Tumor-derived G-CSF induces an immunosuppressive microenvironment in an osteosarcoma model, reducing response to CAR.GD2 T-cells

Authors: Michele Pezzella, Concetta Quintarelli, Maria C. Quadraccia, Andrea Sarcinelli, Simona Manni, Laura Iaffaldano, Alessio Ottaviani, Roselia Ciccone, Antonio Camera, Maria L. D’Amore, Stefano Di Cecca, Matilde Sinibaldi, Marika Guercio, Mariasole Aurigemma, Pamela De Falco, Valentina Fustaino, Rossella Rota, Silvia Pomella, Matteo Cassandri, Angela Di Giannatale, Chiara Agrati, Veronica Bordoni, Federica Guarracino, Michele Massa, Giada Del Baldo, Marco Becilli, Giuseppe M. Milano, Francesca Del Bufalo, Franco Locatelli, Biagio De Angelis

Source: Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-23 (2024)

Subject Terms: GD2, Chimeric antigen receptor (CAR), Sarcoma, ICasp9.2A.GD2.CAR-CD28.4–1BBζ, CAR.GD2 T-cells, EZH2 inhibitor, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/d31ce40cc6e6413095e8c1ada8b07976

Outcomes of children and young adults with B-cell acute lymphoblastic leukemia given blinatumomab as last consolidation treatment before allogeneic hematopoietic stem cell transplantation

Authors: Mattia Algeri, Michele Massa, Daria Pagliara, Valentina Bertaina, Federica Galaverna, Ilaria Pili, Giuseppina Li Pira, Roberto Carta, Francesco Quagliarella, Rita M. Pinto, Chiara Rosignoli, Barbarella Lucarelli, Maria G. Cefalo, Emilia Boccieri, Francesca Benini, Francesca Del Bufalo, Marco Becilli, Pietro Merli, Gerhard Zugmaier, Franco Locatelli

Source: Haematologica, Vol 999, Iss 1 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11811; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/af38db97bf884293a331035c0023a21c

Evaluating cell culture reliability in pediatric brain tumor primary cells through DNA methylation profiling

Authors: Lucia Pedace, Simone Pizzi, Luana Abballe, Maria Vinci, Celeste Antonacci, Sara Patrizi, Claudia Nardini, Francesca Del Bufalo, Sabrina Rossi, Giulia Pericoli, Francesca Gianno, Zein Mersini Besharat, Luca Tiberi, Angela Mastronuzzi, Elisabetta Ferretti, Marco Tartaglia, Franco Locatelli, Andrea Ciolfi, Evelina Miele

Source: npj Precision Oncology, Vol 8, Iss 1, Pp 1-13 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2397-768X

Access URL: https://doaj.org/article/3e271e6514f4435baadb82be0810cbf5

Venetoclax plus cyclophosphamide and topotecan in heavily pre-treated relapsed metastatic neuroblastoma: a single center case series

Authors: Maria Antonietta De Ioris, Francesco Fabozzi, Francesca Del Bufalo, Giada Del Baldo, Maria Felicia Villani, Maria Giuseppina Cefalo, Maria Carmen Garganese, Alessandra Stracuzzi, Federica Tangari, Arturo Maria Greco, Isabella Giovannoni, Roberto Carta, Maria Luisa D’Andrea, Angela Mastronuzzi, Franco Locatelli

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-5 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/d9a3f4ab567b4cb2b052b48621dda13d

Mucosal-associated invariant T cells are functionally impaired in pediatric and young adult patients following allogeneic hematopoietic stem cell transplantation and their recovery correlates with clinical outcomes

Authors: Federica Galaverna, Sara Flamini, Carmen Dolores De Luca, Ilaria Pili, Emilia Boccieri, Francesca Benini, Francesco Quagliarella, Chiara Rosignoli, Marco Rosichini, Shirley Genah, Marialuigia Catanoso, Antonella Cardinale, Gabriele Volpe, Marianna Coccetti, Angela Pitisci, Giuseppina Li Pira, Roberto Carta, Barbarella Lucarelli, Francesca Del Bufalo, Valentina Bertaina, Marco Becilli, Daria Pagliara, Mattia Algeri, Pietro Merli, Franco Locatelli, Enrico Velardi

Source: Haematologica, Vol 999, Iss 1 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11618; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/25f2a926a6bd46bd88584bb02e4a9e44

Allogeneic chimeric antigen receptor T cells for children with relapsed/refractory B-cell precursor acute lymphoblastic leukemia

Authors: Franco Locatelli, Francesca del Bufalo, Concetta Quintarelli

Source: Haematologica, Vol 109, Iss 6 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11596; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/445a1483847e45a2a3cbca19bbf3cda5

Neutralizing IFNγ improves safety without compromising efficacy of CAR-T cell therapy in B-cell malignancies

