Tubastatin A potently inhibits GPX4 activity to potentiate cancer radiotherapy through boosting ferroptosis

Authors: Liu, Shan, Zhang, Hai-Liang, Li, Jing, Ye, Zhi-Peng, Du, Tian, Li, Li-Chao, Guo, Yi-Qing, Yang, Dong, Li, Zhi-Ling, Cao, Jiang-Hua, Hu, Bing-Xin, Chen, Yu-Hong, Feng, Gong-Kan, Li, Zhi-Ming, Deng, Rong, Huang, Jia-Jia, Zhu, Xiao-Feng

Source: In Redox Biology June 2023 62

Indole alkaloids fusarindoles A–E from marine-derived fungus Fusarium equiseti LJ-1

Authors: Dai, Xiao-Ming, Pan, Hui-Lin, Lan, Wen-Jian, Chen, Liu-Ping, Feng, Gong-Kan, Deng, Rong, Zhu, Xiao-Feng, Li, Hou-Jin

Source: In Phytochemistry December 2022 204

Monascuslactams A–D, cytotoxic γ-lactams from marine fungus Monascus albidus BB3

Authors: Guo, Qi, Dai, Xiao-Ming, Lan, Wen-Jian, Chen, Liu-Ping, Lam, Chi-Keung, Feng, Gong-Kan, Deng, Rong, Zhu, Xiao-Feng, Li, Hou-Jin

Source: Natural product research. 36(10):2534-2541

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100151179763.0x000001&indx=1&recIds=ETOCvdc_100151179763.0x000001

Susceptibility of Mitophagy‐Deficient Tumors to Ferroptosis Induction by Relieving the Suppression of Lipid Peroxidation.

Authors: Liu, Shan^1,2,3, Chen, Jing‐Hong^4,5, Li, Li‐Chao¹, Ye, Zhi‐Peng¹, Liu, Jian‐Nan⁶, Chen, Yu‐Hong¹, Hu, Bing‐Xin¹, Tang, Jia‐Hong¹, Feng, Gong‐Kan¹, Li, Zhi‐Ming^1,3, Deng, Chu‐Xia⁵, Deng, Rong¹, Zhu, Xiao‐Feng¹, zhuxfeng@mail.sysu.edu.cn, Zhang, Hai‐Liang¹, zhanghl@sysucc.org.cn

Source: Advanced Science; 12/10/2025, Vol. 12 Issue 6, p1-16, 16p

MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis

Authors: Deng, Rong, Zhang, Hai-Liang, Huang, Jun-Hao, Cai, Rui-Zhao, Wang, Yan, Chen, Yu-Hong, Hu, Bing-Xin, Ye, Zhi-Peng, Li, Zhi-Ling, Mai, Jia, Huang, Yun, Li, Xuan, Peng, Xiao-Dan, Feng, Gong-Kan, Li, Jun-Dong, Tang, Jun, Zhu, Xiao-Feng

Source: Autophagy. 17(10):3011-3029

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135596050.0x000001&indx=1&recIds=ETOCvdc_100135596050.0x000001

CUL3 (cullin 3)-mediated ubiquitination and degradation of BECN1 (beclin 1) inhibit autophagy and promote tumor progression

Authors: Li, Xuan, Yang, Kai-Bin, Chen, Wei, Mai, Jia, Wu, Xiao-Qi, Sun, Ting, Wu, Rui-Yan, Jiao, Lin, Li, Dan-Dan, Ji, Jiao, Zhang, Hai-Liang, Yu, Yan, Chen, Yu-Hong, Feng, Gong-Kan, Deng, Rong, Li, Jun-Dong, Zhu, Xiao-Feng

Source: Autophagy. 17(12):4323-4340

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137218502.0x000001&indx=1&recIds=ETOCvdc_100137218502.0x000001

Clinical significance and function of RDH16 as a tumor‐suppressing gene in hepatocellular carcinoma

Authors: Zhu, Ying‐Hui, Li, Jian‐Biao, Wu, Rui‐Yan, Yu, Yan, Li, Xuan, Li, Zhi‐Ling, Zhang, Hai‐Liang, Feng, Gong‐Kan, Deng, Rong, Zhu, Xiao‐Feng

