Phosphorylation of disordered proteins tunes local and global intramolecular interactions

Authors: Usher, Emery T., Fossat, Martin J., Holehouse, Alex S.

Source: In Biophysical Journal 3 December 2024 123(23):4082-4096

Macromolecular condensation organizes nucleolar sub-phases to set up a pH gradient

Authors: King, Matthew R., Ruff, Kiersten M., Lin, Andrew Z., Pant, Avnika, Farag, Mina, Lalmansingh, Jared M., Wu, Tingting, Fossat, Martin J., Ouyang, Wei, Lew, Matthew D., Lundberg, Emma, Vahey, Michael D., Pappu, Rohit V.

Source: In Cell 11 April 2024 187(8):1889-1906

Quantifying charge state heterogeneity for proteins with multiple ionizable residues

Authors: Fossat, Martin J., Posey, Ammon E., Pappu, Rohit V.

Source: In Biophysical Journal 21 December 2021 120(24):5438-5453

Uncovering the Contributions of Charge Regulation to the Stability of Single Alpha Helices**

Authors: Fossat, Martin J., Posey, Ammon E., Pappu, Rohit V.

Source: Chemphyschem. 24(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181681017.0x000001&indx=1&recIds=ETOCvdc_100181681017.0x000001

A molten globule ensemble primes Arf1-GDP for the nucleotide switch.

Authors: Koduru, Tejaswi, Hantman, Noam, Peters, Edgar V., Jaworek, Michel W., Jinqiu Wang, Siwen Zhang, McCallum, Scott A., Gillilan, Richard E., Fossat, Martin J., Roumestand, Christian, Sagar, Amin, Winter, Roland, Bernadó, Pau, Cherfils, Jacqueline, Royer, Catherine A.

Source: Proceedings of the National Academy of Sciences of the United States of America; 9/24/2024, Vol. 121 Issue 39, p1-12, 54p

Subject Terms: GUANINE nucleotide exchange factors, SMALL-angle X-ray scattering, FOURIER transform spectroscopy, NUCLEAR magnetic resonance, ADP-ribosylation

The consequences of cavity creation on the folding landscape of a repeat protein depend upon context

Authors: Jenkins, Kelly A., Fossat, Martin J., Zhang, Siwen, Rai, Durgesh K., Klein, Sean, Gillilan, Richard, White, Zackary, Gerlich, Grayson, McCallum, Scott A., Winter, Roland, Gruner, Sol M., Barrick, Doug, Royer, Catherine A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Aug . 115(35), E8153-E8161.

Access URL: https://www.jstor.org/stable/26530338

High-Resolution Mapping of a Repeat Protein Folding Free Energy Landscape

Authors: Fossat, Martin J., Dao, Thuy P., Jenkins, Kelly, Dellarole, Mariano, Yang, Yinshan, McCallum, Scott A., Garcia, Angel E., Barrick, Doug, Roumestand, Christian, Royer, Catherine A.

Source: In Biophysical Journal 6 December 2016 111(11):2368-2376

Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures

Authors: Zeng, Xiangze, Liu, Chengwen, Fossat, Martin J., Ren, Pengyu, Chilkoti, Ashutosh, Pappu, Rohit V.

Source: APL materials. 9(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134332011.0x000001&indx=1&recIds=ETOCvdc_100134332011.0x000001

BPS2025 - Charge regulation of intrinsically disordered proteins

Authors: Tomares, Dylan ¹, Ghosh, Souradeep ¹, Palomo, Daniel ¹, Posey, Ammon E. ², King, Matthew R. ¹, Gupta, Nikita ¹, Fossat, Martin J. ³, Pappu, Rohit V. ¹

Source: In Biophysical Journal 13 February 2025 124(3) Supplement 1:556a-556a

How does sequence influence charge regulation of disordered proteins?

Authors: Fossat, Martin J., Posey, Ammon E., Gupta, Nikita, Pappu, Rohit V.

Source: Biophysical journal. 122(S1):200a-200a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186042521.0x000001&indx=1&recIds=ETOCvdc_100186042521.0x000001

Charge state heterogeneity in single alpha helices helps maintain helicity over a large range of pH values

Authors: Fossat, Martin J., Posey, Ammon E., Pappu, Rohit V.

Source: Biophysical journal. 121(S1):300a-300a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178303921.0x000001&indx=1&recIds=ETOCvdc_100178303921.0x000001

Heterogeneous distributions of charge states determine the apparent net charge of intrinsically disordered proteins

Authors: Posey, Ammon E., Fossat, Martin J., Pappu, Rohit V.

Source: Biophysical journal. 121(S1):197a-197a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100155582652.0x000001&indx=1&recIds=ETOCvdc_100155582652.0x000001

Heuristics for the Effects of Sequence and Conformational Contexts on pKA Values of Ionizable Residues Inferred from Q-Canonical Monte Carlo Simulations

Authors: Fossat, Martin J., Posey, Ammon E., Pappu, Rohit V.

Source: Biophysical journal. 118(S1):539a-540a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097837391.0x000001&indx=1&recIds=ETOCvdc_100097837391.0x000001

Quantifying the Effects of Charge Regulation on Disorder-Order Transitions of Highly Charged Protein Sequences

Authors: Posey, Ammon E., Fossat, Martin J., Pappu, Rohit V.

Source: Biophysical journal. 118(S1):540a-541a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097837375.0x000001&indx=1&recIds=ETOCvdc_100097837375.0x000001

Toward Efficient Q-Canonical Monte Carlo Simulations of the Impact of Charge Regulation on Conformational Ensembles of Intrinsically Disordered Proteins

Authors: Fossat, Martin J., Pappu, Rohit V.

Source: Biophysical journal. 120(S1):214a-214a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135823042.0x000001&indx=1&recIds=ETOCvdc_100135823042.0x000001

Asymmetries in Free Energies of Solvation of Charged Residues Influence the Conformational Preferences of Well-Mixed Polyampholytic Disordered Proteins

Authors: Zeng, Xiangze, Fossat, Martin J., Pappu, Rohit V.

Source: Biophysical journal. 120(S1):310a-310a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135816384.0x000001&indx=1&recIds=ETOCvdc_100135816384.0x000001

A High Throughput Method for Exploring the Sequence Space of Polypeptides That Exhibit Thermoresponsive Phase Behavior

Authors: Zeng, Xiangze, Fossat, Martin J., Tang, Nicholas, Chilkoti, Ashutosh, Pappu, Rohit V.

Source: Biophysical journal. 116(S1):200a-200a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093370758.0x000001&indx=1&recIds=ETOCvdc_100093370758.0x000001

Introducing a Novel Multi-Level Method for Simulating the pH Dependence of Charge State Fluctuations and Conformational Ensembles of Intrinsically Disordered Proteins

Authors: Fossat, Martin J., Posey, Ammon E., Pappu, Rohit V.

Source: Biophysical journal. 116(S1):287a-287a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100081262155.0x000001&indx=1&recIds=ETOCvdc_100081262155.0x000001

Uncovering Differences in Hydration Free Energies and Structures for Model Compound Mimics of Charged Side Chains of Amino Acids

Authors: Fossat, Martin J., Zeng, Xiangze, Pappu, Rohit V.

Source: The Journal of Physical Chemistry - Part B; April 2021, Vol. 125 Issue: 16 p4148-4161, 14p

q‑Canonical Monte Carlo Sampling for Modeling the Linkage between Charge Regulation and Conformational Equilibria of Peptides.

Authors: Fossat, Martin J., Pappu, Rohit V.

Source: Journal of Physical Chemistry B; 8/15/2019, Vol. 123 Issue 32, p6952-6967, 16p