Clonal phylogenies inferred from bulk, single cell, and spatial transcriptomic analysis of epithelial cancers.

Authors: Erickson, Andrew^1,2 (AUTHOR) andrew.erickson@nds.ox.ac.uk, Figiel, Sandy¹ (AUTHOR), Rajakumar, Timothy¹ (AUTHOR), Rao, Srinivasa¹ (AUTHOR), Yin, Wencheng¹ (AUTHOR), Doultsinos, Dimitrios¹ (AUTHOR), Magnussen, Anette¹ (AUTHOR), Singh, Reema¹ (AUTHOR), Poulose, Ninu¹ (AUTHOR), Bryant, Richard J.^1,3 (AUTHOR), Cussenot, Olivier¹ (AUTHOR), Hamdy, Freddie C.^1,3 (AUTHOR), Woodcock, Dan¹ (AUTHOR), Mills, Ian G.¹ (AUTHOR), Lamb, Alastair D.^1,3 (AUTHOR)

Source: PLoS ONE. 1/3/2025, Vol. 20 Issue 1, p1-14. 14p.

Subject Terms: *DNA copy number variations, *CANCER genetics, *PROSTATE cancer, *SPATIAL resolution, *MACHINE learning

Clinical Implications of Basic Research: Exploring the Transformative Potential of Spatial 'Omics in Uro-oncology

Authors: Figiel, Sandy ^a, Bates, Anthony ^b, Braun, David A. ^c, Eapen, Renu ^d, Eckstein, Markus ^e, Manley, Brandon J. ^f, Milowsky, Matthew I. ^g, Mitchell, Tom J. ^h, Bryant, Richard J. ^{a, b}, Sfakianos, John P. ⁱ, Lamb, Alastair D. ^{a, b, ⁎}

Source: In European Urology January 2025 87(1):8-14

Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics

Authors: Desai, Trishna A., Hedman, Åsa K., Dimitriou, Marios, Koprulu, Mine, Figiel, Sandy, Yin, Wencheng, Johansson, Mattias, Watts, Eleanor L., Atkins, Joshua R., Sokolov, Aleksandr V., Schiöth, Helgi B., Gunter, Marc J., Tsilidis, Konstantinos K., Martin, Richard M., Pietzner, Maik, Langenberg, Claudia, Mills, Ian G., Lamb, Alastair D., Mälarstig, Anders, Key, Tim J., Travis, Ruth C., Smith-Byrne, Karl

Source: In eBioMedicine July 2024 105

Endogenous ether lipids differentially promote tumor aggressiveness by regulating the SK3 channel

Authors: Papin, Marion, Fontaine, Delphine, Goupille, Caroline, Figiel, Sandy, Domingo, Isabelle, Pinault, Michelle, Guimaraes, Cyrille, Guyon, Nina, Cartron, Pierre François, Emond, Patrick, Lefevre, Antoine, Gueguinou, Maxime, Crottès, David, Jaffrès, Paul-Alain, Ouldamer, Lobna, Maheo, Karine, Fromont, Gaëlle, Potier-Cartereau, Marie, Bougnoux, Philippe, Chantôme, Aurélie, Vandier, Christophe

Source: In Journal of Lipid Research May 2024 65(5)

Persistent organochlorine pesticides in periprostatic adipose tissue from men with prostate cancer: Ethno-geographic variations, association with disease aggressiveness

Authors: Antignac, Jean-Philippe, Figiel, Sandy, Pinault, Michèle, Blanchet, Pascal, Bruyère, Franck, Mathieu, Romain, Lebdai, Souhil, Fournier, Georges, Rigaud, Jerome, Mahéo, Karine, Marchand, Philippe, Guiffard, Ingrid, Bichon, Emmanuelle, le Bizec, Bruno, Multigner, Luc, Fromont, Gaëlle

Source: In Environmental Research 1 January 2023 216 Part 4

Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures.

Authors: Figiel, Sandy¹ (AUTHOR), Yin, Wencheng¹ (AUTHOR), Doultsinos, Dimitrios¹ (AUTHOR), Erickson, Andrew¹ (AUTHOR), Poulose, Ninu¹ (AUTHOR), Singh, Reema¹ (AUTHOR), Magnussen, Anette¹ (AUTHOR), Anbarasan, Thineskrishna^1,2 (AUTHOR), Teague, Renuka^1,3 (AUTHOR), He, Mengxiao⁴ (AUTHOR), Lundeberg, Joakim⁴ (AUTHOR), Loda, Massimo^1,5 (AUTHOR), Verrill, Clare^1,3,6 (AUTHOR), Colling, Richard^1,3 (AUTHOR), Gill, Pelvender S.^1,3 (AUTHOR), Bryant, Richard J.^1,2,6 (AUTHOR), Hamdy, Freddie C.^1,2,6 (AUTHOR), Woodcock, Dan J.¹ (AUTHOR), Mills, Ian G.¹ (AUTHOR), Cussenot, Olivier¹ (AUTHOR)

Source: Molecular Cancer. 10/3/2023, Vol. 22 Issue 1, p1-5. 5p.

