Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1α and nuclear factor erythroid 2-related factor 2.

Authors: Ghosh, Rajeshwary^1,2 (AUTHOR) rghosh7@uthsc.edu, Fatahian, Amir Nima¹ (AUTHOR), Rouzbehani, Omid M T¹ (AUTHOR), Hathaway, Marissa A¹ (AUTHOR), Mosleh, Tariq¹ (AUTHOR), Vinod, Vishaka¹ (AUTHOR), Vowles, Sidney¹ (AUTHOR), Stephens, Sophie L¹ (AUTHOR), Chung, Siu-Lai Desmond¹ (AUTHOR), Cao, Isaac D¹ (AUTHOR), Jonnavithula, Anila¹ (AUTHOR), Symons, J David^1,2 (AUTHOR), Boudina, Sihem^1,2 (AUTHOR) sboudina@u2m2.utah.edu

Source: Cardiovascular Research. Apr2024, Vol. 120 Issue 5, p531-547. 17p.

Subject Terms: *NUCLEAR factor E2 related factor, *HYPOXIA-inducible factors, *HEART diseases

Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-β Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice.

Authors: Bo Sun, Rouzbehani, Omid M. T., Kramer, Ryan J., Ghosh, Rajeshwary, Perelli, Robin M., Atkins, Sage, Fatahian, Amir Nima, Davis, Kathryn, Szulik, Marta W., Goodman, Michael A., Hathaway, Marissa A., Chi, Ellenor, Word, Tarah A., Tunuguntla, Hari, Denfield, Susan W., Wehrens, Xander H. T., Whitehead, Kevin J., Abdelnasser, Hala Y., Warren, Junco S., Mingfu Wu

Source: Circulation: Heart Failure; Dec2023, Vol. 16 Issue 12, p1066-1082, 17p