Source: Hepatology research. 50(1):110-120

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100132311577.0x000001&indx=1&recIds=ETOCvdc_100132311577.0x000001

Cytotoxic alkaloids from the marine shellfish-associated fungus Aspergillus sp. XBB-4 induced by an amino acid-directed strategyElectronic supplementary information (ESI) available: HRESIMS, 1D and 2D NMR spectra of compounds 1–3 and 13; 1D NMR spectra of compounds 4–12; ECD calculation of compounds 1, 3 and 13; crystallographic data of compound 13; composition of each nutrient source in eight culture media and HPLC spectra of extracts from eight culture media. CCDC 1969177. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c9ra10306f

Authors: Qiu, Yi, Guo, Qi, Ran, Yan-Qin, Lan, Wen-Jian, Lam, Chi-Keung, Feng, Gong-Kan, Deng, Rong, Zhu, Xiao-Feng, Li, Hou-Jin, Chen, Liu-Ping

Source: RSC advances. 10(8):4243-4250

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100098706561.0x000001&indx=1&recIds=ETOCvdc_100098706561.0x000001

Inactivated cGAS‐STING Signaling Facilitates Endocrine Resistance by Forming a Positive Feedback Loop with AKT Kinase in ER+HER2– Breast Cancer.

Authors: Zhang, Kai‐Ming^1,2, Zhao, De‐Chang^1,2, Li, Ze‐Yu^3,4, Wang, Yan^1,2, Liu, Jian‐Nan⁵, Du, Tian^1,2, Zhou, Ling¹, Chen, Yu‐Hong¹, Yu, Qi‐Chao^3,4, Chen, Qing‐Shan^1,2, Cai, Rui‐Zhao^1,2, Zhao, Zi‐Xuan^1,2, Shan, Jia‐Lu¹, Hu, Bing‐Xin¹, Zhang, Hai‐Liang¹, Feng, Gong‐Kan¹, Zhu, Xiao‐Feng¹, Tang, Jun^1,2, Deng, Rong¹, dengrong@sysucc.org.cn

Source: Advanced Science; 9/18/2024, Vol. 11 Issue 35, p1-18, 18p

Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.

Authors: Chen, Wei, Yang, Kai-Bin, Zhang, Yuan-Zhe, Lin, Zai-Shan, Chen, Jin-Wei, Qi, Si-Fan, Wu, Chen-Fei, Feng, Gong-Kan, Yang, Da-Jun, Chen, Ming, Zhu, Xiao-Feng, Li, Xuan

Source: Journal of Experimental & Clinical Cancer Research (17569966); 8/31/2024, Vol. 43 Issue 1, p1-20, 20p

Subject Terms: LETHAL mutations, SYNTHETIC genes, REACTIVE oxygen species, GENETIC transcription, PYROPTOSIS

TRPML1 triggers ferroptosis defense and is a potential therapeutic target in AKT-hyperactivated cancer.

Authors: Zhang, Hai-Liang, Hu, Bing-Xin, Ye, Zhi-Peng, Li, Zhi-Ling, Liu, Shan, Zhong, Wen-Qing, Du, Tian, Yang, Dong, Mai, Jia, Li, Li-Chao, Chen, Yu-Hong, Zhu, Xian-Ying, Li, Xuan, Feng, Gong-Kan, Zhu, Xiao-Feng, Deng, Rong

Source: Science Translational Medicine; 6/26/2024, Vol. 16 Issue 753, p1-15, 15p

Subject Terms: PEPTIDES, FUNCTIONAL analysis, CANCER treatment, CELL death, CANCER cells, KINASE inhibitors

NMR screening approach for discovery of new 6-methylpyridinone derivatives from the marine-derived fungus Leptosphaerulina sp.

