Determining the pharmacological potential and biological role of linear pseudoscorpion toxins via functional profiling

Authors: Erkoc, Pelin ^{1, 2, 9}, Schiffmann, Susanne ^{2, 3, 9}, Ulshöfer, Thomas ^{2, 3}, Henke, Marina ^{2, 3}, Marner, Michael ⁴, Krämer, Jonas ^{5, 6}, Predel, Reinhard ⁵, Schäberle, Till F. ^{4, 6, 7}, Hurka, Sabine ^{2, 4}, Dersch, Ludwig ^{2, 4}, Vilcinskas, Andreas ^{2, 4, 6}, Fürst, Robert ^{2, 8, ∗}, Lüddecke, Tim ^{2, 4, 10, ∗∗}

Source: In iScience 19 July 2024 27(7)

(Homo-)harringtonine prevents endothelial inflammation through IRF-1 dependent downregulation of VCAM1 mRNA expression and inhibition of cell adhesion molecule protein biosynthesis

Authors: Burgers, Luisa D., Ciurus, Sarah, Engel, Patrick, Kuntschar, Silvia, Raue, Rebecca, Kiprina, Anastasiia, Primke, Tobias, Schmid, Tobias, Weigert, Andreas, Schmidtko, Achim, Fürst, Robert

Source: In Biomedicine & Pharmacotherapy July 2024 176

Human 5-lipoxygenase regulates transcription by association to euchromatin

Authors: Kreiß, Marius, Oberlis, Julia H., Seuter, Sabine, Bischoff-Kont, Iris, Sürün, Duran, Thomas, Dominique, Göbel, Tamara, Schmid, Tobias, Rådmark, Olof, Brandes, Ralf P., Fürst, Robert, Häfner, Ann-Kathrin, Steinhilber, Dieter

Source: In Biochemical Pharmacology September 2022 203

Inhibition of DYRK1B BY C81 impedes inflammatory processes in leukocytes by reducing STAT3 activity.

Authors: Ciurus, Sarah, Elewa, Mohammed A. F., Palmer, Megan A., Wolf, Anne, Hector, Mandy, Fuhrmann, Dominik C., Thomas, Dominique, Gurke, Robert, Schwalm, Martin P., Berger, Lena, Zech, Thomas J., Burgers, Luisa D., Marschalek, Rolf, Geisslinger, Gerd, Knapp, Stefan, Langmann, Thomas, Bracher, Franz, Weigert, Andreas, Fürst, Robert

Source: Cellular & Molecular Life Sciences; 2/22/2025, Vol. 82 Issue 1, p1-25, 25p

Subject Terms: MEDICAL sciences, INFLAMMATION, EICOSANOIDS, NATURAL products, KINASE inhibitors

Lecanoric acid mediates anti-proliferative effects by an M phase arrest in colon cancer cells

Authors: Roser, Luise A., Erkoc, Pelin, Ingelfinger, Rebecca, Henke, Marina, Ulshöfer, Thomas, Schneider, Ann-Kathrin, Laux, Volker, Geisslinger, Gerd, Schmitt, Imke, Fürst, Robert, Schiffmann, Susanne

Source: In Biomedicine & Pharmacotherapy April 2022 148

Nitroxoline and its derivatives are potent inhibitors of metallo-β-lactamases

Authors: Proschak, Anna, Martinelli, Giada, Frank, Denia, Rotter, Marco J., Brunst, Steffen, Weizel, Lilia, Burgers, Luisa D., Fürst, Robert, Proschak, Ewgenij, Sosič, Izidor, Gobec, Stanislav, Wichelhaus, Thomas A.

Source: In European Journal of Medicinal Chemistry 15 January 2022 228

The natural product vioprolide A exerts anti-inflammatory actions through inhibition of its cellular target NOP14 and downregulation of importin-dependent NF-ĸB p65 nuclear translocation

Authors: Burgers, Luisa D., Luong, Betty, Li, Yanfen, Fabritius, Matthias P., Michalakis, Stylianos, Reichel, Christoph A., Müller, Rolf, Fürst, Robert

Source: In Biomedicine & Pharmacotherapy December 2021 144

Identification of novel anti-cancer agents by the synthesis and cellular screening of a noscapine-based library

Authors: Nemati, Faezeh, Bischoff-Kont, Iris, Salehi, Peyman, Nejad-Ebrahimi, Samad, Mohebbi, Maryam, Bararjanian, Morteza, Hadian, Nasim, Hassanpour, Zahra, Jung, Yvonne, Schaerlaekens, Sofie, Lucena-Agell, Daniel, Oliva, María A., Fürst, Robert, Nasiri, Hamid R.

Source: In Bioorganic Chemistry October 2021 115

Xenocoumacin 2 reduces protein biosynthesis and inhibits inflammatory and angiogenesis-related processes in endothelial cells

Authors: Erkoc, Pelin, Schmitt, Michaela, Ingelfinger, Rebecca, Bischoff-Kont, Iris, Kopp, Larissa, Bode, Helge B., Schiffmann, Susanne, Fürst, Robert

Source: In Biomedicine & Pharmacotherapy August 2021 140

Narciclasine inhibits angiogenic processes by activation of Rho kinase and by downregulation of the VEGF receptor 2

Authors: Bräutigam, Jacqueline, Bischoff, Iris, Schürmann, Christoph, Buchmann, Giulia, Epah, Jeremy, Fuchs, Simone, Heiss, Elke, Brandes, Ralf P., Fürst, Robert

Source: In Journal of Molecular and Cellular Cardiology October 2019 135:97-108

Concise Synthesis of 1, 4‐Benzoquinone‐Based Natural Products as Mitochondrial Complex I Substrates and Substrate‐Based Inhibitors

Authors: Han, Zhenyu, Angerer, Heike, Bischoff, Iris, Qin, Yihan, Stegmann, Dennis, Tuz, Karina, Fritz, Günter, Juarez, Oscar, Fürst, Robert, Lashley, Dana, Nasiri, Hamid R.

