IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells

Authors: Camard, Laetitia ^{1, 10}, Stephen, Tharshana ^{1, 2, 10}, Yahia-Cherbal, Hanane ¹, Guillemot, Vincent ³, Mella, Sébastien ^{2, 3}, Baillet, Victoire ³, Lopez-Maestre, Hélène ³, Capocefalo, Daniele ⁴, Cantini, Laura ⁴, Leloup, Claire ¹, Marsande, Julie ¹, Garro, Katherine ¹, Sienes Bailo, Juan ¹, Dangien, Ambre ^{1, 5}, Pietrosemoli, Natalia ³, Hasan, Milena ², Wang, Huimeng ⁶, Eckle, Sidonia B.G. ⁶, Fourie, Anne M. ⁷, Greving, Carrie ⁷, Joyce-Shaikh, Barbara ⁷, Parker, Raphaelle ⁸, Cua, Daniel J. ⁹, Bianchi, Elisabetta ¹, Rogge, Lars ^{1, 11, ∗}

Source: In iScience 21 February 2025 28(2)

Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer

Authors: Liu, Jared, Chang, Hsin-Wen, Huang, Zhi-Ming, Nakamura, Mio, Sekhon, Sahil, Ahn, Richard, Munoz-Sandoval, Priscila, Bhattarai, Shrishti, Beck, Kristen M., Sanchez, Isabelle M., Yang, Eric, Pauli, Mariela, Arron, Sarah T., Fung-Leung, Wai-Ping, Munoz, Ernesto, Liu, Xuejun, Bhutani, Tina, North, Jeffrey, Fourie, Anne M., Rosenblum, Michael D., Liao, Wilson

Source: In The Journal of Allergy and Clinical Immunology June 2021 147(6):2370-2380

The mode of action of IL-23 in experimental inflammatory arthritic pain and disease.

Authors: Lee, Kevin M.-C., Lupancu, Tanya, Chang, Leon, Manthey, Carl L., Zeeman, Martha, Fourie, Anne M., Hamilton, John A.

Source: Arthritis Research & Therapy; 8/6/2024, Vol. 26 Issue 1, p1-13, 13p

3-Substituted Quinolines as RORγt Inverse Agonists

Authors: Tanis, Virginia M., Venkatesan, Hariharan, Cummings, Maxwell D., Albers, Michael, Kent Barbay, J., Herman, Krystal, Kummer, David A., Milligan, Cynthia, Nelen, Marina I., Nishimura, Rachel, Schlueter, Thomas, Scott, Brian, Spurlino, John, Wolin, Ronald, Woods, Craig, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi

Source: Bioorganic & medicinal chemistry letters. 29(12):1463-1470

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100118028228.0x000001&indx=1&recIds=ETOCvdc_100118028228.0x000001

Characterization and Regulation of the Major Histocompatibility Complex-Encoded Proteins Hsp70-Hom and Hsp70-1/2

Authors: Fourie, Anne M., Peterson, Per A., Yang, Young

Source: Cell Stress & Chaperones, 2001 Jul 01. 6(3), 282-295.

Access URL: https://www.jstor.org/stable/1601770

IL-23 regulation of myeloid cell biology during inflammation

Authors: Lee, Kevin M.-C., Lupancu, Tanya, Chang, Leon, Manthey, Carl L., Zeeman, Martha, Fourie, Anne M., Hamilton, John A.

Source: In Cytokine July 2024 179

Impaired Immunoproteasome Assembly and Immune Responses in PA28$^{-/-}$ Mice

Authors: Preckel, Tobias, Fung-Leung, Wai-Ping, Cai, Zeling, Vitiello, Antonella, Salter-Cid, Luisa, Winqvist, Ola, Wolfe, Tom G., von Herrath, Matthias, Angulo, Ana, Ghazal, Peter, Lee, Jiing-Dwan, Fourie, Anne M., Wu, Ying, Pang, Jesse, Ngo, Karen, Peterson, Per A., Früh, Klaus, Yang, Young

Source: Science, 1999 Dec 01. 286(5447), 2162-2165.

Access URL: https://www.jstor.org/stable/2899995

Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt

Authors: Kummer, David A., Cummings, Maxwell D., Abad, Marta, Barbay, Joseph, Castro, Glenda, Wolin, Ronald, Kreutter, Kevin D., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi

Source: Bioorganic & medicinal chemistry letters. 27(9):2047-2057

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100067919912.0x000001&indx=1&recIds=ETOCvdc_100067919912.0x000001

6-Substituted quinolines as RORγt inverse agonists

Authors: Barbay, J. Kent, Cummings, Maxwell D., Abad, Marta, Castro, Glenda, Kreutter, Kevin D., Kummer, David A., Maharoof, Umar, Milligan, Cynthia, Nishimura, Rachel, Pierce, Joan, Schalk-Hihi, Celine, Spurlino, John, Tanis, Virginia M., Urbanski, Maud, Venkatesan, Hariharan, Wang, Aihua, Woods, Craig, Wolin, Ronald, Xue, Xiaohua, Edwards, James P., Fourie, Anne M., Leonard, Kristi

