Computational Design, Synthesis, and Biological Evaluation of Diimidazole Analogues Endowed with Dual PCSK9/HMG-CoAR-Inhibiting Activity

Authors: Lammi, Carmen, Fassi, Enrico M. A., Manenti, Marco, Brambilla, Marta, Conti, Maria, Li, Jianqiang, Roda, Gabriella, Camera, Marina, Silvani, Alessandra, Grazioso, Giovanni

Source: Journal of medicinal chemistry. 66(12):7943-7958

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633150173&indx=1&recIds=ETOCRN633150173

Mechanistic Insights into the Antibiofilm Mode of Action of Ellagic Acid.

Authors: Ratti, Alessandro¹ (AUTHOR) alessandro.ratti@unimi.it, Fassi, Enrico M. A.¹ (AUTHOR) enrico.fassi@unimi.it, Forlani, Fabio² (AUTHOR) fabio.forlani@unimi.it, Mori, Matteo¹ (AUTHOR) matteo.mori@unimi.it, Villa, Federica² (AUTHOR) francesca.cappitelli@unimi.it, Cappitelli, Francesca² (AUTHOR), Sgrignani, Jacopo³ (AUTHOR) jacopo.sgrignani@irb.usi.ch, Roda, Gabriella¹ (AUTHOR) gabriella.roda@unimi.it, Cavalli, Andrea^3,4 (AUTHOR) andera.cavalli@irb.usi.ch, Villa, Stefania¹ (AUTHOR) stefania.villa@unimi.it, Grazioso, Giovanni¹ (AUTHOR) fabio.forlani@unimi.it

Source: Pharmaceutics. Jun2023, Vol. 15 Issue 6, p1757. 16p.

Subject Terms: *ELLAGIC acid, *REACTIVE oxygen species, *ESCHERICHIA coli, *NAD (Coenzyme)

Computational Design, Synthesis, and Biophysical Evaluation of β-Amido Boronic Acids as SARS-CoV-2 M pro Inhibitors.

Authors: Fassi, Enrico M. A.¹ (AUTHOR), Manenti, Marco² (AUTHOR), Citarella, Andrea² (AUTHOR), Dei Cas, Michele³ (AUTHOR), Casati, Sara⁴ (AUTHOR), Micale, Nicola⁵ (AUTHOR), Schirmeister, Tanja⁶ (AUTHOR), Roda, Gabriella¹ (AUTHOR), Silvani, Alessandra² (AUTHOR) alessandra.silvani@unimi.it, Grazioso, Giovanni¹ (AUTHOR) alessandra.silvani@unimi.it

Source: Molecules. Mar2023, Vol. 28 Issue 5, p2356. 18p.

Subject Terms: *BORONIC acids, *SARS-CoV-2, *SMALL molecules, *VIRUS diseases, *VIRAL genomes, *MONOCLONAL antibodies

Company/Entity: UNITED States. Food & Drug Administration

Exploring Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Autoproteolysis Process by Molecular Simulations: Hints for Drug Design

Authors: Sgrignani, Jacopo, Fassi, Enrico M. A., Lammi, Carmen, Roda, Gabriella, Grazioso, Giovanni

Source: ChemMedChem. 15(16):1601-1607

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107440942.0x000001&indx=1&recIds=ETOCvdc_100107440942.0x000001

Computational Design and Biological Evaluation of Analogs of Lupin Peptide P5 Endowed with Dual PCSK9/HMG-CoAR Inhibiting Activity.

Authors: Lammi, Carmen¹ (AUTHOR) carmen.lammi@unimi.it, Fassi, Enrico M. A.¹ (AUTHOR), Li, Jianqiang¹ (AUTHOR), Bartolomei, Martina¹ (AUTHOR), Benigno, Giulia¹ (AUTHOR), Roda, Gabriella¹ (AUTHOR), Arnoldi, Anna¹ (AUTHOR), Grazioso, Giovanni¹ (AUTHOR) carmen.lammi@unimi.it

Source: Pharmaceutics. Mar2022, Vol. 14 Issue 3, p665. 19p.

Subject Terms: *PEPTIDES, *BIOLOGICAL assay, *LIPOPROTEIN receptors, *PROTEIN-protein interactions, *SUBTILISINS

Unlocking the Antibiofilm Potential of Natural Compounds by Targeting the NADH:quinone Oxidoreductase WrbA.

Authors: Ratti, Alessandro, Fassi, Enrico M. A., Forlani, Fabio, Zangrossi, Maurizio, Mori, Matteo, Cappitelli, Francesca, Roda, Gabriella, Villa, Stefania, Villa, Federica, Grazioso, Giovanni

Source: Antioxidants; Aug2023, Vol. 12 Issue 8, p1612, 17p

Subject Terms: NAD (Coenzyme), QUINONE, ELLAGIC acid, REACTIVE oxygen species, SALICYLIC acid, DRUG target, DIGITAL libraries

Elagolix Sodium Salt and Its Synthetic Intermediates: A Spectroscopic, Crystallographic, and Conformational Study.

Authors: Ciceri, Samuele, Colombo, Diego, Fassi, Enrico M. A., Ferraboschi, Patrizia, Grazioso, Giovanni, Grisenti, Paride, Iannone, Marco, Castellano, Carlo, Meneghetti, Fiorella

Source: Molecules; May2023, Vol. 28 Issue 9, p3861, 21p

Subject Terms: LUTEINIZING hormone releasing hormone receptors, CONFORMATIONAL analysis, ENDOMETRIOSIS, DRUG discovery, UTERINE fibroids, HORMONE receptors, DRUG analysis

Computational Design, Synthesis, and Biological Evaluation of Diimidazole Analogues Endowed with Dual PCSK9/HMG-CoAR-Inhibiting Activity

Authors: Lammi, Carmen, Fassi, Enrico M. A., Manenti, Marco, Brambilla, Marta, Conti, Maria, Li, Jianqiang, Roda, Gabriella, Camera, Marina, Silvani, Alessandra, Grazioso, Giovanni

Source: Journal of Medicinal Chemistry; 20240101, Issue: Preprints

Computational Analysis of Dengue Virus Envelope Protein (E) Reveals an Epitope with Flavivirus Immunodiagnostic Potential in Peptide Microarrays.

Authors: Bergamaschi, Greta¹ gretabergamaschi@gmail.com, Fassi, Enrico M. A.¹ fassi.enrico@yahoo.it, Romanato, Alessandro¹ alessandro.romanato@icrm.cnr.it, D'Annessa, Ilda¹ dnnldi00@uniroma2.it, Odinolfi, Maria Teresa¹ tea.odinolfi@gmail.com, Brambilla, Dario¹ dario.brambilla@icrm.cnr.it, Damin, Francesco¹ francesco.damin@icrm.cnr.it, Chiari, Marcella¹ marcella.chiari@icrm.cnr.it, Gori, Alessandro¹ alessandro.gori@icrm.cnr.it, Colombo, Giorgio^1,2 g.colombo@unipv.it, Cretich, Marina¹ g.colombo@unipv.it

Source: International Journal of Molecular Sciences. Apr2019, Vol. 20 Issue 8, p1921-1921. 1p. 1 Diagram, 1 Chart, 3 Graphs.

Subject Terms: *MOSQUITO vectors, *MOLECULAR dynamics, *ZIKA virus infections, *IMMUNOTHERAPY, *CHEMOSELECTIVITY