An engineered palivizumab IgG2 subclass for synthetic gp130 and fas-mediated signaling

Authors: Wittich, Christoph ¹, Ettich, Julia ¹, Hertell, Marcel ¹, Ghosh Roy, Biswadeep ², Xu, Haifeng C. ², Floss, Doreen M. ¹, Lang, Philipp A. ², Scheller, Jürgen ^{1, ∗}

Source: In Journal of Biological Chemistry March 2025 301(3)

Synthetic trimeric interleukin-6 receptor complexes with a STAT3 phosphorylation dominated activation profile

Authors: Seibel, Christiane, Pudewell, Silke, Rafii, Puyan, Ettich, Julia, Weitz, Hendrik T., Lang, Alexander, Petzsch, Patrick, Köhrer, Karl, Floss, Doreen M., Scheller, Jürgen

Source: In Cytokine December 2024 184

Engineered interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR

Authors: Rafii, Puyan, Cruz, Patricia Rodrigues, Ettich, Julia, Seibel, Christiane, Padrini, Giacomo, Wittich, Christoph, Lang, Alexander, Petzsch, Patrick, Köhrer, Karl, Moll, Jens M., Floss, Doreen M., Scheller, Jürgen

Source: In Journal of Biological Chemistry May 2024 300(5)

Bispecific soluble cytokine receptor-nanobody fusions inhibit Interleukin (IL-)6 trans-signaling and IL-12/23 or tumor necrosis factor (TNF) signaling

Authors: Gesiorowski, Annika, Ettich, Julia, Werner, Julia, Wittich, Christoph, Pieper, Stephan, Padrini, Giacomo, Behnke, Kristina, Floss, Doreen M., Lang, Philipp A., Moll, Jens M., Scheller, Jürgen

Source: In Journal of Biological Chemistry November 2023 299(11)

Respiratory syncytial virus–approved mAb Palivizumab as ligand for anti-idiotype nanobody-based synthetic cytokine receptors

Authors: Ettich, Julia, Wittich, Christoph, Moll, Jens M., Behnke, Kristina, Floss, Doreen M., Reiners, Jens, Christmann, Andreas, Lang, Philipp A., Smits, Sander H.J., Kolmar, Harald, Scheller, Jürgen

Source: In Journal of Biological Chemistry November 2023 299(11)

Synthetic receptor platform to identify loss-of-function single nucleotide variants and designed mutants in the death receptor Fas/CD95

Authors: Minafra, Anna Rita, Rafii, Puyan, Mossner, Sofie, Bazgir, Farhad, Floss, Doreen M., Moll, Jens M., Scheller, Jürgen

Source: In Journal of Biological Chemistry August 2023 299(8)

Taming interleukin‐12: Engineering of bispecific antibody‐based IL‐12 mimetics with biased agonism capacities.

Authors: Lipinski, Britta, Unmuth, Laura, Arras, Paul, Endruszeit, Ron, Becker, Stefan, Rödel, Jonathan Mathias, Scheller, Jürgen, Pudewell, Silke, Floss, Doreen M., Krah, Simon, Harwardt, Julia, Doerner, Achim, Helming, Laura, Xu, Chunxiao, Menrad, Andreas, Evers, Andreas, Kolmar, Harald, Elter, Desislava, Pekar, Lukas, Zielonka, Stefan

Source: Protein Science: A Publication of the Protein Society; Mar2025, Vol. 34 Issue 3, p1-18, 18p

Interleukin‐11 receptor is an alternative α‐receptor for interleukin‐6 and the chimeric cytokine IC7.

Authors: Weitz, Hendrik T., Ettich, Julia, Rafii, Puyan, Wittich, Christoph, Schultz, Laura, Frank, Nils C., Heise, Denise, Krusche, Matthias, Lokau, Juliane, Garbers, Christoph, Behnke, Kristina, Floss, Doreen M., Kolmar, Harald, Moll, Jens M., Scheller, Jürgen

Source: FEBS Journal; Feb2025, Vol. 292 Issue 3, p523-536, 14p

Subject Terms: INTERLEUKIN-6, INTERLEUKIN-6 receptors, WEIGHT loss, CELLULAR immunity, MONOCLONAL antibodies, CYTOKINES, RECEPTOR-ligand complexes

Exclusive inhibition of IL-6 trans-signaling by soluble gp130FlyRFc

Authors: Berg, Anna F., Ettich, Julia, Weitz, Hendrik T., Krusche, Matthias, Floss, Doreen M., Scheller, Jürgen, Moll, Jens M.