Source: Bioorganic & medicinal chemistry letters. 27(23):5277-5283

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100065555094.0x000001&indx=1&recIds=ETOCvdc_100065555094.0x000001

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

Authors: Soroosh, Pejman, Wu, Jiejun, Xue, Xiaohua, Song, Jiao, Sutton, Steven W., Sablad, Marciano, Yu, Jingxue, Nelen, Marina I., Liu, Xuejun, Castro, Glenda, Luna, Rosa, Crawford, Shelby, Banie, Homayon, Dandridge, Rose A., Deng, Xiaohu, Bittner, Anton, Kuei, Chester, Tootoonchi, Mandana, Rozenkrants, Natasha, Herman, Krystal, Gao, Jingjin, Yang, Xia V., Sachen, Kacey, Ngo, Karen, Fung-Leung, Wai-Ping, Nguyen, Steven, de Leon-Tabaldo, Aimee, Blevitt, Jonathan, Zhang, Yan, Cummings, Maxwell D., Rao, Tadimeti, Mani, Neelakandha S., Liu, Changlu, McKinnon, Murray, Milla, Marcos E., Fourie, Anne M., Sun, Siquan

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Aug . 111(33), 12163-12168.

Access URL: https://www.jstor.org/stable/42919184

Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach

Authors: Steeneck, Christoph, Gege, Christian, Kinzel, Olaf, Albers, Michael, Kleymann, Gerald, Schlüter, Thomas, Schulz, Andreas, Xue, Xiaohua, Cummings, Maxwell D., Fourie, Anne M., Leonard, Kristi A., Scott, Brian, Edwards, James P., Hoffmann, Thomas, Goldberg, Steven D.

Source: Bioorganic & medicinal chemistry letters. 30(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115617767.0x000001&indx=1&recIds=ETOCvdc_100115617767.0x000001

Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt

Authors: Gege, Christian, Albers, Michael, Kinzel, Olaf, Kleymann, Gerald, Schlüter, Thomas, Steeneck, Christoph, Hoffmann, Thomas, Xue, Xiaohua, Cummings, Maxwell D., Spurlino, John, Milligan, Cynthia, Fourie, Anne M., Edwards, James P., Leonard, Kristi, Coe, Kevin, Scott, Brian, Pippel, Dan, Goldberg, Steven D.

Source: Bioorganic & medicinal chemistry letters. 30(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115617718.0x000001&indx=1&recIds=ETOCvdc_100115617718.0x000001

Su1743 GUSELKUMAB BINDING TO CD64+ IL-23–PRODUCING MYELOID CELLS ENHANCES POTENCY FOR NEUTRALIZING IL-23 SIGNALING

Authors: Abreu, Maria T., Atreya, Raja, Krueger, James G., Eyerich, Kilian, Greving, Carrie, Hammaker, Deepa, Stoveken, Brian, Hartman, John, Leppard, Kristin L., Sarabia, Indra, Wertheimer, Joshua, Deming, Janise, Kohler, Kristen, Li, He (., Freeman, Tom C., Hart, Amy, Keyes, Brice, Ritchlin, Christopher, McInnes, Iain B., Allez, Matthieu, Fourie, Anne M., Sachen, Kacey

Source: In Gastroenterology 18-21 May 2024 166(5) Supplement:S

Su1738 JNJ-77242113, AN ORAL PEPTIDE SELECTIVELY TARGETING THE IL-23 RECEPTOR, DEMONSTRATES PHARMACODYNAMIC ACTIVITY IN RAT AND HUMAN COLON TISSUE EXPLANTS FOLLOWING ORAL DOSING

Authors: de Leon-Tabaldo, Aimee, Strawn, David, Chang, Leon, Cheng, Xiaoli, Greving, Carrie, Knight, Beverly, Sendecki, Jocelyn, Sherlock, Jonathan, Modi, Nishit B., Kannan, Arun K., Fourie, Anne M.

Source: In Gastroenterology 18-21 May 2024 166(5) Supplement:S

Deletion in the First Cysteine-Rich Repeat of Low Density Lipoprotein Receptor Impairs Its Transport but not Lipoprotein Binding in Fibroblasts from a Subject with Familial Hypercholesterolemia

Authors: Leitersdorf, Eran, Hobbs, Helen H., Fourie, Anne M., Jacobs, Muazzam, Van Der Westhuyzen, Deneys R., Coetzee, Gerhard A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1988 Nov 01. 85(21), 7912-7916.

Access URL: https://www.jstor.org/stable/32538

Anti-Inflammatory Activity of a Potent, Selective Leukotriene A4 Hydrolase Inhibitor in Comparison with the 5-Lipoxygenase Inhibitor Zileuton

Authors: Rao, Navin L., Dunford, Paul J., Xue, Xiaohua, Jiang, Xiaohui, Lundeen, Katherine A., Coles, Fawn, Riley, Jason P., Williams, Kacy N., Grice, Cheryl A., Edwards, James P., Karlsson, Lars, Fourie, Anne M. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics June 2007 321(3):1154-1160

Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase

COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE

Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase

LTA4H modulators and uses thereof