Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use

Authors: Surendran, Praveen, Young, Robin, Barnes, Daniel R., Nielsen, Sune Fallgaard, Rasheed, Asif, Samuel, Maria, Zhao, Wei, Kontto, Jukka, Perola, Markus, Caslake, Muriel, de Craen, Anton J.M., Trompet, Stella, Uria-Nickelsen, Maria, Malarstig, Anders, Reily, Dermot F., Hoek, Maarten, Vogt, Thomas, Jukema, J. Wouter, Sattar, Naveed, Ford, Ian, Packard, Chris J., Alam, Dewan S., Majumder, Abdulla al Shafi, Di Angelantonio, Emanuele, Chowdhury, Rajiv, Amouyel, Philippe, Arveiler, Dominique, Blankenberg, Stefan, Ferrières, Jean, Kee, Frank, Kuulasmaa, Kari, Müller-Nurasyid, Martina, Veronesi, Giovanni, Virtamo, Jarmo, EPIC-CVD Consortium, Frossard, Philippe, Nordestgaard, Børge Grønne, Saleheen, Danish, Danesh, John, Butterworth, Adam S., Howson, Joanna M.M., Erzurumluoglu, A. Mesut, Jackson, Victoria E., Melbourne, Carl A., Varga, Tibor V., Warren, Helen R., Tragante, Vinicius, Tachmazidou, Ioanna, Harris, Sarah E., Evangelou, Evangelos, Marten, Jonathan, Zhang, Weihua, Altmaier, Elisabeth, Luan, Jian’an, Langenberg, Claudia, Scott, Robert A., Yaghootkar, Hanieh, Stirrups, Kathleen, Kanoni, Stavroula, Marouli, Eirini, Karpe, Fredrik, Dominiczak, Anna F., Sever, Peter, Poulter, Neil, Rolandsson, Olov, Baumbach, Clemens, Afaq, Saima, Chambers, John C., Kooner, Jaspal S., Wareham, Nicholas J., Renström, Frida, Hallmans, Göran, Marioni, Riccardo E., Corley, Janie, Starr, John M., Verweij, Niek, de Boer, Rudolf A., van der Meer, Peter, Yavas, Ersin, Vaartjes, Ilonca, Bots, Michiel L., Asselbergs, Folkert W., Grabe, Hans J., Völzke, Henry, Nauck, Matthias, Weiss, Stefan, Pharoah, Paul D.P., Dunning, Alison M., Dennis, Joe G., Thompson, Deborah J., Michailidou, Kyriaki, Easton, Douglas F., Antoniou, Antonis C., Tyrrell, Jessica, Mihailov, Evelin, Samani, Nilesh J., Zhou, Kaixin, Neville, Matthew J., Metspalu, Andres, Palmer, Colin N.A., Hall, Ian P., Strachan, David P., Deary, Ian J., Frayling, Tim M., Hayward, Caroline, van der Harst, Pim, Zeggini, Eleftheria, Understanding Society Scientific Group, Munroe, Patricia B., Jansson, Jan-Håkan, Franks, Paul W., Deloukas, Panos, Caulfield, Mark J., Wain, Louise V., Tobin, Martin D., Brazel, David M., Jiang, Yu, Hughey, Jordan M., Turcot, Valérie, Zhan, Xiaowei, Gong, Jian, Batini, Chiara, Weissenkampen, J. Dylan, Liu, MengZhen, Bertelsen, Sarah, Chou, Yi-Ling, Faul, Jessica D., Haessler, Jeff, Hammerschlag, Anke R., Hsu, Chris, Kapoor, Manav, Lai, Dongbing, Le, Nhung, de Leeuw, Christiaan A., Loukola, Anu, Mangino, Massimo, Pistis, Giorgio, Qaiser, Beenish, Rohde, Rebecca, Shao, Yaming, Stringham, Heather, Wetherill, Leah, Agrawal, Arpana, Bierut, Laura, Chen, Chu, Eaton, Charles B., Goate, Alison, Haiman, Christopher, Heath, Andrew, Iacono, William G., Martin, Nicholas G., Polderman, Tinca J., Reiner, Alex, Rice, John, Schlessinger, David, Scholte, H. Steven, Smith, Jennifer A., Tardif, Jean-Claude, Tindle, Hilary A., van der Leij, Andries R., Boehnke, Michael, Chang-Claude, Jenny, Cucca, Francesco, David, Sean P., Foroud, Tatiana, Kardia, Sharon L.R., Kooperberg, Charles, Laakso, Markku, Lettre, Guillaume, Madden, Pamela, McGue, Matt, North, Kari, Posthuma, Danielle, Spector, Timothy, Stram, Daniel, Weir, David R., Kaprio, Jaakko, Abecasis, Gonçalo R., Liu, Dajiang J., Vrieze, Scott

