Spatial transcriptomic analysis identifies epithelium-macrophage crosstalk in endometriotic lesions

Authors: Burns, Gregory W. ¹, Fu, Zhen ², Vegter, Erin L. ¹, Madaj, Zachary B. ², Greaves, Erin ^{3, 4}, Flores, Idhaliz ^{5, 6}, Fazleabas, Asgerally T. ^{1, 7, ∗}

Source: In iScience 21 February 2025 28(2)

HMGA2 overexpression induces plasticity in myometrial cells and a transcriptomic profile more similar to that of uterine fibroids

Authors: Paul, Emmanuel N., Carpenter, Tyler J., Pavliscak, Laura A., Bennett, Abigail Z., Ochoa-Bernal, Maria Ariadna, Fazleabas, Asgerally T., Teixeira, Jose M.

Source: In F&S Science November 2024 5(4):369-378

A Call for New Theories on the Pathogenesis and Pathophysiology of Endometriosis

Authors: Canis, Michel, Abbott, Jason, Abrao, Mauricio, Al-Jefout, Moamar, Bedaiwy, Mohamed, Benagiano, Giuseppe, Burns, Katherine A., Carmona, Francisco, Chapron, Charles, Critchley, Hilary O.D., de Ziegler, Dominique, Falcone, Tommaso, Fazleabas, Asgerally, Ferrero, Simone, Garcia-Velasco, Juan A., Gargett, Caroline, Greaves, Erin, Griffith, Linda G., Guo, Sun-Wei, Habiba, Marwan, Harada, Tasuku, Hull, Mary Louise, Johnson, Neil P., Kaufman, Yuval, Issacson, Keith B, Khan, Khaleque N., Kim, Mee-Ran, Koninckx, Philippe A., Lessey, Bruce A., Martin, Dan, Matsuzaki, Sachiko, Mishra, Gita, Osuga, Yutaka, Petraglia, Felice, Popov, Alexander, Roman, Horace, Romano, Andrea, Saunders, Philippa, Seckin, Tamer, Somigliana, Edgardo, Taylor, Hugh S., Taylor, Robert N., Vercellini, Paolo, Vigano, Paola

Source: In The Journal of Minimally Invasive Gynecology May 2024 31(5):371-377

The Known, the Unknown and the Future of the Pathophysiology of Endometriosis.

Authors: Ochoa Bernal, Maria Ariadna^1,2 (AUTHOR) ochoaber@msu.edu, Fazleabas, Asgerally T.¹ (AUTHOR) fazleaba@msu.edu

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5815. 34p.

Subject Terms: *ENDOMETRIUM, *ENDOMETRIOSIS, *CHILDBEARING age, *ETIOLOGY of diseases, *PATHOLOGICAL physiology, *PERITONEUM, *INFERTILITY

YAP1 and WWTR1 are required for murine pregnancy initiation.

Authors: Moldovan, Genna E., Massri, Noura, Vegter, Erin L., Pauneto-Delgado, Ivonne N., Burns, Gregory W., Joshi, Niraj, Gu, Bin, Arora, Ripla, Fazleabas, Asgerally T.

Source: Reproduction; Jan2025, Vol. 169 Issue 1, p1-13, 13p

Subject Terms: EPIDERMAL growth factor, YAP signaling proteins, HIPPO signaling pathway, PROGESTERONE receptors, EMBRYOLOGY

Notch signaling in reproduction

Authors: Moldovan, Genna E., Miele, Lucio, Fazleabas, Asgerally T.

Source: In Trends in Endocrinology & Metabolism December 2021 32(12):1044-1057

Clinical consequences of defective decidualization

Authors: Ticconi, Carlo ^*, Di Simone, Nicoletta, Campagnolo, Luisa, Fazleabas, Asgerally

Source: In Tissue and Cell October 2021 72

Cellular heterogeneity and dynamics of the human uterus in healthy premenopausal women.

Authors: Ulrich, Nicole D., Vargo, Alex, Qianyi Ma, Yu-chi Shen, Bazzano, Dominic, Hannum, D. Ford, Gurczynski, Stephen J., Moore, Bethany B., Schon, Samantha, Lieberman, Richard, Shikanov, Ariella, Marsh, Erica E., Fazleabas, Asgerally, Li, Jun Z., Hammoud, Saher Sue

Source: Proceedings of the National Academy of Sciences of the United States of America; 11/5/2024, Vol. 121 Issue 45, p1-12, 52p

Subject Terms: MESSENGER RNA, GENE expression, MENSTRUAL cycle, PROGENITOR cells, MYOMETRIUM

ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

Authors: Wilson, Mike R., Reske, Jake J., Holladay, Jeanne, Neupane, Subechhya, Ngo, Julie, Cuthrell, Nina, Wegener, Marc, Rhodes, Mary, Adams, Marie, Sheridan, Rachael, Hostetter, Galen, Alotaibi, Fahad T., Yong, Paul J., Anglesio, Michael S., Lessey, Bruce A., Leach, Richard E., Teixeira, Jose M., Missmer, Stacey A., Fazleabas, Asgerally T., Chandler, Ronald L.

