Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury

Authors: Irina Petrache, Elisabet Pujadas, Aditya Ganju, Karina A. Serban, Alexander Borowiec, Beatrice Babbs, Irina A. Bronova, Nicholas Egersdorf, Patrick S. Hume, Khushboo Goel, William J. Janssen, Evgeny V. Berdyshev, Carlos Cordon-Cardo, Richard Kolesnick

Source: JCI Insight, Vol 8, Iss 10 (2023)

Subject Terms: COVID-19, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/941d1f0f2b0b4a3796435b73218fab88

Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy

Authors: Matthew J. Justice, Irina Bronova, Kelly S. Schweitzer, Christophe Poirier, Janice S. Blum, Evgeny V. Berdyshev, Irina Petrache

Source: Journal of Lipid Research, Vol 59, Iss 4, Pp 596-606 (2018)

Subject Terms: lysosome, sphingolipids, membrane, endothelial cells, lung, sphingosine, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520339110; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/da0ad77a0abe46929b832b8710148ec7

Sphingosine 1 Phosphate (S1P) Receptor 1 Is Decreased in Human Lung Microvascular Endothelial Cells of Smokers and Mediates S1P Effect on Autophagy

Authors: Khushboo Goel, Erica L. Beatman, Nicholas Egersdorf, April Scruggs, Danting Cao, Evgeny V. Berdyshev, Kelly S. Schweitzer, Irina Petrache

Source: Cells, Vol 10, Iss 5, p 1200 (2021)

Subject Terms: sphingolipids, lung microvascular endothelial cells, chronic obstructive pulmonary disease, autophagy, apoptosis, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/10/5/1200; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/7ba37c51607a47de8a609cbdefb5168f

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression[S]

Authors: Irina Gorshkova, Tong Zhou, Biji Mathew, Jeffrey R. Jacobson, Daisuke Takekoshi, Palash Bhattacharya, Brett Smith, Bulent Aydogan, Ralph R. Weichselbaum, Viswanathan Natarajan, Joe G.N. Garcia, Evgeny V. Berdyshev

Source: Journal of Lipid Research, Vol 53, Iss 8, Pp 1553-1568 (2012)

Subject Terms: sphingosine-1-phospate, dihydrosphingosine-1-phosphate, myriocin, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520418590; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/51f1dd75cab0445c9c1f5a09c28aed9c

Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate[S]

Authors: Deanna L. Siow, Charles D. Anderson, Evgeny V. Berdyshev, Anastasia Skobeleva, Stuart M. Pitson, Binks W. Wattenberg

Source: Journal of Lipid Research, Vol 51, Iss 9, Pp 2546-2559 (2010)

Subject Terms: sphingolipid metabolism, lipid kinase, phosphorylated sphingolipid, sphingosine-1-phosphate lyase, sphingosine, ceramide, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520422850; https://doaj.org/toc/0022-2275

Access URL: https://doaj.org/article/b9694a204b6142418dad7ed55abb33d5

Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo.

Authors: Jose L. Tomsig, Ashley H. Snyder, Evgeny V. Berdyshev, Anastasia Skobeleva, Chifundo Mataya, Viswanathan Natarajan, David N. Brindley, Kevin R. Lynch

Source: Biochemical Journal; May2009, Vol. 419 Issue 3, p611-618, 8p

Subject Terms: PHOSPHATASES, LYSOPHOSPHOLIPIDS, LIPIDS, CELL proliferation, CELL growth, WOUND healing, BLOOD platelets

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Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation.

Authors: Satish Kalari, Nagabhushan Moolky, Srikanth Pendyala, Evgeny V Berdyshev, Cleo Rolle, Rajani Kanteti, Archana Kanteti, Wenli Ma, Donghong He, Aliya N Husain, Hedy L Kindler, Prasad Kanteti, Ravi Salgia, Viswanathan Natarajan

Source: PLoS ONE, Vol 7, Iss 9, p e45330 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3444486?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/cceb3ea0c27c4fb0bf82c7b82837b92b

Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase.

Authors: Evgeny V Berdyshev, Irina Gorshkova, Peter Usatyuk, Satish Kalari, Yutong Zhao, Nigel J Pyne, Susan Pyne, Roger A Sabbadini, Joe G N Garcia, Viswanathan Natarajan

Source: PLoS ONE, Vol 6, Iss 1, p e16571 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3031585?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/cc99e3f2d99b49cfbd0f1ee6c9092044