The S-layer protein of a Clostridium difficile SLCT-11 strain displays a complex glycan required for normal cell growth and morphology

Authors: Richards, Emma, Bouché, Laura, Panico, Maria, Arbeloa, Ana, Vinogradov, Evgeny, Morris, Howard, Wren, Brendan, Logan, Susan M., Dell, Anne, Fairweather, Neil F.

Source: In Journal of Biological Chemistry 23 November 2018 293(47):18123-18137

Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation

Authors: Charlton, Thomas M., Kovacs-Simon, Andrea, Michell, Stephen L., Fairweather, Neil F., Tate, Edward W.

Source: In Chemistry & Biology 19 November 2015 22(11):1562-1573

Cyclic diGMP Regulates Production of Sortase Substrates of Clostridium difficile and Their Surface Exposure through ZmpI Protease-mediated Cleavage

Authors: Peltier, Johann, Shaw, Helen A., Couchman, Edward C., Dawson, Lisa F., Yu, Lu, Choudhary, Jyoti S., Kaever, Volkhard, Wren, Brendan W., Fairweather, Neil F.

Source: In Journal of Biological Chemistry 2 October 2015 290(40):24453-24469

Extracellular DNA, cell surface proteins and c-di-GMP promote biofilm formation in Clostridioides difficile

Authors: Dawson, Lisa F., Peltier, Johann, Hall, Catherine L., Harrison, Mark A., Derakhshan, Maria, Shaw, Helen A., Fairweather, Neil F., Wren, Brendan W.

Source: Scientific reports. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194167189.0x000001&indx=1&recIds=ETOCvdc_100194167189.0x000001

Novel inhibitors of surface layer processing in Clostridium difficile

Authors: Tam Dang, T.H., Fagan, Robert P., Fairweather, Neil F., Tate, Edward W.

Source: In Bioorganic & Medicinal Chemistry 15 January 2012 20(2):614-621

Clostridium difficile Cell Wall Protein CwpV Undergoes Enzyme-independent Intramolecular Autoproteolysis

Authors: Dembek, Marcin, Reynolds, Catherine B., Fairweather, Neil F.

Source: In Journal of Biological Chemistry 6 January 2012 287(2):1538-1544

Clostridium difficile Has Two Parallel and Essential Sec Secretion Systems

Authors: Fagan, Robert P., Fairweather, Neil F.

Source: In Journal of Biological Chemistry 5 August 2011 286(31):27483-27493

Characterisation of a panel of anti-tetanus toxin single-chain Fvs reveals cooperative binding

Authors: Scott, Nathan, Qazi, Omar, Wright, Michael J., Fairweather, Neil F., Deonarain, Mahendra P.

Source: In Molecular Immunology June 2010 47(10):1931-1941

Four Distinct Structural Domains in Clostridium difficile Toxin B Visualized Using SAXS

Authors: Albesa-Jové, David, Bertrand, Thomas, Carpenter, Elisabeth P., Swain, Gemma V., Lim, Jenson, Zhang, Jiancheng, Haire, Lesley F., Vasisht, Nishi, Braun, Veit, Lange, Anton, von Eichel-Streiber, Christoph, Svergun, Dmitri I., Fairweather, Neil F., Brown, Katherine A.

Source: In Journal of Molecular Biology 12 March 2010 396(5):1260-1270

Structure and assembly of the S-layer in C. difficile.

Authors: Lanzoni-Mangutchi, Paola, Banerji, Oishik, Wilson, Jason, Barwinska-Sendra, Anna, Kirk, Joseph A., Vaz, Filipa, O’Beirne, Shauna, Baslé, Arnaud, El Omari, Kamel, Wagner, Armin, Fairweather, Neil F., Douce, Gillian R., Bullough, Per A., Fagan, Robert P., Salgado, Paula S.

Source: Nature Communications; 10/24/2022, Vol. 13 Issue 1, p1-8, 8p

Fusion proteins

Expression of tetanus toxin fragment C in yeast

Expression of recombinant proteins in attenuated bacteria

Expression of tetanus toxin fragment C

Expression of tetanus toxin fragment C in yeast

Vaccination against type F botulinum toxin using attenuated Salmonella enterica var Typhimurium strains expressing the BoNT/F H C fragment

Authors: Foynes, Susan, Holley, Jane L, Garmory, Helen S, Titball, Richard W, Fairweather, Neil F

Source: In Vaccine 2003 21(11):1052-1059

A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain.

Authors: Li, Yan, Foran, Patrick, Fairweather, Neil F.

Source: Biochemistry; June 7 1994, Vol. 33, p7014-7020, 7p

Cloning, nucleotide sequencing, and expression of tetanus toxin fragment C in Escherichia coli.

Authors: Fairweather, Neil F., Lyness, Valerie A., Pickard, Derek J.

Source: Journal of Bacteriology; January 1986, Vol. 165, p21-27, 7p

Cloning, nucleotide sequence and heterologous expression of the protective outer-membrane protein P.68 pertactin from Bordetella bronchiseptica.

Authors: Li, Jingli, Fairweather, Neil F., Novotny, Pavel

Source: Journal of General Microbiology; August 1992, Vol. 138, p1697-1705, 9p

The Crystal Structure of Tetanus Toxin Hc Fragment Complexed with a Synthetic GT1b Analogue Suggests Cross-linking between Ganglioside Receptors and the Toxin

Authors: Fotinou, Constantina ^‡, Emsley, Paul ^‡, Black, Isobel ^‡, Ando, Hiromune ^§, Ishida, Hideharu ^§, Kiso, Makoto ^§, Sinha, Katharine A. ^¶, Fairweather, Neil F. ^¶, Isaacs, Neil W. ^{‡, ‖}

Source: In Journal of Biological Chemistry 24 August 2001 276(34):32274-32281