Source: In Biological Psychiatry 1 June 2019 85(11):946-955

Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity

Authors: Deshmukh, Harshal A, Madsen, Anne Lundager, Viñuela, Ana, Have, Christian Theil, Grarup, Niels, Tura, Andrea, Mahajan, Anubha, Heggie, Alison J, Koivula, Robert W, De Masi, Federico, Tsirigos, Konstantinos K, Linneberg, Allan, Drivsholm, Thomas, Pedersen, Oluf, Sørensen, Thorkild I A, Astrup, Arne, Gjesing, Anette A P, Pavo, Imre, Wood, Andrew R, Ruetten, Hartmut, Jones, Angus G, Koopman, Anitra D M, Cederberg, Henna, Rutters, Femke, Ridderstrale, Martin, Laakso, Markku, McCarthy, Mark I, Frayling, Tim M, Ferrannini, Ele, Franks, Paul W, Pearson, Ewan R, Mari, Andrea, Hansen, Torben, Walker, Mark

Source: Journal of clinical endocrinology & metabolism. 106(1):80-90

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138371778.0x000001&indx=1&recIds=ETOCvdc_100138371778.0x000001

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

Authors: Alizadeh, Behrooz Z., Boezen, H. Marike, Franke, Lude, van der Harst, Pim, Navis, Gerjan, Rots, Marianne, Snieder, Harold, Swertz, Morris, Wolffenbuttel, Bruce H.R., Wijmenga, Cisca, Benjamin, Emelia, Chasman, Daniel I., Dehghan, Abbas, Ahluwalia, Tarunveer Singh, Meigs, James, Tracy, Russell, Ligthart, Symen, Bis, Josh, Eiriksdottir, Gudny, Pankratz, Nathan, Gross, Myron, Rainer, Alex, Wilson, James G., Psaty, Bruce M., Dupuis, Josee, Prins, Bram, Vaso, Urmo, Stathopoulou, Maria, Lehtimaki, Terho, Koenig, Wolfgang, Jamshidi, Yalda, Siest, Sophie, Abbasi, Ali, Uitterlinden, Andre G., Abdollahi, Mohammadreza, Schnabel, Renate, Schick, Ursula M., Nolte, Ilja M., Kraja, Aldi, Hsu, Yi-Hsiang, Tylee, Daniel S., Zwicker, Alyson, Uher, Rudolf, Davey-Smith, George, Morrison, Alanna C., Hicks, Andrew, van Duijn, Cornelia M., Ward-Caviness, Cavin, Boerwinkle, Eric, Rotter, J., Rice, Ken, Lange, Leslie, Perola, Markus, de Geus, Eco, Morris, Andrew P., Makela, Kari Matti, Stacey, David, Eriksson, Johan, Frayling, Tim M., Slagboom, Eline P., Vaez, Ahmad, Võsa, Urmo, Stathopoulou, Maria G., de Vries, Paul S., Prins, Bram P., Van der Most, Peter J., Tanaka, Toshiko, Naderi, Elnaz, Rose, Lynda M., Wu, Ying, Karlsson, Robert, Barbalic, Maja, Lin, Honghuang, Pool, René, Zhu, Gu, Macé, Aurélien, Sidore, Carlo, Trompet, Stella, Mangino, Massimo, Sabater-Lleal, Maria, Kemp, John P., Kacprowski, Tim, Verweij, Niek, Smith, Albert V., Huang, Tao, Marzi, Carola, Feitosa, Mary F., Lohman, Kurt K., Kleber, Marcus E., Milaneschi, Yuri, Mueller, Christian, Huq, Mahmudul, Vlachopoulou, Efthymia, Lyytikäinen, Leo-Pekka, Oldmeadow, Christopher, Deelen, Joris, Zhao, Jing Hua, Feenstra, Bjarke, Amini, Marzyeh, Lahti, Jari, Schraut, Katharina E., Fornage, Myriam, Suktitipat, Bhoom, Chen, Wei-Min, Li, Xiaohui, Nutile, Teresa, Malerba, Giovanni, Luan, Jian’an, Bak, Tom, Schork, Nicholas, Del Greco M., Fabiola, Thiering, Elisabeth, Mahajan, Anubha, Marioni, Riccardo E., Mihailov, Evelin, Eriksson, Joel, Ozel, Ayse Bilge, Zhang, Weihua, Nethander, Maria, Cheng, Yu-Ching, Aslibekyan, Stella, Ang, Wei, Gandin, Ilaria, Yengo, Loïc, Portas, Laura, Kooperberg, Charles, Hofer, Edith, Rajan, Kumar B., Schurmann, Claudia, den Hollander, Wouter, Ahluwalia, Tarunveer S., Zhao, Jing, Draisma, Harmen H.M., Ford, Ian, Timpson, Nicholas, Teumer, Alexander, Huang, Hongyan, Wahl, Simone, Liu, YongMei, Huang, Jie, Uh, Hae-Won, Geller, Frank, Joshi, Peter K., Yanek, Lisa