Polytopic fractional delivery of an HIV vaccine alters cellular responses and results in increased epitope breadth in a phase 1 randomized trial

Authors: Kalichman, Artur, Edlefsen, Paul, Enama, Mary, Hural, John, Holt, Renee, Dunbar, Debora, Crawford, Dave, Maki, Ian, Johannessen, Jan, Estep, Scharla, Grigoriev, Yevgeny, Madenwald, Tamra, Hansen, Marianne, Holman, Drienna, Fair, Ramey, Meyer, Genevieve, Luke-Kilolam, Anya, Miner, Maurine D., deCamp, Allan, Grunenberg, Nicole, De Rosa, Stephen C., Fiore-Gartland, Andrew, Bar, Katherine, Spearman, Paul, Allen, Mary, Yu, Pei-Chun, Manso, Bryce, Frahm, Nicole, Kalams, Spyros, Baden, Lindsey, Keefer, Michael C., Scott, Hyman M., Novak, Richard, Van Tieu, Hong, Tomaras, Georgia D., Kublin, James G., McElrath, M. Juliana, Corey, Lawrence, Frank, Ian

Source: In eBioMedicine February 2024 100

Consistent Cytotoxic-T-Lymphocyte Targeting of Immunodominant Regions in Human Immunodeficiency Virus across Multiple Ethnicities

Authors: Frahm, Nicole, Korber, BT, Adams, CM, Szinger, JJ, Draenert, R, Addo, MM, Feeney, ME, Yusim, K, Sango, K, Brown, NV, SenGupta, D, Piechocka-Trocha, A, Simonis, T, Marincola, FM, Wurcel, AG, Stone, DR, Russell, CJ, Adolf, P, Cohen, D, Roach, T, StJohn, A, Khatri, A, Davis, K, Mullins, J, Goulder, PJR, Walker, BD, Brander, C

Source: Frahm, Nicole and Korber, BT and Adams, CM and Szinger, JJ and Draenert, R and Addo, MM and Feeney, ME and Yusim, K and Sango, K and Brown, NV and SenGupta, D and Piechocka-Trocha, A and Simonis, T and Marincola, FM and Wurcel, AG and Stone, DR and Russell, CJ and Adolf, P and Cohen, D and Roach, T and StJohn, A and Khatri, A and Davis, K and Mullins, J and Goulder, PJR and Walker, BD and Brander, C (2004) Consistent Cytotoxic-T-Lymphocyte Targeting of Immunodominant Regions in Human Immunodeficiency Virus across Multiple Ethnicities. Journal of Virology, 78 (5). pp. 2187-2200.

Relation: http://jvi.asm.org/cgi/content/full/78/5/2187; http://health-equity.pitt.edu/263/

Achieving intracellular cytokine staining assay concordance on two continents to assess HIV vaccine‐induced T‐cell responses

Authors: Dintwe, One B., De Rosa, Stephen C., Huang, Yunda, Flach, Britta S., Manso, Bryce, Carter, Don, Omar, Faatima Laher, Schwedhelm, Katharine V., Yu, Chenchen, Lu, Huiyin, Morris, Daryl, Kee, Jia Jin, Voillet, Valentin, Stirewalt, Michael, Hural, John, Moodie, Zoe, Frahm, Nicole, Cohen, Kristen W., McElrath, M. Juliana, Andersen‐Nissen, Erica

Source: Journal of leukocyte biology. 112(5):1167-1181

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163236470.0x000001&indx=1&recIds=ETOCvdc_100163236470.0x000001

Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trial

Authors: Pantaleo, Giuseppe ^*, Janes, Holly, Karuna, Shelly, Grant, Shannon, Ouedraogo, G Laissa, Allen, Mary, Tomaras, Georgia D, Frahm, Nicole, Montefiori, David C, Ferrari, Guido, Ding, Song, Lee, Carter, Robb, Merlin L, Esteban, Mariano, Wagner, Ralf, Bart, Pierre-Alexandre, Rettby, Nils, McElrath, M Juliana, Gilbert, Peter B, Kublin, James G, Corey, Lawrence

