Multimodal antiproliferative effects of oleanolic acid mitocans: In vitro and in vivo studies

Authors: Puerta, Adrián ^a, González-Bakker, Aday ^a, Romanos, Eduardo ^{b, c, d}, Domínguez, Inmaculada Aguilar ^e, Martínez-Montiel, Mónica ^{e, f}, Merino-Montiel, Penélope ^f, Herrera, Raquel P. ^{c, ⁎}, Gimeno, M. Concepción ^d, Fernández-Bolaños, José G. ^e, López, Óscar ^{e, ⁎}, Padrón, José M. ^{a, ⁎}

Source: In Biochemical Pharmacology April 2025 234

Coumarins-lipophilic cations conjugates: Efficient mitocans targeting carbonic anhydrases

Authors: Fuentes-Aguilar, Alma, González-Bakker, Aday, Jovanović, Mirna, Stojanov, Sofija Jovanović, Puerta, Adrián, Gargano, Adriana, Dinić, Jelena, Vega-Báez, José L., Merino-Montiel, Penélope, Montiel-Smith, Sara, Alcaro, Stefano, Nocentini, Alessio, Pešić, Milica, Supuran, Claudiu T., Padrón, José M., Fernández-Bolaños, José G., López, Óscar

Source: In Bioorganic Chemistry April 2024 145

N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer’s Disease

Authors: Hofmanova, Tereza, Marques, Carolina, García-Sosa, Alfonso T., López, Óscar, Leitzbach, Luisa, Carreiro, Elisabete P., González-Bakker, Aday, Puerta, Adrián, Stark, Holger, Padrón, José M., Fernández-Bolaños, José G., Burke, Anthony J.

Source: In Results in Chemistry December 2023 6

Biotinylated selenocyanates: Potent and selective cytostatic agents

Authors: Roldán-Peña, Jesús M., Puerta, Adrián, Dinić, Jelena, Jovanović Stojanov, Sofija, González-Bakker, Aday, Hicke, Francisco J., Mishra, Atreyee, Piyasaengthong, Akkharadet, Maya, Inés, Walton, James W., Pešić, Milica, Padrón, José M., Fernández-Bolaños, José G., López, Óscar

Source: In Bioorganic Chemistry April 2023 133

Carbohydrate-derived bicyclic selenazolines as new dual inhibitors (cholinesterases/OGA) against Alzheimer’s disease

Authors: Velueta-Viveros, Martha, Martínez-Bailén, Macarena, Puerta, Adrián, Romero-Hernández, Laura L., Křen, Vladimír, Merino-Montiel, Penélope, Montiel-Smith, Sara, Fernandes, Miguel X., Moreno-Vargas, Antonio J., Padrón, José M., López, Óscar, Fernández-Bolaños, José G.

Source: In Bioorganic Chemistry October 2022 127

A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegansElectronic supplementary information (ESI) available. CCDC 2102397. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/d1cc04404d

Authors: García-García, Amalia, Rojas, Sara, Rivas-García, Lorenzo, Navarro-Hortal, María D., Romero-Márquez, Jose M., Fernández-Bolaños, José G., Choquesillo-Lazarte, Duane, Salinas-Castillo, Alfonso, López, Óscar, Quiles, José L., Rodríguez-Diéguez, Antonio

Source: Chemical communications. 58(10):1514-1517

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140087197.0x000001&indx=1&recIds=ETOCvdc_100140087197.0x000001

A hybrid of 1-deoxynojirimycin and benzotriazole induces preferential inhibition of butyrylcholinesterase (BuChE) over acetylcholinesterase (AChE)

Authors: Evangelista, Tereza Cristina Santos, López, Óscar, Puerta, Adrián, Fernandes, Miguel X., Ferreira, Sabrina Baptista, Padrón, José M., Fernández-Bolaños, José G., Sydnes, Magne O., Lindbäck, Emil

Source: Journal of enzyme inhibition and medicinal chemistry. 37(1):2395-2402

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168531550.0x000001&indx=1&recIds=ETOCvdc_100168531550.0x000001

Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis

Authors: Ibáñez-Escribano, Alexandra, Fonseca-Berzal, Cristina, Martínez-Montiel, Mónica, Álvarez-Márquez, Manuel, Gómez-Núñez, María, Lacueva-Arnedo, Manuel, Espinosa-Buitrago, Teresa, Martín-Pérez, Tania, Escario, José Antonio, Merino-Montiel, Penélope, Montiel-Smith, Sara, Gómez-Barrio, Alicia, López, Óscar, Fernández-Bolaños, José G.

Source: Journal of enzyme inhibition and medicinal chemistry. 37(1):781-791

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168530633.0x000001&indx=1&recIds=ETOCvdc_100168530633.0x000001

2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases

Authors: Fuentes-Aguilar, Alma, Merino-Montiel, Penélope, Montiel-Smith, Sara, Meza-Reyes, Socorro, Vega-Báez, José Luis, Puerta, Adrián, Fernandes, Miguel X., Padrón, José M., Petreni, Andrea, Nocentini, Alessio, Supuran, Claudiu T., López, Óscar, Fernández-Bolaños, José G.