Subject Terms: *PROSTATE biopsy, *PROSTATE cancer, *GENE expression profiling, *TRANSCRIPTOMES, *TISSUE differentiation, *GENE expression

Roles of endogenous ether lipids and associated PUFAs in the regulation of ion channels and their relevance for disease

Authors: Fontaine, Delphine ^*, Figiel, Sandy ^*, Félix, Romain ^*, Kouba, Sana ^*, Fromont, Gaëlle ^{*, †}, Mahéo, Karine ^{*, §}, Potier-Cartereau, Marie ^*, Chantôme, Aurélie ^{*, §}, Vandier, Christophe ^*

Source: In Journal of Lipid Research June 2020 61(6):840-858

Functional Organotypic Cultures of Prostate Tissues: A Relevant Preclinical Model that Preserves Hypoxia Sensitivity and Calcium Signaling

Authors: Figiel, Sandy, Pasqualin, Côme, Bery, Fanny, Maupoil, Veronique, Vandier, Christophe, Potier-Cartereau, Marie, Domingo, Isabelle, Guibon, Roseline, Bruyere, Franck, Maheo, Karine, Fromont, Gaelle

Source: In The American Journal of Pathology June 2019 189(6):1268-1275

Fatty acid profile in peri-prostatic adipose tissue and prostate cancer aggressiveness in African–Caribbean and Caucasian patients

Authors: Figiel, Sandy, Pinault, Michelle, Domingo, Isabelle, Guimaraes, Cyrille, Guibon, Roseline, Besson, Pierre, Tavernier, Elsa, Blanchet, Pascal, Multigner, Luc, Bruyère, Franck, Haillot, Olivier, Mathieu, Romain, Vincendeau, Sebastien, Rioux-Leclercq, Nathalie, Lebdai, Souhil, Azzouzi, Abdel-Rahmene, Perrouin-Verbe, Marie-Aimee, Fournier, Georges, Doucet, Laurent, Rigaud, Jerome, Renaudin, Karine, Mahéo, Karine, Fromont, Gaëlle

Source: In European Journal of Cancer March 2018 91:107-115

Clinical significance of epithelial-mesenchymal transition markers in prostate cancer

Authors: Figiel, Sandy, Vasseur, Caroline, Bruyere, Franck, Rozet, Francois, Maheo, Karine, Fromont, Gaelle

Source: In Human Pathology March 2017 61:26-32

Molecular Anatomy of Prostate Cancer and Its Implications in Active Surveillance and Early Intervention Strategies.

Authors: Figiel, Sandy¹, ian.mills@nds.ox.ac.uksandy.figiel@nds.ox.ac.uk, Cancel-Tassin, Géraldine², g.cancel@cerepp.org, Mills, Ian G.¹, alastair.lamb@nds.ox.ac.uk, Lamb, Alastair D.¹, olivier.cussenot@nds.ox.ac.uk, Fromont, Gaelle², gaelle.fromont-hankard@univ-tours.fr, Cussenot, Olivier^1,2

Source: Anatomia; Dec2023, Vol. 2 Issue 4, p300-319, 20p

V12-12 NOVEL METHODOLOGY FOR OPTIMISING FORMALIN FIXED PARAFFIN EMBEDDED PROSTATE CANCER SECTIONS FOR SPATIAL TRANSCRIPTOMICS ANALYSIS.

Authors: Anbarasan, Thineskrishna, Figiel, Sandy, Teague, Renuka, Yin, Wencheng, Colling, Richard, Verrill, Clare, Mills, Ian, Lamb, Alastair

Source: Journal of Urology; 2024 Supplement 5, Vol. 211, pe998-e998, 1p

PD09-08 SPATIAL TRANSCRIPTOMIC CLONAL DECONVOLUTION IDENTIFIES THE 'LETHAL CLONE' IN PROSTATE CANCER AS DEFINED BY ABILITY TO METASTASIZE TO LYMPH NODES.

Authors: Yin, Wencheng, Figiel, Sandy, He, Mengxiao, Teague, Renuka, Anbarasan, Thineskrishna, Ranasinha, Nithesh, Singh, Reema, Poulose, Ninu, Doultsinos, Dimitrios, Abusamra, Sophia, Erickson, Andrew, Loda, Massimo, Verrill, Clare, Colling, Richard, Gill, Pelvender, Bryant, Richard, Cussenot, Olivier, Hamdy, Freddie, Woodcock, Dan, Mills, Ian

Source: Journal of Urology; 2024 Supplement 5, Vol. 211, pe182-e182, 1p

PD09-07 SPATIAL TRANSCRIPTOMIC SIGNATURE FROM MUTATED BENIGN ANCESTRAL CLONE PREDICTS HIGH RISK PROSTATE CANCER.

