International evaluation study of a highly efficient culture assay for detection of residual human pluripotent stem cells in cell therapies

Authors: Watanabe, Takeshi, Yasuda, Satoshi, Chen, Connie L, Delsing, Louise, Fellows, Mick D, Foldes, Gabor, Kusakawa, Shinji, Mouriès, Lucilia Pereira, Sato, Yoji

Source: Regenerative medicine. 18(3):219-227

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188685808.0x000001&indx=1&recIds=ETOCvdc_100188685808.0x000001

A cross-industry survey on photosafety evaluation of pharmaceuticals after implementation of ICH S10

Authors: Bauer, Daniel, Buckley, Lorrene A., Delafoy, Laure, Ellinger-Ziegelbauer, Heidrun, Fellows, Mick D., Gerets, Helga H.J., Howe, Jonathan, Kaijser, Gerry, Nicolette, John, Pettersen, Betty A., Schimpf, Brian

Source: In Regulatory Toxicology and Pharmacology October 2021 125

Improving the Assessment of Risk Factors Relevant to Potential Carcinogenicity of Gene Therapies: A Consensus Article.

Authors: Klapwijk, Jan C., Del Rio Espinola, Alberto, Libertini, Silvana, Collin, Philippe, Fellows, Mick D., Jobling, Susan, Lynch, Anthony M., Martus, HansJoerg, Vickers, Catherine, Zeller, Andreas, Biasco, Luca, Brugman, Martijn H., Bushmann, Frederic D., Cathomen, Toni, Ertl, Hildegrund C.J., Gabriel, Richard, Gao, Guangping, Jadlowsky, Julie K., Kimber, Ian, Lanz, Thomas A.

Source: Human Gene Therapy; Aug2024, Vol. 35 Issue 15/16, p527-542, 16p

Application of Microphysiological Systems for Nonclinical Evaluation of Cell Therapies.

Authors: Candarlioglu, Pelin L., Delsing, Louise, Gauthier, Lauren, Lewis, Lauren, Papadopoulos, George, Freag, May, Chan, Tom S., Homan, Kimberly A., Fellows, Mick D., Pointon, Amy, Kolaja, Kyle

Source: Altex; 2024, Vol. 41 Issue 3, p469-484, 16p

Extracellular vesicles induce minimal hepatotoxicity and immunogenicityElectronic supplementary information (ESI) available. See DOI: 10.1039/c8nr08720b

Authors: SalehThese authors contributed equally to this work., Amer F., Lázaro-Ibáñez, Elisa, Forsgard, Malin A.-M., Shatnyeva, Olga, Osteikoetxea, Xabier, Karlsson, Fredrik, Heath, Nikki, Ingelsten, Madeleine, Rose, Jonathan, Harris, Jayne, Mairesse, Maelle, Bates, Stephanie M., Clausen, Maryam, Etal, Damla, Leonard, Emilyanne, Fellows, Mick D., Dekker, Niek, Edmunds, Nicholas

Source: Nanoscale. 11(14):6990-7001

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100079445479.0x000001&indx=1&recIds=ETOCvdc_100079445479.0x000001

Discovery of benzothiazoles as antimycobacterial agents: Synthesis, structure–activity relationships and binding studies with Mycobacterium tuberculosis decaprenylphosphoryl-β-d-ribose 2′-oxidase

Authors: Landge, Sudhir, Mullick, Amrita B., Nagalapur, Kavitha, Neres, João, Subbulakshmi, Venkita, Murugan, Kannan, Ghosh, Anirban, Sadler, Claire, Fellows, Mick D., Humnabadkar, Vaishali, Mahadevaswamy, Jyothi, Vachaspati, Prakash, Sharma, Sreevalli, Kaur, Parvinder, Mallya, Meenakshi, Rudrapatna, Suresh, Awasthy, Disha, Sambandamurthy, Vasan K., Pojer, Florence, Cole, Stewart T., Balganesh, Tanjore S., Ugarkar, Bheemarao G., Balasubramanian, V., Bandodkar, Balachandra S., Panda, Manoranjan, Ramachandran, Vasanthi

Source: In Bioorganic & Medicinal Chemistry 15 December 2015 23(24):7694-7710

Targeting safety in the clinic for precise genome editing using CRISPR: a genotoxicologist's perspective

Authors: Fellows, Mick D

Source: Personalized medicine. 13(4):279-282

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138520676.0x000001&indx=1&recIds=ETOCvdc_100138520676.0x000001

Precision digital mapping of endogenous and induced genomic DNA breaks by INDUCE-seq.