Authors: Simona Manni, Francesca Del Bufalo, Pietro Merli, Domenico Alessandro Silvestris, Marika Guercio, Simona Caruso, Sofia Reddel, Laura Iaffaldano, Michele Pezzella, Stefano Di Cecca, Matilde Sinibaldi, Alessio Ottaviani, Maria Cecilia Quadraccia, Mariasole Aurigemma, Andrea Sarcinelli, Roselia Ciccone, Zeinab Abbaszadeh, Manuela Ceccarelli, Rita De Vito, Maria Chiara Lodi, Maria Giuseppina Cefalo, Angela Mastronuzzi, Biagio De Angelis, Franco Locatelli, Concetta Quintarelli

Source: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/e13fedf5b3e94ec1a443079d5e0501e7

Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia

Authors: Simona Caruso, Biagio De Angelis, Francesca Del Bufalo, Roselia Ciccone, Samantha Donsante, Gabriele Volpe, Simona Manni, Marika Guercio, Michele Pezzella, Laura Iaffaldano, Domenico Alessandro Silvestris, Matilde Sinibaldi, Stefano Di Cecca, Angela Pitisci, Enrico Velardi, Pietro Merli, Mattia Algeri, Mariachiara Lodi, Valeria Paganelli, Marta Serafini, Mara Riminucci, Franco Locatelli, Concetta Quintarelli

Source: Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-19 (2022)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/a538e2a7f35741f4b65eb6ac393adde9

The peculiar challenge of bringing CAR-T cells into the brain: Perspectives in the clinical application to the treatment of pediatric central nervous system tumors

Authors: Giada Del Baldo, Francesca Del Bufalo, Claudia Pinacchio, Andrea Carai, Concetta Quintarelli, Biagio De Angelis, Pietro Merli, Antonella Cacchione, Franco Locatelli, Angela Mastronuzzi

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: pediatric brain tumors, CAR-T cells, blood-brain barrier, glymphatic system, neurotoxicity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1142597/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4dd8274939b54ffea9f0c941d210bd49

Polymorphonuclear myeloid-derived suppressor cells impair the anti-tumor efficacy of GD2.CAR T-cells in patients with neuroblastoma

Authors: Nicola Tumino, Gerrit Weber, Francesca Besi, Francesca Del Bufalo, Valentina Bertaina, Paola Paci, Linda Quatrini, Laura Antonucci, Matilde Sinibaldi, Concetta Quintarelli, Enrico Maggi, Biagio De Angelis, Franco Locatelli, Lorenzo Moretta, Paola Vacca, Ignazio Caruana

Source: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-7 (2021)

Subject Terms: Neuroblastoma, Polymorphonuclear myeloid-derived suppressor cells, GD2.CAR T-cells, Clinical response, T-cell functionality, Long-term response, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/51f0504736a347c6a8f2d674f1b4901c

αβT- and B-cell-depleted HLA-haploidentical hematopoietic stem cell transplantation in children with myelodysplastic syndromes

Authors: Pietro Merli, Daria Pagliara, Tommaso Mina, Valentina Bertaina, Giuseppina Li Pira, Stefania Lazzaro, Simone Biagini, Federica Galaverna, Luisa Strocchio, Roberto Carta, Maria Luigia Catanoso, Francesco Quagliarella, Marco Becilli, Emilia Boccieri, Francesca Del Bufalo, Arianna Panigari, Annalisa Agostini, Lucia Pedace, Simone Pizzi, Cesare Perotti, Mattia Algeri, Marco Zecca, Franco Locatelli

Source: Haematologica, Vol 107, Iss 12 (2022)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10786; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/0dd6b69d88bb495aad7ddaebc370a058

CAR-T Therapy for Pediatric High-Grade Gliomas: Peculiarities, Current Investigations and Future Strategies

Authors: Laura Antonucci, Gabriele Canciani, Angela Mastronuzzi, Andrea Carai, Giada Del Baldo, Francesca Del Bufalo

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: high-grade gliomas (HGG), CAR-T therapies, immunotherapy, tumor microenvironment (TME), next generation CAR-T cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.867154/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/76f7d746a2194a189b26013d497117bc

Inclusion of the Inducible Caspase 9 Suicide Gene in CAR Construct Increases Safety of CAR.CD19 T Cell Therapy in B-Cell Malignancies

Authors: Marika Guercio, Simona Manni, Iolanda Boffa, Simona Caruso, Stefano Di Cecca, Matilde Sinibaldi, Zeinab Abbaszadeh, Antonio Camera, Roselia Ciccone, Vinicia Assunta Polito, Francesca Ferrandino, Sofia Reddel, Maria Luigia Catanoso, Emilia Bocceri, Francesca Del Bufalo, Mattia Algeri, Biagio De Angelis, Concetta Quintarelli, Franco Locatelli

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: chimeric antigen receptor (CAR T), CD19, suicide gene, immunotherapy, B-cell Acute Lymphoblastic Leukemia, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.755639/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/22257a3336434483b101ea658433576b

Reversible induction of mitophagy by an optogenetic bimodular system

Authors: Pasquale D’Acunzo, Flavie Strappazzon, Ignazio Caruana, Giacomo Meneghetti, Anthea Di Rita, Luca Simula, Gerrit Weber, Francesca Del Bufalo, Luisa Dalla Valle, Silvia Campello, Franco Locatelli, Francesco Cecconi

