Synthesis and biological activity of novel N6-substituted and 2, N6-disubstituted adenine ribo- and 3′- C-methyl-ribonucleosides as antitumor agents

Authors: Cappellacci, Loredana, Petrelli, Riccardo, Franchetti, Palmarisa, Vita, Patrizia, Kusumanchi, Praveen, Kumar, Mohineesh, Jayaram, Hiremagalur N., Zhou, Bingsen, Yen, Yun, Grifantini, Mario

Source: In European Journal of Medicinal Chemistry 2011 46(5):1499-1504

Hydrazone derivatives having potent antitumor activity toward multi-drug resistant tumor cells

Synthesis and potency of novel uracil nucleotides and derivatives as P2Y 2 and P2Y 6 receptor agonists

Authors: Ko, Hyojin, Carter, Rhonda L., Cosyn, Liesbet, Petrelli, Riccardo, de Castro, Sonia, Besada, Pedro, Zhou, Yixing, Cappellacci, Loredana, Franchetti, Palmarisa, Grifantini, Mario, Van Calenbergh, Serge, Harden, T. Kendall, Jacobson, Kenneth A.

Source: In Bioorganic & Medicinal Chemistry 2008 16(12):6319-6332

5′-Carbamoyl derivatives of 2′- C-methyl-purine nucleosides as selective A 1 adenosine receptor agonists: Affinity, efficacy, and selectivity for A 1 receptor from different species

Authors: Cappellacci, Loredana, Franchetti, Palmarisa, Vita, Patrizia, Petrelli, Riccardo, Lavecchia, Antonio, Costa, Barbara, Spinetti, Francesca, Martini, Claudia, Klotz, Karl-Norbert, Grifantini, Mario

Source: In Bioorganic & Medicinal Chemistry 2008 16(1):336-353

NOVEL HYDRAZONE DERIVATIVES HAVING POTENT ANTITUMOR ACTIVITY TOWARD MULTI-DRUG RESISTANT TUMOR CELLS

Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors

Authors: Franchetti, Palmarisa, Cappellacci, Loredana, Pasqualini, Michela, Petrelli, Riccardo, Jayaprakasan, Vetrichelvan, Jayaram, Hiremagalur N., Boyd, Donald B., Jain, Manojkumar D., Grifantini, Mario

Source: In Bioorganic & Medicinal Chemistry 2005 13(6):2045-2053

Temperature dependence of the affinity enhancement of selective adenosine A 1 receptor agonism: a thermodynamic analysis

Authors: Dalpiaz, Alessandro ^*, Pavan, Barbara, Ngos, Françoise Ngo, Franchetti, Palmarisa, IJzerman, Adriaan P

Source: In European Journal of Pharmacology 2002 448(2):123-131

c-nucleoside analogues of furanfurin as ligands to a 1 adenosine receptors

Authors: Franchetti, Palmarisa ^*, Cappellacci, Loredana, Marchetti, Stefano, Martini, Claudia, Costa, Barbara, Varani, Katia, Borea, Pier Andrea, Grifantini, Mario

Source: In Bioorganic & Medicinal Chemistry 2000 8(9):2367-2373

A new acyclic heterodinucleotide active against Human Immunodeficiency Virus and Herpes Simplex Virus

Authors: Franchetti, Palmarisa ^*, Abu Sheikha, Ghassan, Cappellacci, Loredana, Marchetti, Stefano, Grifantini, Mario, Balestra, Emanuela, Perno, Carlo-Federico, Benatti, Umberto, Brandi, Giorgio, Rossi, Luigia, Magnani, Mauro

Source: In Antiviral Research 2000 47(3):149-158

Ribose-modified Mizoribine Analogues: Synthesis and Biological Evaluation.

Authors: Franchetti, Palmarisa¹ (AUTHOR), Pasqualini, Michela¹ (AUTHOR), Cappellacci, Loredana¹ (AUTHOR), Petrelli, Riccardo¹ (AUTHOR), Vita, Patrizia¹ (AUTHOR), Grifantini, Mario¹ (AUTHOR) mario.grifantini@unicam.it, Jayaram, HiremagalurN.² (AUTHOR)

Source: Nucleosides, Nucleotides & Nucleic Acids. Oct2005, Vol. 24 Issue 10-12, p2023-2027. 5p. 3 Diagrams.

Subject Terms: *RIBOSE, *ANTINEOPLASTIC agents, *ENZYME inhibitors, *PENTOSES, *MONOSACCHARIDES

From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: Synthesis and biological evaluation of valproic esters of 3′-C-methyladenosine

Authors: Petrelli, Riccardo, Meli, Maria, Vita, Patrizia, Torquati, Ilaria, Ferro, Arianna, Vodnala, Munender, D’Alessandro, Natale, Tolomeo, Manlio, Del Bello, Fabio, Kusumanchi, Praveen, Franchetti, Palmarisa, Grifantini, Mario, Jayaram, Hiremagalur N., Hofer, Anders, Cappellacci, Loredana

Source: In Bioorganic & Medicinal Chemistry Letters 15 November 2014 24(22):5304-5309

Synthesis and Biological Evaluation of NAD Analogs as Human Pyridine Nucleotide Adenylyltransferase Inhibitors.

Authors: Franchetti, Palmarisa¹, Petrelli, R.¹, Cappellacci, L.¹, Pasqualini, M.¹, Vita, P.¹, Sorci, L.², Mazzola, F.², Raffaelli, N.², Magni, Giulio² magnig@univpm.it

Source: Nucleosides, Nucleotides & Nucleic Acids. May2005, Vol. 24 Issue 5-7, p477-479. 3p. 1 Chart, 1 Graph.

Subject Terms: *NAD (Coenzyme), *PYRIDINE nucleotides, *ENZYME inhibitors, *NUCLEOTIDES, *COENZYMES

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5'-C-Ethyl-tetrazolyl-N ⁶-Substituted Adenosine and 2-Chloro-adenosine Derivatives as Highly Potent Dual Acting A1 Adenosine Receptor Agonists and A3 Adenosine Receptor Antagonists.

Authors: Petrelli, Riccardo, Torquati, Ilaria, Kachler, Sonja, Luongo, Livio, Maione, Sabatino, Franchetti, Palmarisa, Grifantini, Mario, Novellino, Ettore, Lavecchia, Antonio, Klotz, Karl-Norbert, Cappellacci, Loredana

Source: Journal of Medicinal Chemistry; Mar2015, Vol. 58 Issue 5, p2560-2566, 7p

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