Targeting heparan sulfate proteoglycans as an effective strategy for inhibiting cancer cell migration and invasiveness compared to heparin.

Authors: Depau, Lorenzo, Brunetti, Jlenia, Falciani, Chiara, Mandarini, Elisabetta, Zanchi, Marta, Paolocci, Maria Francesca, Garfì, Marta, Pini, Alessandro, Bracci, Luisa

Source: Frontiers in Cell & Developmental Biology; 2025, p1-15, 15p

Subject Terms: CANCER cell differentiation, HEPARAN sulfate proteoglycans, EXTRACELLULAR matrix proteins, CANCER cell migration, EXTRACELLULAR matrix, HEPARIN

Branched oncolytic peptides target HSPGs, inhibit metastasis, and trigger the release of molecular determinants of immunogenic cell death in pancreatic cancer.

Authors: Rencinai, Alessandro, Tollapi, Eva, Marianantoni, Giulia, Brunetti, Jlenia, Henriquez, Tania, Pini, Alessandro, Bracci, Luisa, Falciani, Chiara

Source: Frontiers in Molecular Biosciences; 2024, p01-13, 13p

In vitro inhalation cytotoxicity testing of therapeutic nanosystems for pulmonary infection

Authors: Ritter, Detlef, Knebel, Jan, Niehof, Monika, Loinaz, Iraida, Marradi, Marco, Gracia, Raquel, te Welscher, Yvonne, van Nostrum, Cornelus F., Falciani, Chiara, Pini, Alessandro, Strandh, Magnus, Hansen, Tanja

Source: In Toxicology in Vitro March 2020 63

Antimicrobial activity of two novel antimicrobial peptides AA139 and SET-M33 against clinically and genotypically diverse Klebsiella pneumoniae isolates with differing antibiotic resistance profiles

Authors: van der Weide, Hessel, Vermeulen-de Jongh, Denise M.C., van der Meijden, Aart, Boers, Stefan A., Kreft, Deborah, ten Kate, Marian T., Falciani, Chiara, Pini, Alessandro, Strandh, Magnus, Bakker-Woudenberg, Irma A.J.M., Hays, John P., Goessens, Wil H.F.

Source: In International Journal of Antimicrobial Agents August 2019 54(2):159-166

An antimicrobial molecule mitigates signs of sepsis in vivo and eradicates infections from lung tissue

Authors: Quercini, Leila, Brunetti, Jlenia, Riolo, Giulia, Bindi, Stefano, Scali, Silvia, Lampronti, Ilaria, D'Aversa, Elisabetta, Wronski, Sabine, Pollini, Simona, Gentile, Mariangela, Lupetti, Pietro, Rossolini, Gian Maria, Falciani, Chiara, Bracci, Luisa, Pini, Alessandro

Source: FASEB journal. 34(1):192-207

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134552696.0x000001&indx=1&recIds=ETOCvdc_100134552696.0x000001

Antibacterial and Anti-Inflammatory Activity of Branched Peptides Derived from Natural Host Defense Sequences.

Authors: Meogrossi, Giada, Tollapi, Eva, Rencinai, Alessandro, Brunetti, Jlenia, Scali, Silvia, Paccagnini, Eugenio, Gentile, Mariangela, Lupetti, Pietro, Pollini, Simona, Rossolini, Gian Maria, Bernini, Andrea, Pini, Alessandro, Bracci, Luisa, Falciani, Chiara

Source: Journal of Medicinal Chemistry; 9/26/2024, Vol. 67 Issue 18, p16145-16156, 12p

Are periodontitis and psoriasis associated? A pre‐clinical murine model.

Authors: Marruganti, Crystal, Gaeta, Carlo, Falciani, Chiara, Cinotti, Elisa, Rubegni, Pietro, Alovisi, Mario, Scotti, Nicola, Baldi, Andrea, Bellan, Cristiana, Defraia, Chiara, Fiorino, Fabio, Valensin, Silvia, Bellini, Erika, De Rosa, Antonella, D'Aiuto, Francesco, Grandini, Simone

Source: Journal of Clinical Periodontology; Aug2024, Vol. 51 Issue 8, p1044-1053, 10p

Subject Terms: PSORIASIS, STATISTICAL sampling, MICE, EXPERIMENTAL design, ANIMAL experimentation, OSTEOCLASTS, INFLAMMATION, COMPARATIVE studies, PERIODONTITIS, INTERLEUKINS, TUMOR necrosis factors, DISEASE complications

Safety evaluations of a synthetic antimicrobial peptide administered intravenously in rats and dogs.

Authors: Cresti, Laura^1,2 (AUTHOR), Falciani, Chiara³ (AUTHOR), Cappello, Giovanni^2,3 (AUTHOR), Brunetti, Jlenia³ (AUTHOR), Vailati, Silvia⁴ (AUTHOR), Melloni, Elsa⁴ (AUTHOR), Bracci, Luisa^1,3 (AUTHOR), Pini, Alessandro^1,3 (AUTHOR) pinia@unisi.it

Source: Scientific Reports. 11/11/2022, Vol. 12 Issue 1, p1-18. 18p.

