Identification of two biological subgroups of complex regional pain syndrome type 1 by transcriptomic profiling of skin and blood in women

Authors: Melina Pérez Vertti Valdés, Astrid Jüngel, Pamela Bitterli, Jan Devan, Hubert Rehrauer, Lennart Opitz, Laura Sirucek, Petra Schweinhardt, Sabrina Catanzaro, Oliver Distler, Florian Brunner, Stefan Dudli

Source: Molecular Medicine, Vol 31, Iss 1, Pp 1-17 (2025)

Subject Terms: Complex regional pain syndrome (CRPS), RNA-seq, Peripheral blood mononuclear cells (PBMCs), Cytokine quantification, Chronic pain, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/89bc814634ad4536a6716dd8eaa1408b

Proteomic analysis of serum in a population‐based cohort did not reveal a biomarker for Modic changes

Authors: Friederike Schulze, Juhani Määttä, Sybille Grad, Irina Heggli, Florian Brunner, Mazda Farshad, Oliver Distler, Jaro Karppinen, Jeffrey Lotz, Stefan Dudli

Source: JOR Spine, Vol 7, Iss 3, Pp n/a-n/a (2024)

Subject Terms: degenerative disc disease, low back pain, Modic changes, northern Finland birth cohort, proteomics, serum‐biomarker, Orthopedic surgery, RD701-811

File Description: electronic resource

Relation: https://doaj.org/toc/2572-1143

Access URL: https://doaj.org/article/7c3ff202c6c6465bbc391ef0b30231c1

Impacts of priming on distinct immunosuppressive mechanisms of mesenchymal stromal cells under translationally relevant conditions

Authors: Nick Herger, Irina Heggli, Tamara Mengis, Jan Devan, Leonardo Arpesella, Florian Brunner, Oliver Distler, Stefan Dudli

Source: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)

Subject Terms: Mesenchymal stromal cells, MSC, Priming, 3D culture, Hypoxia, Immunomodulation, Medicine (General), R5-920, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1757-6512

Access URL: https://doaj.org/article/b96746a492834b6298b66dbdca8b54f2

Intervertebral disc microbiome in Modic changes: Lack of result replication underscores the need for a consensus in low‐biomass microbiome analysis

Authors: Tamara Mengis, Natalia Zajac, Laura Bernhard, Irina Heggli, Nick Herger, Jan Devan, Roy Marcus, Florian Brunner, Christoph Laux, Mazda Farshad, Oliver Distler, Stefan Dudli

Source: JOR Spine, Vol 7, Iss 2, Pp n/a-n/a (2024)

Subject Terms: Cutibacterium acnes, metagenomics, microbiome, Modic changes, Orthopedic surgery, RD701-811

File Description: electronic resource

Relation: https://doaj.org/toc/2572-1143

Access URL: https://doaj.org/article/9bcbe9b2e5c743a5860610bbe970c653

The Expression of Toll-like Receptors in Cartilage Endplate Cells: A Role of Toll-like Receptor 2 in Pro-Inflammatory and Pro-Catabolic Gene Expression

Authors: Tamara Mengis, Laura Bernhard, Andrea Nüesch, Irina Heggli, Nick Herger, Jan Devan, Roy Marcus, Christoph J. Laux, Florian Brunner, Mazda Farshad, Oliver Distler, Christine L. Le Maitre, Stefan Dudli

Source: Cells, Vol 13, Iss 17, p 1402 (2024)

Subject Terms: toll-like receptors, cartilage endplate cells, cartilage endplate, disc degeneration, Modic changes, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/13/17/1402; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/e0c15c06dcc14588a9b7a6e35d9b3d9e

Subtypes of complex regional pain syndrome—a systematic review of the literature

Authors: Lone Knudsen, Lana Santoro, Stephen Bruehl, Norman Harden, Florian Brunner

Source: PAIN Reports, Vol 8, Iss 6, p e1111 (2023)

Subject Terms: Anesthesiology, RD78.3-87.3

File Description: electronic resource

Relation: http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001111; https://doaj.org/toc/2471-2531

Access URL: https://doaj.org/article/060051f02283457b9d810491ce5cf358

Sensory phenotypes in complex regional pain syndrome and chronic low back pain—indication of common underlying pathomechanisms

