Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma

Authors: Laura Lorenzo-Sanz, Marta Lopez-Cerda, Victoria da Silva-Diz, Marta H. Artés, Sandra Llop, Rosa M. Penin, Josep Oriol Bermejo, Eva Gonzalez-Suarez, Manel Esteller, Francesc Viñals, Enrique Espinosa, Marc Oliva, Josep M. Piulats, Juan Martin-Liberal, Purificación Muñoz

Source: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6c15c4009def405287d24b7b6ae51b70

Ovarian cancer relies on the PDGFRβ–fibronectin axis for tumorsphere formation and metastatic spread

Authors: Núria Gendrau‐Sanclemente, Agnès Figueras, Kristina Gracova, Álvaro Lahiguera, Elisenda Alsina‐Sanchís, Juan A. Marín‐Jiménez, August Vidal, Xavier Matias‐Guiu, Sergi Fernandez‐Gonzalez, Marc Barahona, Lola Martí, Jordi Ponce, Francesc Viñals

Source: Molecular Oncology, Vol 18, Iss 1, Pp 136-155 (2024)

Subject Terms: fibronectin, HGSOC, metastasis, ovarian cancer, PDGFRβ, tumorspheres, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/4f70daa21e17417cbad7a4fa4f8ad735

Glycosylation defects, offset by PEPCK-M, drive entosis in breast carcinoma cells

Authors: Petra Hyroššová, Marc Aragó, Cristina Muñoz-Pinedo, Francesc Viñals, Pablo M. García-Rovés, Carmen Escolano, Andrés Méndez-Lucas, Jose C. Perales

Source: Cell Death and Disease, Vol 13, Iss 8, Pp 1-12 (2022)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2041-4889

Access URL: https://doaj.org/article/41c574388b094fde98dac164a8e3465d

Generation and Integrated Analysis of Advanced Patient‐Derived Orthoxenograft Models (PDOX) for the Rational Assessment of Targeted Therapies in Endometrial Cancer

Authors: Laura Devis‐Jauregui, August Vidal, Laura Plata‐Peña, Maria Santacana, Sandra García‐Mulero, Nuria Bonifaci, Eulàlia Noguera‐Delgado, Nuria Ruiz, Marta Gil, Eduard Dorca, Francisco J. Llobet, Laura Coll‐Iglesias, Katja Gassner, Maria Martinez‐Iniesta, Ruth Rodriguez‐Barrueco, Marc Barahona, Lola Marti, Francesc Viñals, Jordi Ponce, Rebeca Sanz‐Pamplona, Josep M. Piulats, Ana Vivancos, Xavier Matias‐Guiu, Alberto Villanueva, David Llobet‐Navas

Source: Advanced Science, Vol 10, Iss 1, Pp n/a-n/a (2023)

Subject Terms: endometrial cancer, HER2, patient‐derived orthoxenografts, PDOX, targeted therapies, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/88510e34e7fe4b8697754d4822ed3e67

Histamine signaling and metabolism identify potential biomarkers and therapies for lymphangioleiomyomatosis

Authors: Carmen Herranz, Francesca Mateo, Alexandra Baiges, Gorka Ruiz de Garibay, Alexandra Junza, Simon R Johnson, Suzanne Miller, Nadia García, Jordi Capellades, Antonio Gómez, August Vidal, Luis Palomero, Roderic Espín, Ana I Extremera, Eline Blommaert, Eva Revilla‐López, Berta Saez, Susana Gómez‐Ollés, Julio Ancochea, Claudia Valenzuela, Tamara Alonso, Piedad Ussetti, Rosalía Laporta, Antoni Xaubet, José A Rodríguez‐Portal, Ana Montes‐Worboys, Carlos Machahua, Jaume Bordas, Javier A Menendez, Josep M Cruzado, Roser Guiteras, Christophe Bontoux, Concettina La Motta, Aleix Noguera‐Castells, Mario Mancino, Enrique Lastra, Raúl Rigo‐Bonnin, Jose C Perales, Francesc Viñals, Alvaro Lahiguera, Xiaohu Zhang, Daniel Cuadras, Coline H M van Moorsel, Joanne J van der Vis, Marian J R Quanjel, Harilaos Filippakis, Razq Hakem, Chiara Gorrini, Marc Ferrer, Aslihan Ugun‐Klusek, Ellen Billett, Elżbieta Radzikowska, Álvaro Casanova, María Molina‐Molina, Antonio Roman, Oscar Yanes, Miquel A Pujana

