Bariatric surgery and alcohol and substance use: A case-control survey study

Authors: Speed, Shannon N. ^a, Sherman, Garrick T. ^c, Wang, Tammy ^a, Pince, Claire L. ^a, Sanfilippo, Jenna E. ^a, Montemitro, Chiara ^b, Giorgi, Salvatore ^d, Curtis, Brenda L. ^d, Farinelli, Lisa A. ^a, Farokhnia, Mehdi ^a, Leggio, Lorenzo ^{a, ⁎}

Source: In Drug and Alcohol Dependence 1 February 2025 267

IUPHAR review – Glucagon-like peptide-1 (GLP-1) and substance use disorders: An emerging pharmacotherapeutic target

Authors: Bruns VI, Nicolaus, Tressler, Elizabeth H., Vendruscolo, Leandro F., Leggio, Lorenzo, Farokhnia, Mehdi

Source: In Pharmacological Research September 2024 207

The crosstalk between fibroblast growth factor 21 (FGF21) system and substance use

Authors: Wang, Tammy ^{1, 2, 5}, Tyler, Ryan E. ^{1, 5}, Ilaka, Oyenike ^{1, 3}, Cooper, Diane ⁴, Farokhnia, Mehdi ^{1, 6}, Leggio, Lorenzo ^{1, 6, ∗}

Source: In iScience 19 July 2024 27(7)

Lifetime use of alcohol and cannabis among U.S. adolescents across age: Exploring differential patterns by sex and race/ethnicity using the 2019 NSDUH data

Authors: Farokhnia, Mehdi, Harris, Julia C., Speed, Shannon N., Leggio, Lorenzo, Johnson, Renee M.

Source: In Drug and Alcohol Dependence Reports March 2024 10

Role of aldosterone and mineralocorticoid receptor (MR) in addiction: A scoping review

Authors: Pince, Claire L., Whiting, Kimberly E., Wang, Tammy, Lékó, András H., Farinelli, Lisa A., Cooper, Diane, Farokhnia, Mehdi, Vendruscolo, Leandro F., Leggio, Lorenzo

Source: In Neuroscience and Biobehavioral Reviews November 2023 154

Reduced drug use as an alternative valid outcome in individuals with stimulant use disorders: Findings from 13 multisite randomized clinical trials.

Authors: Amin‐Esmaeili, Masoumeh^1,2 mamines1@jhu.edu, Farokhnia, Mehdi^1,3, Susukida, Ryoko¹, Leggio, Lorenzo^3,4,5,6, Johnson, Renee M.¹, Crum, Rosa M.^1,7,8, Mojtabai, Ramin^1,8

Source: Addiction. May2024, Vol. 119 Issue 5, p833-843. 11p.

Subject Terms: *SUBSTANCE abuse treatment, *COCAINE, *SUBSTANCE abuse, *SECONDARY analysis, *METHAMPHETAMINE, *RISK-taking behavior, *STATISTICAL significance, *CENTRAL nervous system stimulants, *LOGISTIC regression analysis, *TREATMENT effectiveness, *SEVERITY of illness index, *DESCRIPTIVE statistics, *HARM reduction, *ODDS ratio, *URINALYSIS, *CONFIDENCE intervals, *DATA analysis software, *COMORBIDITY, *MENTAL depression

Geographic Terms: UNITED States

Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor

Authors: Deschaine, Sara L., Hedegaard, Morten A., Pince, Claire L., Farokhnia, Mehdi, Moose, Jacob E., Stock, Ingrid A., Adusumalli, Sravani, Akhlaghi, Fatemeh, Hougland, James L., Sulima, Agnieszka, Rice, Kenner C., Koob, George F., Vendruscolo, Leandro F., Holst, Birgitte, Leggio, Lorenzo ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics August 2023 386(2):117-128

Alcohol consumption and childhood trauma impact serum immunoglobulin levels in patients with alcohol use disorder.

Authors: Abshire, Kelly M., Schwandt, Melanie L., Diazgranados, Nancy, Farokhnia, Mehdi, Leggio, Lorenzo

Source: Alcohol, Clinical & Experimental Research; Mar2025, Vol. 49 Issue 3, p599-608, 10p

Subject Terms: STATISTICAL correlation, RESEARCH funding, IMMUNOGLOBULINS, QUESTIONNAIRES, ALCOHOLIC liver diseases, IMMUNE system, SEVERITY of illness index, EMOTIONAL trauma, ALCOHOL-induced disorders, RESEARCH, ALCOHOL drinking, ALCOHOLISM, ANXIETY disorders, ADVERSE childhood experiences, PEOPLE with alcoholism, DISEASE progression, DISEASE risk factors

Changes in plasma ghrelin levels following surgical and non-surgical weight-loss in female rats predict alcohol use

Authors: Orellana, Elise, Horvath, Nelli, Farokhnia, Mehdi, Leggio, Lorenzo, Hajnal, Andras

Source: Brain research bulletin. 188:179-186

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168990921.0x000001&indx=1&recIds=ETOCvdc_100168990921.0x000001

