Confirmed efficacy of etoposide and dexamethasone in HLH treatment: long-term results of the cooperative HLH-2004 study

Authors: Bergsten, Elisabet, Horne, AnnaCarin, Aricó, Maurizio, Astigarraga, Itziar, Egeler, R. Maarten, Filipovich, Alexandra H., Ishii, Eiichi, Janka, Gritta, Ladisch, Stephan, Lehmberg, Kai, McClain, Kenneth L., Minkov, Milen, Montgomery, Scott, Nanduri, Vasanta, Rosso, Diego, Henter, Jan-Inge

Source: In Blood 21 December 2017 130(25):2728-2738

Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome

Authors: Abinun, Mario, Aggarwal, Amita, Akikusa, Jonathan, Al-Mayouf, Sulaiman, Alessio, Maria, Anton, Jordi, Apaz, Maria Teresa, Astigarraga, Itziar, Avcin, Tadej, Ayaz, Nuray Aktay, Barone, Patrizia, Bica, Bianca, Bolt, Isabel, Bovis, Francesca, Breda, Luciana, Chasnyk, Vyacheslav, Cimaz, Rolando, Corona, Fabrizia, Cron, Randy Q., Cuttica, Ruben, Davì, Sergio, Davidsone, Zane, De Cunto, Carmen, De Inocencio, Jaime, Demirkaya, Erkan, Eisenstein, Eli M., Enciso, Sandra, Espada, Graciela, Fischbach, Michel, Frosch, Michael, Gallizzi, Romina, Gamir, Maria Luz, Gao, Yi-Jin, Griffin, Thomas, Grom, Alexei, Hashad, Soad, Hennon, Teresa, Henter, Jan-Inge, Horne, AnnaCarin, Horneff, Gerd, Huasong, Zeng, Huber, Adam, Ilowite, Norman, Insalaco, Antonella, Ioseliani, Maka, Jeng, Michael, Kapović, Agneza Marija, Kasapcopur, Ozgur, Khubchandani, Raju, Kitoh, Toshiyuki, Koné-Paut, Isabelle, de Oliveira, Sheila Knupp Feitosa, Lattanzi, Bianca, Lehmberg, Kai, Lepore, Loredana, Li, Caifeng, Lipton, Jeffrey M., Magni-Manzoni, Silvia, Maritsi, Despoina, Martini, Alberto, McCurdy, Deborah, Merino, Rosa, Micalizzi, Concetta, Miettunen, Paivi, Minoia, Francesca, Mulaosmanovic, Velma, Nichols, Kim E., Nielsen, Susan, Ozen, Seza, Pal, Priyankar, Prahalad, Sampath, Ravelli, Angelo, Rigante, Donato, Rumba-Rozenfelde, Ingrida, Ruperto, Nicolino, Russo, Ricardo, Magalhães, Claudia Saad, Sanner, Helga, Sewairi, Wafaa Mohamed Saad, Shenoi, Susan, Artur Silva, Clovis, Stanevicha, Valda, Sterba, Gary, Stine, Kimo C., Susic, Gordana, Sztajnbok, Flavio, Takei, Syuji, Trauzeddel, Ralf, Tsitsami, Elena, Unsal, Erbil, Uziel, Yosef, Vougiouka, Olga, Wallace, Carol A., Weaver, Lehn, E. Weiss, Jennifer, Weitzman, Sheila, Wouters, Carine, Wulffraat, Nico, Zletni, Mabruka, Arico, Maurizio, Egeler, R. Maarten, Filipovich, Alexandra H., Gadner, Helmut, Imashuku, Shinsaku, Janka, Gritta, Ladisch, Stephan, McClain, Ken L., Webb, David

Source: In The Journal of Pediatrics October 2017 189:72-78

Cytokine Profile of Engraftment Syndrome in Pediatric Hematopoietic Stem Cell Transplant Recipients

Authors: Khandelwal, Pooja, Mellor-Heineke, Sabine, Rehman, Najibah, Lane, Adam, Smiley, Kristi, Villanueva, Joyce, Marsh, Rebecca A., Grimley, Michael S., Davies, Stella M., Filipovich, Alexandra H.

Source: In Biology of Blood and Marrow Transplantation April 2016 22(4):690-697

Alemtuzumab levels impact acute GVHD, mixed chimerism, and lymphocyte recovery following alemtuzumab, fludarabine, and melphalan RIC HCT

Authors: Marsh, Rebecca A. ^*, Lane, Adam, Mehta, Parinda A., Neumeier, Lisa, Jodele, Sonata, Davies, Stella M., Filipovich, Alexandra H.

