Development and validation of the Normalized Organoid Growth Rate (NOGR) metric in brightfield imaging-based assays

Authors: Christophe Deben, Edgar Cardenas De La Hoz, Felicia Rodrigues Fortes, Maxim Le Compte, Sofie Seghers, Steve Vanlanduit, Hendrik Vercammen, Bert Van Den Bogert, Nelson Dusetti, Abraham Lin, Geert Roeyen, Marc Peeters, Hans Prenen, Filip Lardon, Evelien Smits

Source: Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/ccaa7af0afca4fca9dfbdb7f33073087

Characterization of regulated cancer cell death pathways induced by the different modalities of non-thermal plasma treatment

Authors: Eline Biscop, Jana Baroen, Joey De Backer, Wim Vanden Berghe, Evelien Smits, Annemie Bogaerts, Abraham Lin

Source: Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2058-7716

Access URL: https://doaj.org/article/ab4bad6b74104f2f913d5e83908a3ce9

Effect of plasma-induced oxidation on NK cell immune checkpoint ligands: A computational-experimental approach

Authors: Pepijn Heirman, Hanne Verswyvel, Mauranne Bauwens, Maksudbek Yusupov, Jorrit De Waele, Abraham Lin, Evelien Smits, Annemie Bogaerts

Source: Redox Biology, Vol 77, Iss , Pp 103381- (2024)

Subject Terms: Non-thermal plasma, Natural killer cells, Immune checkpoints, Cancer immunotherapy, Umbrella sampling, Oxidative stress, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231724003598; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/cffa3a7a5a524d159e342ddbedc9e089

Protocol for genomic editing in human resting primary NK cells and NK-92 cells via CRISPR-Cas9 ribonucleoproteins

Authors: Tias Verhezen, Ho Wa Lau, Jonas Van Audenaerde, An Wouters, Evelien Smits, Jorrit De Waele

Source: STAR Protocols, Vol 5, Iss 3, Pp 103123- (2024)

Subject Terms: cancer, immunology, CRISPR, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166724002880; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/34be51c4937340bc921941d7ca0f8a8c

Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition

Authors: Christophe Deben, Laurie Freire Boullosa, Felicia Rodrigues Fortes, Edgar Cardenas De La Hoz, Maxim Le Compte, Sofie Seghers, Marc Peeters, Steve Vanlanduit, Abraham Lin, Krijn K. Dijkstra, Paul Van Schil, Jeroen M. H. Hendriks, Hans Prenen, Geert Roeyen, Filip Lardon, Evelien Smits

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)

Subject Terms: Auranofin Repurposing, NSCLC and PDAC Therapy, RNAseq Biomarkers, Drug Synergy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/8c03f6975c524c59adae79b1d8c7f709

IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts

Authors: Astrid Van den Eynde, Laura Gehrcken, Tias Verhezen, Ho Wa Lau, Christophe Hermans, Hilde Lambrechts, Tal Flieswasser, Delphine Quatannens, Gils Roex, Karen Zwaenepoel, Elly Marcq, Philippe Joye, Edgar Cardenas De La Hoz, Christophe Deben, Alessia Gasparini, Pierre Montay-Gruel, Maxim Le Compte, Eva Lion, Filip Lardon, Steven Van Laere, Vasiliki Siozopoulou, Diana Campillo-Davo, Jorrit De Waele, Patrick Pauwels, Julie Jacobs, Evelien Smits, Jonas R. M. Van Audenaerde

Source: Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-19 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/8761eb0063d942beb968b458b3b522ca

Single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer

Authors: Maxim Le Compte, Edgar Cardenas De La Hoz, Sofía Peeters, Felicia Rodrigues Fortes, Christophe Hermans, Andreas Domen, Evelien Smits, Filip Lardon, Timon Vandamme, Abraham Lin, Steve Vanlanduit, Geert Roeyen, Steven Van Laere, Hans Prenen, Marc Peeters, Christophe Deben

Source: npj Precision Oncology, Vol 7, Iss 1, Pp 1-14 (2023)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2397-768X

Access URL: https://doaj.org/article/6632e8a47737498b80b21ca813df1b57

Lack of functional TCR-epitope interaction is associated with herpes zoster through reduced downstream T cell activation

Authors: Marlies Boeren, Nicky de Vrij, My K. Ha, Sebastiaan Valkiers, Aisha Souquette, Sofie Gielis, Mariia Kuznetsova, Jolien Schippers, Esther Bartholomeus, Johan Van den Bergh, Nele Michels, Olivier Aerts, Julie Leysen, An Bervoets, Julien Lambert, Elke Leuridan, Johan Wens, Karin Peeters, Marie-Paule Emonds, George Elias, Niels Vandamme, Hilde Jansens, Wim Adriaensen, Arvid Suls, Stijn Vanhee, Niel Hens, Evelien Smits, Pierre Van Damme, Paul G. Thomas, Philippe Beutels, Peter Ponsaerts, Viggo Van Tendeloo, Peter Delputte, Kris Laukens, Pieter Meysman, Benson Ogunjimi