Source: Journal of enzyme inhibition and medicinal chemistry. 37(1):168-177

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168530128.0x000001&indx=1&recIds=ETOCvdc_100168530128.0x000001

Identification of an acetyl esterase in the supernatant of the environmental strain Bacillus sp. HR21-6

Authors: Sánchez-Barrionuevo, Leyre, Mateos, Jesús, Fernández-Puente, Patricia, Begines, Paloma, Fernández-Bolaños, José G., Gutiérrez, Gabriel, Cánovas, David, Mellado, Encarnación

Source: Biochimie. 198:48-59

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164069137.0x000001&indx=1&recIds=ETOCvdc_100164069137.0x000001

Butyrylcholinesterase inhibitors as potential anti-Alzheimer's agents: an updated patent review (2018-present)

Authors: Fernández-Bolaños, José G., López, Óscar

Source: Expert opinion on therapeutic patents. 32(8):913-932

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156454457.0x000001&indx=1&recIds=ETOCvdc_100156454457.0x000001

Evaluation of chromane derivatives: Promising privileged scaffolds for lead discovery within Alzheimer’s disease

Authors: Moutayakine, Amina, Marques, Carolina, López, Óscar, Bagetta, Donatella, Leitzbach, Luisa, Hagenow, Stefanie, Carreiro, Elisabete P., Stark, Holger, Alcaro, Stefano, Fernández-Bolaños, José G., Burke, Anthony J.

Source: In Bioorganic & Medicinal Chemistry 15 August 2022 68

Multifaceted Sulfonamide-Derived Thiosemicarbazones: Combining Metal Chelation and Carbonic Anhydrases Inhibition in Anticancer Therapy.

Authors: Martínez-Montiel, Mónica, Arrighi, Giulia, Begines, Paloma, González-Bakker, Aday, Puerta, Adrián, Fernandes, Miguel X., Merino-Montiel, Penélope, Montiel-Smith, Sara, Nocentini, Alessio, Supuran, Claudiu T., Padrón, José M., Fernández-Bolaños, José G., López, Óscar

Source: International Journal of Molecular Sciences; Feb2025, Vol. 26 Issue 3, p1225, 23p

Subject Terms: SCHIFF bases, TREATMENT effectiveness, CHEMICAL synthesis, COLUMN chromatography, CHELATION, THIOSEMICARBAZONES

Straightforward access to novel mitochondriotropics derived from 2-arylethanol as potent and selective antiproliferative agents

Authors: Hicke, Francisco J., Puerta, Adrián, Dinić, Jelena, Pešić, Milica, Padrón, José M., López, Óscar, Fernández-Bolaños, José G.

Source: In European Journal of Medicinal Chemistry 15 January 2022 228

Novel 1, 2, 3-triazole epicinchonas: Transitioning from organocatalysis to biological activities

Authors: Barrulas, Pedro, Carreiro, Elisabete P., Veiros, Luis F., Amorim, Ana C., Gut, Giri, Rosenthal, Philip J., López, Óscar, Puerta, Adrián, Padrón, José M., Fernández-Bolaños, José G., Burke, Anthony J.

Source: Synthetic communications. 51(19):2954-2974

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133228171.0x000001&indx=1&recIds=ETOCvdc_100133228171.0x000001

Tacrine-sugar mimetic conjugates as enhanced cholinesterase inhibitorsElectronic supplementary information (ESI) available. See DOI: 10.1039/d0ob02588g

Authors: Oliveira de Santana, Quelli Larissa, Santos Evangelista, Tereza C., Imhof, Petra, Ferreira, Sabrina Baptista, Fernández-Bolaños, José G., Sydnes, Magne O., Lopéz, Óscar, Lindbäck, Emil

Source: Organic & biomolecular chemistry. 19(10):2322-2337

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117347395.0x000001&indx=1&recIds=ETOCvdc_100117347395.0x000001

Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase

Authors: Evangelista, Tereza Cristina Santos, López, Óscar, Ferreira, Sabrina Baptista, Fernández-Bolaños, José G., Sydnes, Magne O., Lindbäck, Emil

Source: Journal of enzyme inhibition and medicinal chemistry. 36(1):1658-1663

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138859682.0x000001&indx=1&recIds=ETOCvdc_100138859682.0x000001

Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors

Authors: Ahuja-Casarín, Ana I., Merino-Montiel, Penélope, Vega-Baez, José Luis, Montiel-Smith, Sara, Fernandes, Miguel X., Lagunes, Irene, Maya, Inés, Padrón, José M., López, Óscar, Fernández-Bolaños, José G.

Source: Journal of enzyme inhibition and medicinal chemistry. 36(1):138-146

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138859214.0x000001&indx=1&recIds=ETOCvdc_100138859214.0x000001

Assessing the Potential of 1,2,3-Triazole-Dihydropyrimidinone Hybrids Against Cholinesterases: In Silico, In Vitro, and In Vivo Studies.

Authors: Gastalho, Carlos M., Sena, Ana M., López, Óscar, Fernández-Bolaños, José G., García-Sosa, Alfonso T., Pereira, Florbela, Antunes, Célia M., Costa, Ana R., Burke, Anthony J., Carreiro, Elisabete P.

Source: International Journal of Molecular Sciences; Oct2024, Vol. 25 Issue 20, p11153, 20p

Subject Terms: CHOLINESTERASES, MOLECULAR docking, GALANTHAMINE, ARTEMIA, ANTIOXIDANTS

N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study

Authors: Marques, Carolina S., López, Óscar, Bagetta, Donatella, Carreiro, Elisabete P., Petralla, Sabrina, Bartolini, Manuela, Hoffmann, Matthias, Alcaro, Stefano, Monti, Barbara, Bolognesi, Maria Laura, Decker, Michael, Fernández-Bolaños, José G., Burke, Anthony J.

Source: In Bioorganic Chemistry May 2020 98