Source: In The Lancet HIV November 2019 6(11):e737-e749

Modification of the Association Between T-Cell Immune Responses and Human Immunodeficiency Virus Type 1 Infection Risk by Vaccine-Induced Antibody Responses in the HVTN 505 Trial

Authors: Fong, Youyi, Shen, Xiaoying, Ashley, Vicki C., Deal, Aaron, Seaton, Kelly E., Yu, Chenchen, Grant, Shannon P., Ferrari, Guido, deCamp, Allan C., Bailer, Robert T., Koup, Richard A., Montefiori, David, Haynes, Barton F., Sarzotti-Kelsoe, Marcella, Graham, Barney S., Carpp, Lindsay N., Hammer, Scott M., Sobieszczyk, Magda, Karuna, Shelly, Swann, Edith, DeJesus, Edwin, Mulligan, Mark, Frank, Ian, Buchbinder, Susan, Novak, Richard M., McElrath, M. Juliana, Kalams, Spyros, Keefer, Michael, Frahm, Nicole A., Janes, Holly E., Gilbert, Peter B., Tomaras, Georgia D.

Source: The Journal of Infectious Diseases, 2018 Apr . 217(8), 1280-1288.

Access URL: https://www.jstor.org/stable/26494492

Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19)

Authors: Barouch, Dan H, Tomaka, Frank L, Wegmann, Frank, Stieh, Daniel J, Alter, Galit, Robb, Merlin L, Michael, Nelson L, Peter, Lauren, Nkolola, Joseph P, Borducchi, Erica N, Chandrashekar, Abishek, Jetton, David, Stephenson, Kathryn E, Li, Wenjun, Korber, Bette, Tomaras, Georgia D, Montefiori, David C, Gray, Glenda, Frahm, Nicole, McElrath, M Juliana, Baden, Lindsey, Johnson, Jennifer, Hutter, Julia, Swann, Edith, Karita, Etienne, Kibuuka, Hannah, Mpendo, Juliet, Garrett, Nigel, Mngadi, Kathy, Chinyenze, Kundai, Priddy, Frances, Lazarus, Erica, Laher, Fatima, Nitayapan, Sorachai, Pitisuttithum, Punnee, Bart, Stephan, Campbell, Thomas, Feldman, Robert, Lucksinger, Gregg, Borremans, Caroline, Callewaert, Katleen, Roten, Raphaele, Sadoff, Jerald, Scheppler, Lorenz, Weijtens, Mo, Feddes-de Boer, Karin, van Manen, Daniëlle, Vreugdenhil, Jessica, Zahn, Roland, Lavreys, Ludo, Nijs, Steven, Tolboom, Jeroen, Hendriks, Jenny, Euler, Zelda, Pau, Maria G, Schuitemaker, Hanneke

Source: In The Lancet 21-27 July 2018 392(10143):232-243

Subtype C ALVAC-HIV and bivalent subtype C gp120/MF59 HIV-1 vaccine in low-risk, HIV-uninfected, South African adults: a phase 1/2 trial

Authors: Bekker, Linda-Gail ^*, Moodie, Zoe, Grunenberg, Nicole, Laher, Fatima, Tomaras, Georgia D, Cohen, Kristen W, Allen, Mary, Malahleha, Mookho, Mngadi, Kathryn, Daniels, Brodie, Innes, Craig, Bentley, Carter, Frahm, Nicole, Morris, Daryl E, Morris, Lynn, Mkhize, Nonhlanhla N, Montefiori, David C, Sarzotti-Kelsoe, Marcella, Grant, Shannon, Yu, Chenchen, Mehra, Vijay L, Pensiero, Michael N, Phogat, Sanjay, DiazGranados, Carlos A, Barnett, Susan W, Kanesa-thasan, Niranjan, Koutsoukos, Marguerite, Michael, Nelson L, Robb, Merlin L, Kublin, James G, Gilbert, Peter B, Corey, Lawrence, Gray, Glenda E, McElrath, M Juliana