Source: Cell Reports, Vol 43, Iss 4, Pp 114062- (2024)

Subject Terms: CP: Immunology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724003905; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/0b4efad8a12a42feb58eab2d4fa7e411

Site-specific 68Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models

Authors: Jonatan Dewulf, Tal Flieswasser, Tim Delahaye, Christel Vangestel, Alan Miranda, Hans de Haard, Julie Jacobs, Evelien Smits, Tim Van den Wyngaert, Filipe Elvas

Source: EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-15 (2023)

Subject Terms: CD70, Nanobody, ImmunoPET, Tumor imaging, Cancer, Medical physics. Medical radiology. Nuclear medicine, R895-920, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2365-421X

Access URL: https://doaj.org/article/527f1504ab2342e59911d47fa04d8a86

Trial watch: chemotherapy-induced immunogenic cell death in oncology

Authors: Jenny Sprooten, Raquel S. Laureano, Isaure Vanmeerbeek, Jannes Govaerts, Stefan Naulaerts, Daniel M. Borras, Lisa Kinget, Jitka Fucíková, Radek Špíšek, Lenka Palová Jelínková, Oliver Kepp, Guido Kroemer, Dmitri V. Krysko, An Coosemans, Rianne D.W. Vaes, Dirk De Ruysscher, Steven De Vleeschouwer, Els Wauters, Evelien Smits, Sabine Tejpar, Benoit Beuselinck, Sigrid Hatse, Hans Wildiers, Paul M. Clement, Peter Vandenabeele, Laurence Zitvogel, Abhishek D. Garg

Source: OncoImmunology, Vol 12, Iss 1 (2023)

Subject Terms: CAR T cells, antigen-presenting cells, chemotherapy, danger signals, dendritic cell, immune-checkpoint blockers, immunogenic cell death, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/7008e019d7c247f4ac120beabac8edc7

Targeting CD70 in combination with chemotherapy to enhance the anti-tumor immune effects in non-small cell lung cancer

Authors: Tal Flieswasser, Astrid Van den Eynde, Laurie Freire Boullosa, Jöran Melis, Christophe Hermans, Céline Merlin, Ho Wa Lau, Jonas Van Audenaerde, Filip Lardon, Evelien Smits, Patrick Pauwels, Julie Jacobs

Source: OncoImmunology, Vol 12, Iss 1 (2023)

Subject Terms: CD70, chemotherapy, combination therapy, immunotherapy, non-small cell lung cancer, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/917fde71ee3a406dbdd2c8728bea3a41

The CD70-CD27 axis in oncology: the new kids on the block

Authors: Tal Flieswasser, Astrid Van den Eynde, Jonas Van Audenaerde, Jorrit De Waele, Filip Lardon, Carsten Riether, Hans de Haard, Evelien Smits, Patrick Pauwels, Julie Jacobs

Source: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-15 (2022)

Subject Terms: CD70, CD27, Hematopoiesis, Oncology, Hematological malignancies, Solid tumors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/43959fe709de45ec82f9d86338cc5c84

In vitro expansion of Wilms’ tumor protein 1 epitope-specific primary T cells from healthy human peripheral blood mononuclear cells

Authors: Sanne van der Heijden, Donovan Flumens, Maarten Versteven, Stefanie Peeters, Hans De Reu, Diana Campillo-Davo, Yannick Willemen, Benson Ogunjimi, Viggo Van Tendeloo, Zwi N. Berneman, Sébastien Anguille, Evelien Smits, Eva Lion

Source: STAR Protocols, Vol 4, Iss 1, Pp 102053- (2023)

Subject Terms: Cell Biology, Cell Culture, Cell Isolation, Flow Cytometry/Mass Cytometry, Cancer, Health Sciences, Science (General), Q1-390

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666166723000114; https://doaj.org/toc/2666-1667

Access URL: https://doaj.org/article/00e507c283384e738fce78407e768998

Trial watch: Dendritic cell (DC)-based immunotherapy for cancer

Authors: Raquel S Laureano, Jenny Sprooten, Isaure Vanmeerbeerk, Daniel M Borras, Jannes Govaerts, Stefan Naulaerts, Zwi N Berneman, Benoit Beuselinck, Kalijn F Bol, Jannie Borst, an Coosemans, Angeliki Datsi, Jitka Fučíková, Lisa Kinget, Bart Neyns, Gerty Schreibelt, Evelien Smits, Rüdiger V Sorg, Radek Spisek, Kris Thielemans, Sandra Tuyaerts, Steven De Vleeschouwer, I Jolanda M de Vries, Yanling Xiao, Abhishek D Garg