Source: ChemMedChem. 15(24):2491-2499

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112199732.0x000001&indx=1&recIds=ETOCvdc_100112199732.0x000001

Welche Pflanzen können bei Leber-/Galleleiden helfen?

Authors: Zündorf, Ilse, Fürst, Robert

Source: Zeitschrift für Phytotherapie. 41(1):5-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187780574.0x000001&indx=1&recIds=ETOCvdc_100187780574.0x000001

Silymarin-Extrakt aus Silybum marianum (L.) Gaertn. gegen alimentär-toxische Leberschäden?

Authors: Jobst, Detmar, Kraft, Karin, Feistel, Björn, Fürst, Robert

Source: Zeitschrift für Phytotherapie. 41(1):32-36

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187780597.0x000001&indx=1&recIds=ETOCvdc_100187780597.0x000001

Pharmaco-epidemiological research on herbal medicinal products in the paediatric population: data from the PhytoVIS study

Authors: Nieber, Karen, Raskopf, Esther, Möller, Johanna, Kelber, Olaf, Fürst, Robert, Shah-Hosseini, Kija, Singh, Jaswinder, Kraft, Karin, Mösgens, Ralph

Source: European journal of pediatrics. 179(3):507-512

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164308306.0x000001&indx=1&recIds=ETOCvdc_100164308306.0x000001

Diversely evolved xibalbin variants from remipede venom inhibit potassium channels and activate PKA-II and Erk1/2 signaling.

Authors: Pinheiro-Junior, Ernesto Lopes, Alirahimi, Ehsan, Peigneur, Steve, Isensee, Jörg, Schiffmann, Susanne, Erkoc, Pelin, Fürst, Robert, Vilcinskas, Andreas, Sennoner, Tobias, Koludarov, Ivan, Hempel, Benjamin-Florian, Tytgat, Jan, Hucho, Tim, von Reumont, Björn M.

Source: BMC Biology; 7/29/2024, Vol. 22 Issue 1, p1-27, 27p

Subject Terms: POTASSIUM channels, VENOM, SODIUM channels, CALCIUM channels, POTASSIUM antagonists, SENSORY neurons

In vitro evaluation of a biomaterial-based anticancer drug delivery system as an alternative to conventional post-surgery bone cancer treatment

Authors: Bischoff, Iris, Tsaryk, Roman, Chai, Feng, Fürst, Robert, Kirkpatrick, Charles James, Unger, Ronald E.

Source: In Materials Science & Engineering C 1 December 2018 93:115-124

Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition

Authors: Glatzel, Daniel K. ^*, Koeberle, Andreas ^†, Pein, Helmut ^†, Löser, Konstantin ^†, Stark, Anna ^*, Keksel, Nelli ^§, Werz, Oliver ^†, Müller, Rolf ^**, Bischoff, Iris ^*, Fürst, Robert ^*

Source: In Journal of Lipid Research February 2018 59(2):298-311

Promoter Activation in Δhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing

Authors: Bode, Edna, Heinrich, Antje K., Hirschmann, Merle, Abebew, Desalegne, Shi, Yan‐Ni, Vo, Tien Duy, Wesche, Frank, Shi, Yi‐Ming, Grün, Peter, Simonyi, Svenja, Keller, Nadine, Engel, Yvonne, Wenski, Sebastian, Bennet, Reuel, Beyer, Sophie, Bischoff, Iris, Buaya, Anthony, Brandt, Sophie, Cakmak, Ibrahim, Çimen, Harun, Eckstein, Simone, Frank, Denia, Fürst, Robert, Gand, Martin, Geisslinger, Gerd, Hazir, Selcuk, Henke, Marina, Heermann, Ralf, Lecaudey, Virginie, Schäfer, Wilhelm, Schiffmann, Susanne, Schüffler, Anja, Schwenk, Rebecca, Skaljac, Marisa, Thines, Eckhard, Thines, Marco, Ulshöfer, Thomas, Vilcinskas, Andreas, Wichelhaus, Thomas A., Bode, Helge B.

Source: Angewandte Chemie. 131(52):19133-19139

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137114778.0x000001&indx=1&recIds=ETOCvdc_100137114778.0x000001

Narciclasine exerts anti‐inflammatory actions by blocking leukocyte–endothelial cell interactions and down‐regulation of the endothelial TNF receptor 1

Authors: Stark, Anna, Schwenk, Rebecca, Wack, Gesine, Zuchtriegel, Gabriele, Hatemler, Melissa G., Bräutigam, Jacqueline, Schmidtko, Achim, Reichel, Christoph A., Bischoff, Iris, Fürst, Robert

Source: FASEB journal. 33(8):8771-8781

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108053804.0x000001&indx=1&recIds=ETOCvdc_100108053804.0x000001

ELOM-080 as Add-On Treatment for Respiratory Tract Diseases – A Review of Clinical Studies Conducted in China

Authors: Fürst, Robert, Luong, Betty, Thomsen, Jörn, Wittig, Thomas

Source: Planta medica. 85(9/10):745-754

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186784404.0x000001&indx=1&recIds=ETOCvdc_100186784404.0x000001