Authors: Iara De Schoenmacker, Laura Sirucek, Paulina S. Scheuren, Robin Lütolf, Lindsay M. Gorrell, Florian Brunner, Armin Curt, Jan Rosner, Petra Schweinhardt, Michèle Hubli

Source: PAIN Reports, Vol 8, Iss 6, p e1110 (2023)

Subject Terms: Anesthesiology, RD78.3-87.3

File Description: electronic resource

Relation: http://journals.lww.com/painrpts/fulltext/10.1097/PR9.0000000000001110; https://doaj.org/toc/2471-2531

Access URL: https://doaj.org/article/b4a6598c9a7c4576b880d2fed9fed0d1

Bone marrow stromal cells in Modic type 1 changes promote neurite outgrowth

Authors: Tamara Mengis, Nick Herger, Irina Heggli, Jan Devan, José Miguel Spirig, Christoph J. Laux, Florian Brunner, Mazda Farshad, Oliver Distler, Stefan Dudli

Source: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Subject Terms: low back pain, neurotrophic, stromal cells, Modic changes, neurite outgrowth, basivertebral nerve, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1286280/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/fcd6b0aa8e7f48a085154dc3c9f4b2c4

Modic type 2 changes are fibroinflammatory changes with complement system involvement adjacent to degenerated vertebral endplates

Authors: Irina Heggli, Christoph J. Laux, Tamara Mengis, Agnieszka Karol, Frédéric Cornaz, Nick Herger, Borbala Aradi‐Vegh, Jonas Widmer, Marco D. Burkhard, Nadja A. Farshad‐Amacker, Sibylle Pfammatter, Witold E. Wolski, Florian Brunner, Oliver Distler, Mazda Farshad, Stefan Dudli

Source: JOR Spine, Vol 6, Iss 1, Pp n/a-n/a (2023)

Subject Terms: degeneration, extracellular matrix, immune response, inflammation, Orthopedic surgery, RD701-811

File Description: electronic resource

Relation: https://doaj.org/toc/2572-1143

Access URL: https://doaj.org/article/657841afdc5748ce9366cb9613e0c393

CD90-positive stromal cells associate with inflammatory and fibrotic changes in modic changes

Authors: Stefan Dudli, Agnieszka Karol, Luca Giudici, Irina Heggli, Christoph J Laux, Jose M Spirig, Florian Wanivenhaus, Michael Betz, Christoph Germann, Nadja Farshad-Amacker, Florian Brunner, Oliver Distler, Mazda Farshad

Source: Osteoarthritis and Cartilage Open, Vol 4, Iss 3, Pp 100287- (2022)

Subject Terms: Low back pain, Modic changes, Bone marrow oedema, Fibrosis, Inflammation, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2665913122000553; https://doaj.org/toc/2665-9131

Access URL: https://doaj.org/article/ff8e8ac0534048d5b0d25da38e6f19f5

The influence of comorbidities on the treatment outcome in symptomatic lumbar spinal stenosis: A systematic review and meta-analysis

Authors: Amandine Bays, Andrea Stieger, Ulrike Held, Lisa J Hofer, Eva Rasmussen-Barr, Florian Brunner, Johann Steurer, Maria M Wertli

Source: North American Spine Society Journal, Vol 6, Iss , Pp 100072- (2021)

Subject Terms: Lumbar spinal stenosis, Comorbidities, Chronic disease, Systematic review, Meta-analysis, Treatment outcome, Orthopedic surgery, RD701-811, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S266654842100024X; https://doaj.org/toc/2666-5484

Access URL: https://doaj.org/article/da1ff74a30b944d0983588f367b7673e

Infectious and autoinflammatory modic type 1 changes have different pathomechanisms

Authors: Irina Heggli, Regula Schüpbach, Nick Herger, Tiziano A. Schweizer, Astrid Jüngel, Nadja Farshad-Amacker, Michael Betz, José Miguel Spirig, Florian Wanivenhaus, Nils H. Ulrich, Florian Brunner, Annelies S. Zinkernagel, Mazda Farshad, Oliver Distler, Stefan Dudli