Authors: Chen, Ting, Lam, Chi-Keung, Chen, Wen-Dan, Chen, Xiao-Hong, Feng, Gong-Kan, Zhu, Xiao-Feng, Lan, Wen-Jian, Li, Hou-Jin

Source: In Arabian Journal of Chemistry February 2017 10(2):288-294

Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of HK2 (hexokinase 2)

Authors: Jiao, Lin, Zhang, Hai-Liang, Li, Dan-Dan, Yang, Ke-Li, Tang, Jun, Li, Xuan, Ji, Jiao, Yu, Yan, Wu, Rui-Yan, Ravichandran, Senthilkumar, Liu, Jian-Jun, Feng, Gong-Kan, Chen, Min-Shan, Zeng, Yi-Xin, Deng, Rong, Zhu, Xiao-Feng

Source: Autophagy. 14(4):671-684

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100062628680.0x000001&indx=1&recIds=ETOCvdc_100062628680.0x000001

Monalbidins A–E, Decalins with Potential Cytotoxic Activities from Marine Derived Fungus Monascus albidus BB3

Authors: Guo, Qi, Lan, Wen‐Jian, Chen, Liu‐Ping, Lam, Chi‐Keung, Feng, Gong‐Kan, Deng, Rong, Zhu, Xiao‐Feng, Li, Hou‐Jin

Source: Chemistry & biodiversity. 18(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121115248.0x000001&indx=1&recIds=ETOCvdc_100121115248.0x000001

ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

Authors: Chen, Jing-Hong, Zhang, Peng, Chen, Wen-Dan, Li, Dan-Dan, Wu, Xiao-Qi, Deng, Rong, Jiao, Lin, Li, Xuan, Ji, Jiao, Feng, Gong-Kan, Zeng, Yi-Xin, Jiang, Jian-Wei, Zhu, Xiao-Feng

Source: Autophagy. 11(2):239-252

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100029041276.0x000001&indx=1&recIds=ETOCETOCvdc_100029041276.0x000001

A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling

Authors: Qin, Juan, Tang, Jun, Jiao, Lin, Ji, Jiao, Chen, Wen-Dan, Feng, Gong-Kan, Gao, You-Heng, Zhu, Xiao-Feng, Deng, Rong

Source: In Life Sciences 4 November 2013 93(18-19):655-663

Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation

Authors: Li, Zhi-Ling, Zhang, Hai-Liang, Huang, Yun, Huang, Jun-Hao, Sun, Peng, Zhou, Ning-Ning, Chen, Yu-Hong, Mai, Jia, Wang, Yan, Yu, Yan, Zhou, Li-Huan, Li, Xuan, Yang, Dong, Peng, Xiao-Dan, Feng, Gong-Kan, Tang, Jun, Zhu, Xiao-Feng, Deng, Rong

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174560955.0x000001&indx=1&recIds=ETOCvdc_100174560955.0x000001

Disruption of super-enhancer-driven tumor suppressor gene RCAN1.4 expression promotes the malignancy of breast carcinoma

Authors: Deng, Rong, Huang, Jun-Hao, Wang, Yan, Zhou, Li-Huan, Wang, Zi-Feng, Hu, Bing-Xin, Chen, Yu-Hong, Yang, Dong, Mai, Jia, Li, Zhi-Ling, Zhang, Hai-Liang, Huang, Yun, Peng, Xiao-Dan, Feng, Gong-Kan, Zhu, Xiao-Feng, Tang, Jun

Source: Molecular cancer. 19(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171908449.0x000001&indx=1&recIds=ETOCvdc_100171908449.0x000001

Upregulation of sestrin 2 expression via JNK pathway activation contributes to autophagy induction in cancer cells

Authors: Zhang, Xiao-Yue, Wu, Xiao-Qi, Deng, Rong, Sun, Ting, Feng, Gong-Kan, Zhu, Xiao-Feng

Source: In Cellular Signalling January 2013 25(1):150-158

Suppressive stroma-immune prognostic signature impedes immunotherapy in ovarian cancer and can be reversed by PDGFRB inhibitors.

Authors: Yang, Dong, Duan, Mei-Han, Yuan, Qiu-Er, Li, Zhi-Ling, Luo, Chuang-Hua, Cui, Lan-Yue, Li, Li-Chao, Xiao, Ying, Zhu, Xian-Ying, Zhang, Hai-Liang, Feng, Gong-Kan, Liu, Guo-Chen, Deng, Rong, Li, Jun-Dong, Zhu, Xiao-Feng

Source: Journal of Translational Medicine; 9/1/2023, Vol. 21 Issue 1, p1-16, 16p

Subject Terms: OVARIAN cancer, GYNECOLOGIC cancer, IMMUNOTHERAPY, IMMUNOSUPPRESSION, IMMUNE checkpoint proteins