Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH)

Alternate Title: V Reunión de Hepatología Traslacional, organizada por la Asociación Española para el Estudio del Hígado (AEEH) (Spanish; Castilian)

Authors: Alvarado-Tapias, Edilmar, Maya-Miles, Douglas, Albillos, Agustin, Aller, Rocio, Ampuero, Javier, Andrade, Raul J., Arechederra, Maria, Aspichueta, Patricia, Banales, Jesus M., Blas-García, Ana, Caparros, Esther, Cardoso Delgado, Teresa, Carrillo-Vico, Antonio, Claria, Joan, Cubero, Francisco Javier, Díaz-Ruiz, Alberto, Fernández-Barrena, Maite G., Fernández-Iglesias, Anabel, Fernández-Veledo, Sonia, Francés, Ruben, Gallego-Durán, Rocío, Gracia-Sancho, Jordi, Irimia, Manuel, Lens, Sabela, Martínez-Chantar, María Luz, Mínguez, Beatriz, Muñoz-Hernández, Rocío, Nogueiras, Rubén, Ramos-Molina, Bruno, Riveiro-Barciela, Mar, Rodríguez-Perálvarez, Manuel L., Romero-Gómez, Manuel, Sabio, Guadalupe, Sancho-Bru, Pau, Ventura-Cots, Meritxell, Vidal, Silvia, Gahete, Manuel D.

Source: In Gastroenterologia y Hepatologia December 2024 47(10)

Caspases compromise SLU7 and UPF1 stability and NMD activity during hepatocarcinogenesis

Authors: Rojo, Carla, Gárate-Rascón, María, Recalde, Miriam, Álava, Ane, Elizalde, María, Azkona, María, Aldabe, Iratxe, Guruceaga, Elisabet, López-Pascual, Amaya, Latasa, M Ujue, Sangro, Bruno, Fernández-Barrena, Maite G., Ávila, Matías A., Arechederra, María, Berasain, Carmen

Source: In JHEP Reports August 2024 6(8)

New insights into the regulation of bile acids synthesis during the early stages of liver regeneration: A human and experimental study

Authors: Uriarte, Iker, Santamaria, Eva, López-Pascual, Amaya, Monte, María J., Argemí, Josepmaria, Latasa, M. Ujue, Adán-Villaescusa, Elena, Irigaray, Ainara, Herranz, Jose M., Arechederra, María, Basualdo, Jorge, Lucena, Felipe, Corrales, Fernando J., Rotellar, Fernando, Pardo, Fernando, Merlen, Gregory, Rainteau, Dominique, Sangro, Bruno, Tordjmann, Thierry, Berasain, Carmen, Marín, Jose J.G., Fernández-Barrena, Maite G., Herrero, Ignacio, Avila, Matias A.

Source: In BBA - Molecular Basis of Disease June 2024 1870(5)

A new FGF15/19‐mediated gut‐to‐heart axis controls cardiac hypertrophy

Authors: Morón‐Ros, Samantha, Blasco‐Roset, Albert, Navarro‐Gascon, Artur, Rupérez, Celia, Zamora, Monica, Crispi, Fatima, Uriarte, Iker, Fernández‐Barrena, Maite G, Avila, Matias, Ferrer‐Curriu, Gemma, Lupón, Josep, Bayés‐Genis, Antoni, Villarroya, Francesc, Gavaldà‐Navarro, Aleix, Planavila, Anna

Source: Journal of pathology. 261(3):335-348

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195221000.0x000001&indx=1&recIds=ETOCvdc_100195221000.0x000001

Mapping early serum proteome signatures of liver regeneration in living donor liver transplant cases

Authors: Carmona‐Rodríguez, Lorena, Gajadhar, Aaron S., Blázquez‐García, Irene, Guerrero, Laura, Fernández‐Rojo, Manuel A., Uriarte, Iker, Mamani‐Huanca, Maricruz, López‐Gonzálvez, Ángeles, Ciordia, Sergio, Ramos, Antonio, Herrero, José Ignacio, Fernández‐Barrena, Maite G., Arechederra, María, Berasain, Carmen, Quiroga, Jorge, Sangro, Bruno, Argemi, Josepmaría, Pardo, Fernando, Rotellar, Fernando, López, Daniel, Barbas, Coral, Ávila, Matías A., Corrales, Fernando J.

Source: BioFactors. 49(4):912-927

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190994617.0x000001&indx=1&recIds=ETOCvdc_100190994617.0x000001

Loss of liver function in chronic liver disease: An identity crisis

Authors: Berasain, Carmen, Arechederra, Maria, Argemí, Josepmaria, Fernández-Barrena, Maite G., Avila, Matías A.

