Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages

Authors: Yan Cheng, Fumou Sun, Daisy V. Alapat, Visanu Wanchai, David Mery, Eric R. Siegel, Hongwei Xu, Sarah Johnson, Wancheng Guo, Clyde Bailey, Cody Ashby, Michael Anton Bauer, Samer Al Hadidi, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Frits van Rhee, Guido Tricot, John D. Shaughnessy, Fenghuang Zhan

Source: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5385

Access URL: https://doaj.org/article/e8dd857feedf48c5930d5a49c2504046

Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis

Authors: Miao Xian, Qiang Wang, Liuling Xiao, Ling Zhong, Wei Xiong, Lingqun Ye, Pan Su, Chuanchao Zhang, Yabo Li, Robert Z. Orlowski, Fenghuang Zhan, Siddhartha Ganguly, Youli Zu, Jianfei Qian, Qing Yi

Source: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7c68ca5a0d7f4a6c884db7a42883b93f

Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing

Authors: Jian-rong Li, Shahram Arsang-Jang, Yan Cheng, Fumou Sun, Anita D’Souza, Binod Dhakal, Parameswaran Hari, Quillan Huang, Paul Auer, Yong Li, Raul Urrutia, Fenghuang Zhan, John D. Shaughnessy, Siegfried Janz, Jing Dong, Chao Cheng

Source: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-9 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5385

Access URL: https://doaj.org/article/82447a8befb941718ae624e1ab75d3e4

Prognostic value of ferritin in ASCT MM patients: integration with GEP models and ISS series systems

Authors: Wancheng Guo, Yihao Zhan, David Mery, Eric R. Siegel, Fumou Sun, Yan Cheng, Timothy Cody Ashby, Zijun Zhang, Clyde Bailey, Daisy V. Alapat, Hongling Peng, Samer Al Hadidi, Sharmilan Thanendrarajan, Carolina Schinke, Maurizio Zangari, Frits van Rhee, Guido Tricot, John D. Shaughnessy, Fenghuang Zhan

Source: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-4 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5385

Access URL: https://doaj.org/article/f59b8168c4bc41abb2bfff80fe089e06

Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth

Authors: Fumou Sun, Yan Cheng, Visanu Wanchai, Wancheng Guo, David Mery, Hongwei Xu, Dongzheng Gai, Eric Siegel, Clyde Bailey, Cody Ashby, Samer Al Hadidi, Carolina Schinke, Sharmilan Thanendrarajan, Yupo Ma, Qing Yi, Robert Z. Orlowski, Maurizio Zangari, Frits van Rhee, Siegfried Janz, Gail Bishop, Guido Tricot, John D. Shaughnessy, Fenghuang Zhan

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/68fd54c5690048f79c63bc21afccca4b

A gene signature can predict risk of MGUS progressing to multiple myeloma

Authors: Fumou Sun, Yan Cheng, Jun Ying, David Mery, Samer Al Hadidi, Visanu Wanchai, Eric R. Siegel, Hongwei Xu, Dongzheng Gai, Timothy Cody Ashby, Clyde Bailey, Jin-Ran Chen, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Siegfried Janz, Bart Barlogie, Frits Van Rhee, Guido Tricot, John D. Shaughnessy, Fenghuang Zhan

Source: Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-5 (2023)

Subject Terms: Multiple myeloma, Monoclonal gammopathy of undetermined significance (MGUS), Gene expression profiling, Gene signature, Prediction model, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/06fafe2671dd496cac7b712408124b7b

Variability of definition of high‐risk multiple myeloma across phase III clinical trials

Authors: Faris Jamal Abu Za'nouneh, Obada Ababneh, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, John D. Shaughnessy Jr, Fenghuang Zhan, Frits vanRhee, Samer Al Hadidi

Source: eJHaem, Vol 4, Iss 2, Pp 454-458 (2023)

Subject Terms: clinical trials, high risk, multiple myeloma, phase III, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2688-6146

Access URL: https://doaj.org/article/092efc3f964b4af8aef42ba95eaf4704

Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics

Authors: Samrat Roy Choudhury, Stephanie D. Byrum, Duah Alkam, Cody Ashby, Fenghuang Zhan, Alan J. Tackett, Frits Van Rhee

Source: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-14 (2023)

Subject Terms: Multiple myeloma, ITGB7, T(14, 16) subgroup, DNA methylation, Super-enhancer, CRISPR, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1868-7083

Access URL: https://doaj.org/article/da8930f7c5b643a592478ee5b0d59690

WDR26 and MTF2 are therapeutic targets in multiple myeloma

Authors: Fumou Sun, Yan Cheng, Jesse D. Riordan, Adam Dupuy, Wendy Dubois, Michael Pisano, Jing Dong, Beverly Mock, Fenghuang Zhan, Parameswaran Hari, Siegfried Janz

Source: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-7 (2021)

Subject Terms: Forward genetic screen, Moloney murine leukemia virus, Plasma cell neoplasia, Carboxy-terminal to LisH (CTLH) complex, Polycomb repressive complex 2 (PRC2), Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/e3500f2676bd455a95eca8832206d940

CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma

Authors: Chunyan Gu, Wang Wang, Xiaozhu Tang, Tingting Xu, Yanxin Zhang, Mengjie Guo, Rongfang Wei, Yajun Wang, Artur Jurczyszyn, Siegfried Janz, Meral Beksac, Fenghuang Zhan, Anja Seckinger, Dirk Hose, Jingxuan Pan, Ye Yang

Source: Molecular Cancer, Vol 20, Iss 1, Pp 1-14 (2021)

Subject Terms: Multiple myeloma, CHEK1, circCHEK1_246aa, Proliferation, Drug resistance, Chromosomal instability, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/3d70242196df4660b1542e1e21333f89

HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA

Authors: Fengjie Jiang, Xiaozhu Tang, Chao Tang, Zhen Hua, Mengying Ke, Chen Wang, Jiamin Zhao, Shengyao Gao, Artur Jurczyszyn, Siegfried Janz, Meral Beksac, Fenghuang Zhan, Chunyan Gu, Ye Yang

Source: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-5 (2021)

Subject Terms: M6A, HNRNPA2B1, Multiple myeloma, MeRIP-Seq, ILF3, RNA stability, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/c3cb7028155f4d2a9ee422768f9230c0

Extracellular vesicle expansion of PMIS‐miR‐210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism

Authors: Steven Eliason, Liu Hong, Yan Sweat, Camille Chalkley, Huojun Cao, Qi Liu, Hank Qi, Hongwei Xu, Fenghuang Zhan, Brad A. Amendt

Source: Clinical and Translational Medicine, Vol 12, Iss 9, Pp n/a-n/a (2022)

Subject Terms: colorectal cancer, microRNA mouse models, microRNA therapeutic, miR‐210, NME1, plasmid‐based microRNA inhibitor system (PMIS), Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/7b101cdb02934189811dc3809d576987

CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation

Authors: Dongzheng Gai, Jin-Ran Chen, James P. Stewart, Intawat Nookaew, Hasem Habelhah, Cody Ashby, Fumou Sun, Yan Cheng, Can Li, Hongwei Xu, Bailu Peng, Tarun K. Garg, Carolina Schinke, Sharmilan Thanendrarajan, Maurizio Zangari, Fangping Chen, Bart Barlogie, Frits van Rhee, Guido Tricot, John D. Shaughnessy Jr., Fenghuang Zhan

Source: The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)

Subject Terms: Bone Biology, Hematology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1558-8238

Access URL: https://doaj.org/article/e0033236077b4a64b805c9d221f71dcc

Macrophages: A communication network linking Porphyromonas gingivalis infection and associated systemic diseases

Authors: Jie Lin, Dingming Huang, Hongwei Xu, Fenghuang Zhan, XueLian Tan

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: Porphyromonas gingivalis, macrophages, immune escape, systemic disease, polarization, inflammasome, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.952040/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7c0740b7dc584de08fe7a9a2ae08f2b0

GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice

Authors: Jin-Ran Chen, Haijun Zhao, Umesh D. Wankhade, Sree V. Chintapalli, Can Li, Dongzheng Gai, Kartik Shankar, Fenghuang Zhan, Oxana P. Lazarenko

Source: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/326219ecf5b84dbc89616cda50c648e4

The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma

Authors: Eileen M. Boyle, Shayu Deshpande, Ruslana Tytarenko, Cody Ashby, Yan Wang, Michael A. Bauer, Sarah K. Johnson, Christopher P. Wardell, Sharmilan Thanendrarajan, Maurizio Zangari, Thierry Facon, Charles Dumontet, Bart Barlogie, Arnaldo Arbini, Even H. Rustad, Francesco Maura, Ola Landgren, Fenghuang Zhan, Frits van Rhee, Carolina Schinke, Faith E. Davies, Gareth J. Morgan, Brian A. Walker

Source: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/190cc8a591d94b4a813749741597a52e

NEK2 induces autophagy‐mediated bortezomib resistance by stabilizing Beclin‐1 in multiple myeloma

Authors: Jiliang Xia, Yanjuan He, Bin Meng, Shilian Chen, Jingyu Zhang, Xuan Wu, Yinghong Zhu, Yi Shen, Xiangling Feng, Yongjun Guan, Chunmei Kuang, Jiaojiao Guo, Qian Lei, Yangbowen Wu, Gang An, Guancheng Li, Lugui Qiu, Fenghuang Zhan, Wen Zhou

Source: Molecular Oncology, Vol 14, Iss 4, Pp 763-778 (2020)

Subject Terms: autophagy, Beclin‐1, multiple myeloma, NEK2, ubiquitination, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/40ca287c80a94d59b45c6f39103fa18a

Chimeric antigen receptor T cell therapies for multiple myeloma

Authors: Chao Wu, Lina Zhang, Qierra R. Brockman, Fenghuang Zhan, Lijuan Chen

Source: Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-12 (2019)

Subject Terms: Chimeric antigen receptors, Multiple myeloma, Immunotherapy, Tumor immunology, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13045-019-0823-5; https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/d5273e61a05c4f8899ce427199920b24

The impact of response kinetics for multiple myeloma in the era of novel agents

Authors: Yuting Yan, Xuehan Mao, Jiahui Liu, Huishou Fan, Chenxing Du, Zengjun Li, Shuhua Yi, Yan Xu, Rui Lv, Wei Liu, Shuhui Deng, Weiwei Sui, Qi Wang, Dehui Zou, Jianxiang Wang, Tao Cheng, Fenghuang Zhan, Yu-Tzu Tai, Chenglu Yuan, Xin Du, Lugui Qiu, Kenneth C. Anderson, Gang An

Source: Blood Advances, Vol 3, Iss 19, Pp 2895-2904 (2019)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920318528; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/ba9e6e03412b466aa552482a4a129eb8

Laboratory Mice – A Driving Force in Immunopathology and Immunotherapy Studies of Human Multiple Myeloma

Authors: Michael Pisano, Yan Cheng, Fumou Sun, Binod Dhakal, Anita D’Souza, Saurabh Chhabra, Jennifer M. Knight, Sridhar Rao, Fenghuang Zhan, Parameswaran Hari, Siegfried Janz

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: genetically engineered mouse models of human cancer, auto- and xenografting, immune, immunodeficient mice models, immune pathogenesis, Myeloma, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.667054/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/cc4625eaeb1c471084a103fb04009478