On-Water Selectivity Switch in Microdroplets in the 1, 2, 3-Triazole Synthesis from Bromoethenesulfonyl Fluoride

Authors: Eremin, Dmitry B., Fokin, Valery V.

Source: Journal of the American Chemical Society. 143(44):18374-18379

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN628028148&indx=1&recIds=ETOCRN628028148

Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase

Authors: Kovarik, Zrinka, Maček Hrvat, Nikolina, Kalisiak, Jarosław, Katalinić, Maja, Sit, Rakesh K., Zorbaz, Tamara, Radić, Zoran, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer

Source: In Toxicology and Applied Pharmacology 1 June 2019 372:40-46

Sulfuryl Fluoride Mediated Synthesis of Amides and Amidines from Ketoximes via Beckmann Rearrangement

Authors: Gurjar, Jitendra, Fokin, Valery V.

Source: Chemistry. 26(46):10402-10405

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107435811.0x000001&indx=1&recIds=ETOCvdc_100107435811.0x000001

Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure

Authors: Sit, Rakesh K., Kovarik, Zrinka, Maček Hrvat, Nikolina, Žunec, Suzana, Green, Carol, Fokin, Valery V. ¹, Sharpless, K. Barry, Radić, Zoran, Taylor, Palmer ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics November 2018 367(2):363-372

Reversal of Tabun Toxicity Enabled by a Triazole‐Annulated Oxime Library—Reactivators of Acetylcholinesterase

Authors: Kovarik, Zrinka, Kalisiak, Jarosław, Hrvat, Nikolina Maček, Katalinić, Maja, Zorbaz, Tamara, Žunec, Suzana, Green, Carol, Radić, Zoran, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer

Source: Chemistry. 25(16):4100-4114

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100082925914.0x000001&indx=1&recIds=ETOCvdc_100082925914.0x000001

Visualizing partial solvation at the air–water interface.

Authors: Judd, Kenneth D., Parsons, Sean W., Eremin, Dmitry B., Fokin, Valery V., Dawlaty, Jahan M.

Source: Chemical Science; 6/14/2024, Vol. 15 Issue 22, p8346-8354, 9p

Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target.

Authors: Grotsch, Katharina, Sadybekov, Anastasiia V., Hiller, Sydney, Zaidi, Saheem, Eremin, Dmitry, Le, Austen, Liu, Yongfeng, Smith, Evan Carlton, Illiopoulis-Tsoutsouvas, Christos, Thomas, Joice, Aggarwal, Shubhangi, Pickett, Julie E., Reyes, Cesar, Picazo, Elias, Roth, Bryan L., Makriyannis, Alexandros, Katritch, Vsevolod, Fokin, Valery V.

Source: ACS Chemical Biology; 4/19/2024, Vol. 19 Issue 4, p866-874, 9p

Neuritogenic activity of bi-functional bis-tryptoline triazole

Authors: Jiaranaikulwanitch, Jutamas, Tadtong, Sarin, Govitrapong, Piyarat, Fokin, Valery V., Vajragupta, Opa

Source: In Bioorganic & Medicinal Chemistry 1 February 2017 25(3):1195-1201

Generation and Aerobic Oxidation of Azavinyl Captodative Radicals.

Authors: Aggarwal, Shubhangi, Richards, William J., Fokin, Valery V.

Source: Journal of the American Chemical Society; 11/15/2023, Vol. 145 Issue 45, p24452-24458, 7p

Centrally acting oximes in reactivation of tabun-phosphoramidated AChE

Authors: Kovarik, Zrinka, Maček, Nikolina, Sit, Rakesh K., Radić, Zoran, Fokin, Valery V., Barry Sharpless, K., Taylor, Palmer

Source: In Chemico-Biological Interactions 25 March 2013 203(1):77-80

Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates

Authors: Radić, Zoran, Sit, Rakesh K., Garcia, Edzna, Zhang, Limin, Berend, Suzana, Kovarik, Zrinka, Amitai, Gabriel, Fokin, Valery V., Barry Sharpless, K., Taylor, Palmer

Source: In Chemico-Biological Interactions 25 March 2013 203(1):67-71

Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity

Authors: Miyamoto, Yukiko, Kalisiak, Jarosław, Korthals, Keith, Lauwaet, Tineke, Cheung, Dae Young, Lozano, Ricardo, Cobo, Eduardo R., Upcroft, Peter, Upcroft, Jacqueline A., Berg, Douglas E., Gillin, Frances D., Fokin, Valery V., Sharpless, K. Barry, Eckmann, Lars

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Oct . 110(43), 17564-17569.

Access URL: https://www.jstor.org/stable/23753272

Synthesis of Selective Agonists for the α7 Nicotinic Acetylcholine Receptor with In Situ Click-Chemistry on Acetylcholine-Binding Protein Templates

Authors: Yamauchi, John G., Gomez, Kimberly, Grimster, Neil, Dufouil, Mikael ¹, Nemecz, Ákos, Fotsing, Joseph R. ², Ho, Kwok-Yiu, Talley, Todd T. ³, Sharpless, K. Barry, Fokin, Valery V., Taylor, Palmer ^*

Source: In Molecular Pharmacology October 2012 82(4):687-699

Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

Authors: Radić, Zoran, Sit, Rakesh K., Kovarik, Zrinka, Berend, Suzana, Garcia, Edzna, Zhang, Limin, Amitai, Gabriel, Green, Carol ^**, Radić, Božica, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer

Source: In Journal of Biological Chemistry 6 April 2012 287(15):11798-11809

Oxime-assisted Acetylcholinesterase Catalytic Scavengers of Organophosphates That Resist Aging

Authors: Cochran, Rory, Kalisiak, Jarosław, Küçükkılınç, Tuba, Radić, Zoran, Garcia, Edzna, Zhang, Limin, Ho, Kwok-Yiu, Amitai, Gabriel, Kovarik, Zrinka, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer

Source: In Journal of Biological Chemistry 26 August 2011 286(34):29718-29724

New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

Authors: Sit, Rakesh K., Radić, Zoran, Gerardi, Valeria, Zhang, Limin, Garcia, Edzna, Katalinić, Maja, Amitai, Gabriel, Kovarik, Zrinka, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer

Source: In Journal of Biological Chemistry 3 June 2011 286(22):19422-19430

Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase

Authors: Radić, Zoran, Kalisiak, Jaroslaw, Fokin, Valery V., Sharpless, K. Barry, Taylor, Palmer

Source: In Chemico-Biological Interactions 2010 187(1):163-166

Copper catalyzed cycloaddition of organic azides and 1-haloalkynes

Arenes participate in 1,3-dipolar cycloaddition with in situ-generated diazoalkenes

Authors: Aggarwal, Shubhangi, Vu, Alexander, Eremin, Dmitry B., Persaud, Rudra, Fokin, Valery V.

Source: Nature Chemistry; June 2023, Vol. 15 Issue: 6 p764-772, 9p

COPPER CATALYZED CYCLOADDITION OF ORGANIC AZIDES AND 1-HALOALKYNES