Source: Journal of hepatology. 78(2):401-414

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185974347.0x000001&indx=1&recIds=ETOCvdc_100185974347.0x000001

Metabolic-associated fatty liver disease: From simple steatosis toward liver cirrhosis and potential complications. Proceedings of the Third Translational Hepatology Meeting, organized by the Spanish Association for the Study of the Liver (AEEH)

Authors: Gallego-Durán, Rocío, Albillos, Agustín, Ampuero, Javier, Arechederra, María, Bañares, Rafael, Blas-García, Ana, Berná, Genoveva, Caparrós, Esther, Delgado, Teresa C., Falcón-Pérez, Juan Manuel, Francés, Rubén, Fernández-Barrena, Maite G., Graupera, Isabel, Iruzubieta, Paula, Nevzorova, Yulia A., Nogueiras, Rubén, Macías, Rocío I.R., Martín, Franz, Sabio, Guadalupe, Soriano, Germán, Vaquero, Javier, Cubero, Francisco Javier, Gracia-Sancho, Jordi

Source: In Gastroenterología y Hepatología (English Edition) November 2022 45(9):724-734

Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models

Authors: Olaizola, Paula, Lee-Law, Pui Yuen, Fernandez-Barrena, Maite G., Alvarez, Laura, Cadamuro, Massimiliano, Azkargorta, Mikel, O’Rourke, Colm J., Caballero-Camino, Francisco J., Olaizola, Irene, Macias, Rocio I.R., Marin, Jose J.G., Serrano-Maciá, Marina, Martinez-Chantar, Maria L., Avila, Matias A., Aspichueta, Patricia, Calvisi, Diego F., Evert, Matthias, Fabris, Luca, Castro, Rui E., Elortza, Felix, Andersen, Jesper B., Bujanda, Luis, Rodrigues, Pedro M., Perugorria, Maria J., Banales, Jesus M.

Source: In Journal of Hepatology July 2022 77(1):177-190

Quantitative proteomic analysis unveils a critical role of VARS1 in hepatocellular carcinoma aggressiveness through the modulation of MAGI1 expression.

Authors: Hermán-Sánchez, Natalia, del Rio-Moreno, Mercedes, Ciria, Rubén, Sánchez-Frias, Marina E., Fernández-Barrena, Maite G., Uriarte, Iker, Chicano-Galvez, Eduardo, Ortea, Ignacio, Peralbo-Molina, Ángela, Briceño, Javier, Avila, Matías A., Rodríguez-Perálvarez, Manuel, Luque, Raúl M., López-Cánovas, Juan L., Gahete, Manuel D.

Source: Molecular Cancer; 1/14/2025, Vol. 24 Issue 1, p1-16, 16p

Subject Terms: AMINOACYL-tRNA synthetases, MEDICAL sciences, CYTOLOGY, LIFE sciences, HEPATOCELLULAR carcinoma

FOSL1 promotes cholangiocarcinoma via transcriptional effectors that could be therapeutically targeted

Authors: Vallejo, Adrián, Erice, Oihane, Entrialgo-Cadierno, Rodrigo, Feliu, Iker, Guruceaga, Elizabeth, Perugorria, Maria J., Olaizola, Paula, Muggli, Alexandra, Macaya, Irati, O’Dell, Michael, Ruiz-Fernandez de Cordoba, Borja, Ortiz-Espinosa, Sergio, Hezel, Aram F., Arozarena, Imanol, Lecanda, Fernando, Avila, Matias A., Fernandez-Barrena, Maite G., Evert, Matthias, Ponz-Sarvise, Mariano, Calvisi, Diego F., Banales, Jesus M., Vicent, Silve

Source: In Journal of Hepatology August 2021 75(2):363-376

Splicing Factor SLU7 Prevents Oxidative Stress‐Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage

Authors: Gárate‐Rascón, María, Recalde, Miriam, Jimenez, Maddalen, Elizalde, María, Azkona, María, Uriarte, Iker, Latasa, M. Uxue, Urtasun, Raquel, Bilbao, Idoia, Sangro, Bruno, Garcia‐Ruiz, Carmen, Fernandez‐Checa, José C., Corrales, Fernando J, Esquivel, Argitxu, Pineda‐Lucena, Antonio, Fernández‐Barrena, Maite G., Ávila, Matías A., Arechederra, María, Berasain, Carmen

Source: Hepatology. 74(5):2791-2807

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136860554.0x000001&indx=1&recIds=ETOCvdc_100136860554.0x000001

Comprehensive in silico CpG methylation analysis in hepatocellular carcinoma identifies tissue- and tumor-type specific marks disconnected from gene expression.