Authors: Dobbs, Felix M., van Eijk, Patrick, Fellows, Mick D., Loiacono, Luisa, Nitsch, Roberto, Reed, Simon H.

Source: Nature Communications; 7/9/2022, Vol. 13 Issue 1, p1-11, 11p

Subject Terms: DOUBLE-strand DNA breaks, DIGITAL mapping, DIGITAL maps, GENOME editing, DNA damage, CRISPRS

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors

Authors: Poch, Christine M., Foo, Kylie S., De Angelis, Maria Teresa, Jennbacken, Karin, Santamaria, Gianluca, Bähr, Andrea, Wang, Qing-Dong, Reiter, Franziska, Hornaschewitz, Nadja, Zawada, Dorota, Bozoglu, Tarik, My, Ilaria, Meier, Anna, Dorn, Tatjana, Hege, Simon, Lehtinen, Miia L., Tsoi, Yat Long, Hovdal, Daniel, Hyllner, Johan, Schwarz, Sascha, Sudhop, Stefanie, Jurisch, Victoria, Sini, Marcella, Fellows, Mick D., Cummings, Matthew, Clarke, Jonathan, Baptista, Ricardo, Eroglu, Elif, Wolf, Eckhard, Klymiuk, Nikolai, Lu, Kun, Tomasi, Roland, Dendorfer, Andreas, Gaspari, Marco, Parrotta, Elvira, Cuda, Giovanni, Krane, Markus, Sinnecker, Daniel, Hoppmann, Petra, Kupatt, Christian, Fritsche-Danielson, Regina, Moretti, Alessandra, Chien, Kenneth R., Laugwitz, Karl-Ludwig

Source: Nature Cell Biology; May 2022, Vol. 24 Issue: 5 p659-671, 13p

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Extracellular vesicles induce minimal hepatotoxicity and immunogenicity.

Authors: Saleh, Amer F., Lázaro-Ibáñez, Elisa, Forsgard, Malin A.-M., Shatnyeva, Olga, Osteikoetxea, Xabier, Karlsson, Fredrik, Heath, Nikki, Ingelsten, Madeleine, Rose, Jonathan, Harris, Jayne, Mairesse, Maelle, Bates, Stephanie M., Clausen, Maryam, Etal, Damla, Leonard, Emilyanne, Fellows, Mick D., Dekker, Niek, Edmunds, Nicholas

Source: Nanoscale; 4/14/2019, Vol. 11 Issue 14, p6990-7001, 12p

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The 3T3 neutral red uptake phototoxicity test: Practical experience and implications for phototoxicity testing – The report of an ECVAM–EFPIA workshop

Authors: Ceridono, Mara, Tellner, Pär, Bauer, Daniel, Barroso, João, Alépée, Nathalie, Corvi, Raffaella, De Smedt, Ann, Fellows, Mick D., Gibbs, Neil K., Heisler, Eckhard, Jacobs, Abigail, Jirova, Dagmar, Jones, David, Kandárová, Helena, Kasper, Peter, Akunda, Jacqueline Kinyamu, Krul, Cyrille, Learn, Douglas, Liebsch, Manfred, Lynch, Anthony M., Muster, Wolfgang, Nakamura, Kazuichi, Nash, J. Frank, Pfannenbecker, Uwe, Phillips, Gareth, Robles, Catherine, Rogiers, Vera, Van De Water, Femke, Liminga, Ulla Wändel, Vohr, Hans-Werner, Wattrelos, Olivier, Woods, Julie, Zuang, Valérie, Kreysa, Joachim, Wilcox, Phil

Source: In Regulatory Toxicology and Pharmacology August 2012 63(3):480-488

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Investigating Mesenchymal Stem Cell Sources for VEGFA mRNA Transfection and In Vivo Protein Exposure

Authors: Menzies, Robert I., Graneli, Cecilia, Zhou, Alex X., Hong, Xuechong, Dahlqvist, Ulrika, Vaithilingam, Vijayaganapathy, Hölttä, Mikko, Henderson, Neil, Bates, Stephanie M., Fellows, Mick D., Forslöw, Anna, Zhu, Xiang yang, Ahlström, Christine, Boianelli, Alessandro, Hicks, Ryan, Lerman, Lilach O., Hansen, Pernille B. Laerkegaard

Source: Journal of the American Society of Nephrology; November 2023, Vol. 34 Issue: 11, Number 11 Supplement 11 p1072-1072, 1p

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