Analysis of the spatiotemporal dynamics of vascular injury and regeneration following experimental Spinal Cord Injury

Authors: Christian J. Entenmann, Emily J. von Bronewski, Lilly Waldmann, Lea Meyer, Katharina Kersting, Laurens T. Roolfs, Lasse M. Schleker, Melina Nieminen-Kelhä, Irina Kremenetskaia, Frank L. Heppner, Michael G. Fehlings, Peter Vajkoczy, Vanessa Hubertus

Source: Brain and Spine, Vol 5, Iss , Pp 104191- (2025)

Subject Terms: Spinal cord injury, Vascular injury, Vascular proliferation, Blood spinal cord barrier, Revascularization, Angiogenesis, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772529425000104; https://doaj.org/toc/2772-5294

Access URL: https://doaj.org/article/0bf3ae4d76094fd29d44ece5b7366f72

Testicular large B‐cell lymphoma is genetically similar to PCNSL and distinct from nodal DLBCL

Authors: Alfredo Rivas‐Delgado, Cristina López, Guillem Clot, Ferran Nadeu, Marta Grau, Gerard Frigola, Jan Bosch‐Schips, Josefine Radke, Naveed Ishaque, Miguel Alcoceba, Gustavo Tapia, Luis Luizaga, Carmen Barcena, Nicholas Kelleher, Neus Villamor, Tycho Baumann, Ana Muntañola, Juan M. Sancho‐Cia, Alejandro M. García‐Sancho, Eva Gonzalez‐Barca, Estella Matutes, Jordi A. Brito, Kennosuke Karube, Itziar Salaverria, Anna Enjuanes, Stefan Wiemann, Frank L. Heppner, Reiner Siebert, Fina Climent, Elías Campo, Eva Giné, Armando López‐Guillermo, Silvia Beà

Source: HemaSphere, Vol 8, Iss 10, Pp n/a-n/a (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/ec3ea50f5fa34445b7bb245aac1171ed

Differential contribution of THIK-1 K+ channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia

Authors: Ali Rifat, Bernardino Ossola, Roland W. Bürli, Lee A. Dawson, Nicola L. Brice, Anna Rowland, Marina Lizio, Xiao Xu, Keith Page, Pawel Fidzinski, Julia Onken, Martin Holtkamp, Frank L. Heppner, Jörg R. P. Geiger, Christian Madry

Source: Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-17 (2024)

Subject Terms: Ion channels, Microglia, Neuroinflammation, Human brain, Neocortex, Purinergic signalling, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/208476be51d34f6da4991c7759669750

Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles

Authors: Tom Aschman, Emanuel Wyler, Oliver Baum, Andreas Hentschel, Rebekka Rust, Franziska Legler, Corinna Preusse, Lil Meyer-Arndt, Ivana Büttnerova, Alexandra Förster, Derya Cengiz, Luiz Gustavo Teixeira Alves, Julia Schneider, Claudia Kedor, Judith Bellmann-Strobl, Aminaa Sanchin, Hans-Hilmar Goebel, Markus Landthaler, Victor Corman, Andreas Roos, Frank L. Heppner, Helena Radbruch, Friedemann Paul, Carmen Scheibenbogen, Nora F. Dengler, Werner Stenzel

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-20 (2023)

Subject Terms: SARS-CoV-2, Post-COVID syndrome, Post-acute sequelae of COVID-19 (PASC), Post-infectious syndrome, Microangiopathy, Basement membrane thickening, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/b65fc0fea9634e6a9d9eb0b43f7c5637

Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19

Authors: Ronja Mothes, Anna Pascual-Reguant, Ralf Koehler, Juliane Liebeskind, Alina Liebheit, Sandy Bauherr, Lars Philipsen, Carsten Dittmayer, Michael Laue, Regina von Manitius, Sefer Elezkurtaj, Pawel Durek, Frederik Heinrich, Gitta A. Heinz, Gabriela M. Guerra, Benedikt Obermayer, Jenny Meinhardt, Jana Ihlow, Josefine Radke, Frank L. Heppner, Philipp Enghard, Helena Stockmann, Tom Aschman, Julia Schneider, Victor M. Corman, Leif E. Sander, Mir-Farzin Mashreghi, Thomas Conrad, Andreas C. Hocke, Raluca A. Niesner, Helena Radbruch, Anja E. Hauser

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1b2247b6d5234d329b89d09ddd2a8d84

Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and development

Authors: Kiara Freitag, Pascale Eede, Andranik Ivanov, Nele Sterczyk, Shirin Schneeberger, Tatiana Borodina, Sascha Sauer, Dieter Beule, Frank L. Heppner

Source: Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/05135891432948ffa78bb4d70ca947ef

Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain

Authors: Anna-Lena Lang, Tiffany Eulalio, Eddie Fox, Koya Yakabi, Syed A. Bukhari, Claudia H. Kawas, Maria M. Corrada, Stephen B. Montgomery, Frank L. Heppner, David Capper, Daniel Nachun, Thomas J. Montine

Source: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-17 (2022)

Subject Terms: Methylation, Brain, Deconvolution, 90 plus, Old age, Alzheimer’s disease, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/82f8940d6f2f4bc9861cf6d8e21d981f

P1122: A PROSPECTIVE, NON-INTERVENTIONAL STUDY OF REAL-WORLD TREATMENT AND OUTCOME IN SECONDARY CNS LYMPHOMA

Authors: Stefan Habringer, Uta Demel, Anne-Katrin Fietz, Felicitas Lammer, Roland Schroers, Silvia Hofer, Osnat Bairey, Jan Braess, Anna Sofia Meier-Stiegen, Reingard Stuhlmann, Martin Schmidt-Hieber, Johannes Hoffmann, Bettina Zinngrebe, Ulrich Kaiser, Peter Reimer, Robert Möhle, Peter Fix, Heinz-Gert Höffkes, Ulrich Langenkamp, Christian Meyer Zum Büschenfelde, Olaf Hopfer, Andrea Stoltefuß, Paul La Rosée, Henning Blasberg, Karin Jordan, Stephan Kaun, Meike Unteroberdörster, Ann-Christin von Brünneck, David Capper, Frank L. Heppner, Björn Chapuy, Martin Janz, Stefan Schwartz, Frank Konietschke, Peter Vajkoczy, Agnieszka Korfel, Ulrich Keller

Source: HemaSphere, Vol 7, p e23520df (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000971384.23520.df; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/d67d23a0e17241f095d53631b5f4bf8c

Airway epithelial immunoproteasome subunit LMP7 protects against rhinovirus infection

Authors: Kris Genelyn Dimasuay, Niccolette Schaunaman, Bruce Berg, Diana Cervantes, Elke Kruger, Frank L. Heppner, Deborah A. Ferrington, Hong Wei Chu

Source: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/4dca76a769574fdeb2b6694c152d344a

ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19

Authors: Maik Pietzner, Robert Lorenz Chua, Eleanor Wheeler, Katharina Jechow, Julian D. S. Willett, Helena Radbruch, Saskia Trump, Bettina Heidecker, Hugo Zeberg, Frank L. Heppner, Roland Eils, Marcus A. Mall, J. Brent Richards, Leif-Erik Sander, Irina Lehmann, Sören Lukassen, Nicholas J. Wareham, Christian Conrad, Claudia Langenberg

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7bddc4d6d42748edbe382377dc878d84

Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer’s disease mouse model

Authors: Kiara Freitag, Nele Sterczyk, Sarah Wendlinger, Benedikt Obermayer, Julia Schulz, Vadim Farztdinov, Michael Mülleder, Markus Ralser, Judith Houtman, Lara Fleck, Caroline Braeuning, Roberto Sansevrino, Christian Hoffmann, Dragomir Milovanovic, Stephan J. Sigrist, Thomas Conrad, Dieter Beule, Frank L. Heppner, Marina Jendrach