Source: EMBO Molecular Medicine, Vol 13, Iss 9, Pp 1-21 (2021)

Subject Terms: biomarker, histamine, lymphangioleiomyomatosis, mTOR, therapy, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/51f572bcdff644bcab3c3cc538fd0d47

PEPCK-M recoups tumor cell anabolic potential in a PKC-ζ-dependent manner

Authors: Petra Hyroššová, Marc Aragó, Juan Moreno-Felici, Xiarong Fu, Andrés Mendez-Lucas, Pablo M. García-Rovés, Shawn Burgess, Agnès Figueras, Francesc Viñals, Jose C. Perales

Source: Cancer & Metabolism, Vol 9, Iss 1, Pp 1-15 (2021)

Subject Terms: PEPCK, PEPCK-M, PCK2, Phosphoenolpyruvate carboxykinase, Cancer metabolism, PEP, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2049-3002

Access URL: https://doaj.org/article/ea3bb9ae5dc54432a043d7bb1d6a674e

Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors

Authors: Álvaro Lahiguera, Petra Hyroššová, Agnès Figueras, Diana Garzón, Roger Moreno, Vanessa Soto‐Cerrato, Iain McNeish, Violeta Serra, Conxi Lazaro, Pilar Barretina, Joan Brunet, Javier Menéndez, Xavier Matias‐Guiu, August Vidal, Alberto Villanueva, Barbie Taylor‐Harding, Hisashi Tanaka, Sandra Orsulic, Alexandra Junza, Oscar Yanes, Cristina Muñoz‐Pinedo, Luís Palomero, Miquel Àngel Pujana, José Carlos Perales, Francesc Viñals

Source: EMBO Molecular Medicine, Vol 12, Iss 6, Pp 1-23 (2020)

Subject Terms: BCRA, cancer metabolism, metformin, OXPHOS, PARP inhibitors, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/85fc4cae15594bc18ccb7a3706bee159

Rethinking growth factors: the case of BMP9 during vessel maturation

Authors: Ferran Medina-Jover, Antoni Riera-Mestre, Francesc Viñals

Source: Vascular Biology, Vol 4, Iss 1, Pp R1-R14 (2022)

Subject Terms: bmp9, growth factors, maturation, alk1, endoglin, hereditary haemorrhagic telangiectasia, Diseases of the circulatory (Cardiovascular) system, RC666-701, Physiology, QP1-981

File Description: electronic resource

Relation: https://vb.bioscientifica.com/view/journals/vb/4/1/VB-21-0019.xml; https://doaj.org/toc/2516-5658

Access URL: https://doaj.org/article/37449286c97640ef843e0b5dc2fbe651

Regulation of the MDM2‐p53 pathway by the ubiquitin ligase HERC2

Authors: Jesús García‐Cano, Susana Sánchez‐Tena, Joan Sala‐Gaston, Agnès Figueras, Francesc Viñals, Ramon Bartrons, Francesc Ventura, Jose Luis Rosa

Source: Molecular Oncology, Vol 14, Iss 1, Pp 69-86 (2020)

Subject Terms: DNA damage, HERC2, MDM2, NEURL4, p53, tumor suppressor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/6f9d70fe7e744495b4e32a83a146b70f

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility

Authors: Ana Angulo-Urarte, Pedro Casado, Sandra D. Castillo, Piotr Kobialka, Maria Paraskevi Kotini, Ana M. Figueiredo, Pau Castel, Vinothini Rajeeve, Maria Milà-Guasch, Jaime Millan, Cora Wiesner, Helena Serra, Laia Muixi, Oriol Casanovas, Francesc Viñals, Markus Affolter, Holger Gerhardt, Stephan Huveneers, Heinz-Georg Belting, Pedro R. Cutillas, Mariona Graupera

