Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain

Authors: Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E. Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J. O’Neill, Florian Wegner, Stefan Barghorn, Günter U. Höglinger, Roland G. Heym

Source: Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-17 (2023)

Subject Terms: Alzheimer’s disease, Tau seeding, Seed amplification assay (SAA), Real-time quaking induced conversion assay (RT-QuIC), Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/78bf1f0ec959455f9e1ccbfb0ccf720b

Acute Levodopa Challenge in Atypical Parkinsonism: Comprehensive Analysis of Individual Motor Responses

Authors: Lan Ye, Sam Sadeghi Sani, Linda Veith Sanches, Lea Farina Magdalena Krey, Florian Wegner, Matthias Höllerhage, Christoph Schrader, Günter Höglinger, Martin Klietz

Source: Brain Sciences, Vol 14, Iss 10, p 991 (2024)

Subject Terms: progressive supranuclear palsy, multiple system atrophy, acute levodopa challenge, treatment, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3425/14/10/991; https://doaj.org/toc/2076-3425

Access URL: https://doaj.org/article/0981210e93614e8c8f561db0d770b4de

Impact of the Anticholinergic Burden on Disease-Specific Symptoms in Parkinsonian Syndromes

Authors: Romina Mahmoudi, Stephan Greten, Linda Veith Sanches, Lea Krey, Sarana Ulaganathan, Günter U. Höglinger, Johannes Heck, Florian Wegner, Martin Klietz

Source: Brain Sciences, Vol 14, Iss 8, p 805 (2024)

Subject Terms: anticholinergic burden, Parkinsonian syndromes, polypharmacy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3425/14/8/805; https://doaj.org/toc/2076-3425

Access URL: https://doaj.org/article/4964798184344823866905271889de3a

Correction: Tau seed amplification assay reveals relationship between seeding and pathological forms of tau in Alzheimer’s disease brain

Authors: Bryan Frey, David Holzinger, Keenan Taylor, Dagmar E. Ehrnhoefer, Andreas Striebinger, Sandra Biesinger, Laura Gasparini, Michael J. O’Neill, Florian Wegner, Stefan Barghorn, Günter U. Höglinger, Roland G. Heym

Source: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-1 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/116466ed0c3c4ab5a3caa5ae928acbff

Case report: Early-onset Parkinson's disease with initial spastic paraparesis and hyperreflexia caused by compound heterozygous PRKN-gene exon 2 and 4 deletions

Authors: Ida Jensen, Corinna Hendrich, Martin Klietz, Georg Berding, Günter U. Höglinger, Florian Wegner

Source: Frontiers in Neurology, Vol 13 (2022)

Subject Terms: PRKN-gene, Parkin, PRKN2, young onset parkinsonism, early onset Parkinson's disease (EOPD), exon 2, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2022.969232/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/4660c6cdfe614710814c97ed99543bd5

Severe allo-immune antibody-associated peripheral and central nervous system diseases after allogeneic hematopoietic stem cell transplantation

Authors: Martin W. Hümmert, Michael Stadler, Lothar Hambach, Stefan Gingele, Martin Bredt, Mike P. Wattjes, Gudrun Göhring, Letizia Venturini, Nora Möhn, Martin Stangel, Corinna Trebst, Arnold Ganser, Florian Wegner, Thomas Skripuletz

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c675c306039d4e41a2256268f7fe09c0

iPSC-Derived Striatal Medium Spiny Neurons from Patients with Multiple System Atrophy Show Hypoexcitability and Elevated α-Synuclein Release

Authors: Lisa M. Henkel, Svenja Kankowski, Thiemo M. Moellenkamp, Nadine J. Smandzich, Sigrid Schwarz, Alessio Di Fonzo, Gudrun Göhring, Günter Höglinger, Florian Wegner

Source: Cells, Vol 12, Iss 2, p 223 (2023)

Subject Terms: induced pluripotent stem cells (iPSCs), striatal medium spiny neurons (MSNs), multiple system atrophy (MSA), α-synuclein, hypoexcitability, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/2/223; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/1473e21a1d714024809d2525b9e91f13

Cerebral Microstructural Alterations in Patients With Early Parkinson’s Disease Detected With Quantitative Magnetic Resonance Measurements

Authors: Martin Klietz, M. Handan Elaman, Nima Mahmoudi, Patrick Nösel, Mareike Ahlswede, Florian Wegner, Günter U. Höglinger, Heinrich Lanfermann, Xiao-Qi Ding

