Oncolytic viruses expressing MATEs facilitate target-independent T-cell activation in tumors

Authors: Malin Peter, Bettina Mundt, Arne Menze, Norman Woller, Valery Volk, Amanda M Ernst, Leon A Öhler, Steven R Talbot, Heiner Wedemeyer, Christine Falk, Friedrich Feuerhake, Thomas C Wirth, Florian Kühnel

Source: EMBO Molecular Medicine, Vol 17, Iss 2, Pp 265-300 (2025)

Subject Terms: MATE, T-cell Engager, CD3, Oncolytic Adenovirus, Tat-PTD, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/2d8fb8b3196847fba23552784535f34a

MiR-129-5p exerts Wnt signaling-dependent tumor-suppressive functions in hepatocellular carcinoma by directly targeting hepatoma-derived growth factor HDGF

Authors: Nicole Huge, Thea Reinkens, Reena Buurman, Maria Sandbothe, Anke Bergmann, Hannah Wallaschek, Beate Vajen, Amelie Stalke, Melanie Decker, Marlies Eilers, Vera Schäffer, Oliver Dittrich-Breiholz, Engin Gürlevik, Florian Kühnel, Brigitte Schlegelberger, Thomas Illig, Britta Skawran

Source: Cancer Cell International, Vol 22, Iss 1, Pp 1-16 (2022)

Subject Terms: HCC, HDAC inhibitors, miRNA sequencing, ERK signaling, Wnt signaling, miRNA replacement therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/3da413d23a3548bfa6c3093759f16cd4

PD-1/CTLA-4 blockade leads to expansion of CD8+PD-1int TILs and results in tumor remission in experimental liver cancer

Authors: Sandra Bufe, Artur Zimmermann, Sarina Ravens, Immo Prinz, Laura Elisa Buitrago-Molina, Robert Geffers, Norman Woller, Florian Kühnel, Steven R. Talbot, Fatih Noyan, Michael Peter Manns, Heiner Wedemeyer, Matthias Hardtke-Wolenski, Elmar Jaeckel, Ana C. Davalos-Misslitz

Source: Liver Cancer (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.karger.com/Article/FullText/526899; https://doaj.org/toc/2235-1795; https://doaj.org/toc/1664-5553

Access URL: https://doaj.org/article/965c2a4212154815948f7cc4a347137a

Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation

Authors: Paulo L. Pfitzinger, Laura Fangmann, Kun Wang, Elke Demir, Engin Gürlevik, Bettina Fleischmann-Mundt, Jennifer Brooks, Jan G. D’Haese, Steffen Teller, Andreas Hecker, Moritz Jesinghaus, Carsten Jäger, Lei Ren, Rouzanna Istvanffy, Florian Kühnel, Helmut Friess, Güralp Onur Ceyhan, Ihsan Ekin Demir

Source: Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-15 (2020)

Subject Terms: Cholinergic, Acetylcholinesterase, Pancreatic cancer, Parasympathomimetics, Electroporation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/b723c6b0993b4138b7a61f13032d92be

Waves from the centre: probing PBH and other macroscopic dark matter with LISA

Authors: Florian Kühnel, Andrew Matas, Glenn D. Starkman, Katherine Freese

Source: European Physical Journal C: Particles and Fields, Vol 80, Iss 7, Pp 1-7 (2020)

Subject Terms: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798

File Description: electronic resource

Relation: http://link.springer.com/article/10.1140/epjc/s10052-020-8183-4; https://doaj.org/toc/1434-6044; https://doaj.org/toc/1434-6052

Access URL: https://doaj.org/article/ee3b5ed9719d4f89aea09e9f63b11742

Solar Evolution Models with a Central Black Hole

Authors: Earl P. Bellinger, Matt E. Caplan, Taeho Ryu, Deepika Bollimpalli, Warrick H. Ball, Florian Kühnel, R. Farmer, S. E. de Mink, Jørgen Christensen-Dalsgaard

Source: The Astrophysical Journal, Vol 959, Iss 2, p 113 (2023)

Subject Terms: Stellar evolution, Primordial black holes, Dark matter, Astrophysics, QB460-466

File Description: electronic resource

Relation: https://doaj.org/toc/1538-4357

Access URL: https://doaj.org/article/a421c3f39dcc4332b7c897950ddde847

Enhanced detectability of spinning primordial black holes

Authors: Florian Kühnel

Source: European Physical Journal C: Particles and Fields, Vol 80, Iss 3, Pp 1-4 (2020)

Subject Terms: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798

File Description: electronic resource

Relation: http://link.springer.com/article/10.1140/epjc/s10052-020-7807-z; https://doaj.org/toc/1434-6044; https://doaj.org/toc/1434-6052

Access URL: https://doaj.org/article/a616ec9d499e456aac0483219a815530

On stochastic effects and primordial black-hole formation

Authors: Florian Kühnel, Katherine Freese

Source: European Physical Journal C: Particles and Fields, Vol 79, Iss 11, Pp 1-5 (2019)

Subject Terms: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798

File Description: electronic resource

Relation: http://link.springer.com/article/10.1140/epjc/s10052-019-7466-0; https://doaj.org/toc/1434-6044; https://doaj.org/toc/1434-6052

Access URL: https://doaj.org/article/59b291770131438e8243f87a5c2af3bc

Decaying dark matter in halos of primordial black holes

Authors: Florian Kühnel, Tommy Ohlsson

Source: European Physical Journal C: Particles and Fields, Vol 79, Iss 8, Pp 1-5 (2019)

Subject Terms: Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798

File Description: electronic resource

Relation: http://link.springer.com/article/10.1140/epjc/s10052-019-7173-x; https://doaj.org/toc/1434-6044; https://doaj.org/toc/1434-6052

Access URL: https://doaj.org/article/892012fd5ae047b7a64996ec84ebd69c

Molecular retargeting of antibodies converts immune defense against oncolytic viruses into cancer immunotherapy

Authors: Julia Niemann, Norman Woller, Jennifer Brooks, Bettina Fleischmann-Mundt, Nikolas T. Martin, Arnold Kloos, Sarah Knocke, Amanda M. Ernst, Michael P. Manns, Stefan Kubicka, Thomas C. Wirth, Rita Gerardy-Schahn, Florian Kühnel

Source: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5216df34738f45e49e9168b8b9041417

Ste20-like Kinase STK25: A Potential Target in Prevention and Therapy of NASH-Associated Hepatocellular Carcinoma?