R., Trabetti, Elisabetta, Lehne, Benjamin, Vozzi, Diego, Verbanck, Marie, Biino, Ginevra, Saba, Yasaman, Meulenbelt, Ingrid, O’Connell, Jeff R., Laakso, Markku, Giulianini, Franco, Magnusson, Patrik K.E., Ballantyne, Christie M., Hottenga, Jouke Jan, Montgomery, Grant W., Rivadineira, Fernando, Rueedi, Rico, Steri, Maristella, Herzig, Karl-Heinz, Stott, David J., Menni, Cristina, Frånberg, Mattias, St. Pourcain, Beate, Felix, Stephan B., Pers, Tune H., Bakker, Stephan J.L., Kraft, Peter, Peters, Annette, Vaidya, Dhananjay, Delgado, Graciela, Smit, Johannes H., Großmann, Vera, Sinisalo, Juha, Seppälä, Ilkka, Williams, Stephen R., Holliday, Elizabeth G., Moed, Matthijs, Langenberg, Claudia, Räikkönen, Katri, Ding, Jingzhong, Campbell, Harry, Sale, Michele M., Chen, Yii-Der I., James, Alan L., Ruggiero, Daniela, Soranzo, Nicole, Hartman, Catharina A., Smith, Erin N., Berenson, Gerald S., Fuchsberger, Christian, Hernandez, Dena, Tiesler, Carla M.T., Giedraitis, Vilmantas, Liewald, David, Fischer, Krista, Mellström, Dan, Larsson, Anders, Wang, Yunmei, Scott, William R., Lorentzon, Matthias, Beilby, John, Ryan, Kathleen A., Pennell, Craig E., Vuckovic, Dragana, Balkau, Beverly, Concas, Maria Pina, Schmidt, Reinhold, Mendes de Leon, Carlos F., Bottinger, Erwin P., Kloppenburg, Margreet, Paternoster, Lavinia, Boehnke, Michael, Musk, A.W., Willemsen, Gonneke, Evans, David M., Madden, Pamela A.F., Kähönen, Mika, Kutalik, Zoltán, Zoledziewska, Magdalena, Karhunen, Ville, Kritchevsky, Stephen B., Sattar, Naveed, Lachance, Genevieve, Clarke, Robert, Harris, Tamara B., Raitakari, Olli T., Attia, John R., van Heemst, Diana, Kajantie, Eero, Sorice, Rossella, Gambaro, Giovanni, Scott, Robert A., Hicks, Andrew A., Ferrucci, Luigi, Standl, Marie, Lindgren, Cecilia M., Starr, John M., Karlsson, Magnus, Lind, Lars, Li, Jun Z., Chambers, John C., Mori, Trevor A., de Geus, Eco J.C.N., Heath, Andrew C., Martin, Nicholas G., Auvinen, Juha, Buckley, Brendan M., de Craen, Anton J.M., Waldenberger, Melanie, Strauch, Konstantin, Meitinger, Thomas, Scott, Rodney J., McEvoy, Mark, Beekman, Marian, Bombieri, Cristina, Ridker, Paul M., Mohlke, Karen L., Pedersen, Nancy L., Boomsma, Dorret I., Whitfield, John B., Strachan, David P., Hofman, Albert, Vollenweider, Peter, Cucca, Francesco, Jarvelin, Marjo-Riitta, Jukema, J. Wouter, Spector, Tim D., Hamsten, Anders, Zeller, Tanja, Uitterlinden, André G., Nauck, Matthias, Gudnason, Vilmundur, Qi, Lu, Grallert, Harald, Borecki, Ingrid B., Rotter, Jerome I., März, Winfried, Wild, Philipp S., Lokki, Marja-Liisa, Boyle, Michael, Salomaa, Veikko, Melbye, Mads, Eriksson, Johan G., Wilson, James F., Penninx, Brenda W.J.H., Becker, Diane M., Worrall, Bradford B., Gibson, Greg, Krauss, Ronald M., Ciullo, Marina, Zaza, Gianluigi, Wareham, Nicholas J., Oldehinkel, Albertine J., Palmer, Lyle J., Murray, Sarah S., Pramstaller, Peter P., Bandinelli, Stefania, Heinrich, Joachim, Ingelsson, Erik, Deary, Ian J., Mägi, Reedik, Vandenput, Liesbeth, Desch, Karl C., Kooner, Jaspal S., Ohlsson, Claes, Hayward, Caroline, Lehtimäki, Terho, Shuldiner, Alan R., Arnett, Donna K., Beilin, Lawrence J., Robino, Antonietta, Froguel, Philippe, Pirastu, Mario, Jess, Tine, Loos, Ruth J.F., Evans, Denis A., Schmidt, Helena, Smith, George Davey, Slagboom, P. Eline, Tracy, Russell P., Visvikis-Siest, Sophie, Reiner, Alex P., Bis, Joshua C., Franco, Oscar H., Benjamin, Emelia J., Dupuis, Josée

