FGFR Inhibition in Urothelial Carcinoma

Authors: Li, Roger ^{a, b, ⁎}, Linscott, Joshua ^a, Catto, James W.F. ^c, Daneshmand, Siamak ^d, Faltas, Bishoy M. ^e, Kamat, Ashish M. ^f, Meeks, Joshua J. ^g, Necchi, Andrea ^{h, i}, Pradere, Benjamin ^j, Ross, Jeffrey S. ^{k, l}, van der Heijden, Michiel S. ^m, van Rhijn, Bas W.G. ⁿ, Loriot, Yohann ^o

Source: In European Urology February 2025 87(2):110-122

Novel Use of Circulating Tumor DNA to Identify Muscle-invasive and Non–organ-confined Upper Tract Urothelial Carcinoma

Authors: Huelster, Heather L., Gould, Billie, Schiftan, Elizabeth A., Camperlengo, Lucia, Davaro, Facundo, Rose, Kyle M., Soupir, Alex C., Jia, Shidong, Zheng, Tiantian, Sexton, Wade J., Pow-Sang, Julio, Spiess, Philippe E., Daniel Grass, G., Wang, Liang, Wang, Xuefeng, Vosoughi, Aram, Necchi, Andrea, Meeks, Joshua J., Faltas, Bishoy M., Du, Pan, Li, Roger

Source: In European Urology March 2024 85(3):283-292

Integration of whole-exome and anchored PCR-based next generation sequencing significantly increases detection of actionable alterations in precision oncology

Authors: Beg, Shaham, Bareja, Rohan, Ohara, Kentaro, Eng, Kenneth Wha, Wilkes, David C., Pisapia, David J., Zoughbi, Wael Al, Kudman, Sarah, Zhang, Wei, Rao, Rema, Manohar, Jyothi, Kane, Troy, Sigouros, Michael, Xiang, Jenny Zhaoying, Khani, Francesca, Robinson, Brian D., Faltas, Bishoy M., Sternberg, Cora N., Sboner, Andrea, Beltran, Himisha, Elemento, Olivier, Mosquera, Juan Miguel

Source: In Translational Oncology January 2021 14(1)

Urine Biopsy as Dynamic Biomarker to Enhance Clinical Staging of Bladder Cancer in Radical Cystectomy Candidates.

Authors: Satyal, Uttam, Valentine, Henkel, Liu, David, Slifker, Michael, Lallas, Costas D., Trabulsi, Edouard J., Bukavina, Laura, Szeto, Lauren, Hoffman-Censits, Jean H., Mouw, Kent W., Faltas, Bishoy M., Grivas, Petros, Ibragimova, Ilsiya, Porten, Sima P., Van Allen, Eliezer M., Geynisman, Daniel M., Parker, Daniel C., O'Neill, John P., Drevik, Johnathan, Christianson, Sarah S.

Source: JCO Precision Oncology; 12/1/2024, Vol. 8, p1-10, 10p

Subject Terms: NEOADJUVANT chemotherapy, TRANSITIONAL cell carcinoma, URINALYSIS, CANCER patients, CISPLATIN, BLADDER cancer

Molecular Characterization of Upper Tract Urothelial Carcinoma in the Era of Next-generation Sequencing: A Systematic Review of the Current Literature

Authors: Hassler, Melanie R., Bray, Freddie, Catto, James W.F., Grollman, Arthur P., Hartmann, Arndt, Margulis, Vitaly, Matin, Surena F., Roupret, Morgan, Sfakianos, John P., Shariat, Shahrokh F. ^⁎, Faltas, Bishoy M.

Source: In European Urology August 2020 78(2):209-220

Proteomic and genomic signatures of repeat instability in cancer and adjacent normal tissues

Authors: Persi, Erez, Prandi, Davide, Wolf, Yuri I., Pozniak, Yair, Barnabas, Georgina D., Levanon, Keren, Barshack, Iris, Barbieri, Christopher, Gasperini, Paola, Beltran, Himisha, Faltas, Bishoy M., Rubin, Mark A., Geiger, Tamar, Koonin, Eugene V., Demichelis, Francesca, Horn, David

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Aug . 116(34), 16987-16996.

Access URL: https://www.jstor.org/stable/26850572

Clinical features of neuroendocrine prostate cancer

Authors: Conteduca, Vincenza, Oromendia, Clara, Eng, Kenneth W., Bareja, Rohan, Sigouros, Michael, Molina, Ana, Faltas, Bishoy M., Sboner, Andrea, Mosquera, Juan Miguel, Elemento, Olivier, Nanus, David M., Tagawa, Scott T., Ballman, Karla V., Beltran, Himisha

Source: In European Journal of Cancer November 2019 121:7-18

The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution

Authors: Nguyen, Duy D., Hooper, William F., Liu, Weisi, Chu, Timothy R., Geiger, Heather, Shelton, Jennifer M., Shah, Minita, Goldstein, Zoe R., Winterkorn, Lara, Helland, Adrienne, Sigouros, Michael, Manohar, Jyothi, Moyer, Jenna, Al Assaad, Majd, Semaan, Alissa, Cohen, Sandra, Madorsky Rowdo, Florencia, Wilkes, David, Osman, Mohamed, Singh, Rahul R., Sboner, Andrea, Valentine, Henkel L., Abbosh, Phillip, Tagawa, Scott T., Nanus, David M., Nauseef, Jones T., Sternberg, Cora N., Molina, Ana M., Scherr, Douglas, Inghirami, Giorgio, Mosquera, Juan Miguel, Elemento, Olivier, Robine, Nicolas, Faltas, Bishoy M.

