Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs

Authors: Maxeiner, Joachim, Sharma, Rahul, Amrhein, Carolin, Gervais, Frederic, Duda, Maria, Ward, Jonathan, Mikkelsen, Lars Friis, Forster, Roy, Malewicz, Michal, Krishnan, Jaya

Source: In Journal of Pharmacological and Toxicological Methods March-April 2021 108

Shared Learnings on the New EMA First-in-Human and Early Clinical Trial Guideline: Proceedings From a DIAlogue Session at DIA Europe 2018

Authors: van der Laan, Jan Willem, Benson, Charles T., Janssens, Walter, Bos, Jeroen, Stahl, Elke, Brady, Joseph T., Wändel-Liminga, Ulla, Corriol-Rohou, Solange, Forster, Roy, Hartmann, Andreas, Pertel, Peter Einar, Robertson, Sarah M., Silva-Lima, Beatriz, Malik, Raleigh E., Chibout, Salah-Dine

Source: Therapeutic innovation & regulatory science. 54(2):462-467

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173618854.0x000001&indx=1&recIds=ETOCvdc_100173618854.0x000001

A human relevance investigation of PPARα-mediated key events in the hepatocarcinogenic mode of action of propaquizafop in rats

Authors: Strupp, Christian, Bomann, Werner H., Spézia, François, Gervais, Frédéric, Forster, Roy, Richert, Lysiane, Singh, Pramila

Source: In Regulatory Toxicology and Pharmacology June 2018 95:348-361

Urinary system

Authors: Weichert, Charles K.

Contributors: Torrey, Theodore W., Forster, Roy P.

File Description: text

Availability: https://www.accessscience.com/content/article/a724000

Assessment of phototoxicity in pigmented Long-Evans rat: sparfloxacin and 8-methoxypsoralen

Authors: Turnock, Stephen, Gerbeix, Cédric, Thirion-Delalande, Catherine, Pearson, Nick, Forster, Roy

Source: In Regulatory Toxicology and Pharmacology February 2018 92:303-314

The emerging role of in vitro electrophysiological methods in CNS safety pharmacology

Authors: Accardi, Michael V., Pugsley, Michael K., Forster, Roy, Troncy, Eric, Huang, Hai, Authier, Simon

Source: In Journal of Pharmacological and Toxicological Methods September-October 2016 81:47-59

QT interval correction for drug-induced changes in body temperature during integrated cardiovascular safety assessment in regulatory toxicology studies in dogs: A case study

Authors: El Amrani, Abdel-Ilah, El Amrani-Callens, Francine, Loriot, Stéphane, Singh, Pramila, Forster, Roy

Source: In Journal of Pharmacological and Toxicological Methods September-October 2016 81:136-143

Carcinogenicity testing of eliglustat in mice and rats

Authors: Dagher, Rafif, Watzinger, Malene, Chevalier, Guillaume, Thirion-Delalande, Catherine, Gervais, Frederic, Forster, Roy

Source: In Regulatory Toxicology and Pharmacology October 2015 73(1):401-412

Reproductive safety evaluation of L-Ergothioneine

Authors: Forster, Roy ^*, Spézia, François, Papineau, Dominique, Sabadie, Caroline, Erdelmeier, Irene, Moutet, Marc, Yadan, Jean-Claude

Source: In Food and Chemical Toxicology June 2015 80:85-91

Safety evaluation of a whey protein fraction containing a concentrated amount of naturally occurring TGF-β2

Authors: Forster, Roy, Bourtourault, Michel, Chung, Yong Joo, Silvano, Jérémy, Sire, Guillaume, Spezia, François, Puel, Caroline, Descotes, Jacques, Mikogami, Takashi

Source: In Regulatory Toxicology and Pharmacology August 2014 69(3):398-407

Biodistribution and predictive hepatic gene expression of intravenous iron sucrose

Authors: Elford, Peter, Bouchard, Johanne, Jaillet, Léonore, Pearson, Nick, Rogue, Alexandra, Sabadie, Caroline, Forster, Roy

Source: In Journal of Pharmacological and Toxicological Methods November-December 2013 68(3):374-383

Impact of housing conditions on cardiovascular parameters in telemetry-implanted cynomolgus monkeys

Authors: El Amrani, Abdel-Ilah, Loriot, Stephane, El Amrani-Callens, Francine, Duclos, Marie-Eve, Singh, Pramila, Forster, Roy

Source: Journal of pharmacological and toxicological methods. 105

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Study designs for the nonclinical safety testing of new vaccine products

Authors: Forster, Roy

Source: In Journal of Pharmacological and Toxicological Methods July-August 2012 66(1):1-7

Dual effect of clonidine on QT interval duration and body temperature in cynomolgus monkeys: QT correction formula for changes in core body temperature

Authors: El Amrani, Abdel-Ilah, Huang, Hai, Loriot, Stephane, El Amrani, Francine, Singh, Pramila, Authier, Simon, Forster, Roy

Source: Journal of pharmacological and toxicological methods. 99

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134613652.0x000001&indx=1&recIds=ETOCvdc_100134613652.0x000001

The minipig as a platform for new technologies in toxicology

Authors: Forster, Roy, Ancian, Philippe, Fredholm, Merete, Simianer, Henner, Whitelaw, Bruce

Source: In Journal of Pharmacological and Toxicological Methods 2010 62(3):227-235

The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: Conclusions and recommendations

Authors: Forster, Roy, Bode, Gerd, Ellegaard, Lars, van der Laan, Jan-Willem

Source: In Journal of Pharmacological and Toxicological Methods 2010 62(3):236-242

Dual effect of clonidine on QT interval duration and body temperature in cynomolgus monkeys: QT correction formula for changes in core body temperature

Authors: El Amrani, Abdel-Ilah, Huang, Hai, Loriot, Stephane, El Amrani, Francine, Singh, Pramila, Authier, Simon, Forster, Roy

Source: Journal of pharmacological and toxicological methods. 99

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100090990825.0x000001&indx=1&recIds=ETOCvdc_100090990825.0x000001

Mutagenicity of benzyl chloride in the Salmonella/microsome mutagenesis assay depends on exposure conditions

Authors: Fall, Mamadou, Haddouk, Hasnaà, Morin, Jean-Paul, Forster, Roy

Source: In Mut.Res.-Genetic Toxicology and Environmental Mutagenesis 2007 633(1):13-20

Use of Thin Kidney Slices and Isolated Renal Tubules for Direct Study of Cellular Transport Kinetics

Authors: Forster, Roy P.

Source: Science, 1948 Jul . 108(2794), 65-67.

Access URL: https://www.jstor.org/stable/1677552

Thyroid hormone perturbation in a minipig model

Authors: Singh, Pramila, Nielsen, Jonas Boje, Decorde, Joachim, Erratico, Claudio-Alberto, Fonsi, Massimiliano, Richert, Lysiane, Parmentier, Céline, Untrau, Meiggie, Forster, Roy, Bentz, Sandrine, Spézia, François

Source: REPRODUCTIVE TOXICOLOGY -NEW YORK. 80:31-32

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100066923811.0x000001&indx=1&recIds=ETOCvdc_100066923811.0x000001