Source: In Blood 28 January 2016 127(4):503-512

Pathogenesis of Hemophagocytic Lymphohistiocytosis

Authors: Filipovich, Alexandra H., Chandrakasan, Shanmuganathan

Source: In Hematology/Oncology Clinics of North America October 2015 29(5):895-902

Experience with Alemtuzumab, Fludarabine, and Melphalan Reduced-Intensity Conditioning Hematopoietic Cell Transplantation in Patients with Nonmalignant Diseases Reveals Good Outcomes and That the Risk of Mixed Chimerism Depends on Underlying Disease, Stem Cell Source, and Alemtuzumab Regimen

Authors: Marsh, Rebecca A., Rao, Marepalli B., Gefen, Aharon, Bellman, Denise, Mehta, Parinda A., Khandelwal, Pooja, Chandra, Sharat, Jodele, Sonata, Myers, Kasiani C., Grimley, Michael, Dandoy, Christopher, El-Bietar, Javier, Kumar, Ashish R., Leemhuis, Tom, Zhang, Kejian, Bleesing, Jack J., Jordan, Michael B., Filipovich, Alexandra H., Davies, Stella M.

Source: In Biology of Blood and Marrow Transplantation August 2015 21(8):1460-1470

Peripheral Blood CD38 Bright CD8+ Effector Memory T Cells Predict Acute Graft-versus-Host Disease

Authors: Khandelwal, Pooja, Lane, Adam, Chaturvedi, Vijaya, Owsley, Erika, Davies, Stella M., Marmer, Daniel, Filipovich, Alexandra H., Jordan, Michael B., Marsh, Rebecca A.

Source: In Biology of Blood and Marrow Transplantation July 2015 21(7):1215-1222

Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

Authors: Lo, Bernice, Zhang, Kejian, Lu, Wei, Zheng, Lixin, Zhang, Qian, Kanellopoulou, Chrysi, Zhang, Yu, Liu, Zhiduo, Fritz, Jill M., Marsh, Rebecca, Husami, Ammar, Kissell, Diane, Nortman, Shannon, Chaturvedi, Vijaya, Haines, Hilary, Young, Lisa R., Mo, Jun, Filipovich, Alexandra H., Bleesing, Jack J., Mustillo, Peter, Stephens, Michael, Rueda, Cesar M., Chougnet, Claire A., Hoebe, Kasper, McElwee, Joshua, Hughes, Jason D., Karakoc-Aydiner, Elif, Matthews, Helen F., Price, Susan, Su, Helen C., Rao, V. Koneti, Lenardo, Michael J., Jordan, Michael B.

Source: Science, 2015 Jul . 349(6246), 436-440.

Access URL: http://www.jstor.org/stable/24748538

Outcomes of Donor Lymphocyte Infusion for Treatment of Mixed Donor Chimerism after a Reduced-Intensity Preparative Regimen for Pediatric Patients with Nonmalignant Diseases

Authors: Haines, Hilary L., Bleesing, Jack J., Davies, Stella M., Hornung, Lindsey, Jordan, Michael B., Marsh, Rebecca A., Filipovich, Alexandra H.

Source: In Biology of Blood and Marrow Transplantation February 2015 21(2):288-292

Recommendations for live viral and bacterial vaccines in immunodeficient patients and their close contacts

Authors: Shearer, William T., Fleisher, Thomas A., Buckley, Rebecca H., Ballas, Zuhair, Ballow, Mark, Blaese, R. Michael, Bonilla, Francisco A., Conley, Mary Ellen, Cunningham-Rundles, Charlotte, Filipovich, Alexandra H., Fuleihan, Ramsay, Gelfand, Erwin W., Hernandez-Trujillo, Vivian, Holland, Steven M., Hong, Richard, Lederman, Howard M., Malech, Harry L., Miles, Stephen, Notarangelo, Luigi D., Ochs, Hans D., Orange, Jordan S., Puck, Jennifer M., Routes, John M., Stiehm, E. Richard, Sullivan, Kathleen, Torgerson, Troy, Winkelstein, Jerry

Source: In The Journal of Allergy and Clinical Immunology April 2014 133(4):961-966

Primary Immune Deficiency Treatment Consortium (PIDTC) report

Authors: Griffith, Linda M., Cowan, Morton J., Notarangelo, Luigi D., Kohn, Donald B., Puck, Jennifer M., Pai, Sung-Yun, Ballard, Barbara, Bauer, Sarah C., Bleesing, Jack J.H., Boyle, Marcia, Brower, Amy, Buckley, Rebecca H., van der Burg, Mirjam, Burroughs, Lauri M., Candotti, Fabio, Cant, Andrew J., Chatila, Talal, Cunningham-Rundles, Charlotte, Dinauer, Mary C., Dvorak, Christopher C., Filipovich, Alexandra H., Fleisher, Thomas A., Bobby Gaspar, Hubert, Gungor, Tayfun, Haddad, Elie, Hovermale, Emily, Huang, Faith, Hurley, Alan, Hurley, Mary, Iyengar, Sumathi, Kang, Elizabeth M., Logan, Brent R., Long-Boyle, Janel R., Malech, Harry L., McGhee, Sean A., Modell, Fred, Modell, Vicki, Ochs, Hans D., O'Reilly, Richard J., Parkman, Robertson, Rawlings, David J., Routes, John M., Shearer, William T., Small, Trudy N. ^†, Smith, Heather, Sullivan, Kathleen E., Szabolcs, Paul, Thrasher, Adrian, Torgerson, Troy R., Veys, Paul, Weinberg, Kenneth, Zuniga-Pflucker, Juan Carlos