Role of the ghrelin system in alcohol use disorder and alcohol‐associated liver disease: A narrative review

Authors: Kharbanda, Kusum K., Farokhnia, Mehdi, Deschaine, Sara L., Bhargava, Raghav, Rodriguez‐Flores, Marcela, Casey, Carol A., Goldstone, Anthony P., Jerlhag, Elisabet, Leggio, Lorenzo, Rasineni, Karuna

Source: Alcoholism. 46(12):2149-2159

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168733677.0x000001&indx=1&recIds=ETOCvdc_100168733677.0x000001

Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review

Authors: Nicolas, Céline ^{1, *}, Zlebnik, Natalie E. ^{1, *}, Farokhnia, Mehdi, Leggio, Lorenzo, Ikemoto, Satoshi, Shaham, Yavin ^*

Source: In Pharmacological Reviews January 2022 74(1):119-140

Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder

Authors: Kärkkäinen, Olli, Farokhnia, Mehdi, Klåvus, Anton, Auriola, Seppo, Lehtonen, Marko, Deschaine, Sara L., Piacentino, Daria, Abshire, Kelly M., Jackson, Shelley N., Leggio, Lorenzo

Source: Alcoholism. 45(11):2207-2216

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135743198.0x000001&indx=1&recIds=ETOCvdc_100135743198.0x000001

Neuroendocrine Response to Exogenous Ghrelin Administration, Combined With Alcohol, in Heavy-Drinking Individuals: Findings From a Randomized, Double-Blind, Placebo-Controlled Human Laboratory Study

Authors: Farokhnia, Mehdi, Abshire, Kelly M, Hammer, Aaron, Deschaine, Sara L, Saravanakumar, Anitha, Cobbina, Enoch, You, Zhi-Bing, Haass-Koffler, Carolina L, Lee, Mary R, Akhlaghi, Fatemeh, Leggio, Lorenzo

Source: International journal of neuropsychopharmacology. 24(6):464-476

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123915418.0x000001&indx=1&recIds=ETOCvdc_100123915418.0x000001

Racial Differences in the Association Between Alcohol Drinking and Cigarette Smoking: Preliminary Findings From an Alcohol Research Program

Authors: Harris, Julia C, Mereish, Ethan H, Faulkner, Monica L, Assari, Shervin, Choi, Kelvin, Leggio, Lorenzo, Farokhnia, Mehdi

Source: Alcohol and alcoholism. 57(3):330-339

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165584509.0x000001&indx=1&recIds=ETOCvdc_100165584509.0x000001

Effects of exogenous ghrelin administration and ghrelin receptor blockade, in combination with alcohol, on peripheral inflammatory markers in heavy-drinking individuals: Results from two human laboratory studies

Authors: Farokhnia, Mehdi, Portelli, Jeanelle, Lee, Mary R., McDiarmid, Gray R., Munjal, Vikas, Abshire, Kelly M., Battista, Jillian T., Browning, Brittney D., Deschaine, Sara L., Akhlaghi, Fatemeh, Leggio, Lorenzo

Source: In Brain Research 1 August 2020 1740

Endocrine effects of the novel ghrelin receptor inverse agonist PF-5190457: Results from a placebo-controlled human laboratory alcohol co-administration study in heavy drinkers

Authors: Lee, Mary R., Farokhnia, Mehdi, Cobbina, Enoch, Saravanakumar, Anitha, Li, Xiaobai, Battista, Jillian T., Farinelli, Lisa A., Akhlaghi, Fatemeh, Leggio, Lorenzo

Source: In Neuropharmacology 15 June 2020 170

A human laboratory study on the link between alcohol administration and circulating fibroblast growth factor 21 (FGF21) in individuals with alcohol use disorder

Authors: Farokhnia, Mehdi, Wang, Tammy, Jourdan, Tony, Godlewski, Grzegorz, Farinelli, Lisa A., Kunos, George, Leggio, Lorenzo

Source: Drug and alcohol dependence. 245

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185615304.0x000001&indx=1&recIds=ETOCvdc_100185615304.0x000001

Investigating the relationship between early life adversity, inflammation and alcohol use

Authors: Battista, Jillian T., Piacentino, Daria, Schwandt, Melanie L., Lee, Mary R., Faulkner, Monica L., Farokhnia, Mehdi, Leggio, Lorenzo

Source: Addiction biology. 28(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181414633.0x000001&indx=1&recIds=ETOCvdc_100181414633.0x000001

Intravenous administration of ghrelin increases serum cortisol and aldosterone concentrations in heavy-drinking alcohol-dependent individuals: Results from a double-blind, placebo-controlled human laboratory study

Authors: Haass-Koffler, Carolina L., Long, Victoria M., Farokhnia, Mehdi, Magill, Molly, Kenna, George A., Swift, Robert M., Leggio, Lorenzo

Source: In Neuropharmacology 1 November 2019 158

Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder

Authors: Farokhnia, Mehdi, Faulkner, Monica L., Piacentino, Daria, Lee, Mary R., Leggio, Lorenzo

Source: In Physiology & Behavior 15 May 2019 204:49-57