Source: Frontiers in Aging Neuroscience, Vol 13 (2021)

Subject Terms: Parkinson’s disease, relative proton density, T1 relaxation time, T2 relaxation time, T2′ relaxation time, quantitative MRI analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2021.763331/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/ed1a0bc67e3144ab8b928e22361fc844

Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2

Authors: Shuyong Zhu, Nancy Stanslowsky, Jorge Fernández-Trillo, Tamrat M. Mamo, Pengfei Yu, Norman Kalmbach, Birgit Ritter, Reto Eggenschwiler, Werner J.D. Ouwendijk, David Mzinza, Likai Tan, Andreas Leffler, Michael Spohn, Richard J.P. Brown, Kai A. Kropp, Volkhard Kaever, Teng-Cheong Ha, Pratibha Narayanan, Adam Grundhoff, Reinhold Förster, Axel Schambach, Georges M.G.M. Verjans, Manuela Schmidt, Andreas Kispert, Tobias Cantz, Ana Gomis, Florian Wegner, Abel Viejo-Borbolla

Source: Stem Cell Research, Vol 56, Iss , Pp 102535- (2021)

Subject Terms: Human induced pluripotent stem cells, Small molecule-derived neural precursor cells, Low threshold mechanoreceptors, Bulbous sensory nerve ending, Piezo1, Piezo2, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506121003822; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/c19fa53982d04aa9802dafcb4602256b

Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins

Authors: Masin Abo-Rady, Norman Kalmbach, Arun Pal, Carina Schludi, Antje Janosch, Tanja Richter, Petra Freitag, Marc Bickle, Anne-Karin Kahlert, Susanne Petri, Stefan Stefanov, Hannes Glass, Selma Staege, Walter Just, Rajat Bhatnagar, Dieter Edbauer, Andreas Hermann, Florian Wegner, Jared L. Sterneckert

Source: Stem Cell Reports, Vol 14, Iss 3, Pp 390-405 (2020)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221367112030031X; https://doaj.org/toc/2213-6711

Access URL: https://doaj.org/article/15576128a76a4db4a3714084cbbcfe19

Phenotypes and malignancy risk of different FUS mutations in genetic amyotrophic lateral sclerosis

Authors: Marcel Naumann, Kevin Peikert, Rene Günther, Anneke J. van derKooi, Eleonora Aronica, Annemarie Hübers, Veronique Danel, Philippe Corcia, Francisco Pan‐Montojo, Sebahattin Cirak, Göknur Haliloglu, Albert C. Ludolph, Anand Goswami, Peter M. Andersen, Johannes Prudlo, Florian Wegner, Philip Van Damme, Jochen H. Weishaupt, Andreas Hermann

Source: Annals of Clinical and Translational Neurology, Vol 6, Iss 12, Pp 2384-2394 (2019)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2328-9503

Access URL: https://doaj.org/article/29d3f763bcef4f7cab2c7d82907db880

iPS Cell-Based Model for MAPT Haplotype as a Risk Factor for Human Tauopathies Identifies No Major Differences in TAU Expression

Authors: Tabea Strauß, Amir Marvian-Tayaranian, Eldem Sadikoglou, Ashutosh Dhingra, Florian Wegner, Dietrich Trümbach, Wolfgang Wurst, Peter Heutink, Sigrid C. Schwarz, Günter U. Höglinger

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: TAU, α-SYNUCLEIN, iPSC, disease modeling, NGN2 neurons, MAPT haplotype, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.726866/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/7a7d357f6ff54cdda6f043525ffd79a5

Ventral Telencephalic Patterning Protocols for Induced Pluripotent Stem Cells

Authors: Victor Krajka, Maximilian Naujock, Martje G. Pauly, Felix Stengel, Britta Meier, Nancy Stanslowsky, Christine Klein, Philip Seibler, Florian Wegner, Philipp Capetian

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: induced pluripotent stem cells, medial ganglionic eminence, Sonic hedgehog, XAV-939, purmorphamine, basal forebrain cholinergic neurons, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.716249/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/047a8be5c089422d895f615c4fc75e4e

Reduced Expression of GABAA Receptor Alpha2 Subunit Is Associated With Disinhibition of DYT-THAP1 Dystonia Patient-Derived Striatal Medium Spiny Neurons

