Management of pulmonary vascular disease associated with congenital left-to-right shunts: A single-center experience

Authors: Nawaytou, Hythem, Lakkaraju, Ramya, Stevens, Leah, Reddy, Vadiyala Mohan, Swami, Naveen, Keller, Roberta L., Teitel, David F., Fineman, Jeffrey R.

Source: In The Journal of Thoracic and Cardiovascular Surgery January 2025 169(1):231-241

Mitochondrial fission produces a Warburg effect via the oxidative inhibition of prolyl hydroxylase domain-2

Authors: Sun, Xutong ^{a, 1}, Yegambaram, Manivannan ^{a, 1}, Lu, Qing ^a, Garcia Flores, Alejandro E. ^a, Pokharel, Marissa D. ^{a, b}, Soto, Jamie ^a, Aggarwal, Saurabh ^b, Wang, Ting ^{a, c}, Fineman, Jeffrey R. ^{d, e}, Black, Stephen M. ^{a, b, c, ⁎}

Source: In Redox Biology April 2025 81

The mitochondrial redistribution of ENOS is regulated by AKT1 and dimer status

Authors: Sun, Xutong, Moreno Caceres, Santiago, Yegambaram, Manivannan, Lu, Qing, Pokharel, Marissa D., Boehme, Jason T., Datar, Sanjeev A., Aggarwal, Saurabh, Wang, Ting, Fineman, Jeffrey R., Black, Stephen M.

Source: In Nitric Oxide 1 November 2024 152:90-100

Defining the Typical Course of Persistent Pulmonary Hypertension of the Newborn: When to Think Beyond Reversible Causes

Authors: Tsoi, Stephanie M. ^{1, ∗}, Steurer, Martina ^{1, 2, 3}, Nawaytou, Hythem ⁴, Cheung, Shannon ¹, Keller, Roberta L. ², Fineman, Jeffrey R. ^{1, 5}

Source: In The Journal of Pediatrics October 2024 273

Inflammatory lung injury is associated with endothelial cell mitochondrial fission and requires the nitration of RhoA and cytoskeletal remodeling

Authors: Pokharel, Marissa D., Fu, Panfeng, Garcia-Flores, Alejandro, Yegambaram, Manivannan, Lu, Qing, Sun, Xutong, Unwalla, Hoshang, Aggarwal, Saurabh, Fineman, Jeffrey R., Wang, Ting, Black, Stephen M.

Source: In Free Radical Biology and Medicine 20 August 2024 221:125-135

Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics

Authors: Pokharel, Marissa D., Garcia-Flores, Alejandro, Marciano, David, Franco, Maria C., Fineman, Jeffrey R., Aggarwal, Saurabh, Wang, Ting, Black, Stephen M.

Source: In Redox Biology April 2024 70

Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation

Authors: Boehme, Jason T., Sun, Xutong, Lu, Qing, Barton, Jubilee, Wu, Xiaomin, Gong, Wenhui, Raff, Gary W., Datar, Sanjeev A., Wang, Ting, Fineman, Jeffrey R., Black, Stephen M.

Source: In Nitric Oxide 1 January 2024 142:58-68

Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III

Authors: Yegambaram, Manivannan, Sun, Xutong, Lu, Qing, Jin, Yan, Ornatowski, Wojciech, Soto, Jamie, Aggarwal, Saurabh, Wang, Ting, Tieu, Kim, Gu, Haiwei, Fineman, Jeffrey R., Black, Stephen M.

Source: In Free Radical Biology and Medicine January 2024 210:183-194

Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1

Authors: Yegambaram, Manivannan, Kumar, Sanjiv, Wu, Xiaomin, Lu, Qing, Sun, Xutong, Garcia Flores, Alejandro, Meadows, Mary Louise, Barman, Scott, Fulton, David, Wang, Ting, Fineman, Jeffrey R., Black, Stephen M.

Source: In Nitric Oxide 1 November 2023 140-141:50-57

Metabolic reprogramming, oxidative stress, and pulmonary hypertension

Authors: Pokharel, Marissa D., Marciano, David P., Fu, Panfeng, Franco, Maria Clara, Unwalla, Hoshang, Tieu, Kim, Fineman, Jeffrey R., Wang, Ting, Black, Stephen M.

Source: In Redox Biology August 2023 64

Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission

Authors: Lu, Qing, Sun, Xutong, Yegambaram, Manivannan, Ornatowski, Wojciech, Wu, Xiaomin, Wang, Hui, Garcia-Flores, Alejandro, Da Silva, Victoria, Zemskov, Evgeny A., Tang, Haiyang, Fineman, Jeffrey R., Tieu, Kim, Wang, Ting, Black, Stephen M.

