PlasmoFAB: A Benchmark to Foster Machine Learning for Plasmodium falciparum Protein Antigen Candidate Prediction

Authors: Ditz, Jonas Christian, Wistuba-Hamprecht, Jacqueline, Maier, Timo, Fendel, Rolf, Pfeifer, Nico, Reuter, Bernhard

Subject Terms: Quantitative Biology - Quantitative Methods, Computer Science - Machine Learning

Access URL: http://arxiv.org/abs/2301.06454

PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults

Authors: Tumbo, Anneth, Lorenz, Freia-Raphaella, Yang, Annie S.P., Sefried, Stephanie, Schindler, Tobias, Mpina, Maximilian, Dangy, Jean-Pierre, Milando, Florence A., Rashid, Mohammed A., Nyaulingo, Gloria, Ramadhani, Kamaka, Jongo, Said, Felgner, Philip L., Abebe, Yonas, Sim, B. Kim Lee, Church, L.W. Preston, Richie, Thomas L., Billingsley, Peter F., Murshedkar, Tooba, Hoffman, Stephen L., Abdulla, Salim, Kremsner, Peter G., Mordmüller, Benjamin, Daubenberger, Claudia, Fendel, Rolf

Source: In eBioMedicine October 2024 108

A pharmacokinetic–pharmacodynamic model for chemoprotective agents against malaria

Authors: Cherkaoui‐Rbati, Mohammed H., Andenmatten, Nicole, Burgert, Lydia, Egbelowo, Oluwaseun F., Fendel, Rolf, Fornari, Chiara, Gabel, Michael, Ward, John, Möhrle, Jörg J., Gobeau, Nathalie

Source: CPT: pharmacometrics & systems pharmacology. 12(1):50-61

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100170799775.0x000001&indx=1&recIds=ETOCvdc_100170799775.0x000001

First-in-human use of a modular capsid virus-like vaccine platform: an open-label, non-randomised, phase 1 clinical trial of the SARS-CoV-2 vaccine ABNCoV2

Authors: Smit, Merel J, Sander, Adam F, Ariaans, Maud B P A, Fougeroux, Cyrielle, Heinzel, Constanze, Fendel, Rolf, Esen, Meral, Kremsner, Peter G, ter Heine, Rob, Wertheim, Heiman F, Idorn, Manja, Riis Paludan, Søren, Underwood, Alexander P, Binderup, Alekxander, Ramirez, Santseharay, Bukh, Jens, Soegaard, Max, Erdogan, Sayit M, Gustavsson, Tobias, Clemmensen, Stine, Theander, Thor G, Salanti, Ali, Hamborg, Mette, de Jongh, Willem A, McCall, Matthew B B, Nielsen, Morten A, Mordmüller, Benjamin G, Dagil, Robert, Goksøyr, Louise, Hulen, Thomas M, Janitzek, Christoph, Jensen, Daniel S, Justesen, Sune, Khalifé, Paul K, Kreidenweiss, Andrea, Lança, Telma, Lie-Andersen, Olivia, Teelen, Karina, Vidal-Calvo, Elena, Paludan, Søren Riis

Source: In The Lancet Microbe March 2023 4(3):e140-e148

Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19

Authors: Rüter, Jule, Pallerla, Srinivas Reddy, Meyer, Christian G., Casadei, Nicolas, Sonnabend, Michael, Peter, Silke, Nurjadi, Dennis, Linh, Le Thi Kieu, Fendel, Rolf, Göpel, Siri, Riess, Olaf, Kremsner, Peter G., Velavan, Thirumalaisamy P.

Source: International journal of infectious diseases. 122:427-436

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195572745.0x000001&indx=1&recIds=ETOCvdc_100195572745.0x000001

Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

Authors: Lovesio, Luciano, Diez, Fabián, Grazziani, Franco, Ganaha, Maria Cristina, Zalatnik, Viviana Judith, Dittrich, Ricardo Julio, Espínola, Lidia, Lambert, Sandra, Longhi, Andrea, Vecchio, Claudia, Mastruzzo, María, Fernandez, Alberto, Borchowiek, Silvina, Potito, Roberto, Ahuad Guerrero, Rodolfo Andres, Guardiani, Fernando Martin, Castella, Sofia, Foccoli, Monica, Pedernera, Aldana, Braida, Ariel, Durigan, Virginia, Martella, Carolina, Bobat, Antonela, Boggia, Bruno Emilio, Nemi, Sergio Andrés, Tartaglione, Javier Gerardo, Piedimonte, Fabián César, De Bie, Jessie, Reynales Londoño, Humberto, Rodríguez Ordoñez, Paula Andrea, García Cruz, Johanna Marcela, Bautista Toloza, Leonardo, Ladino González, Margot Cecilia, Zambrano Ochoa, Adriana Pilar, Prieto Pradera, Iñigo, Torres Hernandez, Daniela, Mazo Elorza, Diana Patricia, Collazos Lennis, Maria Fernanda, Vanegas Dominguez, Beatriz, Solano Mosquera, Lina Marianur, Fendel, Rolf, Fleischmann, Wim Alexander, Koehne, Erik, Kreidenweiss, Andrea, Köhler, Carsten, Esen, Meral, Horn, Carola, Eberts, Sandra, Kroidl, Arne, Huber, Kristina, Thiel, Verena, Mazara Rosario, Sonia, Reyes, Gilda, Rivera, Laura, Donastorg, Yeycy, Lantigua, Flavia, Torres Almanzar, Dania, Candelario, Rosalba, Peña Mendez, Lourdes, Rosario Gomez, Nadia, Portolés-Pérez, Antonio, Ascaso del Río, Ana, Laredo Velasco, Leonor, Bustinduy Odriozola, Maria Jesus, Larrea Arranz, Igor, Martínez Alcorta, Luis Ignacio, Durán Laviña, María Isabel, Imaz-Ayo, Natale, Meijide, Susana, García-de-Vicuña, Aitor, Santorcuato, Ana, Gallego, Mikel, Aguirre-García, Gloria Mayela, Olmos Vega, Jocelyn, González Limón, Pablo, Vázquez Villar, Andrea, Chávez Barón, Jaime, Arredondo Saldaña, Felipe, Luján Palacios, Juan de Dios, Camacho Choza, Laura Julia, Vázquez Saldaña, Eduardo Gabriel, Ortega Dominguez, Sandra Janeth, Vega Orozco, Karen Sofia, Torres Quiroz, Ivonne Aimee, Martinez Avendaño, Alejandro, Herrera Sanchez, Javier, Guzman, Esperanza, Castro Castrezana, Laura, Ruiz Palacios y Santos, Guillermo Miguel, de Winter, Ronald Frank Jacobus, de Jonge, Hanna K, Schnyder, Jenny L, Boersma, Wim, Hessels, Lisa, Djamin, Remco, van der Sar, Simone, DeAntonio, Rodrigo, Peña, Moisés, Rebollon, Gabriel, Rojas, Marianela, Escobar, Johnny, Hammerschlag Icaza, Bruno, Wong T, Digna Y, Barrera Perigault, Paulo, Ruiz, Sergio, Chan, Milagros, Arias Hoo, Dommie Janneth, Gil, Ana I, Celis, Carlos R, Balmaceda, Maria Pia, Flores, Omar, Ochoa, Mayra, Peña, Bia, de la Flor, Carolina, Webb, Camille María, Cornejo, Enrique, Sanes, Fatima, Mayorga, Valerie, Valdiviezo, Gladys, Ramírez Lamas, Suzanne Pamela, Grandez Castillo, Gustavo Alberto, Lama, Javier R, Matta Aguirre, Milagros Erika, Arancibia Luna, Lesly Angela, Carbajal Paulet, Óscar, Zambrano Ortiz, José, Camara, Anais, Guzman Quintanilla, Fernanda, Diaz-Parra, Carmen, Morales-Oliva, Jose, Cornejo, Rubelio E, Ricalde, Sheby A, Vidal, Jhonny, Rios Nogales, Luis, Cheatham-Seitz, Darline, Gregoraci, Giorgia, Brecx, Alain, Walz, Lisa, Vahrenhorst, Dominik, Seibel, Tobias, Quintini, Gianluca, Kremsner, Peter G ^{*, *}, Ahuad Guerrero, Rodolfo Andrés, Arana-Arri, Eunate, Aroca Martinez, Gustavo Jose, Bonten, Marc, Chandler, Reynaldo, Corral, Gonzalo, De Block, Eddie Jan Louis, Ecker, Lucie, Gabor, Julian Justin, Garcia Lopez, Carlos Alberto, Gonzales, Lucy, Granados González, María Angélica, Gorini, Nestor, Grobusch, Martin P, Hrabar, Adrian D, Junker, Helga, Kimura, Alan, Lanata, Claudio F, Lehmann, Clara, Leroux-Roels, Isabel, Mann, Philipp, Martinez-Reséndez, Michel Fernando, Ochoa, Theresa J, Poy, Carlos Alberto, Reyes Fentanes, Maria Jose, Rivera Mejia, Luis Maria, Ruiz Herrera, Vida Veronica, Sáez-Llorens, Xavier, Schönborn-Kellenberger, Oliver, Schunk, Mirjam, Sierra Garcia, Alexandra, Vergara, Itziar, Verstraeten, Thomas, Vico, Marisa, Oostvogels, Lidia ^*