Source: In The American Journal of Human Genetics 1 November 2018 103(5):691-706

A Common Haplotype of the Glucokinase Gene Alters Fasting Glucose and Birth Weight: Association in Six Studies and Population-Genetics Analyses

Authors: Weedon, Michael N., Clark, Vanessa J., Qian, Yudong, Ben-Shlomo, Yoav, Timpson, Nicholas, Ebrahim, Shah, Lawlor, Debbie A., Pembrey, Marcus E., Ring, Susan, Wilkin, Terry J., Voss, Linda D., Jeffery, Alison N., Metcalf, Brad, Ferrucci, Luigi, Corsi, Anna Maria, Murray, Anna, Melzer, David, Knight, Bridget, Shields, Bev, Smith, George Davey, Hattersley, Andrew T., Di Rienzo, Anna, Frayling, Tim M. ^*

Source: In The American Journal of Human Genetics December 2006 79(6):991-1001

Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity

Authors: Deshmukh, Harshal A, Madsen, Anne Lundager, Viñuela, Ana, Have, Christian Theil, Grarup, Niels, Tura, Andrea, Mahajan, Anubha, Heggie, Alison J, Koivula, Robert W, De Masi, Federico, Tsirigos, Konstantinos K, Linneberg, Allan, Drivsholm, Thomas, Pedersen, Oluf, Sørensen, Thorkild I A, Astrup, Arne, Gjesing, Anette A P, Pavo, Imre, Wood, Andrew R, Ruetten, Hartmut, Jones, Angus G, Koopman, Anitra D M, Cederberg, Henna, Rutters, Femke, Ridderstrale, Martin, Laakso, Markku, McCarthy, Mark I, Frayling, Tim M, Ferrannini, Ele, Franks, Paul W, Pearson, Ewan R, Mari, Andrea, Hansen, Torben, Walker, Mark

Source: The Journal of Clinical Endocrinology & Metabolism; January 2021, Vol. 106 Issue: 1 p80-90, 11p