Authors: Selma Staege, Anna Kutschenko, Hauke Baumann, Hannes Glaß, Lisa Henkel, Thomas Gschwendtberger, Norman Kalmbach, Martin Klietz, Andreas Hermann, Katja Lohmann, Philip Seibler, Florian Wegner

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: DYT-THAP1, genetic dystonia, induced pluripotent stem cells, striatal medium spiny neurons, GABAA receptor, calcium dynamics, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.650586/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/e430a2e0bfeb42c5b6f33e85eb50634e

Validation of the Parkinson’s Disease Caregiver Burden Questionnaire in Progressive Supranuclear Palsy

Authors: Martin Klietz, Hannah V. Eichel, Selma Staege, Anna Kutschenko, Gesine Respondek, Meret K. Huber, Stephan Greten, Günter U. Höglinger, Florian Wegner

Source: Parkinson's Disease, Vol 2021 (2021)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2090-8083; https://doaj.org/toc/2042-0080

Access URL: https://doaj.org/article/f61584a31b43463d918926e99ef7cde9

Case Report: Daratumumab in a Patient With Severe Refractory Anti-NMDA Receptor Encephalitis

Authors: Dominica Ratuszny, Thomas Skripuletz, Florian Wegner, Matthias Groß, Christine Falk, Roland Jacobs, Heiner Ruschulte, Martin Stangel, Kurt-Wolfram Sühs

Source: Frontiers in Neurology, Vol 11 (2020)

Subject Terms: anti-NMDA receptor encephalitis, autoimmune encephalitis, bortezomib, daratumumab, critical care, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2020.602102/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/e098815f11d84266a6172e3ba96c4b91

Postinfectious Onset of Myasthenia Gravis in a COVID-19 Patient

Authors: Meret Huber, Sophia Rogozinski, Wolfram Puppe, Carsten Framme, Günter Höglinger, Karsten Hufendiek, Florian Wegner

Source: Frontiers in Neurology, Vol 11 (2020)

Subject Terms: anosmia/ageusia, COVID-19, diplopia, neurological manifestation, postinfectious myasthenia gravis, SARS-CoV-2, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fneur.2020.576153/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/ea3cdc39f6424f46a10c716f0bf7c1ac

Analysis of Parkinson’s Disease Outpatient Counselling for Advance Directive Creation: A Cross-Sectional Questionnaire-Based Survey of German General Practitioners and Neurologists

Authors: Ida Jensen, Almut Bretschneider, Stephanie Stiel, Florian Wegner, Günter U. Höglinger, Martin Klietz

Source: Brain Sciences, Vol 12, Iss 6, p 749 (2022)

Subject Terms: advance directives, palliative medicine, Parkinson’s disease, PwP, advance care planning, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3425/12/6/749; https://doaj.org/toc/2076-3425

Access URL: https://doaj.org/article/9b27e2e7972f41b197d70bb1664f3f48

Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS

Authors: René Günther, Arun Pal, Chloe Williams, Vitaly L. Zimyanin, Maria Liehr, Cläre von Neubeck, Mechthild Krause, Mrudula G. Parab, Susanne Petri, Norman Kalmbach, Stefan L. Marklund, Jared Sterneckert, Peter Munch Andersen, Florian Wegner, Jonathan D. Gilthorpe, Andreas Hermann

Source: Cells, Vol 11, Iss 7, p 1246 (2022)

Subject Terms: SOD1, ALS1, mitochondria, live cell imaging, axonal trafficking, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/7/1246; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/a384eecc4dc6440ea19379b4d2551e7d

Neuropsychiatric Symptoms in Parkinson’s Disease Patients Are Associated with Reduced Health-Related Quality of Life and Increased Caregiver Burden

Authors: Hannah von Eichel, Johanne Heine, Florian Wegner, Sophia Rogozinski, Stephanie Stiel, Adrian Groh, Lea Krey, Günter U. Höglinger, Martin Klietz

Source: Brain Sciences, Vol 12, Iss 1, p 89 (2022)

Subject Terms: Parkinson’s disease, neuropsychiatric symptoms, SEND-PD, caregiver burden, health-related quality of life, depression, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3425/12/1/89; https://doaj.org/toc/2076-3425

Access URL: https://doaj.org/article/5dd55cc1f8f74bd8b089eb7b1f65cfd4