Source: In Cytokine: X December 2021 3(4)

Current status and relevance of single nucleotide polymorphisms in IL-6-/IL-12-type cytokine receptors

Authors: Scheller, Jürgen, Berg, Anna, Moll, Jens M., Floss, Doreen M., Jungesblut, Christopher

Source: In Cytokine December 2021 148

Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction

Authors: Georgy, Jacqueline, Arlt, Yvonne, Moll, Jens M., Ouzin, Meryem, Weitz, Hendrik T., Gremer, Lothar, Willbold, Dieter, Grötzinger, Joachim, Thives-Kurenbach, Felix, Scheller, Jürgen, Floss, Doreen M.

Source: In Journal of Biological Chemistry November 2021 297(5)

Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130

Authors: Mossner, Sofie, Kuchner, Marcus, Fazel Modares, Nastaran, Knebel, Birgit, Al-Hasani, Hadi, Floss, Doreen M., Scheller, Jürgen ^*

Source: In Journal of Biological Chemistry 28 August 2020 295(35):12378-12397

Deciphering site 3 interactions of interleukin 12 and interleukin 23 with their cognate murine and human receptors

Authors: Esch, Alessandra, Masiarz, Anna, Mossner, Sofie, Moll, Jens M., Grötzinger, Joachim, Schröder, Jutta, Scheller, Jürgen, Floss, Doreen M. ^*

Source: In Journal of Biological Chemistry 24 July 2020 295(30):10478-10492

Naturally occurring and synthetic constitutive-active cytokine receptors in disease and therapy

Authors: Floss, Doreen M., Scheller, Jürgen

Source: In Cytokine and Growth Factor Reviews June 2019 47:1-20

Immunoreceptor Engineering and Synthetic Cytokine Signaling for Therapeutics

Authors: Scheller, Jürgen, Engelowski, Erika, Moll, Jens M., Floss, Doreen M.

Source: In Trends in Immunology March 2019 40(3):258-272

Combined deletion of the fibronectin-type III domains and the stalk region results in ligand-independent, constitutive activation of the Interleukin 6 signal-transducing receptor gp130

Authors: Lamertz, Larissa, Floss, Doreen M., Scheller, Jürgen

Source: In Cytokine October 2018 110:428-434

IL‐6 Trans‐signaling Controls Liver Regeneration After Partial Hepatectomy

Authors: Fazel Modares, Nastaran, Polz, Robin, Haghighi, Fereshteh, Lamertz, Larissa, Behnke, Kristina, Zhuang, Yuan, Kordes, Claus, Häussinger, Dieter, Sorg, Ursula R., Pfeffer, Klaus, Floss, Doreen M., Moll, Jens M., Piekorz, Roland P., Ahmadian, M. Reza, Lang, Philipp A., Scheller, Jürgen

Source: Hepatology. 70(6):2075-2091

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093622854.0x000001&indx=1&recIds=ETOCvdc_100093622854.0x000001

Exploring the landscape of synthetic IL‐6‐type cytokines.

Authors: Scheller, Jürgen, Ettich, Julia, Wittich, Christoph, Pudewell, Silke, Floss, Doreen M., Rafii, Puyan

Source: FEBS Journal; May2024, Vol. 291 Issue 10, p2030-2050, 21p

Subject Terms: CYTOKINES, CYTOKINE receptors, CHIMERIC proteins, TYPE 2 diabetes, BRAIN injuries

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor

Authors: Monhasery, Niloufar, Moll, Jens, Cuman, Carly, Franke, Manuel, Lamertz, Larissa, Nitz, Rebecca, Görg, Boris, Häussinger, Dieter, Lokau, Juliane, Floss, Doreen M., Piekorz, Roland, Dimitriadis, Eva, Garbers, Christoph, Scheller, Jürgen

Source: In Cell Reports 26 July 2016 16(4):1067-1081

Human and Murine Interleukin 23 Receptors Are Novel Substrates for A Disintegrin and Metalloproteases ADAM10 and ADAM17

Authors: Franke, Manuel, Schröder, Jutta, Monhasery, Niloufar, Ackfeld, Theresa, Hummel, Thorben M., Rabe, Björn, Garbers, Christoph, Becker-Pauly, Christoph, Floss, Doreen M., Scheller, Jürgen

Source: In Journal of Biological Chemistry 13 May 2016 291(20):10551-10561