Expanding the repertoire reveals recurrent, cryptic, and hematopoietic HLA class I minor histocompatibility antigens

Authors: Fuchs, Kyra J., van de Meent, Marian, Honders, M. Willy, Khatri, Indu, Kester, Michel G. D., Koster, Eva A. S., Koutsoumpli, Georgia, de Ru, Arnoud H., van Bergen, Cornelis A. M., van Veelen, Peter A., ’t Hoen, Peter A. C., van Balen, Peter, van den Akker, Erik B., Veelken, J. Hendrik, Halkes, Constantijn J. M., Falkenburg, J. H. Frederik, Griffioen, Marieke

Source: In Blood 2 May 2024 143(18):1856-1872

Human T cells recognize HLA-DP–bound peptides in two orientations

Authors: Klobuch, Sebastian, Lim, Jia Jia, van Balen, Peter, Kester, Michel G. D., de Klerk, Wendy, de Ru, Arnoud H., Pothast, Cilia R., Jedema, Inge, Drijfhout, Jan W., Rossjohn, Jamie, Reid, Hugh H., van Veelen, Peter A., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Dec 01. 119(49), 1-9.

Access URL: https://www.jstor.org/stable/27209472

Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM

Authors: Meurer, Thuja ^*, Crivello, Pietro ^*, Metzing, Maximilian, Kester, Michel, Megger, Dominik A., Chen, Weiqiang, van Veelen, Peter A., van Balen, Peter, Westendorf, Astrid M., Homa, Georg, Layer, Sophia E., Turki, Amin T., Griffioen, Marieke, Horn, Peter A., Sitek, Barbara, Beelen, Dietrich W., Falkenburg, J. H. Frederik, Arrieta-Bolaños, Esteban, Fleischhauer, Katharina ^*

Source: In Blood 18 February 2021 137(7):923-928

A minority of T cells recognizing tumor-associated antigens presented in self-HLA can provoke antitumor reactivity

Authors: Roex, Marthe C.J. ^{1, 1}, Hageman, Lois ¹, Veld, Sabrina A.J. ¹, van Egmond, Esther ¹, Hoogstraten, Conny ¹, Stemberger, Christian ², Germeroth, Lothar ², Einsele, Hermann ³, Falkenburg, J. H. Frederik ¹, Jedema, Inge ¹

Source: In Blood 23 July 2020 136(4):455-467

Multiple Knockout of Classical HLA Class II β-Chains by CRISPR/Cas9 Genome Editing Driven by a Single Guide RNA

Authors: Crivello, Pietro, Ahci, Müberra, Maaßen, Fabienne, Wossidlo, Natalie, Arrieta-Bolaños, Esteban, Heinold, Andreas, Lange, Vinzenz, Falkenburg, J. H. Frederik, Horn, Peter A., Fleischhauer, Katharina

Source: Journal of immunology. 202(6):1895-1906

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN619448970&indx=1&recIds=ETOCRN619448970

Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure

Authors: Wachsmann, Tassilo L. A., Wouters, Anne K., Remst, Dennis F. G., Hagedoorn, Renate S., Meeuwsen, Miranda H., van Diest, Eline, Leusen, Jeanette, Kuball, Jürgen, Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

Source: Oncoimmunology. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168532684.0x000001&indx=1&recIds=ETOCvdc_100168532684.0x000001

Hotspot DNA Methyltransferase 3A (DNMT3A) and Isocitrate Dehydrogenase 1 and 2 (IDH1/2) Mutations in Acute Myeloid Leukemia and Their Relevance as Targets for Immunotherapy.

Authors: Struckman, Nadine E., de Jong, Rob C. M., Honders, M. Willy, Smith, Sophie-Anne I., van der Lee, Dyantha I., Koutsoumpli, Georgia, de Ru, Arnoud H., Mikesch, Jan-Henrik, van Veelen, Peter A., Falkenburg, J. H. Frederik, Griffioen, Marieke

Source: Biomedicines; May2024, Vol. 12 Issue 5, p1086, 17p

Subject Terms: ACUTE myeloid leukemia, ISOCITRATE dehydrogenase, PRELEUKEMIA, METHYLTRANSFERASES, TANDEM mass spectrometry, IMMUNOTHERAPY

Self-sufficient primary natural killer cells engineered to express T cell receptors and interleukin-15 exhibit improved effector function and persistence.

Authors: van Hees, Els P., Morton, Laura T., Remst, Dennis F. G., Wouters, Anne K., Van den Eynde, Astrid, Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

Source: Frontiers in Immunology; 2024, p1-12, 12p

Subject Terms: KILLER cells, T cell receptors, IMMUNE response, INTERLEUKIN-15, GENE expression

A flexible MHC class I multimer loading system for large-scale detection of antigen-specific T cells

Authors: Luimstra, Jolien J., Garstka, Malgorzata A., Roex, Marthe C. J., Redeker, Anke, Janssen, George M. C., van Veelen, Peter A., Arens, Ramon, Falkenburg, J. H. Frederik, Neefjes, Jacques, Ovaa, Huib

Source: Journal of experimental medicine. 215(5):1493-1504

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615832611&indx=1&recIds=ETOCRN615832611

High Mutation Frequency of the PIGA Gene in T Cells Results in Reconstitution of GPI Anchor^—/CD52^— T Cells That Can Give Early Immune Protection after Alemtuzumab-Based T Cell—Depleted Allogeneic Stem Cell Transplantation

Authors: Loeff, Floris C., Falkenburg, J. H. Frederik, Hageman, Lois, Huisman, Wesley, Veld, Sabrina A. J., van Egmond, H. M. Esther, van de Meent, Marian, von dem Borne, Peter A., Veelken, Hendrik, Halkes, Constantijn J. M.