Source: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-19 (2022)

Subject Terms: Alzheimer’s disease, Neuroinflammation, Microglia, Astrocytes, Autophagy, Spermidine, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/6ec625ec673842d59b1af73f89fb8e97

The genomic and transcriptional landscape of primary central nervous system lymphoma

Authors: Josefine Radke, Naveed Ishaque, Randi Koll, Zuguang Gu, Elisa Schumann, Lina Sieverling, Sebastian Uhrig, Daniel Hübschmann, Umut H. Toprak, Cristina López, Xavier Pastor Hostench, Simone Borgoni, Dilafruz Juraeva, Fabienne Pritsch, Nagarajan Paramasivam, Gnana Prakash Balasubramanian, Matthias Schlesner, Shashwat Sahay, Marc Weniger, Debora Pehl, Helena Radbruch, Anja Osterloh, Agnieszka Korfel, Martin Misch, Julia Onken, Katharina Faust, Peter Vajkoczy, Dag Moskopp, Yawen Wang, Andreas Jödicke, Lorenz Trümper, Ioannis Anagnostopoulos, Dido Lenze, Ralf Küppers, Michael Hummel, Clemens A. Schmitt, Otmar D. Wiestler, Stephan Wolf, Andreas Unterberg, Roland Eils, Christel Herold-Mende, Benedikt Brors, ICGC MMML-Seq Consortium, Reiner Siebert, Stefan Wiemann, Frank L. Heppner

Source: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/cd868cc84a9442afabebbc3638875fab

COVID-19: Autopsy findings in six patients between 26 and 46 years of age

Authors: Selina Greuel, Jana Ihlow, Mihnea-Paul Dragomir, Simon Streit, Victor Max Corman, Linus Haberbosch, David Winkler, Jenny Meinhardt, Tom Aschman, Julia Schneider, Iryna Trotsyuk, Catarina Alisa Kunze, Lukas Maurer, Helena Radbruch, Frank L. Heppner, David Horst, Sefer Elezkurtaj

Source: International Journal of Infectious Diseases, Vol 108, Iss , Pp 274-281 (2021)

Subject Terms: COVID-19, SARS-CoV-2, Cause of death, Autopsy, Younger, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1201971221004720; https://doaj.org/toc/1201-9712

Access URL: https://doaj.org/article/0595539e3f164cfe9a2ebafdf53c9a07

Development of Beta-Amyloid-Specific CAR-Tregs for the Treatment of Alzheimer’s Disease

Authors: Valerie Saetzler, Tobias Riet, Andrea Schienke, Pierre Henschel, Kiara Freitag, Alexander Haake, Frank L. Heppner, Laura Elisa Buitrago-Molina, Fatih Noyan, Elmar Jaeckel, Matthias Hardtke-Wolenski

Source: Cells, Vol 12, Iss 16, p 2115 (2023)

Subject Terms: chimeric antigen receptor, Alzheimer’s disease, beta-amyloid, regulatory T cells, single-chain fragment, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/16/2115; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/f72eecfb2b00440c95d4793a333c7460

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

Authors: Nils C. Gassen, Jan Papies, Thomas Bajaj, Jackson Emanuel, Frederik Dethloff, Robert Lorenz Chua, Jakob Trimpert, Nicolas Heinemann, Christine Niemeyer, Friderike Weege, Katja Hönzke, Tom Aschman, Daniel E. Heinz, Katja Weckmann, Tim Ebert, Andreas Zellner, Martina Lennarz, Emanuel Wyler, Simon Schroeder, Anja Richter, Daniela Niemeyer, Karen Hoffmann, Thomas F. Meyer, Frank L. Heppner, Victor M. Corman, Markus Landthaler, Andreas C. Hocke, Markus Morkel, Nikolaus Osterrieder, Christian Conrad, Roland Eils, Helena Radbruch, Patrick Giavalisco, Christian Drosten, Marcel A. Müller