Source: In The Lancet Infectious Diseases March 2022 22(3):329-340

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells

Authors: Singh, Yogesh ^{a, b, f, ∗, 1}, Trautwein, Christoph ^{c, 1}, Fendel, Rolf ^{d, 1}, Krickeberg, Naomi ^d, Berezhnoy, Georgy ^c, Bissinger, Rosi ^e, Ossowski, Stephan ^{a, b}, Salker, Madhuri S. ^f, Casadei, Nicolas ^{a, b}, Riess, Olaf ^{a, b, ∗∗}

Source: In Heliyon June 2021 7(6)

Automated total nucleic acid extraction with magnetic beads for the detection of Plasmodium falciparum in large study cohorts.

Authors: Inoue, Juliana, Huber, Nina, Fendel, Rolf, Held, Jana

Source: Malaria Journal; 12/23/2024, Vol. 23 Issue 1, p1-8, 8p

Subject Terms: NUCLEIC acid isolation methods, NUCLEIC acids, PLASMODIUM falciparum, GENETIC transcription, MALARIA prevention

40 How FHR-1 deficiency affects the infection with the malaria pathogen Plasmodium falciparum

Authors: Reiß, Timo, Gonzalez-Delgado, Andres, Rosa, Thiago, Venrath, Jennifer, Bläsius, Katharina, Zipfel, Peter F., Bruchhaus, Iris, Bachmann, Anna, Fendel, Rolf, Skerka, Christine, Pradel, Gabriele

Source: Immunobiology. 228(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195973535.0x000001&indx=1&recIds=ETOCvdc_100195973535.0x000001

Monitoring the threatened utility of malaria rapid diagnostic tests by novel high-throughput detection of Plasmodium falciparum hrp2 and hrp3 deletions: A cross-sectional, diagnostic accuracy study

Authors: Kreidenweiss, Andrea, Trauner, Franziska, Rodi, Miriam, Koehne, Erik, Held, Jana, Wyndorps, Lea, Manouana, Gédéon Prince, McCall, Matthew, Adegnika, Ayola Akim, Lalremruata, Albert, Kremsner, Peter G., Fendel, Rolf, Sandri, Thaisa Lucas

Source: In EBioMedicine December 2019 50:14-22

Machine learning prediction of malaria vaccine efficacy based on antibody profiles.

Authors: Wistuba-Hamprecht, Jacqueline, Reuter, Bernhard, Fendel, Rolf, Hoffman, Stephen L., Campo, Joseph J., Felgner, Philip L., Kremsner, Peter G., Mordmüller, Benjamin, Pfeifer, Nico

Source: PLoS Computational Biology; 6/7/2024, Vol. 20 Issue 6, p1-23, 23p

Subject Terms: VACCINE effectiveness, MALARIA vaccines, SUPERVISED learning, MACHINE learning, SUPPORT vector machines, IMMUNOGLOBULINS

Evaluating Malaria Rapid Diagnostic Tests and Microscopy for Detecting Plasmodium Infection and Status of Plasmodium falciparum Histidine-Rich Protein 2/3 Gene Deletions in Southeastern Nigeria.

Authors: Ikegbunam, Moses, Maurer, Maike, Abone, Harrison, Ezeagwuna, Dorothy, Sandri, Thaisa Lucas, Esimone, Charles, Ojurongbe, Olusola, Woldearegai, Tamirat Gebru, Kreidenweiss, Andrea, Held, Jana, Fendel, Rolf

Source: American Journal of Tropical Medicine & Hygiene; May2024, Vol. 110 Issue 5, p902-909, 8p

The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections.

