Newly Proposed Dose of Daclatasvir to Prevent Lethal SARS-CoV-2 Infection in Human Transgenic ACE-2 Mice

Authors: Mayara Mattos, Carolina Q. Sacramento, André C. Ferreira, Natalia Fintelman-Rodrigues, Filipe S. Pereira-Dutra, Caroline Souza de Freitas, João S. M. Gesto, Jairo R. Temerozo, Aline de Paula Dias Da Silva, Mariana T. G. Moreira, Rafael S. C. Silva, Gabriel P. E. Silveira, Douglas P. Pinto, Heliana M. Pereira, Laís B. Fonseca, Marcelo Alves Ferreira, Camilla Blanco, João P. B. Viola, Dumith Chequer Bou-Habib, Patrícia T. Bozza, Thiago Moreno L. Souza

Source: Viruses, Vol 16, Iss 12, p 1856 (2024)

Subject Terms: SARS-CoV-2, anti-HCV drugs, exonuclease, error prone, K18-hACE2 mice, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4915/16/12/1856; https://doaj.org/toc/1999-4915

Access URL: https://doaj.org/article/51b59679bfcd43f8b39448b4729181d7

Prevention of lipid droplet accumulation by DGAT1 inhibition ameliorates sepsis-induced liver injury and inflammation

Authors: Lívia Teixeira, Filipe S. Pereira-Dutra, Patrícia A. Reis, Tamires Cunha-Fernandes, Marcos Y. Yoshinaga, Luciana Souza-Moreira, Ellen K. Souza, Ester A. Barreto, Thiago P. Silva, Hugo Espinheira-Silva, Tathiany Igreja, Maísa M. Antunes, Ana Cristina S. Bombaça, Cassiano F. Gonçalves-de-Albuquerque, Gustavo B. Menezes, Eugênio D. Hottz, Rubem F.S. Menna-Barreto, Clarissa M. Maya-Monteiro, Fernando A. Bozza, Sayuri Miyamoto, Rossana C.N. Melo, Patrícia T. Bozza

Source: JHEP Reports, Vol 6, Iss 2, Pp 100984- (2024)

Subject Terms: immunometabolism, inflammation, sepsis, MODS, steatosis, lipid peroxidation, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589555923003154; https://doaj.org/toc/2589-5559

Access URL: https://doaj.org/article/78f65ec2abf54078b0c5adb7c1518e41

Lipid compartments and lipid metabolism as therapeutic targets against coronavirus

Authors: Daniella Cesar-Silva, Filipe S. Pereira-Dutra, Ana Lucia Moraes Giannini, Clarissa M. Maya-Monteiro, Cecília Jacques G. de Almeida

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: lipid nanodomains, caveolae, caveolin, lipid droplets, coronavirus, SARS-CoV-2, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1268854/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e219bf7af02046ef8737bf968223378f

Severe influenza infection is associated with inflammatory programmed cell death in infected macrophages

Authors: André C. Ferreira, Carolina Q. Sacramento, Filipe S. Pereira-Dutra, Natália Fintelman-Rodrigues, Priscila P. Silva, Mayara Mattos, Caroline S. de Freitas, Andressa Marttorelli, Gabrielle R. de Melo, Mariana M. Campos, Isaclaudia G. Azevedo-Quintanilha, Aluana S. Carlos, João Vítor Emídio, Cristiana C. Garcia, Patrícia T. Bozza, Fernando A. Bozza, Thiago M. L. Souza

Source: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

Subject Terms: influenza virus, necroptosis, TNF, etanercept, macrophages, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcimb.2023.1067285/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/0836dd826fee4902a18acb63980080a8

Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts

Authors: Lívia Teixeira, Jairo R. Temerozo, Filipe S. Pereira-Dutra, André Costa Ferreira, Mayara Mattos, Barbara Simonson Gonçalves, Carolina Q. Sacramento, Lohanna Palhinha, Tamires Cunha-Fernandes, Suelen S. G. Dias, Vinicius Cardoso Soares, Ester A. Barreto, Daniella Cesar-Silva, Natalia Fintelman-Rodrigues, Camila R. R. Pão, Caroline S. de Freitas, Patrícia A. Reis, Eugenio D. Hottz, Fernando A. Bozza, Dumith C. Bou-Habib, Elvira M. Saraiva, Cecília J. G. de Almeida, João P. B. Viola, Thiago Moreno L. Souza, Patricia T. Bozza

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: statin, COVID-19, inflammation, lipid rafts, SARS-CoV-2, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.820131/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/39df5290aece4fe5890ecbf76dc10dc2