Authors: Florian Kühnel, PhD

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 676-677 (2022)

Subject Terms: Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X21002381; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/3e79c3cccc4a4db7998c7ee6c5f465c1

Immunohistochemical Characterization and Sensitivity to Human Adenovirus Serotypes 3, 5, and 11p of New Cell Lines Derived from Human Diffuse Grade II to IV Gliomas

Authors: Minna Niittykoski, Mikael von und zu Fraunberg, Miika Martikainen, Tuomas Rauramaa, Arto Immonen, Susanna Koponen, Ville Leinonen, Markus Vähä-Koskela, Qiwei Zhang, Florian Kühnel, Ya-Fang Mei, Seppo Ylä-Herttuala, Juha E. Jääskeläinen, Ari Hinkkanen

Source: Translational Oncology, Vol 10, Iss 5, Pp 772-779 (2017)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1936523317302188; https://doaj.org/toc/1936-5233; https://doaj.org/toc/1944-7124

Access URL: https://doaj.org/article/5cf8fbba303a4a31bebd174798fea849

Virotherapy in Germany—Recent Activities in Virus Engineering, Preclinical Development, and Clinical Studies

Authors: Dirk M. Nettelbeck, Mathias F. Leber, Jennifer Altomonte, Assia Angelova, Julia Beil, Susanne Berchtold, Maike Delic, Jürgen Eberle, Anja Ehrhardt, Christine E. Engeland, Henry Fechner, Karsten Geletneky, Katrin Goepfert, Per Sonne Holm, Stefan Kochanek, Florian Kreppel, Lea Krutzke, Florian Kühnel, Karl Sebastian Lang, Antonio Marchini, Markus Moehler, Michael D. Mühlebach, Ulrike Naumann, Roman Nawroth, Jürg Nüesch, Jean Rommelaere, Ulrich M. Lauer, Guy Ungerechts

Source: Viruses, Vol 13, Iss 8, p 1420 (2021)

Subject Terms: oncolytic virus, virotherapy, research in Germany, virus engineering, virus targeting, therapeutic transgene, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/13/8/1420; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/2afbc836e8844aa9a40984a8fca1af73

Live vaccines—a short‐cut to cancer viro‐immunotherapy

Authors: Thomas C Wirth, Julia Niemann, Florian Kühnel

Source: EMBO Molecular Medicine, Vol 12, Iss 1, Pp 1-2 (2019)

Subject Terms: Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/affb6d67f5ca4f5fa188d3709c0b00cc

Neoantigen Targeting—Dawn of a New Era in Cancer Immunotherapy?

Authors: Thomas C. Wirth, Florian Kühnel

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: neoantigens, vaccination, personalized cancer immunotherapy, adoptive transfer, mutations, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.01848/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/55ea5bd8e3994d01ba2a76c12a206453

Verschränkte Ungleichheit. : Praktiken der Intersektionalität in der Frühen Neuzeit.

Authors: Matthias Bähr, Florian Kühnel

Resource Type: eBook.

Subjects: Intersectionality (Sociology)--Europe--Congresses

Categories: HISTORY / Social History, HISTORY / Europe / Western, SOCIAL SCIENCE / Minority Studies, SOCIAL SCIENCE / Discrimination

ITOC2 – 010. Virotherapy overcomes tumour resistance to PD1-immunotherapy by broad mutanome-directed T cell responses

Authors: Norman, Woller, Engin, Gürlevik, Bettina, Fleischmann-Mundt, Sarah, Knocke, Robert, Geffers, Michael, Manns P., Stefan, Kubicka, Florian, Kühnel

Source: In European Journal of Cancer March 2015 51 Supplement 1:S4-S4

ITOC2 – 027. Redirecting adenovirus-specific T cells by a tumour-specific T cell receptor for therapy of hepatocellular carcinoma

Authors: Cristina, Ureche I., Engin, Guerlevik, Norman, Woller, Arnold, Kloos, Bettina, Fleischmann-Mundt, Michael, Manns P., Stefan, Kubicka, Florian, Kuehnel

Source: In European Journal of Cancer March 2015 51 Supplement 1:S10-S10

ITOC2 – 030. Identification of the neoantigen Ndufs1-V491A for investigations on immunotherapies in murine tumour models

Authors: Anja, Schumacher, Norman, Woller, Sarah, Knocke, Julia, Niemann, Engin, Gürlevik, Bettina, Fleischmann-Mundt, Michael, Manns P., Florian, Kühnel

Source: In European Journal of Cancer March 2015 51 Supplement 1:S11-S11

ITOC2 – 012. Neoadjuvant immune checkpoint blockade for pancreatic cancer prevents local tumour recurrence through tissue resident antitumoural CD8+ CD103+ T cells

Authors: Jennifer, Brooks, Bettina, Fleischmann-Mundt, Norman, Woller, Stefan, Kubicka, Florian, Kühnel, Engin, Gürlevik

Source: In European Journal of Cancer March 2015 51 Supplement 1:S4-S5