Source: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c60f6787e577415b9bffa0b9f6b7962a

Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients

Authors: Gabriela Jiménez-Valerio, Mar Martínez-Lozano, Nicklas Bassani, August Vidal, María Ochoa-de-Olza, Cristina Suárez, Xavier García-del-Muro, Joan Carles, Francesc Viñals, Mariona Graupera, Stefano Indraccolo, Oriol Casanovas

Source: Cell Reports, Vol 15, Iss 6, Pp 1134-1143 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716304284; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/2afd30781c004640908513ef1b5d3d17

PI3K (Phosphatidylinositol 3-Kinase) Activation and Endothelial Cell Proliferation in Patients with Hemorrhagic Hereditary Telangiectasia Type 1

Authors: Adriana Iriarte, Agnes Figueras, Pau Cerdà, José María Mora, Anna Jucglà, Rosa Penín, Francesc Viñals, Antoni Riera-Mestre

Source: Cells, Vol 8, Iss 9, p 971 (2019)

Subject Terms: hemorrhagic hereditary telangiectasia, rare diseases, telangiectasia, transforming growth factor-beta (TGF-β), Smad pathway, phosphatidylinositol 3-kinase, mTOR inhibitors, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/8/9/971; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/ccc6b7bfe3f042af947a7d253d8b3e32

Dibenzylxanthines as PPEPCK-M Inhibitors for Cancer Therapy

Authors: Marc Aragó, Sergio Rodríguez-Arévalo, Petra Hyrossova, Juan Moreno, Sònia Abás, Agnès Figueras, Belén Pérez, Francesc Viñals, María Carmen Escolano, José Carlos Perales

Source: Proceedings, Vol 22, Iss 1, p 79 (2019)

Subject Terms: n/a, General Works

File Description: electronic resource

Relation: https://www.mdpi.com/2504-3900/22/1/79; https://doaj.org/toc/2504-3900

Access URL: https://doaj.org/article/8fbe6ed00984477a97d55c55f358737c

CDK‐mediated activation of the SCFFBXO28 ubiquitin ligase promotes MYC‐driven transcription and tumourigenesis and predicts poor survival in breast cancer

Authors: Diana Cepeda, Hwee‐Fang Ng, Hamid Reza Sharifi, Salah Mahmoudi, Vanessa Soto Cerrato, Erik Fredlund, Kristina Magnusson, Helén Nilsson, Alena Malyukova, Juha Rantala, Daniel Klevebring, Francesc Viñals, Nimesh Bhaskaran, Siti Mariam Zakaria, Aldwin Suryo Rahmanto, Stefan Grotegut, Michael Lund Nielsen, Cristina Al‐Khalili Szigyarto, Dahui Sun, Mikael Lerner, Sanjay Navani, Martin Widschwendter, Mathias Uhlén, Karin Jirström, Fredrik Pontén, James Wohlschlegel, Dan Grandér, Charles Spruck, Lars‐Gunnar Larsson, Olle Sangfelt

Source: EMBO Molecular Medicine, Vol 5, Iss 7, Pp 1067-1086 (2013)

Subject Terms: Breast cancer, CDK, F‐box protein, FBXO28, MYC, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/5062dd7638fb498c83728c328d552d33

Correction: Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

Authors: Paula Lopez-Serra, Miguel Marcilla, Alberto Villanueva, Antonio Ramos-Fernandez, Anna Palau, Lucía Leal, Jessica E. Wahi, Fernando Setien-Baranda, Karolina Szczesna, Catia Moutinho, Anna Martinez-Cardus, Holger Heyn, Juan Sandoval, Sara Puertas, August Vidal, Xavier Sanjuan, Eva Martinez-Balibrea, Francesc Viñals, Jose C. Perales, Jesper B. Bramsem, Torben F. Ørntoft, Claus L. Andersen, Josep Tabernero, Ultan McDermott, Matthew B. Boxer, Matthew G. Vander Heiden, Juan Pablo Albar, Manel Esteller

Source: Nature Communications, Vol 7, Iss 1, Pp 1-2 (2016)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1212820cdf384abb99b859bb04a5fec8