Francesco Codicè, Gabriele Orlando, Joost Schymkowitz, Frederic Rousseau, Yves Moreau

Source: Current Research in Structural Biology, Vol 4, Iss , Pp 167-174 (2022)

Subject Terms: Single aminoacid variants, Molecular phenotype, Variant-effect predictor, Database, Bioinformatics, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2665928X22000125; https://doaj.org/toc/2665-928X

Access URL: https://doaj.org/article/dbf0949d1fa947d0b05c9dcf5b321c6c

Enhanced therapeutic window for antimicrobial Pept-ins by investigating their structure-activity relationship.

Authors: Guiqin Wu, Laleh Khodaparast, Ladan Khodaparast, Matthias De Vleeschouwer, Nikolaos Louros, Rodrigo Gallardo, Pengpeng Yi, Frederic Rousseau, Joost Schymkowitz

Source: PLoS ONE, Vol 18, Iss 3, p e0283674 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/bf9a2434720d42e7b40e62e020a273d1

Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions

Authors: Shu Liu, André Hossinger, Stefanie-Elisabeth Heumüller, Annika Hornberger, Oleksandra Buravlova, Katerina Konstantoulea, Stephan A. Müller, Lydia Paulsen, Frederic Rousseau, Joost Schymkowitz, Stefan F. Lichtenthaler, Manuela Neumann, Philip Denner, Ina M. Vorberg

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3c987601848e42e7821270559f3b20a9

MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome

Authors: Cedric Thues, Jorge S. Valadas, Liesbeth Deaulmerie, Ann Geens, Amit K. Chouhan, Ramon Duran-Romaña, Joost Schymkowitz, Frederic Rousseau, Michaela Bartusel, Rizwan Rehimi, Alvaro Rada-Iglesias, Patrik Verstreken, Hilde Van Esch

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/21a523c5582d4005ad24a2cf349d7f1b

Heating Wheat Gluten Promotes the Formation of Amyloid-like Fibrils

Authors: Margarita Monge-Morera, Marlies A. Lambrecht, Lomme J. Deleu, Nikolaos N. Louros, Frederic Rousseau, Joost Schymkowitz, Jan A. Delcour

Source: ACS Omega, Vol 6, Iss 3, Pp 1823-1833 (2021)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2470-1343

Access URL: https://doaj.org/article/a50b5a69a4b74efab4ebc6196c48cc5a

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities

Authors: Nikolaos Louros, Gabriele Orlando, Matthias De Vleeschouwer, Frederic Rousseau, Joost Schymkowitz

Source: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2a64a32adfa14ef9a2a2d237d6f0b10b