Source: In The Lancet HIV July 2018 5(7):e366-e378

CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells

Authors: Maurice, Nicholas, McElrath, M., Andersen-Nissen, Erica, Frahm, Nicole, Prlic, Martin

Source: Nature communications. 10(1):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190886960.0x000001&indx=1&recIds=ETOCvdc_100190886960.0x000001

Higher T-Cell Responses Induced by DNA/rAd5 HIV-1 Preventive Vaccine Are Associated With Lower HIV-1 Infection Risk in an Efficacy Trial

Authors: Janes, Holly E., Cohen, Kristen W., Frahm, Nicole, De Rosa, Stephen C., Sanchez, Brittany, Hural, John, Magaret, Craig A., Karuna, Shelly, Bentley, Carter, Gottardo, Raphael, Finak, Greg, Grove, Douglas, Shen, Mingchao, Graham, Barney S., Koup, Richard A., Mulligan, Mark J., Koblin, Beryl, Buchbinder, Susan P., Keefer, Michael C., Adams, Elizabeth, Anude, Chuka, Corey, Lawrence, Sobieszczyk, Magdalena, Hammer, Scott M., Gilbert, Peter B., McElrath, M. Juliana

Source: The Journal of Infectious Diseases, 2017 May 01. 215(9), 1376-1385.

Access URL: https://www.jstor.org/stable/26364973

Predictors of durable immune responses six months after the last vaccination in preventive HIV vaccine trials

Authors: Huang, Yunda, Zhang, Lily, Janes, Holly, Frahm, Nicole, Isaacs, Abby, Kim, Jerome H., Montefiori, David, McElrath, M. Julie, Tomaras, Georgia D., Gilbert, Peter B.

Source: In Vaccine 22 February 2017 35(8):1184-1193

The epigenetic landscape of T cell exhaustion

Authors: Sen, Debattama R., Kaminski, James, Barnitz, R. Anthony, Kurachi, Makoto, Gerdemann, Ulrike, Yates, Kathleen B., Tsao, Hsiao-Wei, Godec, Jernej, LaFleur, Martin W., Brown, Flavian D., Tonnerre, Pierre, Chung, Raymond T., Tully, Damien C., Allen, Todd M., Frahm, Nicole, Lauer, Georg M., Wherry, E. John, Yosef, Nir, Haining, W. Nicholas

Source: Science, 2016 Dec 01. 354(6316), 1165-1169.

Access URL: https://www.jstor.org/stable/44711123

Lower Viral Loads and Slower CD4⁺ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02

Authors: Leitman, Ellen M., Hurst, Jacob, Mori, Masahiko, Kublin, James, Ndung'u, Thumbi, Walker, Bruce D., Carlson, Jonathan, Gray, Glenda E., Matthews, Philippa C., Frahm, Nicole, Goulder, Philip J.R.

Source: The Journal of Infectious Diseases, 2016 Aug 01. 214(3), 379-389.

Access URL: http://www.jstor.org/stable/44007311

Dissecting Polyclonal Vaccine-Induced Humoral Immunity against HIV Using Systems Serology

Authors: Chung, Amy W., Kumar, Manu P., Arnold, Kelly B., Yu, Wen Han, Schoen, Matthew K., Dunphy, Laura J., Suscovich, Todd J., Frahm, Nicole, Linde, Caitlyn, Mahan, Alison E., Hoffner, Michelle, Streeck, Hendrik, Ackerman, Margaret E., McElrath, M. Juliana, Schuitemaker, Hanneke, Pau, Maria G., Baden, Lindsey R., Kim, Jerome H., Michael, Nelson L., Barouch, Dan H., Lauffenburger, Douglas A., Alter, Galit

Source: In Cell 5 November 2015 163(4):988-998

Vaccination With Heterologous HIV-1 Envelope Sequences and Heterologous Adenovirus Vectors Increases T-Cell Responses to Conserved Regions: HVTN 083