Source: Journal of immunology. 200(6):2199-2208

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615198351&indx=1&recIds=ETOCRN615198351

Risk factors for graft-versus-host- disease after donor lymphocyte infusion following T-cell depleted allogeneic stem cell transplantation.

Authors: Koster, Eva A. S., von dem Borne, Peter A., van Balen, Peter, Marijt, Erik W. A., Tjon, Jennifer M. L., Snijders, Tjeerd J. F., van Lammeren, Daniëlle, Veelken, Hendrik, Falkenburg, J. H. Frederik, Halkes, Constantijn J. M., de Wreede, Liesbeth C.

Source: Frontiers in Immunology; 2024, p01-12, 12p

Subject Terms: STEM cell transplantation, DISEASE risk factors, LYMPHOPENIA, LYMPHOCYTES, T cells, MYELODYSPLASTIC syndromes

Combining BCMA-targeting CAR T cells with TCR-engineered T-cell therapy to prevent immune escape of multiple myeloma

Authors: Wachsmann, Tassilo L. A., Meeuwsen, Miranda H., Remst, Dennis F. G., Buchner, Karen, Wouters, Anne K., Hagedoorn, Renate S., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

Source: In Blood Advances 24 October 2023 7(20):6178-6183

Complement-dependent cytotoxicity induced by therapeutic antibodies in B-cell acute lymphoblastic leukemia is dictated by target antigen expression levels and augmented by loss of membrane-bound complement inhibitors

Authors: Loeff, Floris C., van Egmond, H. M. Esther, Nijmeijer, Bart A., Falkenburg, J. H. Frederik, Halkes, Constantijn J., Jedema, Inge

Source: Leukemia & lymphoma. 58(9):2185-2195

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100048570525.0x000001&indx=1&recIds=ETOCvdc_100048570525.0x000001

Therapeutic targeting of the BCR-associated protein CD79b in a TCR-based approach is hampered by aberrant expression of CD79b

Authors: Jahn, Lorenz ^*, Hombrink, Pleun, Hassan, Chopie, Kester, MichelG.D., van der Steen, Dirk M., Hagedoorn, Renate S., Falkenburg, J. H. Frederik, van Veelen, Peter A., Heemskerk, MirjamH.M.

Source: In Blood 5 February 2015 125(6):949-958

Naturally Processed Non-canonical HLA-A*02:01 Presented Peptides

Authors: Hassan, Chopie, Chabrol, Eric, Jahn, Lorenz, Kester, Michel G.D., de Ru, Arnoud H., Drijfhout, Jan W., Rossjohn, Jamie ^**, Falkenburg, J. H. Frederik, Heemskerk, Mirjam H.M., Gras, Stephanie, van Veelen, Peter A.

Source: In Journal of Biological Chemistry 30 January 2015 290(5):2593-2603

TCR targeting hematopoiesis to cure leukemia

Authors: Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

Source: Blood; September 2024, Vol. 144 Issue: 10 p1031-1033, 3p

CD4^+ T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation

Authors: Lamers, Cor H. J., Wijers, Rebecca, van Bergen, Comelis A. M., Somers, Judith A. E., Braakman, Eric, Gratama, Jan Willem, Debets, Reno, Falkenburg, J. H. Frederik, Cornelissen, Jan J.

Source: Blood. 128(17):2165-2174

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN608591837&indx=1&recIds=ETOCRN608591837

Long‐term in vitro persistence of magnetic properties after magnetic bead‐based cell separation of T cells

Authors: Laghmouchi, Aicha, Hoogstraten, Conny, Falkenburg, J. H. Frederik, Jedema, Inge

Source: Scandinavian journal of immunology. 92(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108147568.0x000001&indx=1&recIds=ETOCvdc_100108147568.0x000001

Characterization of the T-Cell-Mediated Immune Response Against the Aspergillus fumigatus Proteins Crf1 and Catalase 1 in Healthy Individuals

Authors: Jolink, Hetty, Meijssen, Isabelle C., Hagedoorn, Renate S., Arentshorst, Mark, Drijfhout, Jan W., Mulder, Arend, Claas, Frans H. J., van Dissel, Jaap T., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

Source: The Journal of Infectious Diseases, 2013 Sep 01. 208(5), 847-856.

Access URL: http://dx.doi.org/10.1093/infdis/jit237

Joint models quantify associations between immune cell kinetics and alloimmunological events after allogeneic stem cell transplantation and subsequent donor lymphocyte infusion.

Authors: Koster, Eva A. S., Bonneville, Edouard F., von dem Borne, Peter A., van Balen, Peter, Marijt, Erik W. A., Tjon, Jennifer M. L., Snijders, Tjeerd J. F., van Lammeren, Daniëlle, Veelken, Hendrik, Putter, Hein, Falkenburg, J. H. Frederik, Halkes, Constantijn J. M., de Wreede, Liesbeth C.

Source: Frontiers in Immunology; 2023, p1-14, 14p

Subject Terms: STEM cell transplantation, HEMATOPOIETIC stem cell transplantation, KILLER cells, LYMPHOCYTES