Authors: Bilbao, Idoia, Recalde, Miriam, Daian, Fabrice, Herranz, José Maria, Elizalde, María, Iñarrairaegui, Mercedes, Canale, Matteo, Fernández-Barrena, Maite G., Casadei-Gardini, Andrea, Sangro, Bruno, Ávila, Matías A., Landecho Acha, Manuel F., Berasain, Carmen, Arechederra, María

Source: Journal of Physiology & Biochemistry; Nov2024, Vol. 80 Issue 4, p865-879, 15p

Epigenetics in hepatocellular carcinoma development and therapy: The tip of the iceberg

Authors: Fernández-Barrena, Maite G., Arechederra, María, Colyn, Leticia, Berasain, Carmen, Avila, Matias A.

Source: In JHEP Reports December 2020 2(6)

Hepatic progenitor cells, senescence and IL-6 as the main players in combined hepatocellular-cholangiocarcinoma development

Authors: Arechederra, María, Fernández-Barrena, Maite G.

Source: Journal of hepatology. 77(6):1479-1481

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178375607.0x000001&indx=1&recIds=ETOCvdc_100178375607.0x000001

Chromatin dynamics during liver regeneration

Authors: Arechederra, Maria, Berasain, Carmen, Avila, Matias A., Fernández-Barrena, Maite G.

Source: In Seminars in Cell and Developmental Biology January 2020 97:38-46

Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: New therapeutic targets

Authors: Santos‐Laso, Alvaro, Izquierdo‐Sanchez, Laura, Rodrigues, Pedro M., Huang, Bing Q., Azkargorta, Mikel, Lapitz, Ainhoa, Munoz‐Garrido, Patricia, Arbelaiz, Ander, Caballero-Camino, Francisco J., Fernández‐Barrena, Maite G., Jimenez‐Agüero, Raul, Argemi, Josepmaria, Aragon, Tomas, Elortza, Felix, Marzioni, Marco, Drenth, Joost P. H., LaRusso, Nicholas F., Bujanda, Luis, Perugorria, Maria J., Banales, Jesus M., Andersson, Emma

Source: Liver international. 40(7):1670-1685

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107582178.0x000001&indx=1&recIds=ETOCvdc_100107582178.0x000001

Sweet dreams could be made of this: carbohydrate‐responsive element‐binding protein (ChREBP) as a target for hepatocellular carcinoma therapy.

Authors: Fernández‐Barrena, Maite G., Avila, Matías A.

Source: Molecular Oncology; Sep2024, Vol. 18 Issue 9, p2107-2110, 4p

Bile acids, FGF15/19 and liver regeneration: From mechanisms to clinical applications

Authors: Alvarez-Sola, Gloria, Uriarte, Iker, Latasa, Maria U., Jimenez, Maddalen, Barcena-Varela, Marina, Santamaría, Eva, Urtasun, Raquel, Rodriguez-Ortigosa, Carlos, Prieto, Jesús, Berraondo, Pedro, Fernandez-Barrena, Maite G., Berasain, Carmen, Avila, Matías A.

Source: In BBA - Molecular Basis of Disease April 2018 1864(4) Part B:1326-1334

The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis

Authors: Santamaría, Eva, Rodríguez‐Ortigosa, Carlos M., Uriarte, Iker, Latasa, Maria U., Urtasun, Raquel, Alvarez‐Sola, Gloria, Bárcena‐Varela, Marina, Colyn, Leticia, Arcelus, Sara, Jiménez, Maddalen, Deutschmann, Kathleen, Peleteiro‐Vigil, Ana, Gómez‐Cambronero, Julian, Milkiewicz, Malgorzata, Milkiewicz, Piotr, Sangro, Bruno, Keitel, Verena, Monte, Maria J., Marin, Jose J.G., Fernández‐Barrena, Maite G., Ávila, Matias A., Berasain, Carmen

Source: Hepatology. 69(4):1632-1647

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083096065.0x000001&indx=1&recIds=ETOCvdc_100083096065.0x000001

SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma

Authors: Merino-Azpitarte, Maite, Lozano, Elisa, Perugorria, María J., Esparza-Baquer, Aitor, Erice, Oihane, Santos-Laso, Álvaro, O'Rourke, Colm J., Andersen, Jesper B., Jiménez-Agüero, Raúl, Lacasta, Adelaida, D'Amato, Mauro, Briz, Óscar, Jalan-Sakrikar, Nidhi, Huebert, Robert C., Thelen, Kristen M., Gradilone, Sergio A., Aransay, Ana M., Lavín, José L., Fernández-Barrena, Maite G., Matheu, Ander, Marzioni, Marco, Gores, Gregory J., Bujanda, Luis, Marin, José J.G., Banales, Jesús M.

Source: In Journal of Hepatology July 2017 67(1):72-83