Authors: HVTN 083 Study Group, NIAID HVTN, Walsh, Stephen R., Moodie, Zoe, Fiore-Gartland, Andrew J., Morgan, Cecilia, Wilck, Marissa B., Hammer, Scott M., Buchbinder, Susan P., Kalams, Spyros A., Goepfert, Paul A., Mulligan, Mark J., Keefer, Michael C., Baden, Lindsey R., Swann, Edith M., Grant, Shannon, Ahmed, Hasan, Li, Fusheng, Hertz, Tomer, Self, Steven G., Friedrich, David, Frahm, Nicole, Liao, Hua-Xin, Montefiori, David C., Tomaras, Georgia D., McElrath, M. Juliana, Hural, John, Graham, Barney S., Jin, Xia

Source: The Journal of Infectious Diseases, 2016 Feb . 213(4), 541-550.

Access URL: http://www.jstor.org/stable/24716425

Current views on the potential for development of a HIV vaccine

Authors: Cohen, Kristen W., Frahm, Nicole

Source: Expert opinion on biological therapy. 17(3):295-303

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106499757.0x000001&indx=1&recIds=ETOCvdc_100106499757.0x000001

Establishment and maintenance of a PBMC repository for functional cellular studies in support of clinical vaccine trials

Authors: Sambor, Anna, Garcia, Ambrosia, Berrong, Mark, Pickeral, Joy, Brown, Sara, Rountree, Wes, Sanchez, Ana, Pollara, Justin, Frahm, Nicole, Keinonen, Sarah, Kijak, Gustavo H., Roederer, Mario, Levine, Gail, D'Souza, M. Patricia, Jaimes, Maria, Koup, Richard, Denny, Thomas, Cox, Josephine, Ferrari, Guido

Source: In Journal of Immunological Methods July 2014 409:107-116

The External Quality Assurance Oversight Laboratory (EQAPOL) proficiency program for IFN-gamma enzyme-linked immunospot (IFN-γ ELISpot) assay

Authors: Sanchez, Ana M., Rountree, Wes, Berrong, Mark, Garcia, Ambrosia, Schuetz, Alexandra, Cox, Josephine, Frahm, Nicole, Manak, Mark, Sarzotti-Kelsoe, Marcella, D'Souza, M. Patricia, Denny, Thomas, Ferrari, Guido

Source: In Journal of Immunological Methods July 2014 409:31-43

Vaccine-elicited Human T Cells Recognizing Conserved Protein Regions Inhibit HIV-1

Authors: Borthwick, Nicola, Ahmed, Tina, Ondondo, Beatrice, Hayes, Peter, Rose, Annie, Ebrahimsa, Umar, Hayton, Emma-Jo, Black, Antony, Bridgeman, Anne, Rosario, Maximillian, Hill, Adrian VS, Berrie, Eleanor, Moyle, Sarah, Frahm, Nicole, Cox, Josephine, Colloca, Stefano, Nicosia, Alfredo, Gilmour, Jill, McMichael, Andrew J, Dorrell, Lucy, Hanke, Tomáš ^*

Source: In Molecular Therapy February 2014 22(2):464-475

Measuring inhibition of HIV replication by ex vivo CD8+ T cells

Authors: Slichter, Chloe K., Friedrich, David P., Smith, Rebecca J., Walsh, Paula N., Mize, Greg, Czartoski, Julie L., McElrath, M. Juliana, Frahm, Nicole

Source: In Journal of Immunological Methods February 2014 404:71-80

The Safety and Immunogenicity of an Interleukin-12–Enhanced Multiantigen DNA Vaccine Delivered by Electroporation for the Treatment of HIV-1 Infection

Authors: Jacobson, Jeffrey M., Zheng, Lu, Wilson, Cara C., Tebas, Pablo, Matining, Roy M., Egan, Michael A., Eldridge, John, Landay, Alan L., Clifford, David B., Luetkemeyer, Anne F., Tiu, Jennifer, Martinez, Ana L., Janik, Jennifer, Spitz, Teresa A., Hural, John, McElrath, Juliana, Frahm, Nicole

Source: Journal of acquired immune deficiency syndromes. 71(2):163-171

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100037134570.0x000001&indx=1&recIds=ETOCvdc_100037134570.0x000001