PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease

Authors: Sachan, Vatsal, Le Dévéhat, Maïlys, Roubtsova, Anna, Essalmani, Rachid, Laurendeau, Jean-Francois, Garçon, Damien, Susan-Resiga, Delia, Duval, Stéphanie, Mikaeeli, Sahar, Hamelin, Josée, Evagelidis, Alexandra, Chong, Michael, Paré, Guillaume, Chernetsova, Elizabeta, Gao, Zu-Hua, Robillard, Isabelle, Ruiz, Matthieu, Trinh, Vincent Quoc-Huy, Estall, Jennifer L., Faraj, May, Austin, Richard C., Sauvageau, Martin, Prat, Annik, Kiss, Robert S., Seidah, Nabil G.

Source: In Metabolism January 2024 150

Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: Functional regulation of LDLR levels

Authors: Fruchart Gaillard, Carole, Ouadda, Ali Ben Djoudi, Ciccone, Lidia, Girard, Emmanuelle, Mikaeeli, Sepideh, Evagelidis, Alexandra, Le Dévéhat, Maïlys, Susan-Resiga, Delia, Lajeunesse, Evelyne Cassar, Nozach, Hervé, Ramos, Oscar Henrique Pereira, Thureau, Aurélien, Legrand, Pierre, Prat, Annik, Dive, Vincent, Seidah, Nabil G.

Source: In Molecular Metabolism January 2023 67

Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin

Authors: Susan-Resiga, Delia, Girard, Emmanuelle, Essalmani, Rachid, Roubtsova, Anna, Marcinkiewicz, Jadwiga, Derbali, Rabeb M., Evagelidis, Alexandra, Byun, Jae H., Lebeau, Paul F., Austin, Richard C., Seidah, Nabil G.

Source: In Journal of Biological Chemistry October 2021 297(4)

The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity

Authors: Durand, Loreleï, Duval, Stéphanie, Evagelidis, Alexandra, Guillemot, Johann, Dianati, Vahid, Sikorska, Emilia, Schu, Peter ^**, Day, Robert, Seidah, Nabil G.

Source: In Journal of Biological Chemistry 14 February 2020 295(7):2068-2083

Corrigendum to “PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease” [Metabolism Volume 150, January 2024, 155736, PMID: 7967646]

Authors: Sachan, Vatsal, LeDévéhat, Maïlys, Roubtsova, Anna, Essalmani, Rachid, Laurendeau, Jean-Francois, Garçon, Damien, Susan-Sesiga, Delia, Duval, Stéphanie, Mikaeeli, Sahar, Hamelin, Josée, Evagelidis, Alexandra, Chong, Michael, Paré, Guillaume, Chernetsova, Elizabeta, Gao, Zu-Hua, Robillard, Isabelle, Ruiz, Matthieu, Trinh, Vincent Quoc-Huy, Estall, Jennifer L., Faraj, May, Austin, Richard C., Sauvageau, Martin, Prat, Annik, Kiss, Robert S., Seidah, Nabil G.

Source: In Metabolism December 2024 161

Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor)

Authors: Ben Djoudi Ouadda, Ali, Gauthier, Marie-Soleil, Susan-Resiga, Delia, Girard, Emmanuelle, Essalmani, Rachid, Black, Miles, Marcinkiewicz, Jadwiga, Forget, Diane, Hamelin, Josée, Evagelidis, Alexandra, Ly, Kevin, Day, Robert, Galarneau, Luc, Corbin, Francois, Coulombe, Benoit, Çaku, Artuela, Tagliabracci, Vincent S., Seidah, Nabil G.

Source: Arteriosclerosis, thrombosis, and vascular biology. 39(10):1996-2013

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100089122379.0x000001&indx=1&recIds=ETOCvdc_100089122379.0x000001

Stimulatory and Inhibitory Protein Kinase C Consensus Sequences Regulate the Cystic Fibrosis Transmembrane Conductance Regulator

Authors: Chappe, Valerie, Hinkson, Deborah A., Howell, L. Daniel, Evagelidis, Alexandra, Liao, Jie, Chang, Xiu-Bao, Riordan, John R., Hanrahan, John W.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2004 Jan 01. 101(1), 390-395.

Access URL: https://www.jstor.org/stable/3148430

Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C.

Authors: Mikaeeli, Sepideh, Ben Djoudi Ouadda, Ali, Evagelidis, Alexandra, Essalmani, Rachid, Ramos, Oscar Henrique Pereira, Fruchart-Gaillard, Carole, Seidah, Nabil G.

Source: Cells (2073-4409); May2024, Vol. 13 Issue 10, p857, 28p

Subject Terms: HISTOCOMPATIBILITY class I antigens, TRAFFIC regulations, IRON in the body, FAMILIAL hypercholesterolemia, PROTEIN-protein interactions, PROTEINS

SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-to-Cell Fusion via Activation of SREBP-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2.