Source: Brain and Spine, Vol 1, Iss , Pp 100019- (2021)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772529421000199; https://doaj.org/toc/2772-5294

Access URL: https://doaj.org/article/202a8160e709484ba482d51515f91d20

Acute microglia ablation induces neurodegeneration in the somatosensory system

Authors: Stephen J. Rubino, Lior Mayo, Isabella Wimmer, Victoria Siedler, Florian Brunner, Simon Hametner, Asaf Madi, Amanda Lanser, Thais Moreira, Dustin Donnelly, Laura Cox, Rafael Machado Rezende, Oleg Butovsky, Hans Lassmann, Howard L. Weiner

Source: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/9d3a63c0ded44732a54cfe43f20342b8

Acrylonitrile and Pullulan Based Nanofiber Mats as Easily Accessible Scaffolds for 3D Skin Cell Models Containing Primary Cells

Authors: Markus Rimann, Astrid Jüngel, Sara Mousavi, Nicole Moeschlin, Maurizio Calcagni, Karin Wuertz-Kozak, Florian Brunner, Stefan Dudli, Oliver Distler, Christian Adlhart

Source: Cells, Vol 11, Iss 3, p 445 (2022)

Subject Terms: 3D cell culture, microenvironment, tissue engineering, biomaterial, alternative methods, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/11/3/445; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/71889c544a624fc7ad1d76dda16966bc

Validation of the Orebro musculoskeletal pain screening questionnaire in patients with chronic neck pain

Authors: Anke Langenfeld, Carolien Bastiaenen, Florian Brunner, Jaap Swanenburg

Source: BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018)

Subject Terms: Validation, OMPSQ, Chronic, Neck pain, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13104-018-3269-x; https://doaj.org/toc/1756-0500

Access URL: https://doaj.org/article/70983664fe3841f5a1cdaca58c871641

Prognostic function to estimate the probability of meaningful clinical improvement after surgery - Results of a prospective multicenter observational cohort study on patients with lumbar spinal stenosis.

Authors: Ulrike Held, Jakob M Burgstaller, Maria M Wertli, Giuseppe Pichierri, Sebastian Winklhofer, Florian Brunner, François Porchet, Mazda Farshad, Johann Steurer

Source: PLoS ONE, Vol 13, Iss 11, p e0207126 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC6224088?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/2f61659cc27841e7aa17d8508fe817b2

Usefulness of bone scintigraphy for the diagnosis of Complex Regional Pain Syndrome 1: A systematic review and Bayesian meta-analysis.

Authors: Maria M Wertli, Florian Brunner, Johann Steurer, Ulrike Held

Source: PLoS ONE, Vol 12, Iss 3, p e0173688 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5354289?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/806aaed56fcb486abff463d93e34205a

Quantification of Extent, Density, and Status of Aquatic Reed Beds Using Point Clouds Derived from UAV–RGB Imagery

Authors: Nicolás Corti Meneses, Florian Brunner, Simon Baier, Juergen Geist, Thomas Schneider

Source: Remote Sensing, Vol 10, Iss 12, p 1869 (2018)

Subject Terms: UAV, UAS, RPAS, vegetation status, vegetation mapping, Phragmites australis, point cloud, structure from motion, Science

File Description: electronic resource

Relation: https://www.mdpi.com/2072-4292/10/12/1869; https://doaj.org/toc/2072-4292

Access URL: https://doaj.org/article/50d736c7acc84d17a7e4d2680d436721

Incomplete reporting of baseline characteristics in clinical trials: an analysis of randomized controlled trials and systematic reviews involving patients with chronic low back pain.

Authors: Maria M Wertli, Manuela Schöb, Florian Brunner, Johann Steurer

Source: PLoS ONE, Vol 8, Iss 3, p e58512 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23505524/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/cd77976ec83242dc9e239abfb712a243

Clinical value of prognostic instruments to identify patients with an increased risk for osteoporotic fractures: systematic review.

Authors: Johann Steurer, Cyrill Haller, HansJörg Häuselmann, Florian Brunner, Lucas M Bachmann

Source: PLoS ONE, Vol 6, Iss 5, p e19994 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3097232?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6252b8623404403e8641c7fdce8b4d7f