Source: In The Journal of Allergy and Clinical Immunology February 2014 133(2):335-347

Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency

Authors: Wada, Taizo, Kanegane, Hirokazu, Ohta, Kazuhide, Katoh, Fumiyo, Imamura, Toshihiko, Nakazawa, Yozo, Miyashita, Ritsuko, Hara, Junichi, Hamamoto, Kazuko, Yang, Xi, Filipovich, Alexandra H., Marsh, Rebecca A., Yachie, Akihiro

Source: In Cytokine January 2014 65(1):74-78

MicroRNA activation signature in patients with hemophagocytic lymphohistiocytosis and reversibility with disease-specific therapy

Authors: Sumegi, Janos, Nestheide, Shawnagay, Aronow, Bruce, Fletcher, David, Keddache, Mehdi, Villanueva, Joyce, Zhang, Kejian, Filipovich, Alexandra H.

Source: Journal of allergy and clinical immunology. 137(1):309-312

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069967964.0x000001&indx=1&recIds=ETOCvdc_100069967964.0x000001

An Intermediate Alemtuzumab Schedule Reduces the Incidence of Mixed Chimerism Following Reduced-Intensity Conditioning Hematopoietic Cell Transplantation for Hemophagocytic Lymphohistiocytosis

Authors: Marsh, Rebecca A., Kim, Mi-Ok, Liu, Chunyan, Bellman, Denise, Hart, Laura, Grimley, Michael, Kumar, Ashish, Jodele, Sonata, Myers, Kasiani C., Chandra, Sharat, Leemhuis, Tom, Mehta, Parinda A., Bleesing, Jack J., Davies, Stella M., Jordan, Michael B., Filipovich, Alexandra H.

Source: In Biology of Blood and Marrow Transplantation November 2013 19(11):1625-1631

Hemophagocytic Lymphohistiocytosis: Advances in Pathophysiology, Diagnosis, and Treatment

Authors: Chandrakasan, Shanmuganathan, Filipovich, Alexandra H.

Source: In The Journal of Pediatrics November 2013 163(5):1253-1259

Gene-expression signatures differ between different clinical forms of familial hemophagocytic lymphohistiocytosis

Authors: Sumegi, Janos ^*, Nestheide, Shawnagay V., Barnes, Michael G., Villanueva, Joyce, Zhang, Kejian, Grom, Alexei A., Filipovich, Alexandra H.

Source: In Blood 14 February 2013 121(7):e14-e24

Allogeneic hematopoietic cell transplantation for XIAP deficiency: an international survey reveals poor outcomes

Authors: Marsh, Rebecca A. ^*, Rao, Kanchan, Satwani, Prakash, Lehmberg, Kai, Müller, Ingo, Li, Dandan, Kim, Mi-Ok, Fischer, Alain, Latour, Sylvain, Sedlacek, Petr, Barlogis, Vincent, Hamamoto, Kazuko, Kanegane, Hirokazu, Milanovich, Sam, Margolis, David A., Dimmock, David, Casper, James, Douglas, Dorothea N., Amrolia, Persis J., Veys, Paul, Kumar, Ashish R., Jordan, Michael B., Bleesing, Jack J., Filipovich, Alexandra H.

Source: In Blood 7 February 2013 121(6):877-883

Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion

Authors: Ye, Shaojing, Karim, Zubair A., Al Hawas, Rania, Pessin, Jeffery E., Filipovich, Alexandra H., Whiteheart, Sidney W.

Source: In Blood 20 September 2012 120(12):2484-2492

Munc18b/STXBP2 is required for platelet secretion

Authors: Al Hawas, Rania, Ren, Qiansheng, Ye, Shaojing, Karim, Zubair A., Filipovich, Alexandra H., Whiteheart, Sidney W.

Source: In Blood 20 September 2012 120(12):2493-2500

Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH

Authors: Zhang, Kejian, Jordan, Michael B., Marsh, Rebecca A., Johnson, Judith A., Kissell, Diane, Meller, Jarek, Villanueva, Joyce, Risma, Kimberly A., Wei, Qian, Klein, Peter S., Filipovich, Alexandra H.

Source: In Blood 24 November 2011 118(22):5794-5798