Source: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/20ed3b924c8c43a6a43fe7c1750bfd88

The Pitfall of Ganglioneuroblastoma-Nodular Diagnosis: Clinical and Imaging Considerations over a Rare Bifocal Sporadic Case

Authors: Claudio Montante, Francesco Fabozzi, Maria Felicia Villani, Maria Luisa D’Andrea, Alessandra Stracuzzi, Gian Luigi Natali, Giada Del Baldo, Francesca Del Bufalo, Maria Carmen Garganese, Annalisa Serra, Paolo Tomà, Rita Alaggio, Sabina Vennarini, Giovanna Stefania Colafati, Angela Mastronuzzi, Maria Antonietta De Ioris

Source: Diagnostics, Vol 12, Iss 12, p 3221 (2022)

Subject Terms: ganglioneuroblastoma, neuroblastoma, multifocal tumor, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2075-4418/12/12/3221; https://doaj.org/toc/2075-4418

Access URL: https://doaj.org/article/6d5659691e324aefbd3b0dd920b9882b

Innovative and Promising Strategies to Enhance Effectiveness of Immunotherapy for CNS Tumors: Where Are We?

Authors: Concetta Quintarelli, Antonio Camera, Roselia Ciccone, Iside Alessi, Francesca Del Bufalo, Andrea Carai, Giada Del Baldo, Angela Mastronuzzi, Biagio De Angelis

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: CNS, brain tumor, immunotherapy, chimeric antigen receptor, T cell receptor, oncolytic virotherapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.634031/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9bc24268f583434ca2716ef9663f1b3b

Strategy to prevent epitope masking in CAR.CD19+ B-cell leukemia blasts

Authors: Marco Ruella, Valentina Bertaina, Franco Locatelli, Antonio Camera, Biagio De Angelis, Francesca Del Bufalo, Concetta Quintarelli, Pietro Merli, Marika Guercio, Simona Manni, Iolanda Boffa, Matilde Sinibaldi, Stefano Di Cecca, Simona Caruso, Zeinab Abbaszadeh, Biancamaria Cembrola, Roselia Ciccone, Alberto Orfao, Lourdes Martin-Martin, Sara Gutierrez-Herrero, Maria Herrero-Garcia, Gianni Cazzaniga, Vittorio Nunes, Simona Songia, Paolo Marcatili, Frederikke I Marin, Luciana Vinti, Mattia Algeri

Source: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/9/6/e001514.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/fc993e58dfde4d03ab19898c5289c470

Identification of New Soluble Factors Correlated With the Development of Graft Failure After Haploidentical Hematopoietic Stem Cell Transplantation

Authors: Gerrit Weber, Luisa Strocchio, Francesca Del Bufalo, Mattia Algeri, Daria Pagliara, Claudia Manuela Arnone, Biagio De Angelis, Concetta Quintarelli, Franco Locatelli, Pietro Merli, Ignazio Caruana

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: graft failure, cytokines, chemokines, inflammation, Th1 T cells, macrophage activation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.613644/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/8b17ef6090324a80add00b824a4e0896

Cancer Predisposition Syndromes Associated With Pediatric High-Grade Gliomas

Authors: Giulia Ceglie, Giada Del Baldo, Emanuele Agolini, Martina Rinelli, Antonella Cacchione, Francesca Del Bufalo, Maria Vinci, Roberto Carta, Luigi Boccuto, Evelina Miele, Angela Mastronuzzi, Franco Locatelli, Andrea Carai

Source: Frontiers in Pediatrics, Vol 8 (2020)

Subject Terms: brain tumors, cancer predisposition, genetics of cancer, pediatric neuro- oncology, high grade gliomas, Pediatrics, RJ1-570

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fped.2020.561487/full; https://doaj.org/toc/2296-2360

Access URL: https://doaj.org/article/d07abd43c62743318c21bb4489f59dbe

CD28.OX40 co-stimulatory combination is associated with long in vivo persistence and high activity of CAR.CD30 T-cells

Authors: Marika Guercio, Domenico Orlando, Stefano Di Cecca, Matilde Sinibaldi, Iolanda Boffa, Simona Caruso, Zeinab Abbaszadeh, Antonio Camera, Biancamaria Cembrola, Katia Bovetti, Simona Manni, Ignazio Caruana, Roselia Ciccone, Francesca Del Bufalo, Pietro Merli, Luciana Vinti, Katia Girardi, Annalisa Ruggeri, Cristiano De Stefanis, Marco Pezzullo, Ezio Giorda, Marco Scarsella, Rita De Vito, Sabina Barresi, Andrea Ciolfi, Marco Tartaglia, Lorenzo Moretta, Franco Locatelli, Concetta Quintarelli, Biagio De Angelis

Source: Haematologica, Vol 106, Iss 4 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9747; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/47f7780fa4f341798474cf24f1f0e5d0