Source: Nature; November 2024, Vol. 635 Issue: 8037 p219-228, 10p

Rationale for co-targeting CDK4/6 and FGFR pathways in urothelial carcinoma

Authors: Shohdy, Kyrillus S., Vlachostergios, Panagiotis J., Abdel-Malek, Raafat R., Faltas, Bishoy M.

Source: Expert opinion on therapeutic targets. 23(2):83-86

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100075037432.0x000001&indx=1&recIds=ETOCvdc_100075037432.0x000001

The molecular limitations of biomarker research in bladder cancer

Authors: Vlachostergios, Panagiotis J., Faltas, Bishoy M.

Source: World journal of urology. 37(5):837-848

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125601027.0x000001&indx=1&recIds=ETOCvdc_100125601027.0x000001

Blocking immune checkpoints in prostate, kidney, and urothelial cancer: An overview

Authors: Alme, Angela K.B., Karir, Beerinder S., Faltas, Bishoy M., Drake, Charles G.

Source: In Urologic Oncology: Seminars and Original Investigations April 2016 34(4):171-181

Radical Cystectomy for Bladder Cancer in Patients With and Without a History of Pelvic Irradiation: Survival Outcomes and Diversion-related Complications

Authors: Nguyen, Daniel P., Al Hussein Al Awamlh, Bashir, Faltas, Bishoy M., O'Malley, Padraic, Ayangbesan, Abimbola, Inoyatov, Igor M., Scherr, Douglas S.

Source: In Urology July 2015 86(1):99-107

A Pilot Study on Hyperthermic Intraperitoneal Chemotherapy after Radical or Partial Cystectomy with Pelvic Lymph Node Dissection for High-risk Muscle-invasive Bladder Cancer

Authors: Borregales, Leonardo D., Venkat, Siv, Posada Calderon, Lina, Lewicki, Patrick, Flynn, Thomas, Faltas, Bishoy M., Molina, Ana M., Golombos, David M., O'Malley, Padraic, Scherr, Douglas S.

Source: In European Urology December 2023 84(6):604-606

Immunotherapy in the Treatment of Localized Genitourinary Cancers.

Authors: Necchi, Andrea, Faltas, Bishoy M., Slovin, Susan F., Meeks, Joshua J., Pal, Sumanta K., Schwartz, Lawrence H., Huang, Richard S. P., Li, Roger, Manley, Brandon, Chahoud, Jad, Ross, Jeffrey S., Spiess, Philippe E.

Source: JAMA Oncology; Oct2023, Vol. 9 Issue 10, p1447-1454, 8p

Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer

Authors: Klümper, Niklas, Cox, Alexander, Sjödahl, Gottfrid, Roghmann, Florian, Bolenz, Christian, Hartmann, Arndt, Grünwald, Viktor, Faltas, Bishoy M., Hölzel, Michael, Eckstein, Markus

Source: Nature Reviews Urology; 20240101, Issue: Preprints p1-12, 12p

A combinatorial genetic strategy for exploring complex genotype–phenotype associations in cancer

Authors: Li, Shan, Wong, Alicia, Sun, Huiyun, Bhatia, Vipul, Javier, Gerardo, Jana, Sujata, Wu, Qian, Montgomery, Robert B., Wright, Jonathan L., Lam, Hung-Ming, Hsieh, Andrew C., Faltas, Bishoy M., Haffner, Michael C., Lee, John K.

Source: Nature Genetics; 20240101, Issue: Preprints p1-6, 6p

Common germline-somatic variant interactions in advanced urothelial cancer

Authors: Vosoughi, Aram, Zhang, Tuo, Shohdy, Kyrillus S., Vlachostergios, Panagiotis J., Wilkes, David C., Bhinder, Bhavneet, Tagawa, Scott T., Nanus, David M., Molina, Ana M., Beltran, Himisha, Sternberg, Cora N., Motanagh, Samaneh, Robinson, Brian D., Xiang, Jenny, Fan, Xiao, Chung, Wendy K., Rubin, Mark A., Elemento, Olivier, Sboner, Andrea, Mosquera, Juan Miguel, Faltas, Bishoy M.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188959972.0x000001&indx=1&recIds=ETOCvdc_100188959972.0x000001

Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers

Authors: Sfakianos, John P., Daza, Jorge, Hu, Yang, Anastos, Harry, Bryant, Geoffrey, Bareja, Rohan, Badani, Ketan K., Galsky, Matthew D., Elemento, Olivier, Faltas, Bishoy M., Mulholland, David J.

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174608915.0x000001&indx=1&recIds=ETOCvdc_100174608915.0x000001

Metastasectomy in older adults with urothelial carcinoma: Population-based analysis of use and outcomes

Authors: Faltas, Bishoy M., Gennarelli, Renee L., Elkin, Elena, Nguyen, Daniel P., Hu, Jim, Tagawa, Scott T.

Source: In Urologic Oncology: Seminars and Original Investigations January 2018 36(1):9-9

Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling

Authors: Robinson, Brian D., Vlachostergios, Panagiotis J., Bhinder, Bhavneet, Liu, Weisi, Li, Kailyn, Moss, Tyler J., Bareja, Rohan, Park, Kyung, Tavassoli, Peyman, Cyrta, Joanna, Tagawa, Scott T., Nanus, David M., Beltran, Himisha, Molina, Ana M., Khani, Francesca, Miguel Mosquera, Juan, Xylinas, Evanguelos, Shariat, Shahrokh F., Scherr, Douglas S., Rubin, Mark A., Lerner, Seth P., Matin, Surena F., Elemento, Olivier, Faltas, Bishoy M.

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130876261.0x000001&indx=1&recIds=ETOCvdc_100130876261.0x000001