Source: In Journal of Biological Chemistry April 2023 299(4)

Defining Longer-Term Outcomes in an Ovine Model of Moderate Perinatal Hypoxia-Ischemia

Authors: Mike, Jana Krystofova, Wu, Katherine Y., White, Yasmine, Pathipati, Praneeti, Ndjamen, Blaise, Hutchings, Rachel S., Losser, Courtney, Vento, Christian, Arellano, Kimberly, Vanhatalo, Oona, Ostrin, Samuel, Windsor, Christine, Ha, Janica, Alhassen, Ziad, Goudy, Brian D., Vali, Payam, Lakshminrusimha, Satyan, Gobburu, Jogarao V.S., Long-Boyle, Janel, Chen, Peggy, Wu, Yvonne W., Fineman, Jeffrey R., Ferriero, Donna M., Maltepe, Emin

Source: Developmental neuroscience. 44(4/5):277-294

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161330012.0x000001&indx=1&recIds=ETOCvdc_100161330012.0x000001

Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling.

Authors: Liang, Ying, Ornatowski, Wojciech, Lu, Qing, Sun, Xutong, Yegambaram, Manivannan, Feng, Anlin, Dong, Yishu, Aggarwal, Saurabh, Unwalla, Hoshang J., Fineman, Jeffrey R., Black, Stephen M., Wang, Ting

Source: International Journal of Molecular Sciences; Feb2025, Vol. 26 Issue 3, p1352, 16p

Subject Terms: NITRIC-oxide synthases, PULMONARY arterial hypertension, CONGENITAL heart disease, ENDOTHELIAL cells, PULMONARY artery

MicroRNA in pediatric pulmonary hypertension microRNA profiling to inform disease classification, severity, and treatment response in pediatric pulmonary hypertension.

Authors: Smith, Michael A., Chiacchia, Sam, Boehme, Jason, Datar, Sanjeev A., Morell, Emily, Keller, Roberta L., Romer, Amy, Colglazier, Elizabeth, Parker, Claire, Becerra, Jasmine, Fineman, Jeffrey R.

Source: American Journal of Physiology: Heart & Circulatory Physiology; Jan2025, Vol. 328 Issue 1, pH47-H57, 11p

Subject Terms: PULMONARY artery diseases, PULMONARY hypertension, NOSOLOGY, CHILD patients, HYPERTENSION

Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system

Authors: Wu, Xiaomin, Sun, Xutong, Sharma, Shruti, Lu, Qing, Yegambaram, Manivannan, Hou, Yali, Wang, Ting, Fineman, Jeffrey R., Black, Stephen M.

Source: In Nitric Oxide 1 March 2021 108:12-19

Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics

Authors: Lu, Qing, Zemskov, Evgeny A., Sun, Xutong, Wang, Hui, Yegambaram, Manivannan, Wu, Xiaomin, Garcia-Flores, Alejandro, Song, Shanshan, Tang, Haiyang, Kangath, Archana, Cabanillas, Gabriela Zubiate, Yuan, Jason X.-J., Wang, Ting, Fineman, Jeffrey R., Black, Stephen M.

Source: In Redox Biology January 2021 38

Practice patterns of pulmonary hypertension secondary to left heart disease among pediatric pulmonary hypertension providers

Authors: Nawaytou, Hythem, Fineman, Jeffrey R., Moledina, Shahin, Ivy, Dunbar, Abman, Steven H., Del Cerro, Maria J.

Source: Pulmonary circulation. 11(1):1-8

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138772485.0x000001&indx=1&recIds=ETOCvdc_100138772485.0x000001

Mortality from Pulmonary Hypertension in the Pediatric Cardiac ICU

Authors: Morell, Emily, Gaies, Michael, Fineman, Jeffrey R., Charpie, John, Rao, Rohit, Sasaki, Jun, Zhang, Wenying, Reichle, Garrett, Banerjee, Mousumi, Tabbutt, Sarah

Source: American journal of respiratory and critical care medicine. 204(4):454-461

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627298417&indx=1&recIds=ETOCRN627298417

Perinatal Caffeine Administration Improves Outcomes in an Ovine Model of Neonatal Hypoxia-Ischemia.

Authors: Mike, Jana K., White, Yasmine, Ha, Janica, Iranmahboub, Ariana, Hawkins, Cheryl, Hutchings, Rachel S., Vento, Christian, Manzoor, Hadiya, Aijun Wang, Goudy, Brian D., Vali, Payam, Lakshminrusimha, Satyan, Gobburu, Jogarao V. S., Long-Boyle, Janel, Fineman, Jeffrey R., Ferriero, Donna M., Maltepe, Emin

Source: Stroke (00392499); Nov2024, Vol. 55 Issue 11, p2705-2715, 11p

Inhalable Advanced Co-Spray Dried Microparticles/Nanoparticles of a Novel RhoA/Rho Kinase Inhibitor with Lung Surfactant Biomimetic Phospholipids for Targeted Lung Delivery.

Authors: Ruiz, Victor H., Encinas-Basurto, David, Ortega-Alarcon, Neftali, Eedara, Basanth Babu, Fineman, Jeffrey R., Black, Stephen M., Mansour, Heidi M.

Source: ACS Pharmacology & Translational Science; 10/11/2024, Vol. 7 Issue 10, p3241-3254, 14p