Source: OncoImmunology, Vol 11, Iss 1 (2022)

Subject Terms: Dendritic cells, DAMPs, TAAs, antigen cross-presentation, T cell priming, immune checkpoint blockers, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-402X

Access URL: https://doaj.org/article/be78d83094d145fe958410723c8c8404

The pro- and anti-tumoral properties of gap junctions in cancer and their role in therapeutic strategies

Authors: Maria C. Oliveira, Hanne Verswyvel, Evelien Smits, Rodrigo M. Cordeiro, Annemie Bogaerts, Abraham Lin

Source: Redox Biology, Vol 57, Iss , Pp 102503- (2022)

Subject Terms: Gap junctions, Anti-cancer immunity, Oxidative stress, Bystander effect, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231722002750; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/0af25333717b4ebe9ebf4a889438de68

The prognostic impact of the immune signature in head and neck squamous cell carcinoma

Authors: Hasan Baysal, Vasiliki Siozopoulou, Hannah Zaryouh, Christophe Hermans, Ho Wa Lau, Hilde Lambrechts, Erik Fransen, Ines De Pauw, Julie Jacobs, Marc Peeters, Patrick Pauwels, Jan Baptist Vermorken, Evelien Smits, Filip Lardon, Jorrit De Waele, An Wouters

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: squamous cell carcinoma of the head and neck (HNSCC), the Cancer Genome Atlas (TCGA), immune composition, immune checkpoint ligands, prognostic markers, clinicopathological characteristics, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1001161/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/c58e7c1d2db342af9441c51ad1dbe781

The effect of local non‐thermal plasma therapy on the cancer‐immunity cycle in a melanoma mouse model

Authors: Abraham Lin, Joey De Backer, Delphine Quatannens, Bart Cuypers, Hanne Verswyvel, Edgar Cardenas De La Hoz, Bart Ribbens, Vasiliki Siozopoulou, Jonas Van Audenaerde, Elly Marcq, Filip Lardon, Kris Laukens, Steve Vanlanduit, Evelien Smits, Annemie Bogaerts

Source: Bioengineering & Translational Medicine, Vol 7, Iss 3, Pp n/a-n/a (2022)

Subject Terms: cancer‐immunity cycle, cancer therapy, cold atmospheric plasma, melanoma, non‐thermal plasma, plasma oncology, Chemical engineering, TP155-156, Biotechnology, TP248.13-248.65, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2380-6761

Access URL: https://doaj.org/article/17eb6880cebd4836b899d3e52353311c

NTRK Fusions in a Sarcomas Series: Pathology, Molecular and Clinical Aspects

Authors: Vasiliki Siozopoulou, Elly Marcq, Koen De Winne, Koen Norga, Gertjan Schmitz, Valerie Duwel, Philippe Delvenne, Evelien Smits, Patrick Pauwels

Source: Pathology and Oncology Research, Vol 28 (2022)

Subject Terms: sarcoma, prognosis, NTRK fusion, TRK immunohistochemistry, NTRK fusion partner, histology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Pathology, RB1-214

File Description: electronic resource

Relation: https://www.por-journal.com/articles/10.3389/pore.2022.1610423/full; https://doaj.org/toc/1532-2807

Access URL: https://doaj.org/article/0c194190c2a14a9a8d6fd0293ef53a92

Anti-Tumor Potency of Short-Term Interleukin-15 Dendritic Cells Is Potentiated by In Situ Silencing of Programmed-Death Ligands

Authors: Maarten Versteven, Donovan Flumens, Diana Campillo-Davó, Hans De Reu, Laura Van Bruggen, Stefanie Peeters, Viggo Van Tendeloo, Zwi Berneman, Harry Dolstra, Sébastien Anguille, Willemijn Hobo, Evelien Smits, Eva Lion

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: dendritic cells, interleukin-15, programmed death (PD)-1, programmed death 1 ligand, siRNA, Wilms’ tumor 1 (WT1), Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.734256/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e0e0883d60f5415c9f97216c8a1d9417

Preexisting memory CD4 T cells in naïve individuals confer robust immunity upon hepatitis B vaccination

Authors: George Elias, Pieter Meysman, Esther Bartholomeus, Nicolas De Neuter, Nina Keersmaekers, Arvid Suls, Hilde Jansens, Aisha Souquette, Hans De Reu, Marie-Paule Emonds, Evelien Smits, Eva Lion, Paul G Thomas, Geert Mortier, Pierre Van Damme, Philippe Beutels, Kris Laukens, Viggo Van Tendeloo, Benson Ogunjimi

Source: eLife, Vol 11 (2022)

Subject Terms: CD4 T cell, T cell receptor, TCR repertoire, vaccination, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/68388; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/ef8d3322e4b24849bf9e4eef3c1cad40