Lack of neuroprotection after systemic administration of the soluble TNF inhibitor XPro1595 in an rAAV6-α-Syn + PFFs-induced rat model for Parkinson's disease

Authors: Filip Fredlund, Claes Fryklund, Olivia Trujeque-Ramos, Hannah A. Staley, Joaquin Pardo, Kelvin C. Luk, Malú G. Tansey, Maria Swanberg

Source: Neurobiology of Disease, Vol 207, Iss , Pp 106841- (2025)

Subject Terms: TNF, Parkinson's disease, Neurodegeneration, Neuroinflammation, α-Synuclein, PFF, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996125000579; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/f20c8e30213f458cba955dc06999d567

Nigral transcriptomic profiles in Engrailed-1 hemizygous mouse models of Parkinson’s disease reveal upregulation of oxidative phosphorylation-related genes associated with delayed dopaminergic neurodegeneration

Authors: Lautaro Francisco Belfiori, Alfredo Dueñas Rey, Dorottya Mária Ralbovszki, Itzia Jimenez-Ferrer, Filip Fredlund, Sagar Shivayogi Balikai, Dag Ahrén, Kajsa Atterling Brolin, Maria Swanberg

Source: Frontiers in Aging Neuroscience, Vol 16 (2024)

Subject Terms: Parkinson’s disease, substantia nigra, neurodegeneration, transcriptomics, genetic susceptibility, mitochondria, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnagi.2024.1337365/full; https://doaj.org/toc/1663-4365

Access URL: https://doaj.org/article/3a6bbb21d16d411381688c34692a243c