Source: In Cell Reports 10 November 2020 33(6)

Aberrant activation of Notch1 signaling in the mouse uterine epithelium promotes hyper‐proliferation by increasing estrogen sensitivity

Authors: Xu, Qi‐Xin, Madhavan, Manoj, Wei, Shu‐Wen, Zhang, Wang‐Qing, Lu, Lei, Wang, Ke‐Zhi, Genna, Moldovan, Song, Yong, Zhao, Yu, Shao, Huan‐Ting, Kang, Jin‐Wen, Fazleabas, Asgerally T., Arora, Ripla, Su, Ren‐Wei

Source: FASEB journal. 37(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188533942.0x000001&indx=1&recIds=ETOCvdc_100188533942.0x000001

Interleukin-6 (IL-6) Activates the NOTCH1 Signaling Pathway Through E-Proteins in Endometriotic Lesions

Authors: Song, Yong, Su, Ren-Wei, Joshi, Niraj R, Kim, Tae Hoon, Lessey, Bruce A, Jeong, Jae-Wook, Fazleabas, Asgerally T

Source: Journal of clinical endocrinology & metabolism. 105(5):1316-1326

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100114470557.0x000001&indx=1&recIds=ETOCvdc_100114470557.0x000001

Establishment of an Immortalized Endometriotic Stromal Cell Line from Human Ovarian Endometrioma

Authors: Song, Yong, Joshi, Niraj R., Vegter, Erin, Hrbek, Samantha, Lessey, Bruce A., Fazleabas, Asgerally T.

Source: Reproductive sciences. 27(11):2082-2091

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173616217.0x000001&indx=1&recIds=ETOCvdc_100173616217.0x000001

The Regulation of MicroRNA-21 by Interleukin-6 and Its Role in the Development of Fibrosis in Endometriotic Lesions.

Authors: Ochoa Bernal, Maria Ariadna, Song, Yong, Joshi, Niraj, Burns, Gregory W., Paul, Emmanuel N., Vegter, Erin, Hrbek, Samantha, Sempere, Lorenzo F., Fazleabas, Asgerally T.

Source: International Journal of Molecular Sciences; Aug2024, Vol. 25 Issue 16, p8994, 24p

Subject Terms: TRANSFORMING growth factors-beta, GENE expression, CHILDBEARING age, PERITONEUM, EPITHELIAL cells

Icon immunoconjugate treatment results in regression of red lesions in a non-human primate (Papio anubis) model of endometriosis

Authors: Hufnagel, Demetra, Goetz, Teddy G., Hu, Zhiwei, Nyachieo, Atunga, D’Hooghe, Thomas, Fazleabas, Asgerally, Duleba, Antoni, Krikun, Graciela, Taylor, Hugh S., Lockwood, Charles J.

Source: In Reproductive Biology March 2018 18(1):109-114

Authors’ Reply

Authors: Canis, Michel, Abbott, Jason, Abrao, Mauricio, Al-Jefout, Moamar, Bedaiwy, Mohamed, Benagiano, Giuseppe, Burns, Katherine A., Carmona, Francisco, Chapron, Charles, Critchley, Hilary, de Ziegler, Dominique, Falcone, Tommaso, Fazleabas, Asgerally, Ferrero, Simone, Garcia-Velasco, Juan G., Gargett, Caroline, Greaves, Erin, Griffith, Linda, Habiba, Marwan, Harada, Tasuku, Hull, Mary, Kaufman, Yuval, Issacson, Keith, Khan, Khaleque, Kim, Mee-ran, Koninckx, Philippe, Lessey, Bruce, Martin, Dan, Matsuzaki, Sachiko, Mishra, Gita, Osuga, Yutaka, Petraglia, Felice, Popov, Alexander, Roman, Horace, Romano, Andrea, Seckin, Tamer, Saounders, Philippa, Somigliana, Edgardo, Guo, Sun-Wei, Taylor, Hugh, Vercellini, Paolo, Vigano, Paola, Johnson, Neil P.

Source: In The Journal of Minimally Invasive Gynecology July 2024 31(7):624-626

The Notch Family Transcription Factor, RBPJκ, Modulates Glucose Transporter and Ovarian Steroid Hormone Receptor Expression During Decidualization

Authors: Strug, Michael R., Su, Ren-Wei, Kim, Tae Hoon, Jeong, Jae-Wook, Fazleabas, Asgerally

Source: Reproductive sciences. 26(6):774-784

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN620895075&indx=1&recIds=ETOCRN620895075

ARID1A and PI3-kinase pathway mutations in the endometrium drive epithelial transdifferentiation and collective invasion

Authors: Wilson, Mike, Reske, Jake, Holladay, Jeanne, Wilber, Genna, Rhodes, Mary, Koeman, Julie, Adams, Marie, Johnson, Ben, Su, Ren-Wei, Joshi, Niraj, Patterson, Amanda, Shen, Hui, Leach, Richard, Teixeira, Jose, Fazleabas, Asgerally, Chandler, Ronald

Source: Nature communications. 10(1):1-18

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189204247.0x000001&indx=1&recIds=ETOCvdc_100189204247.0x000001

Bisphenol A impairs decidualization of human uterine stromal fibroblasts

Authors: Olson, Mark R., Su, Renwei, Flaws, Jodi A., Fazleabas, Asgerally T.

Source: In Reproductive Toxicology October 2017 73:339-344

Modulation of the Baboon (Papio anubis) Uterine Endometrium by Chorionic Gonadotrophin during the Period of Uterine Receptivity

Authors: Fazleabas, Asgerally T., Donnelly, Kathleen M., Srinivasan, Sudha, Fortman, Jeffrey D., Miller, Josephine B.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1999 Mar 01. 96(5), 2543-2548.

Access URL: https://www.jstor.org/stable/47098

Macrophage Migration Inhibitory Factor Receptor, CD74, is Overexpressed in Human and Baboon (Papio Anubis) Endometriotic Lesions and Modulates Endometriotic Epithelial Cell Survival and Interleukin 8 Expression

Authors: Nothnick, Warren B., Falcone, Tommaso, Olson, Mark R., Fazleabas, Asgerally T., Tawfik, Ossama W., Graham, Amanda

Source: Reproductive sciences. 25(11):1557-1566

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN617933457&indx=1&recIds=ETOCRN617933457