Authors: Essalmani, Rachid, Andréo, Ursula, Evagelidis, Alexandra, Le Dévéhat, Maïlys, Pereira Ramos, Oscar Henrique, Fruchart Gaillard, Carole, Susan-Resiga, Delia, Cohen, Éric A., Seidah, Nabil G.

Source: Viruses (1999-4915); Feb2023, Vol. 15 Issue 2, p360, 23p

Subject Terms: PROPROTEIN convertases, ANGIOTENSIN converting enzyme, METALLOPROTEINASES, SARS-CoV-2, CATALYTIC domains, VIRAL envelope proteins

PKC phosphorylation modulates PKA-dependent binding of the R domain to other domains of CFTR.

Authors: Seavilleklein, Gage, Amer, Noha, Evagelidis, Alexandra

Source: American Journal of Physiology; November 2008 pt1, Vol. 295 Issue 5, pC1366-C1375, 10p

Asymmetric structure of the cystic fibrosis transmembrane conductance regulator chloride pore suggested by mutagenesis of the twelfth transmembrane region.

Authors: Gupta, Jyoti, Evagelidis, Alexandra, Hanrahan, John W.

Source: Biochemistry; June 5 2001, Vol. 40 Issue 22, p6620-6627, 8p

Role of protein phosphatases in the activation of CFTR (ABCC7) by genistein and bromotetramisole.

Authors: Luo, Jiexin, Zhu, Tang, Evagelidis, Alexandra

Source: American Journal of Physiology; July 2000 pt1, Vol. 279 Issue 1, pC108-C119, 12p

Molecular Determinants of Anion Selectivity in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore

Authors: Linsdell, Paul, Evagelidis, Alexandra, Hanrahan, John W.

Source: In Biophysical Journal 2000 78(6):2973-2982

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CFTR Regulation by Phosphorylation.

Authors: Walker, John M., Skach, William R., Zhu, Tang, Deborah A. R., Hinkson, Dahan, David, Evagelidis, Alexandra, Hanrahan, John W.

Source: Cystic Fibrosis Methods & Protocols; 2002, p99-109, 11p

Enhanced Ca²⁺ entry due to Orail plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways.

Authors: Balghi, Haouaria, Robert, Renaud, Rappaz, Benjamin, Xuexin Zhang, Wohlhuter-Haddad, Adeline, Evagelidis, Alexandra, Luo, Yishan, Goepp, Julie, Ferraro, Pasquale, Romto, Philippe, Trebak, Mohamed, Wiseman, Paul W., Thomas, David Y., Hanrahan, John W.

Source: FASEB Journal; Dec2011, Vol. 25 Issue 12, p4274-4291, 18p

Subject Terms: CYSTIC fibrosis, LUNG diseases, GENETIC disorders, ENDOPLASMIC reticulum, ORGANELLES

Phosphorylation of CFTR by PKA promotes binding of the regulatory domain.

Authors: Chappe, Valerie, Irvine, Thomas, Jie Liao, Evagelidis, Alexandra, Hanrahan, John W.

Source: EMBO Journal; 8/3/2005, Vol. 24 Issue 15, p2730-2740, 11p

Subject Terms: PHOSPHORYLATION, GLYCOSYLATION, CYSTIC fibrosis, PROTEIN kinases, NUCLEOTIDES, MESSENGER RNA

Regulation of the CFTR channel by phosphorylation.

Authors: Dahan, David, Evagelidis, Alexandra, Hanrahan, John W., Hinkson, Deborah A. R., Jia, Yanlin, Luo, Jiexin, Zhu, Tang

Source: Pflügers Archiv: European Journal of Physiology; Nov2001 Supplement 1, Vol. 443, pS92-S96, 5p

Subject Terms: CYSTIC fibrosis, GENETIC disorders, PANCREATIC diseases, LUNG diseases, PROTEIN kinases, PHOSPHATASES

Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity.

Authors: Essalmani, Rachid¹, Jain, Jaspreet², Susan-Resiga, Delia¹, Andréo, Ursula^1,2, Evagelidis, Alexandra¹, Derbali, Rabeb Mouna¹, Huynh, David N.¹, Dallaire, Frédéric², Laporte, Mélanie³, Delpal, Adrien³, Sutto-Ortiz, Priscila³, Coutard, Bruno⁴, Mapa, Claudine⁵, Wilcoxen, Keith⁵, Decroly, Etienne³, Pham, Tram N.Q.², Cohen, Éric A.^2,6 eric.cohen@ircm.qc.ca, Seidah, Nabil G.¹ seidahn@ircm.qc.ca

Source: Journal of Virology. Apr2022, Vol. 96 Issue 8, p1-24. 24p.

Subject Terms: *SARS-CoV-2, *CHIMERIC proteins