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Authors: Erzurumluoglu, A. Mesut, Liu, Mengzhen, Jackson, Victoria E., Barnes, Daniel R., Datta, Gargi, Melbourne, Carl A., Young, Robin, Batini, Chiara, Surendran, Praveen, Jiang, Tao, Adnan, Sheikh Daud, Afaq, Saima, Agrawal, Arpana, Altmaier, Elisabeth, Antoniou, Antonis C., Asselbergs, Folkert W., Baumbach, Clemens, Bierut, Laura, Bertelsen, Sarah, Boehnke, Michael, Bots, Michiel L., Brazel, David M, Chambers, John C., Chang-Claude, Jenny, Chen, Chu, Corley, Janie, Chou, Yi-Ling, David, Sean P., de Boer, Rudolf A., de Leeuw, Christiaan A., Dennis, Joe G., Dominiczak, Anna F., Dunning, Alison M., Easton, Douglas F., Eaton, Charles, Elliott, Paul, Evangelou, Evangelos, Faul, Jessica D., Foroud, Tatiana, Goate, Alison, Gong, Jian, Grabe, Hans J., Haessler, Jeff, Haiman, Christopher, Hallmans, Göran, Hammerschlag, Anke R., Harris, Sarah E., Hattersley, Andrew, Heath, Andrew, Hsu, Chris, Iacono, William G., Kanoni, Stavroula, Kapoor, Manav, Kaprio, Jaakko, Kardia, Sharon L., Karpe, Fredrik, Kontto, Jukka, Kooner, Jaspal S., Kooperberg, Charles, Kuulasmaa, Kari, Laakso, Markku, Lai, Dongbing, Langenberg, Claudia, Le, Nhung, Lettre, Guillaume, Loukola, Anu, Luan, Jian’an, Madden, Pamela A. F., Mangino, Massimo, Marioni, Riccardo E., Marouli, Eirini, Marten, Jonathan, Martin, Nicholas G., McGue, Matt, Michailidou, Kyriaki, Mihailov, Evelin, Moayyeri, Alireza, Moitry, Marie, Müller-Nurasyid, Martina, Naheed, Aliya, Nauck, Matthias, Neville, Matthew J., Nielsen, Sune Fallgaard, North, Kari, Perola, Markus, Pharoah, Paul D. P., Pistis, Giorgio, Polderman, Tinca J., Posthuma, Danielle, Poulter, Neil, Qaiser, Beenish, Rasheed, Asif, Reiner, Alex, Renström, Frida, Rice, John, Rohde, Rebecca, Rolandsson, Olov, Samani, Nilesh J., Samuel, Maria, Schlessinger, David, Scholte, Steven H, Scott, Robert A., Sever, Peter, Shao, Yaming, Shrine, Nick, Smith, Jennifer A., Starr, John M., Stirrups, Kathleen, Stram, Danielle, Stringham, Heather M., Tachmazidou, Ioanna, Tardif, Jean-Claude, Thompson, Deborah J., Tindle, Hilary A., Tragante, Vinicius, Trompet, Stella, Turcot, Valerie, Tyrrell, Jessica, Vaartjes, Ilonca, van der Leij, Andries R, van der Meer, Peter, Varga, Tibor V., Verweij, Niek, Völzke, Henry, Wareham, Nicholas J., Warren, Helen R., Weir, David R., Weiss, Stefan, Wetherill, Leah, Yaghootkar, Hanieh, Yavas, Ersin, Jiang, Yu, Chen, Fang, Zhan, Xiaowei, Zhang, Weihua, Zhao, Wei, Zhao, Wei, Zhou, Kaixin, Amouyel, Philippe, Blankenberg, Stefan, Caulfield, Mark J., Chowdhury, Rajiv, Cucca, Francesco, Deary, Ian J., Deloukas, Panos, Di Angelantonio, Emanuele, Ferrario, Marco, Ferrières, Jean, Franks, Paul W., Frayling, Tim M., Frossard, Philippe, Hall, Ian P., Hayward, Caroline, Jansson, Jan-Håkan, Jukema, J. Wouter, Kee, Frank, Männistö, Satu, Metspalu, Andres, Munroe, Patricia B., Nordestgaard, Børge Grønne, Palmer, Colin N. A., Salomaa, Veikko, Sattar, Naveed, Spector, Timothy, Strachan, David Peter, van der Harst, Pim, Zeggini, Eleftheria, Saleheen, Danish, Butterworth, Adam S., Wain, Louise V., Abecasis, Goncalo R., Danesh, John, Tobin, Martin D., Vrieze, Scott, Liu, Dajiang J., Howson, Joanna M. M.

Source: Molecular Psychiatry; October 2020, Vol. 25 Issue: 10 p2392-2409, 18p

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