Authors: Wichers-Misterek, Jan Stephan^1,2,3, Krumkamp, Ralf^1,4, Held, Jana^5,6, von Thien, Heidrun^1,2,3, Wittmann, Irene⁷, Höppner, Yannick Daniel^1,2,3,4, Ruge, Julia M.^1,2,3,4, Moser, Kara⁸, Dara, Antoine⁸, Strauss, Jan^1,2,3, Esen, Meral^5,6,9, Fendel, Rolf^5,6, Sulyok, Zita^5,6, Jeninga, Myriam D.⁷, Kremsner, Peter G.^5,6,10, Sim, B. Kim Lee¹¹, Hoffman, Stephen L.¹¹, Duffy, Michael F.¹², Otto, Thomas D.¹³, Gilberger, Tim-Wolf^1,2,3

Source: PLoS Pathogens; 6/29/2023, Vol. 18 Issue 6, p1-27, 27p

Characterization of new anti-IL-6 antibodies revealed high potency candidates for intracellular cytokine detection and specific targeting of IL-6 receptor binding sites

Authors: Chouman, Karinna, Korioth-Schmitz, Birgit, Sack, Markus, Schmitz, Jörn Engelbert, Pham, Anh Tuan, Fischer, Rainer, Barth, Stefan, Klockenbring, Torsten, Fendel, Rolf

Source: European cytokine network. 29(2):59-72

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152387298.0x000001&indx=1&recIds=ETOCvdc_100152387298.0x000001

The efficient elimination of solid tumor cells by EGFR-specific and HER2-specific scFv-SNAP fusion proteins conjugated to benzylguanine-modified auristatin F

Authors: Woitok, Mira, Klose, Diana, Niesen, Judith, Richter, Wolfgang, Abbas, Muhammad, Stein, Christoph, Fendel, Rolf, Bialon, Magdalena, Püttmann, Christiane, Fischer, Rainer, Barth, Stefan, Kolberg, Katharina ^*

Source: In Cancer Letters 28 October 2016 381(2):323-330

A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor

Authors: Niesen, Judith, Hehmann-Titt, Grit, Woitok, Mira, Fendel, Rolf, Barth, Stefan, Fischer, Rainer, Stein, Christoph ^*

Source: In Cancer Letters 1 May 2016 374(2):229-240

Isolation and light chain shuffling of a Plasmodium falciparum AMA1-specific human monoclonal antibody with growth inhibitory activity

Authors: Seidel-Greven, Melanie, Addai-Mensah, Otchere, Spiegel, Holger, Chiegoua Dipah, Gwladys Nina, Schmitz, Stefan, Breuer, Gudrun, Frempong, Margaret, Reimann, Andreas, Klockenbring, Torsten, Fischer, Rainer, Barth, Stefan, Fendel, Rolf

Source: Malaria journal. 20(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191381491.0x000001&indx=1&recIds=ETOCvdc_100191381491.0x000001

SNAP-Tag Technology: A Useful Tool To Determine Affinity Constants and Other Functional Parameters of Novel Antibody Fragments

Authors: Niesen, Judith, Sack, Markus, Seidel, Melanie, Fendel, Rolf, Barth, Stefan, Fischer, Rainer, Stein, Christoph

Source: Bioconjugate chemistry. 27(8):1931-1941

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631258917&indx=1&recIds=ETOCRN631258917

Mucosal response of inactivated and recombinant COVID‐19 vaccines in Congolese individuals.

Authors: Mouzinga, Freisnel H., Heinzel, Constanze, Lissom, Abel, Kreidenweiss, Andrea, Batchi‐Bouyou, Armel L., Mbama Ntabi, Jacques D., Djontu, Jean C., Ngumbi, Etienne, Kremsner, Peter G., Fendel, Rolf, Ntoumi, Francine

Source: Immunity, Inflammation & Disease; Dec2023, Vol. 11 Issue 12, p1-11, 11p

Subject Terms: COVID-19 vaccines, BACTERIAL vaccines, COVID-19, BCG vaccines, ANTIBODY formation, ENZYME-linked immunosorbent assay, VACCINATION status

Schistosoma co-infection protects against brain pathology but does not prevent severe disease and death in a murine model of cerebral malaria

Authors: Bucher, Kirsten, Dietz, Klaus, Lackner, Peter, Pasche, Bastian, Fendel, Rolf, Mordmüller, Benjamin, Ben-Smith, Anne, Hoffmann, Wolfgang H.

Source: In International Journal for Parasitology 2011 41(1):21-31