Authors: Anbarasan, Thineskrishna, Yin, Wencheng, Figiel, Sandy, Mills, Ian, Lamb, Alastair

Source: Journal of Urology; 2024 Supplement 5, Vol. 211, pe181-e181, 1p

PD09-06 EXPLORING STROMAL DYNAMICS IN PROSTATE CANCER: INSIGHTS FROM SPATIAL TRANSCRIPTOMIC ANALYSES.

Authors: Figiel, Sandy, Yin, Wencheng, He, Mengxiao, Teague, Renuka, Anbarasan, Thineskrishna, Ranasinha, Nithesh, Abusamra, Sophia, Singh, Reema, Doultsinos, Dimitrios, Poulose, Ninu, Erickson, Andrew, Verrill, Clare, Colling, Richard, Gill, Pelvender, Bryant, Richard J., Cussenot, Olivier, Loda, Massimo, Hamdy, Freddie C., Woodcock, Dan J., Mills, Ian G.

Source: Journal of Urology; 2024 Supplement 5, Vol. 211, pe181-e181, 1p

Hypoxia Promotes Prostate Cancer Aggressiveness by Upregulating EMT-Activator Zeb1 and SK3 Channel Expression.

Authors: Bery, Fanny¹ (AUTHOR) fanny.bery@etu.univ-tours.fr, Figiel, Sandy¹ (AUTHOR) sandy.figiel@gmail.com, Kouba, Sana¹ (AUTHOR) sana.kouba@etu.univ-tours.fr, Fontaine, Delphine¹ (AUTHOR) delphine.fontaine@etu.univ-tours.fr, Guéguinou, Maxime¹ (AUTHOR) maxime.gueguinou@univ-tours.fr, Potier-Cartereau, Marie¹ (AUTHOR) marie.potier-cartereau@univ-tours.fr, Vandier, Christophe¹ (AUTHOR) christophe.vandier@univ-tours.fr, Guibon, Roseline^1,2 (AUTHOR) roseline.guibon@univ-tours.fr, Bruyère, Franck³ (AUTHOR) f.bruyere@chu-tours.fr, Fromont, Gaëlle^1,2 (AUTHOR) gaelle.fromont-hankard@univ-tours.fr, Mahéo, Karine¹ (AUTHOR) karine.maheo@univ-tours.fr

Source: International Journal of Molecular Sciences. Jul2020, Vol. 21 Issue 13, p4786-4786. 1p.

Subject Terms: *PROSTATE cancer, *LINOLEIC acid, *EPITHELIAL-mesenchymal transition, *ETHER lipids, *HYPOXEMIA, *EICOSAPENTAENOIC acid, *CALCIUM channels, *HYPOXIA-inducible factor 1

Functional Organotypic Cultures of Prostate Tissues

Authors: Figiel, Sandy, Pasqualin, Côme, Bery, Fanny, Maupoil, Veronique, Vandier, Christophe, Potier-Cartereau, Marie, Domingo, Isabelle, Guibon, Roseline, Bruyere, Franck, Maheo, Karine, Fromont, Gaelle

Source: American Journal of Pathology; 20240101, Issue: Preprints

A Novel Calcium-Mediated EMT Pathway Controlled by Lipids: An Opportunity for Prostate Cancer Adjuvant Therapy.

Authors: Figiel, Sandy¹ (AUTHOR) sandy.figiel@gmail.com, Bery, Fanny¹ (AUTHOR) fannybery@hotmail.fr, Chantôme, Aurélie^1,2 (AUTHOR) aurelie.chantome@med.univ-tours.fr, Fontaine, Delphine¹ (AUTHOR) delphine.fontaine@etu.univ-tours.fr, Pasqualin, Côme^2,3 (AUTHOR) veronique.maupoil@univ-tours.fr, Maupoil, Véronique^2,3 (AUTHOR), Domingo, Isabelle¹ (AUTHOR) isabelle.domingo@univ-tours.fr, Guibon, Roseline⁴ (AUTHOR) roseline.guibon@univ-tours.fr, Bruyère, Franck⁴ (AUTHOR) f.bruyere@chu-tours.fr, Potier-Cartereau, Marie¹ (AUTHOR) marie.potier-cartereau@univ-tours.fr, Vandier, Christophe¹ (AUTHOR) christophe.vandier@univ-tours.fr, Fromont, Gaëlle^1,4 (AUTHOR) gaelle.fromont-hankard@univ-tours.fr, Mahéo, Karine^1,2 (AUTHOR) karine.maheo@univ-tours.fr

Source: Cancers. Nov2019, Vol. 11 Issue 11, p1814-1814. 1p.

Subject Terms: *LIPID metabolism, *ADIPOSE tissues, *ANTINEOPLASTIC agents, *CALCIUM, *CELL lines, *CELLULAR signal transduction, *COMBINED modality therapy, *EPITHELIAL cells, *PROSTATE tumors, *TRANSCRIPTION factors, *DNA-binding proteins, *LINOLEIC acid, *EICOSAPENTAENOIC acid, *DISEASE progression, *CELL survival, *IN vitro studies, *PHARMACODYNAMICS