Subject Terms: *ANTIMICROBIAL peptides, *DOGS, *RESPIRATORY measurements, *LABORATORY dogs, *CLINICAL biochemistry, *RATS, *ANTIBIOTICS

Investigations into the killing activity of an antimicrobial peptide active against extensively antibiotic-resistant K. pneumon iae and P. aeruginosa

Authors: van der Weide, Hessel, Brunetti, Jlenia, Pini, Alessandro, Bracci, Luisa, Ambrosini, Chiara, Lupetti, Pietro, Paccagnini, Eugenio, Gentile, Mariangela, Bernini, Andrea, Niccolai, Neri, Jongh, Denise Vermeulen-de, Bakker-Woudenberg, Irma A.J.M., Goessens, Wil H.F., Hays, John P., Falciani, Chiara

Source: In BBA - Biomembranes October 2017 1859(10):1796-1804

Near-infrared quantum dots labelled with a tumor selective tetrabranched peptide for in vivo imaging

Authors: Brunetti, Jlenia, Riolo, Giulia, Gentile, Mariangela, Bernini, Andrea, Paccagnini, Eugenio, Falciani, Chiara, Lozzi, Luisa, Scali, Silvia, Depau, Lorenzo, Pini, Alessandro, Lupetti, Pietro, Bracci, Luisa

Source: Journal of nanobiotechnology. 16(1):1-10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161452807.0x000001&indx=1&recIds=ETOCvdc_100161452807.0x000001

Immunomodulatory and Anti-inflammatory Activity in Vitro and in Vivo of a Novel Antimicrobial Candidate

Authors: Brunetti, Jlenia ^{‡, 1}, Roscia, Giulia ^{‡, 1}, Lampronti, Ilaria ^§, Gambari, Roberto ^§, Quercini, Leila ^‡, Falciani, Chiara ^¶, Bracci, Luisa ^‡, Pini, Alessandro ^{‡, 2}

Source: In Journal of Biological Chemistry 2 December 2016 291(49):25742-25748

Models of In-Vivo Bacterial Infections for the Development of Antimicrobial Peptide-based Drugs

Authors: Brunetti, Jlenia, Falciani, Chiara, Bracci, Luisa, Pini, Alessandro

Source: Current topics in medicinal chemistry. 17(5):613-619

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094347855.0x000001&indx=1&recIds=ETOCvdc_100094347855.0x000001

The Development of Antimicrobial Peptides as New Antibacterial Drugs

Authors: Roscia, Giulia, Falciani, Chiara, Bracci, Luisa, Pini, Alessandro

Source: Current protein & peptide science. 14(8):641-649

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100027174627.0x000001&indx=1&recIds=ETOCETOCvdc_100027174627.0x000001

Regioselective functionalization of quinolin-4(1 H)-ones via sequential palladium-catalyzed reactions

Authors: Mugnaini, Claudia, Falciani, Chiara, De Rosa, Maria, Brizzi, Antonella, Pasquini, Serena, Corelli, Federico

Source: In Tetrahedron 2011 67(32):5776-5783

In Vivo Efficacy and Toxicity of an Antimicrobial Peptide in a Model of Endotoxin-Induced Pulmonary Inflammation.

Authors: Cresti, Laura, Cappello, Giovanni, Vailati, Silvia, Melloni, Elsa, Brunetti, Jlenia, Falciani, Chiara, Bracci, Luisa, Pini, Alessandro

Source: International Journal of Molecular Sciences; May2023, Vol. 24 Issue 9, p7967, 13p

Subject Terms: ANTIMICROBIAL peptides, PEPTIDES, ENDOTOXINS, PEPTIDE antibiotics, GRAM-negative bacteria, INFLAMMATION, BODY weight

Extracellular Vesicles of Pseudomonas : Friends and Foes.

Authors: Henriquez, Tania, Falciani, Chiara

Source: Antibiotics (2079-6382); Apr2023, Vol. 12 Issue 4, p703, 13p

Subject Terms: EXTRACELLULAR vesicles, PSEUDOMONAS, PSEUDOMONADACEAE, PSEUDOMONAS aeruginosa, GRAM-negative bacteria, DRUG resistance in bacteria, PSEUDOMONAS syringae

Inhalable Polymeric Nanoparticles for Pulmonary Delivery of Antimicrobial Peptide SET-M33: Antibacterial Activity and Toxicity In Vitro and In Vivo.

Authors: Cresti, Laura, Conte, Gemma, Cappello, Giovanni, Brunetti, Jlenia, Falciani, Chiara, Bracci, Luisa, Quaglia, Fabiana, Ungaro, Francesca, d'Angelo, Ivana, Pini, Alessandro

Source: Pharmaceutics; Jan2023, Vol. 15 Issue 1, p3, 20p

Subject Terms: ANTIMICROBIAL peptides, ANTIBACTERIAL agents, ACUTE toxicity testing, PEPTIDES, LUNG development

Branched peptides as bioactive molecules for drug design

Authors: Brunetti, Jlenia, Falciani, Chiara, Bracci, Luisa, Pini, Alessandro

Source: Peptide science. 110(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084452991.0x000001&indx=1&recIds=ETOCvdc_100084452991.0x000001

Antimicrobial Peptides Active in In Vitro Models of Endodontic Bacterial Infections Modulate Inflammation in Human Cardiac Fibroblasts.

Authors: Marianantoni, Giulia, Meogrossi, Giada, Tollapi, Eva, Rencinai, Alessandro, Brunetti, Jlenia, Marruganti, Crystal, Gaeta, Carlo, Pini, Alessandro, Bracci, Luisa, Ferrari, Marco, Grandini, Simone, Falciani, Chiara

Source: Pharmaceutics; Oct2022, Vol. 14 Issue 10, pN.PAG-N.PAG, 15p

Subject Terms: ANTIMICROBIAL peptides, BACTERIAL diseases, ANTIBIOTICS, FIBROBLASTS, ENDODONTICS, PEPTIDES

NEUROTENSIN-DERIVED BRANCHED PEPTIDES AND USES THEREOF