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a210cbf8766241fd8d824076b3b287b5

Assessing and improving the validity of COVID-19 autopsy studies - A multicentre approach to establish essential standards for immunohistochemical and ultrastructural analyses

Authors: Susanne Krasemann, Carsten Dittmayer, Saskia von Stillfried, Jenny Meinhardt, Fabian Heinrich, Kristin Hartmann, Susanne Pfefferle, Edda Thies, Regina von Manitius, Tom Alex David Aschman, Josefine Radke, Anja Osterloh, Simone Schmid, Eva Miriam Buhl, Jana Ihlow, Frank Dubois, Viktor Arnhold, Sefer Elezkurtaj, David Horst, Andreas Hocke, Sara Timm, Sebastian Bachmann, Victor Corman, Hans-Hilmar Goebel, Jakob Matschke, Stephanie Stanelle-Bertram, Gülsah Gabriel, Danielle Seilhean, Homa Adle-Biassette, Benjamin Ondruschka, Matthias Ochs, Werner Stenzel, Frank L. Heppner, Peter Boor, Helena Radbruch, Michael Laue, Markus Glatzel

Source: EBioMedicine, Vol 83, Iss , Pp 104193- (2022)

Subject Terms: SARS-CoV-2, COVID-19, Autopsy, Immunohistochemistry, Electron microscopy, Pathology, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396422003747; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/8c3f588c9dc544439b18fd7f7d5e9f6b

Causes of death and comorbidities in hospitalized patients with COVID-19

Authors: Sefer Elezkurtaj, Selina Greuel, Jana Ihlow, Edward Georg Michaelis, Philip Bischoff, Catarina Alisa Kunze, Bruno Valentin Sinn, Manuela Gerhold, Kathrin Hauptmann, Barbara Ingold-Heppner, Florian Miller, Hermann Herbst, Victor Max Corman, Hubert Martin, Helena Radbruch, Frank L. Heppner, David Horst

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/87b08c6236304a3d8e02d2752ab143b8

Loss of USP18 in microglia induces white matter pathology

Authors: Marius Schwabenland, Omar Mossad, Adam G. Peres, Franziska Kessler, Feres Jose Mocayar Maron, Laura-Adela Harsan, Thomas Bienert, Dominik von Elverfeldt, Klaus-Peter Knobeloch, Ori Staszewski, Frank L. Heppner, Marije E. C. Meuwissen, Grazia M. S. Mancini, Marco Prinz, Thomas Blank

Source: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-6 (2019)

Subject Terms: Microglia, Type I interferon, Usp18, White matter, Phagocytosis, Corpus callosum, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-019-0757-8; https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/236b33d0bdba497fb77c847152b3950b

Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients

Authors: Josefine Radke, Arend Koch, Fabienne Pritsch, Elisa Schumann, Martin Misch, Claudia Hempt, Klaus Lenz, Franziska Löbel, Fabienne Paschereit, Frank L. Heppner, Peter Vajkoczy, Randi Koll, Julia Onken

Source: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-9 (2019)

Subject Terms: Glioblastoma, Temozolomide (TMZ), O(6)-Methylguanine-DNA methyltransferase (MGMT), Methylation specific PCR (MSP), Pyrosequencing (PSQ), IDH (isocitrate dehydrogenase), Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-019-0745-z; https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/46257491055d467c96bc511dbfbdcba7

Intravenous injection of beta-amyloid seeds promotes cerebral amyloid angiopathy (CAA)

Authors: Michael Burwinkel, Manuel Lutzenberger, Frank L. Heppner, Walter Schulz-Schaeffer, Michael Baier

Source: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-6 (2018)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-018-0511-7; https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/2397fac1c4c646b6a68d1d10c29c454d